| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subhamita Maitra, Mahasweta Chatterjee, Anirban Roychowdhury, Chinmay Kumar Panda, Swagata Sinha, Kanchan Mukhopadhya. Specific dopaminergic genetic variants influence impulsivity, cognitive deficit, and disease severity of Indian ADHD probands. Molecular biology reports. 2022-05-13. PMID:35553330. |
since the dopaminergic system is the primary target for pharmaceutical intervention in adhd, we investigated the association between adhd-related imp and functional gene variants of the dopamine transporter (slc6a3) and catechol-o-methyltransferase involved in dopamine clearance. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ashley Y Gao, Patrick A Link, Sophie J Bakri, Andrew J Haa. Dopamine Receptor Signaling Regulates Fibrotic Activation of Retinal Pigmented Epithelial Cells. American journal of physiology. Cell physiology. 2022-05-11. PMID:35544697. |
drd2 and drd5 are the dominant dopaminergic receptors expressed in arpe-19 cells and tgfβ stimulates enhances autocrine release of dopamine which we show further exasperates fibrotic activation. |
2022-05-11 |
2023-08-13 |
human |
| Björn Falkenburger, Theodoros Kalliakoudas, Heinz Reichman. Adaptive changes in striatal projection neurons explain the long duration response and the emergence of dyskinesias in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-05-10. PMID:35538324. |
moreover, dyskinesias are considered signs of excessive dopaminergic neurotransmission in parkinson's disease, but they are typically more severe on the body side that is more strongly affected by dopamine depletion. |
2022-05-10 |
2023-08-13 |
Not clear |
| Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukl. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022-05-09. PMID:35533351. |
further, the dize-mediated activation of ace2 led to increased tyrosine hydroxylase (th) and dopamine transporters (dat) expression in the rat brain, indicating the protection of dopaminergic (daergic) neurons from 6-ohda induced neurotoxicity. |
2022-05-09 |
2023-08-13 |
rat |
| Joseph P Schacht, Yeongbin Im, Michaela Hoffman, Konstantin E Voronin, Sarah W Book, Raymond F Anto. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-05-06. PMID:35523943. |
inhibition of catechol-o-methyltransferase (comt), the enzyme primarily responsible for cortical dopamine inactivation, may increase cortical dopamine, especially among individuals with genetically mediated lower dopaminergic tone, such as comt rs4680 (val158met) val-allele homozygotes. |
2022-05-06 |
2023-08-13 |
human |
| Arata Oh-Nishi, Yuji Nagai, Chie Seki, Tetsuya Suhara, Takafumi Minamimoto, Makoto Higuch. Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model. Brain, behavior, & immunity - health. vol 22. 2022-05-02. PMID:35496774. |
mia in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (poly i:c), which causes decreased striatal dopamine d2 receptor (d2r) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. |
2022-05-02 |
2023-08-13 |
rat |
| B A Schuster, S Sowden, A J Rybicki, D S Fraser, C Press, P Holland, J L Coo. Dopaminergic modulation of dynamic emotion perception. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-02. PMID:35501156. |
interestingly, whilst a dependence of dopaminergic drug effects on individual baseline dopamine function has been well established in other cognitive domains, the emotion recognition literature so far has failed to account for these possible interindividual differences. |
2022-05-02 |
2023-08-13 |
human |
| B A Schuster, S Sowden, A J Rybicki, D S Fraser, C Press, P Holland, J L Coo. Dopaminergic modulation of dynamic emotion perception. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-02. PMID:35501156. |
results highlight the need for future studies to account for baseline dopamine and suggest putative mechanisms underlying the dopaminergic modulation of emotion recognition. |
2022-05-02 |
2023-08-13 |
human |
| Hye-Sun Lim, Gunhyuk Par. Resilin, an insect-derived elastomeric protein, protects dopaminergic neurons in Parkinson disease models. Neuroscience letters. 2022-05-01. PMID:35490904. |
the primary cause of pd is the degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) region that subsequently reduces the dopamine content in the striatum (st); this is a promising therapeutic target for pd. |
2022-05-01 |
2023-08-13 |
mouse |
| Enhui He, You Zhou, Jinping Luo, Shihong Xu, Kui Zhang, Yilin Song, Mixia Wang, Shengwei Xu, Yuchuan Dai, Gucheng Yang, Jingyu Xie, Zhaojie Xu, Wanwan Zhu, Yu Deng, Qi Xu, Xinxia Ca. Sensitive detection of electrophysiology and dopamine vesicular exocytosis of hESC-derived dopaminergic neurons using multifunctional microelectrode array. Biosensors & bioelectronics. vol 209. 2022-04-28. PMID:35483214. |
sensitive detection of electrophysiology and dopamine vesicular exocytosis of hesc-derived dopaminergic neurons using multifunctional microelectrode array. |
