| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nace Mikus, Sebastian Korb, Claudia Massaccesi, Christian Gausterer, Irene Graf, Matthäus Willeit, Christoph Eisenegger, Claus Lamm, Giorgia Silani, Christoph Mathy. Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers. eLife. vol 11. 2022-12-05. PMID:36468832. |
drugs that target opioid and dopamine receptors are notorious for inducing maladaptive habitual drug consumption; yet, how the opioidergic and dopaminergic neurotransmitter systems contribute to the arbitration between habitual and goal-directed behaviour is poorly understood. |
2022-12-05 |
2023-08-14 |
human |
| Xin Liu, Zhao-Yan Cheng, Yan-Feng Li, Chao Liu, Chen Wang, Gong Xiao-Jian, Ling H. Dopamine D2 receptor agonist Bromocriptine ameliorates Aβ European journal of pharmacology. 2022-12-05. PMID:36470446. |
studies have shown that the dysfunction of the dopaminergic system is related to a variety of pathophysiology of ad, and the expression of dopamine d2 receptor (drd2) in the brains of ad patients and animal models is significantly downregulated, suggesting that drd2 may represent a therapeutic target for ad. |
2022-12-05 |
2023-08-14 |
Not clear |
| P Sivakumar, K B Nagashanmugam, S Priyatharshni, R Lavanya, N Prabhu, S Ponnusam. Review on the interactions between dopamine metabolites and α-Synuclein in causing Parkinson's disease. Neurochemistry international. 2022-12-02. PMID:36460239. |
it is generally believed that dopamine (da) metabolite in dopaminergic (daergic) neurons promotes the aggregation of toxic α-syn oligomers and protofibrils, whereas da inhibits the formation of toxic fibers and even degrades the toxic fibers. |
2022-12-02 |
2023-08-14 |
Not clear |
| Ashley C Parr, Heidi C Riek, Brian C Coe, Giovanna Pari, Mario Masellis, Connie Marras, Douglas P Muno. Genetic Variation in the Dopamine System is Associated with Mixed-Strategy Decision-Making in Parkinson's Patients. The European journal of neuroscience. 2022-12-01. PMID:36453013. |
using a within-subject, multi-center design, patients were examined on and off dopaminergic therapy, and genetic variation was examined via a multilocus genetic profile score representing the additive effects of three single nucleotide polymorphisms (snps) that influence dopamine transmission: rs4680 (comt val |
2022-12-01 |
2023-08-14 |
human |
| Shuai-Nan Zhang, Hong-Mei Li, Qi Liu, Xu-Zhao Li, Wu-de Yang, Ying Zho. Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson's disease against oxidative stress and neuroexcitatory toxicity. Biomedical chromatography : BMC. 2022-12-01. PMID:36453605. |
in the pd model, st and its active compounds (caffeic acid and gallic acid) may protect dopaminergic neurons (maximum recovery rate for dopamine: 49.5%) from oxidative stress (prkn, ros, no, etc.) |
2022-12-01 |
2023-08-14 |
mouse |
| Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Huiyan Sun, Hongquan Wan. Salsolinol Induces Parkinson's Disease Through Activating NLRP3-Dependent Pyroptosis and the Neuroprotective Effect of Acteoside. Neurotoxicity research. 2022-12-01. PMID:36454451. |
endogenous neurotoxin 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroiso-quinoline (salsolinol, sal) is a dopamine metabolite that is toxic to dopaminergic neurons in vitro and in vivo, and is involved in the pathogenesis of parkinson's disease (pd). |
2022-12-01 |
2023-08-14 |
mouse |
| Yongjun Wang, Zhengjia Pu, Yiran Zhang, Zhaohui Du, Zeming Guo, Qunhua Ba. Exercise training has a protective effect in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model with improved neural and intestinal pathology and modified intestinal flora. Behavioural brain research. 2022-12-01. PMID:36455673. |
the results showed in these pd mice, exercise training improved their motility, increased the dopamine (da) content in the striatum, along with promoted the gene expression of tyrosine hydroxylase and brain-derived neurotrophic factor in the striatum, which suggests this exercise training might protect striatal dopaminergic neurons from mptp damage; the results also showed exercise training promoted recovery from ileal pathology, reduced the gene expression of intestinal inflammatory factors, and significantly altered the composition and structure of the intestinal flora in these mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Taejeong Kim, Hyun Jin Kim, Wonseok Choi, Yeong Mi Lee, Jung Hyun Pyo, Junseok Lee, Jeesu Kim, Jihoon Kim, Joung-Hun Kim, Chulhong Kim, Won Jong Ki. Deep brain stimulation by blood-brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound. Nature biomedical engineering. 2022-12-01. PMID:36456857. |
the release of nitric oxide temporarily disrupted tight junctions in the blood-brain barrier, allowing for the accumulation of the nanoparticles into brain parenchyma, and the piezoelectrically induced output current stimulated the release of dopamine by dopaminergic neuron-like cells. |
2022-12-01 |
2023-08-14 |
mouse |
| Xiaofeng Wang, Naixu Shi, Baiao Wu, Lin Yuan, Jiapeng Chen, Cong Ye, Miao Ha. Bioinformatics analysis of gene expression profile and functional analysis in periodontitis and Parkinson's disease. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36437997. |
the hub genes were then subjected to go enrichment analysis, which revealed that the dopamine biosynthetic process, dopaminergic synapse and dopamine-binding terms, and dopaminergic synapse and serotonergic synapse pathways were primarily where they were expressed. |
