| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haruo Nishijima, Fumiaki Mori, Tamaki Kimura, Yasuo Miki, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyam. Cabergoline, a long-acting dopamine agonist, attenuates L-dopa-induced dyskinesia without L-dopa sparing in a rat model of Parkinson's disease. Neuroscience research. 2022-02-12. PMID:35150767. |
long-acting dopamine agonists may reduce the risk of lid by continuous dopaminergic stimulation. |
2022-02-12 |
2023-08-13 |
rat |
| P Riedel, I M Domachowska, Y Lee, P T Neukam, L Tönges, S C Li, T Goschke, M N Smolk. L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task. Psychopharmacology. 2022-02-11. PMID:35147724. |
however, in humans, studies on the stability-flexibility balance using a dopaminergic agent and/or measurement of brain dopamine are scarce. |
2022-02-11 |
2023-08-13 |
Not clear |
| Amy C Leach, Elizabeth G Pitts, Cody A Siciliano, Mark J Ferri. α7 nicotinic acetylcholine receptor modulation of accumbal dopamine release covaries with novelty seeking. The European journal of neuroscience. 2022-02-10. PMID:35141983. |
dopamine release dynamics in the nucleus accumbens (nac) covaries with response to novelty and differences in dopaminergic signaling are thought to be a major underlying driver of the link between novelty seeking and drug use vulnerability. |
2022-02-10 |
2023-08-13 |
rat |
| Haruka Takeshige-Amano, Taku Hatano, Koji Kamagata, Christina Andica, Wataru Uchida, Masahiro Abe, Takashi Ogawa, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattor. White matter microstructures in Parkinson's disease with and without impulse control behaviors. Annals of clinical and translational neurology. 2022-02-09. PMID:35137566. |
impulse control behaviors (icbs) in parkinson's disease (pd) are thought to be caused by an overdose of dopaminergic therapy in the relatively spared ventral striatum, or by hypersensitivity of this region to dopamine. |
2022-02-09 |
2023-08-13 |
Not clear |
| Pan Chen, Hong Cheng, Fuli Zheng, Shaojun Li, Julia Bornhorst, Bobo Yang, Kun He Lee, Tao Ke, Yunhui Li, Tanja Schwerdtle, Xiaobo Yang, Aaron B Bowman, Michael Aschne. BTBD9 attenuates manganese induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway. Human molecular genetics. 2022-02-08. PMID:35134179. |
in caenorhabditis elegans, loss of hpo-9 (btbd9 homolog) resulted in more susceptibility to mn-induced oxidative stress and mitochondrial dysfunction, as well as decreased dopamine levels and alternations of dopaminergic neuronal morphology and behavior. |
2022-02-08 |
2023-08-13 |
human |
| Tõnis Tokko, Grete Miškinyte, Diva Eensoo, Jaanus Harr. Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism. Nordic journal of psychiatry. 2022-02-07. PMID:35130472. |
dopaminergic dysfunction has been found to occur in adhd, with the dopamine transporter (dat) gene vntr polymorphism ( |
2022-02-07 |
2023-08-13 |
Not clear |
| Lauren Cummins, Marshall E Cate. Istradefylline: A novel agent in the treatment of "off" episodes associated with levodopa/carbidopa use in Parkinson disease. The mental health clinician. vol 12. issue 1. 2022-02-04. PMID:35116210. |
istradefylline is an alternative option to dopaminergic drugs such as dopamine agonists, monoamine oxidase b inhibitors, and catechol-o-methyltransferase inhibitors as an adjunct to l/c in patients with motor fluctuations, but clinical use will further define its role in treatment of pd. |
2022-02-04 |
2023-08-13 |
Not clear |
| Khalid A El-Saiy, Rabab H Sayed, Ayman E El-Sahar, Esraa A Kandi. Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats. Chemico-biological interactions. 2022-02-01. PMID:35104487. |
venlafaxine administration was noted to decrease α-synuclein accumulation and preserve dopaminergic neurons along with restoration of striatal dopamine levels and motor recovery. |
2022-02-01 |
2023-08-13 |
rat |
| Jan Kehr, Fu-Hua Wang, Fumio Ichinose, Shimako Yoshitake, Bence Farkas, Béla Kiss, Nika Adha. Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D Frontiers in psychiatry. vol 12. 2022-01-31. PMID:35095615. |
preferential effects of cariprazine on counteracting the disruption of social interaction and decrease in extracellular dopamine levels induced by the dopamine d the negative and cognitive symptoms of schizophrenia and related disorders may be due to reduced dopaminergic tone in cortical brain areas. |
2022-01-31 |
2023-08-13 |
Not clear |
| Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter Sim. Subcellular proteomics of dopamine neurons in the mouse brain. eLife. vol 11. 2022-01-31. PMID:35098924. |
dopaminergic neurons modulate neural circuits and behaviors via dopamine release from expansive, long range axonal projections. |
