| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I N Rozhkova, S V Okotrub, E Yu Brusentsev, K E Uldanova, E А Chuyko, V A Naprimerov, T V Lipina, T G Amstislavskaya, S Ya Amstislavsk. Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 2. 2023-04-17. PMID:37063509. |
thus, a change in social-conditioned place preference in clstn2-ko mice as well as a higher number of neurons expressing type 2 dopamine receptors and tyrosine hydroxylase in the vta, the key structure of the mesolimbic dopaminergic pathway, were observed. |
2023-04-17 |
2023-08-14 |
mouse |
| Julia E R Nickols, Serdar M Dursun, Anna M W Taylo. Preclinical evidence for the use of the atypical antipsychotic, brexpiprazole, for opioid use disorder. Neuropharmacology. 2023-04-17. PMID:37068603. |
recently, the use of dopamine partial agonists has been proposed as a potential strategy to restore dopaminergic signalling during drug withdrawal, while avoiding the adverse side effects associated with stronger modulators of dopaminergic transmission. |
2023-04-17 |
2023-08-14 |
mouse |
| Yoon-Sang Oh, Joong-Seok Kim, Chul Hyoung Lyoo, Hosung Ki. Obstructive Sleep Apnea and Striatal Dopamine Availability in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-04-13. PMID:37046390. |
striatal dopamine uptake is a surrogate marker of nigral dopaminergic cell damage. |
2023-04-13 |
2023-08-14 |
Not clear |
| Zevelou Koza, Mohamad Ayajuddin, Abhik Das, Rahul Chaurasia, Limamanen Phom, Sarat Chandra Yenisett. Sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: Insights from Frontiers in neuroscience. vol 17. 2023-04-07. PMID:37025374. |
sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: insights from sexual dysfunction (sd) is one of the most common non-motor symptoms of parkinson's disease (pd) and remains the most neglected, under-reported, and under-recognized aspect of pd. |
2023-04-07 |
2023-08-14 |
Not clear |
| Brianna Cocuzzo, Kristy A Fisher, Clara L Alvarez Villalb. Neuroleptic Malignant Syndrome Status Post Anoxic Brain Injury: A Case Presentation of Heightened Susceptibility in the Brain Injury Population. Cureus. vol 15. issue 3. 2023-04-07. PMID:37025743. |
further investigation is necessary to expand upon the existing literature suggesting the role of alternative agents, including amantadine, due to its impact on dopaminergic transmission, as well as dopamine and glutamine release. |
2023-04-07 |
2023-08-14 |
Not clear |
| Purnima Padmanabhan, Agostina Casamento-Moran, Aram Kim, Anthony J Gonzalez, Alexander Pantelyat, Ryan T Roemmich, Vikram S Chi. Dopamine facilitates the translation of physical exertion into assessments of effort. NPJ Parkinson's disease. vol 9. issue 1. 2023-04-03. PMID:37005418. |
to test dopamine's role in the translation of effortful exertion into assessments of effort, we had participants with parkinson's disease, in dopamine depleted (off dopaminergic medication) and elevated (on dopaminergic medication) states, exert levels of physical exertion and retrospectively assess how much effort they exerted. |
2023-04-03 |
2023-08-14 |
human |
| Berhanu Geresu Kibret, Ana Canseco-Alba, Emmanuel S Onaivi, Ephrem Engidawor. Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation. Frontiers in behavioral neuroscience. vol 17. 2023-04-03. PMID:37009000. |
crosstalk between the endocannabinoid and mid-brain dopaminergic systems: implication in dopamine dysregulation. |
2023-04-03 |
2023-08-14 |
Not clear |
| Berhanu Geresu Kibret, Ana Canseco-Alba, Emmanuel S Onaivi, Ephrem Engidawor. Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation. Frontiers in behavioral neuroscience. vol 17. 2023-04-03. PMID:37009000. |
the cross-talk between the ecs and the dopaminergic system has important influence in various dopamine-related neurobiological and pathologic conditions and investigating this interaction might help identify therapeutic targets and options in disorders of the cns associated with dopamine dysregulation. |
2023-04-03 |
2023-08-14 |
Not clear |
| Juan Segura-Aguilar, Bengt Mannervi. A Preclinical Model for Parkinson's Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978921. |
the presence of neuromelanin-containing dopaminergic neurons in the postmortem brain of healthy elderly people suggests that neuromelanin synthesis is a normal and harmless process despite the fact that it requires oxidation of dopamine to three ortho-quinones that are potentially toxic, especially aminochrome. |
2023-03-29 |
2023-08-14 |
