| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
after physical (knife-cut) or chemically-mediated (tetrodotoxin 300 nm, 1.5 microliters; 1.0 microliters min-1) interruption of nerve conduction in the nigrostriatal tract, there was a marked increase in the synthesis and metabolism of dopamine in the isolated dopaminergic nerve terminals of the striatum. |
1990-08-08 |
2023-08-11 |
rat |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
it is concluded (a) that there is a significant presynaptic, and/or local circuit mechanism capable of activating the synthesis and metabolism of dopamine in the isolated, striatal, dopaminergic nerve terminals. |
1990-08-08 |
2023-08-11 |
rat |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
furthermore, haloperidol can act directly on the striatal, dopaminergic nerve terminal, to cause an increase in the synthesis and metabolism of striatal dopamine. |
1990-08-08 |
2023-08-11 |
rat |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
(b) after degeneration of the striatal dopaminergic nerves, the denervated striatum retains the ability to synthesize (from l-dopa) and metabolize dopamine, to the same degree as the intact, innervated, contralateral striatum. |
1990-08-08 |
2023-08-11 |
rat |
| C Hindelang, J M Félix, F M Laurent, M J Klein, M E Stoecke. Ontogenesis of proopiomelanocortin gene expression and regulation in the rat pituitary intermediate lobe. Molecular and cellular endocrinology. vol 70. issue 3. 1990-08-08. PMID:2361568. |
the effects of acute or chronic postnatal treatment with a dopamine antagonist (haloperidol) or a dopamine agonist (bromocriptine) show that the physiological dopaminergic inhibitory control of pomc gene expression operates as early as postnatal day 5. |
1990-08-08 |
2023-08-11 |
rat |
| H Gerbe. [Abnormal hormone values: do drugs play a role? Abnormal prolactin, TSH and thyroid hormone values]. Schweizerische medizinische Wochenschrift. vol 120. issue 23. 1990-08-02. PMID:2163099. |
serum tsh is decreased by glucocorticoids, somatostatin, dopaminergic agents, a-adrenergic blockers, etc., and increased by neuroleptics and other dopamin antagonists, cimetidine, clomiphene, spironolactone, etc. |
1990-08-02 |
2023-08-11 |
Not clear |
| A Chéramy, L Barbeito, G Godeheu, J M Desce, A Pittaluga, T Galli, F Artaud, J Glowinsk. Respective contributions of neuronal activity and presynaptic mechanisms in the control of the in vivo release of dopamine. Journal of neural transmission. Supplementum. vol 29. 1990-08-01. PMID:1972733. |
studies performed in several in vivo and in vitro conditions have demonstrated that the release of dopamine from nerve terminals of the nigrostriatal dopaminergic neurons depends not only on the activity of dopaminergic cells but also on presynaptic regulations by heterologous fibers. |
1990-08-01 |
2023-08-11 |
Not clear |
| A S Undie, E Friedma. Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:1972756. |
the action of the dopamine d1 receptor agonist, skf38393, was blocked by sch23390 (d1-selective antagonist), but not by sulpiride (d2-selective antagonist), atropine (muscarinic antagonist), prazosin (alpha-1 adrenoceptor antagonist) or methiotepin and methysergide (serotonergic antagonists), indicating that the observed effects of dopaminergic agonists were selectively mediated through the d1 dopamine receptor. |
1990-07-31 |
2023-08-11 |
rat |
| W C Graham, A R Crossman, G N Woodruf. Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. I. 6-OHDA lesions of ascending mesencephalic dopaminergic pathways in the rat. Brain research. vol 514. issue 1. 1990-07-31. PMID:2113410. |
the selective dopaminergic antagonist ligands [3h]sch 23390 and [3h]sulpiride were used to reveal autoradiographically dopamine d1 and d2 receptors, respectively, in brain sections from rats which had received unilateral 6-hydroxydopamine (6-ohda) injections destroying ascending nigrostriatal neurones. |
1990-07-31 |
2023-08-11 |
rat |
| W C Graham, A R Crossman, G N Woodruf. Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. I. 6-OHDA lesions of ascending mesencephalic dopaminergic pathways in the rat. Brain research. vol 514. issue 1. 1990-07-31. PMID:2113410. |
loss of forebrain dopaminergic terminals was assessed autoradiographically using [3h]mazindol to label dopamine uptake sites. |
1990-07-31 |
2023-08-11 |
rat |