2022-01-31 |
2023-08-13 |
mouse |
| Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter Sim. Subcellular proteomics of dopamine neurons in the mouse brain. eLife. vol 11. 2022-01-31. PMID:35098924. |
we identify numerous proteins encoded by dopamine neuron-enriched genes in striatal dopaminergic axons, including ion channels with previously undescribed axonal localization. |
2022-01-31 |
2023-08-13 |
mouse |
| Mengyao Zhao, Linlin Deng, Xiaoxuan Lu, Liqiang Fan, Yang Zhu, Liming Zha. The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. Environmental science and pollution research international. 2022-01-28. PMID:35088269. |
moreover, acr caused neurological defects associated with gait abnormality and neuronal loss while suppressing the acetylcholine (ach) and dopamine (da) levels and increasing the protein expression of α-synuclein (α-syn), further inhibiting cholinergic and dopaminergic neuronal function. |
2022-01-28 |
2023-08-13 |
mouse |
| Narmadhaa Sivagurunathan, Aghil T S Ambatt, Latchoumycandane Calivaratha. Role of Long Non-Coding RNAs in the Pathogenesis of Alzheimer's and Parkinson's diseases. Current aging science. 2022-01-27. PMID:35081899. |
ad is a neurological condition that leads to dementia and cognitive decline due to neuronal cell death in the brain, whereas pd is a movement disorder affecting neuro-motor function and is developed due to the death of the dopaminergic neurons in the brain which results in decreased dopamine levels. |
2022-01-27 |
2023-08-13 |
Not clear |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |
| Skye Hsin-Hsien Yeh, Chi-Jung Tsai, Tsung-Hsun Yu, Yung-Hsiao Chiang, Shinn-Zong Lin, Nan-Jing Peng, Wen-Sheng Huan. 99mTc-TRODAT-1 SPECT Revealed That Striatal Dopamine Transport Availability Significantly Decreases in Late Mid-Aged Healthy Taiwanese and Then Remains Stable. Clinical nuclear medicine. 2022-01-26. PMID:35081059. |
neuroimaging studies in the past 20 years have documented an age-related decline in striatal dopamine transporters (dats), which is a marker of dopaminergic neurodegeneration; however, concerns about ethnic variations in the decline in dat with age have not been addressed. |
2022-01-26 |
2023-08-13 |
Not clear |
| Shih-Hua Chou, Yen-Ju Chen, Chien-Po Liao, Chun-Liang Pa. A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress. Neuroscience research. 2022-01-25. PMID:35074444. |
mutations in cat-2 and dat-1, which control dopamine synthesis and reuptake, respectively, impair this learned bacterial avoidance, suggesting that dopaminergic modulation is essential. |
2022-01-25 |
2023-08-13 |
caenorhabditis_elegans |
| Concepció Marin, Mireya Fuentes, Isam Alobid, Valeria Tubita, María Jesús Rojas-Lechuga, Joaquim Mullo. Olfactory Bulb Excitotoxicity as a Gap-Filling Mechanism Underlying the Link Between Traumatic Brain Injury-Induced Secondary Neuronal Degeneration and Parkinson's Disease-Like Pathology. Neurochemical research. 2022-01-24. PMID:35067829. |
we examined the number of nigral dopaminergic neurons (th +), nigral α-synuclein expression, the striatal dopamine transporter (dat) expression, and motor performance after bilateral ob n-methyl-d-aspartate (nmda)-induced excitotoxic lesions in rodents. |
2022-01-24 |
2023-08-13 |
Not clear |
| Lelania Bilodeau, Lorraine Beama. Differential Expression of Three Dopamine Receptors in Varroa-Resistant Honey Bees. Journal of insect science (Online). vol 22. issue 1. 2022-01-23. PMID:35066590. |
differential expression of all three dopamine receptors suggests a role for the dopaminergic system in varroa resistance and suggests that further characterization of these receptors for breeding potential is warranted. |
2022-01-23 |
2023-08-13 |
bee |
| Marios G Krokidis, Georgios N Dimitrakopoulos, Aristidis G Vrahatis, Christos Tzouvelekis, Dimitrios Drakoulis, Foteini Papavassileiou, Themis P Exarchos, Panayiotis Vlamo. A Sensor-Based Perspective in Early-Stage Parkinson's Disease: Current State and the Need for Machine Learning Processes. Sensors (Basel, Switzerland). vol 22. issue 2. 2022-01-22. PMID:35062370. |
parkinson's disease (pd) is a progressive neurodegenerative disorder associated with dysfunction of dopaminergic neurons in the brain, lack of dopamine and the formation of abnormal lewy body protein particles. |
2022-01-22 |
2023-08-13 |
Not clear |
| Ichiro Kawahata, Kohji Fukunag. Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy. Journal of pharmacological sciences. vol 148. issue 2. 2022-01-22. PMID:35063140. |
heart-type fabp (hfabp, fabp3) is rich in dopaminergic neurons and interacts with dopamine d2 receptors, specifically the long type (d |
2022-01-22 |
2023-08-13 |
Not clear |