| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Héctor Alberto González-Usigli, Genaro Gabriel Ortiz, Claudia Charles-Niño, Mario Alberto Mireles-Ramírez, Fermín Paul Pacheco-Moisés, Blanca Miriam de Guadalupe Torres-Mendoza, José de Jesús Hernández-Cruz, Daniela Lucero Del Carmen Delgado-Lara, Luis Javier Ramírez-Jiran. Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson's Disease: A Basic and Clinical Approach. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979318. |
the main histopathological hallmarks of parkinson's disease (pd) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Héctor Alberto González-Usigli, Genaro Gabriel Ortiz, Claudia Charles-Niño, Mario Alberto Mireles-Ramírez, Fermín Paul Pacheco-Moisés, Blanca Miriam de Guadalupe Torres-Mendoza, José de Jesús Hernández-Cruz, Daniela Lucero Del Carmen Delgado-Lara, Luis Javier Ramírez-Jiran. Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson's Disease: A Basic and Clinical Approach. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979318. |
the destruction of the striatal dopaminergic pathway and blocking of striatal dopamine receptors cause motor deficits in humans and experimental animal models induced by some environmental agents. |
2023-03-29 |
2023-08-14 |
Not clear |
| Jana Lubec, Ahmed M Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Höger, Gert Lube. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979402. |
although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (dat) inhibitors are not sufficiently specific as they also target other transporters and receptors, thus showing unwanted side effects. |
2023-03-29 |
2023-08-14 |
rat |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
we evaluated the impact of the inflammatory pain in the vta synapses by performing immunohistochemical characterization of specific markers for gabaergic (gad65/67) and dopaminergic neurons (dopamine transporter (dat), dopamine d2 receptor (d2r) and tyrosine hydroxylase (th)). |
2023-03-29 |
2023-08-14 |
rat |
| Cherish A Taylor, Stephanie M Grant, Thomas Jursa, Ashvini Melkote, Rebecca Fulthorpe, Michael Aschner, Donald R Smith, Rueben A Gonzales, Somshuvra Mukhopadhya. SLC30A10 manganese transporter in the brain protects against deficits in motor function and dopaminergic neurotransmission under physiological conditions. Metallomics : integrated biometal science. 2023-03-29. PMID:36990693. |
the neuromotor dysfunction of adult pan-neuronal/glial slc30a10 knockouts was associated with a profound reduction in evoked striatal dopamine release without dopaminergic neurodegeneration or changes in striatal tissue dopamine levels. |
2023-03-29 |
2023-08-14 |
mouse |
| Jessica C Nelson, Hannah Shoenhard, Michael Granat. Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity. PLoS genetics. vol 19. issue 3. 2023-03-27. PMID:36972301. |
moreover, we find that in module 1 the palmitoyltransferase hip14 cooperates with dopamine and nmda signaling to drive habituation, while in module 3 the adaptor protein complex subunit ap2s1 drives habituation by antagonizing dopamine signaling, revealing two distinct and opposing roles for dopaminergic neuromodulation in the regulation of behavioral plasticity. |
2023-03-27 |
2023-08-14 |
zebrafish |
| Iris Titos, Alen Juginović, Alexandra Vaccaro, Keishi Nambara, Pavel Gorelik, Ofer Mazor, Dragana Rogulj. A gut-secreted peptide suppresses arousability from sleep. Cell. 2023-03-23. PMID:36958331. |
ccha1 signals to a small group of dopamine neurons in the brain to modulate their activity; the dopaminergic activity regulates the behavioral responsiveness of animals to vibrations. |
2023-03-23 |
2023-08-14 |
mouse |
| Chonghui Wei, Xuan Xie, Yue Mou, Shiqi Cheng, Jin Yang, Kaixin Xue, Kewei Yu, Xinru Lin, Chunfen Zhang, Yujie Zhao, Xingyu Luo, Yilin Wan. Controllable synthesis of MoS The Analyst. 2023-03-20. PMID:36938870. |
controllable synthesis of mos dopamine (da) plays an essential role in dopaminergic neuronal behavior and disease. |
2023-03-20 |
2023-08-14 |
Not clear |
| Michael Freissmut. Regulated Rapid Round Trips: Endocytotic Cycling of the Dopamine Transporter Shapes Motor Learning. The Journal of biological chemistry. 2023-03-19. PMID:36935007. |
they showed that dat cycling in the presynaptic specialization of dopaminergic neurons is subject to control by a cell-autonomous loop comprising dopamine autoreceptors and metabotropic glutamate receptors. |
2023-03-19 |
2023-08-14 |
mouse |
| Bethany Keen, Adam Cawley, Brian Reedy, Glenys Noble, Jaymie Loy, Shanlin F. 3-Methoxytyrosine as an indicator of dopaminergic manipulation in equine plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1220. 2023-03-18. PMID:36933516. |