2022-04-28 |
2023-08-13 |
human |
| Jochem van Kempen, Christian Brandt, Claudia Distler, Mark A Bellgrove, Alexander Thiel. Dopamine influences attentional rate modulation in Macaque posterior parietal cortex. Scientific reports. vol 12. issue 1. 2022-04-28. PMID:35484302. |
although dopamine has historically been studied in relation to frontal functioning, emerging evidence suggests important dopaminergic influences in parietal cortex. |
2022-04-28 |
2023-08-13 |
monkey |
| Beth Fairfield, Caterina Padulo, Nicola Mammarella, Sara Fontanella, Annalina Sarra, Fani Konstantinidou, Liborio Stuppia, Valentina Gatt. Dopamine-related polymorphisms and Affective Working Memory in aging. Neurobiology of learning and memory. 2022-04-26. PMID:35472439. |
the neurotransmitter dopamine (da) is a key regulatory component of executive functioning and dysfunction in dopaminergic circuity has been shown to result in impaired working memory. |
2022-04-26 |
2023-08-13 |
human |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Natasha M Puri, Giovanna R Romano, Ting-Yu Lin, Quynh N Mai, Roshanak Iranneja. The organic cation Transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus. eLife. vol 11. 2022-04-25. PMID:35467530. |
here, using novel nanobody-based biosensors, we demonstrate for the first time that the dopamine d1 receptor (d1dr), the primary mediator of dopaminergic signaling in the brain and kidney, not only functions on the plasma membrane but becomes activated at the golgi apparatus in the presence of its ligand. |
2022-04-25 |
2023-08-13 |
Not clear |
| Louise C Parr-Brownlie, Christy A Itoga, Judith R Walters, Conor F Underwoo. Oscillatory waveform sharpness asymmetry changes in motor thalamus and motor cortex in a rat model of Parkinson's disease. Experimental neurology. 2022-04-24. PMID:35461830. |
hypoactive layer v pyramidal neuron firing in dopamine lesioned rats is unlikely to be driven by vavl thalamus and may, therefore, reflect the loss of mesocortical dopaminergic afferents and/or changes in intrinsic excitability. |
2022-04-24 |
2023-08-13 |
rat |
| Karl Ebner, Simone B Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J Leban, Nicolas Singewald, Mario Engelmann, Gert Lube. The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice. Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454095. |
paralleling these behavioral effects, the systemic administration of 10 mg/kg ce-158 caused a rapid and sustained elevation of extracellular dopamine in the nucleus accumbens, a brain area where dopaminergic signaling plays a key role in learning and memory function, of freely moving mice, while 1 mg/kg was not sufficient for altering dopamine levels. |
2022-04-23 |
2023-08-13 |
mouse |
| R Pivonello, C Pivonello, C Simeoli, M C De Martino, A Cola. The dopaminergic control of Cushing's syndrome. Journal of endocrinological investigation. 2022-04-23. PMID:35460460. |
corticotroph pituitary and extra-pituitary tumours, as well as adrenal tumours and lesions responsible for cs express dopamine receptors (drs), which have been found to mediate inhibition of hormone secretion and/or cell proliferation in experimental setting, suggesting that dopaminergic system, particularly drs, might represent a target for the treatment of cs. |
2022-04-23 |
2023-08-13 |
Not clear |
| Andrew B Hawkey, Erica Pippen, Bruny Kenou, Zade Holloway, Theodore A Slotkin, Frederic J Seidler, Edward D Levi. Persistent Neurobehavioral and Neurochemical Anomalies in Middle-Aged Rats after Maternal Diazinon Exposure. Toxicology. 2022-04-22. PMID:35452779. |
across adulthood, the continued potential for behavioral defects was associated with altered dopaminergic function, characterized by enhanced dopamine utilization that was regionally-selective (striatum but not frontal/parietal cortex). |
2022-04-22 |
2023-08-13 |
rat |
| Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryosuke Takahashi, Nobukatsu Sawamot. Motor progression and nigrostriatal neurodegeneration in Parkinson's disease. Annals of neurology. 2022-04-16. PMID:35428994. |
here, we aimed to clarify the correlation between motor impairments and striatal dopaminergic terminal degeneration and nigral neuromelanin-laden dopamine neuron loss at early to advanced stages of pd. |
2022-04-16 |
2023-08-13 |
Not clear |
| Amanda R Burmeister, Juozas Gordevicius, Emmanuel N Paul, Christina Houck, Sonia George, Martha L Escobar Galvis, Qiong Sha, Patrik Brundin, J Andrew Pospisilik, Karen Racicot, Lena Brundi. Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. Neurobiology of disease. 2022-04-13. PMID:35417751. |
adults exhibit great variability in the numbers of nigral dopamine neurons, suggesting that factors during embryonic or early life regulate the development and physiology of dopaminergic neurons. |
2022-04-13 |
2023-08-13 |
mouse |