2022-11-28 |
2023-08-14 |
Not clear |
| Aleksandra Pytel, Jan Aleksander Beszlej, Monika Biercewicz, Anna Roszmann, Dorota Krówczyńska, Aleksandra Kołtuniu. The Effect of Frailty Syndrome on the Quality of Life of Individuals with Parkinson's Disease: A Pilot Observational and Multicenter Study on the Polish Population. International journal of environmental research and public health. vol 19. issue 22. 2022-11-26. PMID:36429942. |
parkinson's disease (pd) is a neurodegenerative disorder involving decreased dopamine release and atrophy of dopaminergic neurons of the substantia nigra. |
2022-11-26 |
2023-08-14 |
Not clear |
| Laura A Struzyna, Kevin D Browne, Justin C Burrell, Wisberty J Gordián Vélez, Kathryn L Wofford, Hilton M Kaplan, N Sanjeeva Murthy, H Isaac Chen, John E Duda, Rodrigo A España, D Kacy Culle. Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430464. |
immunohistochemistry and fscv established that transplanted te-nsps survived, maintained their axonal tract projections, extended dopaminergic neurites into host tissue, and released dopamine in the striatum. |
2022-11-26 |
2023-08-14 |
rat |
| Carmen Costas-Ferreira, Társila Romero, Rafael Durán, Lilian R F Far. Role of voltage-sensitive Ca Toxicology letters. 2022-11-25. PMID:36427774. |
these results show that gla-induced dopamine release could be produced by the activation of a wide range of striatal vscc located at the synaptic terminals and axons of striatal dopaminergic neurons, especially n-type vscc. |
2022-11-25 |
2023-08-14 |
Not clear |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
our small molecule-based protocol generates highly enriched midbrain dopaminergic (mda) neurons: molecular identity was confirmed using single-cell rna sequencing and proteomics, and functional identity was established through dopamine synthesis, and measures of electrophysiological activity. |
2022-11-24 |
2023-08-14 |
human |
| Ganesh R Pawar, Yogeeta O Agrawal, Kartik T Nakhate, Chandragouda R Patil, Charu Sharma, Shreesh Ojha, Umesh B Mahajan, Sameer N Goya. Ghrelin alleviates depression-like behaviour in rats subjected to high-fat diet and diurnal rhythm disturbance. American journal of translational research. vol 14. issue 10. 2022-11-18. PMID:36398212. |
while depression is associated with dopamine dysfunction in the ventral tegmental area (vta), ghrelin enhances the dopaminergic activity in the vta. |
2022-11-18 |
2023-08-14 |
rat |
| Zachary Gaertner, Maite Azcorra, Daniel A Dombeck, Rajeshwar Awatraman. Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology. Neurobiology of disease. 2022-11-13. PMID:36372290. |
recently, dopamine (da) neurons of the substantia nigra pars compacta (snc) and adjacent ventral tegmental area (vta) have been revealed to be diverse not only when comparing between these two dopaminergic nuclei, but within them, and with the distribution of identified subtypes often agnostic to traditional neuroanatomical boundaries (saunders et al., 2018a; hook et al., 2018; kramer et al., 2018; la manno et al., 2016; poulin et al., 2014; tiklova et al., 2019; poulin et al., 2018). |
2022-11-13 |
2023-08-14 |
human |
| Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. |
dopamine is crucially involved in decision-making and overstimulation within dopaminergic pathways can lead to impulsive behaviour, including a desire to take risks and reduced deliberation before acting. |
2022-11-09 |
2023-08-14 |
human |
| Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. |
these behavioural changes are side effects of treatment with dopaminergic drugs in parkinson disease, but their likelihood of occurrence is difficult to predict and may be influenced by the individual's baseline endogenous dopamine state, and indeed correlate with sensation-seeking personality traits. |
2022-11-09 |
2023-08-14 |
human |
| Stephanie T Hirschbichler, John C Rothwell, Sanjay G Manoha. Dopamine increases risky choice while D2 blockade shortens decision time. Experimental brain research. 2022-11-09. PMID:36350356. |
furthermore, our data suggest that the actual dopaminergic drug effect may be dependent on the individual's baseline dopamine state, which may influence our therapeutic decision as clinicians in the future. |
2022-11-09 |
2023-08-14 |
human |
| Shu-Mei Wang, Bess Yin-Hung Lam, Li-Chieh Kuo, Hsiao-Man Hsu, Wen-Chen Ouyan. Facial and upper-limb movement abnormalities in individuals with psychotic-like experiences: a motion analysis study. European archives of psychiatry and clinical neuroscience. 2022-11-09. PMID:36350375. |
compensatory changes in dopaminergic neural pathways in response to elevated dopamine might explain connection between slow movements and irregular muscle contraction. |
2022-11-09 |
2023-08-14 |
Not clear |
| Rachel M Wise, Annika Wagener, Urban M Fietzek, Thomas Klopstock, Eugene V Mosharov, Fabio A Zucca, David Sulzer, Luigi Zecca, Lena F Burbull. Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and neurodegeneration with brain iron accumulation disorders. Neurobiology of disease. 2022-11-09. PMID:36351559. |
dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been implicated as potential contributors to the unique vulnerability of substantia nigra dopaminergic neurons which preferentially decline in parkinson's disease and some rare neurodegenerative disorders with shared pathological features. |
2022-11-09 |
2023-08-14 |
Not clear |