the use of catechol-o-methyltransferase inhibitors may mask doping agents, primarily levodopa, administered to racehorses and prolong the stimulating effects of dopaminergic compounds such as dopamine. |
2023-03-18 |
2023-08-14 |
Not clear |
| Max V McDermott, Akila Ram, Matthew T Mattoon, Emmaline E Haderlie, Megan C Raddatz, Madi K Thomason, Erin N Bobec. A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice. Pharmacology, biochemistry, and behavior. 2023-03-18. PMID:36933620. |
in the major dopaminergic structure, the ventral tegmental area (vta), gpr171 appeared to be primarily localized in dopamine neurons while prosaas is outside of dopamine neurons. |
2023-03-18 |
2023-08-14 |
mouse |
| Jenny-Ann Phan, Dean F Wong, Natalie H S Chang, Yoshitaka Kumakura, William R Bauer, Albert Gjedd. Transient equilibrium determination of dopamine D Frontiers in nuclear medicine (Lausanne, Switzerland). vol 2. 2023-03-17. PMID:36926525. |
transient equilibrium determination of dopamine d long-term alteration of dopaminergic neurotransmission is known to modulate the d |
2023-03-17 |
2023-08-14 |
Not clear |
| Timothy H C Cheung, Yunmin Ding, Xiaoxi Zhuang, Un Jung Kan. Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 12. 2023-03-15. PMID:36920928. |
these findings suggest that reinforcement and maintenance of movements-even movements not leading to explicit rewards-are fundamental functions of dopamine and provide potential mechanisms for the hitherto unexplained "long-duration response" by dopaminergic therapies in pd. |
2023-03-15 |
2023-08-14 |
mouse |
| Zhengjie Yang, Yijie Xie, Kaixin Dou, Liying Yang, Anmu Xi. Associations of striatal dopamine transporter binding with motor and non-motor symptoms in early Parkinson's disease. Clinical and translational science. 2023-03-14. PMID:36915231. |
dopamine transporter (dat) imaging is an in vivo tool to assess presynaptic dopaminergic function in the clinical practices of parkinson's disease (pd). |
2023-03-14 |
2023-08-14 |
Not clear |
| Emily DiMarco, Renata Sadibolova, Angela Jiang, Brittany Liebenow, Rachel E Jones, Ihtsham Ul Haq, Mustafa S Siddiqui, Devin B Terhune, Kenneth T Kishid. Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909605. |
decreasing striatal dopamine efficacy is at the core of parkinson's disease (pd) motor symptoms and changes in dopaminergic action have been associated with many comorbid non-motor symptoms in pd. |
2023-03-13 |
2023-08-14 |
Not clear |
| Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-Ii Choi, Lars Olson, Barry J Hoffer, Kuan-Yin Tsen. PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902115. |
to explore dopaminergic transmission, fast scan cyclic voltammetry (fscv) was utilized to measure presynaptic dopamine (da) dynamics in striatal slices following drug treatments. |
2023-03-11 |
2023-08-14 |
mouse |
| Francesco Porta, Alessandro Neirotti, Marco Spad. Restless legs syndrome in DNAJC12 deficiency. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-10. PMID:36897462. |
its pathogenesis is hypothesized to involve the dopaminergic system, also in the light of the response of rls to ex adiuvantibus treatment with dopamine agonists. |
2023-03-10 |
2023-08-14 |
Not clear |
| Renata Matraszek-Gawron, Mirosława Chwil, Karol Terlecki, Michał Marian Skoczyla. Current Knowledge of the Antidepressant Activity of Chemical Compounds from Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-03-08. PMID:36678554. |
this systematic review on antidepressant compounds in saffron crocus and their mechanisms of action and side effects is based on publications released between 1995−2022 and data indexed in 15 databases under the following search terms: antidepressant effect, central nervous system, crocus sativus, cognitive impairement, crocin, crocetin, depression, dopamine, dopaminergic and serotonergic systems, picrocrocin, phytotherapy, neurotransmitters, safranal, saffron, serotonin, and biologically active compounds. |
2023-03-08 |
2023-08-16 |
Not clear |
| Hongli Li, Min Gao, Ziyu Chen, Zhenyu Zhou, Wei Li, Xiaoyang Zhang, Xi Jiang, Lingling Luo, Fei Li, Gaorui Wang, Yu Zhang, Xingxu Huang, Jingning Zhu, Shengjie Fan, Xiaojun Wu, Cheng Huan. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytotherapy research : PTR. 2023-03-08. PMID:36883794. |
parkinson's disease (pd) is a chronic neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and the striatum, leading to dopamine (da) deficiency in the striatum and typical motor symptoms. |
2023-03-08 |
2023-08-14 |
mouse |