Not clear |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Héctor Alberto González-Usigli, Genaro Gabriel Ortiz, Claudia Charles-Niño, Mario Alberto Mireles-Ramírez, Fermín Paul Pacheco-Moisés, Blanca Miriam de Guadalupe Torres-Mendoza, José de Jesús Hernández-Cruz, Daniela Lucero Del Carmen Delgado-Lara, Luis Javier Ramírez-Jiran. Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson's Disease: A Basic and Clinical Approach. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979318. |
the main histopathological hallmarks of parkinson's disease (pd) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Héctor Alberto González-Usigli, Genaro Gabriel Ortiz, Claudia Charles-Niño, Mario Alberto Mireles-Ramírez, Fermín Paul Pacheco-Moisés, Blanca Miriam de Guadalupe Torres-Mendoza, José de Jesús Hernández-Cruz, Daniela Lucero Del Carmen Delgado-Lara, Luis Javier Ramírez-Jiran. Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson's Disease: A Basic and Clinical Approach. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979318. |
the destruction of the striatal dopaminergic pathway and blocking of striatal dopamine receptors cause motor deficits in humans and experimental animal models induced by some environmental agents. |
2023-03-29 |
2023-08-14 |
Not clear |
| Jana Lubec, Ahmed M Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Höger, Gert Lube. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979402. |
although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (dat) inhibitors are not sufficiently specific as they also target other transporters and receptors, thus showing unwanted side effects. |
2023-03-29 |
2023-08-14 |
rat |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
we evaluated the impact of the inflammatory pain in the vta synapses by performing immunohistochemical characterization of specific markers for gabaergic (gad65/67) and dopaminergic neurons (dopamine transporter (dat), dopamine d2 receptor (d2r) and tyrosine hydroxylase (th)). |
2023-03-29 |
2023-08-14 |
rat |
| Cherish A Taylor, Stephanie M Grant, Thomas Jursa, Ashvini Melkote, Rebecca Fulthorpe, Michael Aschner, Donald R Smith, Rueben A Gonzales, Somshuvra Mukhopadhya. SLC30A10 manganese transporter in the brain protects against deficits in motor function and dopaminergic neurotransmission under physiological conditions. Metallomics : integrated biometal science. 2023-03-29. PMID:36990693. |
the neuromotor dysfunction of adult pan-neuronal/glial slc30a10 knockouts was associated with a profound reduction in evoked striatal dopamine release without dopaminergic neurodegeneration or changes in striatal tissue dopamine levels. |
2023-03-29 |
2023-08-14 |
mouse |
| Jessica C Nelson, Hannah Shoenhard, Michael Granat. Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity. PLoS genetics. vol 19. issue 3. 2023-03-27. PMID:36972301. |
moreover, we find that in module 1 the palmitoyltransferase hip14 cooperates with dopamine and nmda signaling to drive habituation, while in module 3 the adaptor protein complex subunit ap2s1 drives habituation by antagonizing dopamine signaling, revealing two distinct and opposing roles for dopaminergic neuromodulation in the regulation of behavioral plasticity. |
2023-03-27 |
2023-08-14 |
zebrafish |
| Iris Titos, Alen Juginović, Alexandra Vaccaro, Keishi Nambara, Pavel Gorelik, Ofer Mazor, Dragana Rogulj. A gut-secreted peptide suppresses arousability from sleep. Cell. 2023-03-23. PMID:36958331. |
ccha1 signals to a small group of dopamine neurons in the brain to modulate their activity; the dopaminergic activity regulates the behavioral responsiveness of animals to vibrations. |
2023-03-23 |
2023-08-14 |
mouse |
| Chonghui Wei, Xuan Xie, Yue Mou, Shiqi Cheng, Jin Yang, Kaixin Xue, Kewei Yu, Xinru Lin, Chunfen Zhang, Yujie Zhao, Xingyu Luo, Yilin Wan. Controllable synthesis of MoS The Analyst. 2023-03-20. PMID:36938870. |
controllable synthesis of mos dopamine (da) plays an essential role in dopaminergic neuronal behavior and disease. |
2023-03-20 |
2023-08-14 |
Not clear |
| Michael Freissmut. Regulated Rapid Round Trips: Endocytotic Cycling of the Dopamine Transporter Shapes Motor Learning. The Journal of biological chemistry. 2023-03-19. PMID:36935007. |
they showed that dat cycling in the presynaptic specialization of dopaminergic neurons is subject to control by a cell-autonomous loop comprising dopamine autoreceptors and metabotropic glutamate receptors. |
2023-03-19 |
2023-08-14 |
mouse |
| Bethany Keen, Adam Cawley, Brian Reedy, Glenys Noble, Jaymie Loy, Shanlin F. 3-Methoxytyrosine as an indicator of dopaminergic manipulation in equine plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1220. 2023-03-18. PMID:36933516. |
the use of catechol-o-methyltransferase inhibitors may mask doping agents, primarily levodopa, administered to racehorses and prolong the stimulating effects of dopaminergic compounds such as dopamine. |
2023-03-18 |
2023-08-14 |
Not clear |