| W C Graham, A R Crossman, G N Woodruf. Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. I. 6-OHDA lesions of ascending mesencephalic dopaminergic pathways in the rat. Brain research. vol 514. issue 1. 1990-07-31. PMID:2113410. |
these results suggest that dopamine d2 receptors are more susceptible than d1 receptors to changes after dopaminergic denervation, which is expressed as an increase in the density of binding sites revealed here with [3h]sulpiride. |
1990-07-31 |
2023-08-11 |
rat |
| W C Graham, C E Clarke, S Boyce, M A Sambrook, A R Crossman, G N Woodruf. Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. II. Unilateral intra-carotid infusion of MPTP in the monkey (Macaca fascicularis). Brain research. vol 514. issue 1. 1990-07-31. PMID:2192772. |
the selective dopaminergic antagonist ligands [3h]sch 23390 and [3h]sulpiride were used to reveal autoradiographically dopamine d1 and d2 receptors, respectively, in brain sections from monkeys which had received unilateral intracarotid infusions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), causing loss of dopamine-containing neurones of the substantia nigra pars compacta. |
1990-07-31 |
2023-08-11 |
monkey |
| W C Graham, C E Clarke, S Boyce, M A Sambrook, A R Crossman, G N Woodruf. Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. II. Unilateral intra-carotid infusion of MPTP in the monkey (Macaca fascicularis). Brain research. vol 514. issue 1. 1990-07-31. PMID:2192772. |
loss of forebrain dopaminergic terminals was assessed autoradiographically using [3h]mazindol to label dopamine uptake sites. |
1990-07-31 |
2023-08-11 |
monkey |
| M Valchár, J J Bonnet, J Costenti. Chronic modification of dopaminergic transmission and its effects on binding characteristics of dopamine transporter ligand 3H-GBR 12783 in the striatum. Activitas nervosa superior. vol 31. issue 4. 1990-07-24. PMID:2561622. |
chronic modification of dopaminergic transmission and its effects on binding characteristics of dopamine transporter ligand 3h-gbr 12783 in the striatum. |
1990-07-24 |
2023-08-11 |
Not clear |
| V Tesar, J Petrtýl, J Jedlicka, K Horký, I Gregorová, J Kopecká, J Marek, Z Marecek, V Korda. [The effect of dopamine on hemodynamic and hormonal parameters in liver cirrhosis]. Casopis lekaru ceskych. vol 129. issue 17. 1990-07-19. PMID:2140956. |
dopamine administration was not associated with an increase of the cardiac output, heart rate or peripheral resistance; the infusion had only purely dopaminergic effects. |
1990-07-19 |
2023-08-11 |
Not clear |
| G J Marek, G Vosmer, L S Seide. Dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons. Brain research. vol 513. issue 2. 1990-07-16. PMID:2140952. |
dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons. |
1990-07-16 |
2023-08-11 |
rat |
| M Buonamici, M A Cervini, A C Rossi, L Sebastiani, A Raffaelli, P Bagnol. Injections of 6-hydroxydopamine in the substantia nigra of the rat brain: morphological and biochemical effects. Behavioural brain research. vol 38. issue 1. 1990-07-12. PMID:2112003. |
in active rats, at any survival time, dopaminergic fluorescence in the nigrostriatal system as well as dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) content of the nucleus caudatus-putamen drastically decreased on the brain side ipsilateral to the injection. |
1990-07-12 |
2023-08-11 |
rat |
| M Koulu, J Lappalainen, J Hietala, B Sjöhol. Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding. Psychopharmacology. vol 101. issue 2. 1990-07-12. PMID:2140903. |
the effects of chronic administration of the selective 5-ht3 receptor antagonist ondansetron (gr38032f) on dopamine (da) and 5-hydroxytryptamine (5-ht) metabolism in the major ascending dopaminergic neurons and on striatal d2-receptor binding characteristics were investigated. |
1990-07-12 |
2023-08-11 |
Not clear |
| J F Marshall, A J Rosenstei. Age-related decline in rat striatal dopamine metabolism is regionally homogeneous. Neurobiology of aging. vol 11. issue 2. 1990-07-11. PMID:2348901. |
the results provide evidence that the effects of aging on striatal dopamine receptors are dissociable from the influences on the dopaminergic innervation of this structure, suggesting independent control of pre- and postsynaptic elements of these synapses during the lifespan. |
1990-07-11 |
2023-08-11 |
rat |
| S Boesgaard, C Hagen, J Hangaard, A N Andersen, E Eldru. Effect of dopamine and a dopamine D-1 receptor agonist on pulsatile thyrotrophin secretion in normal women. Clinical endocrinology. vol 32. issue 4. 1990-07-06. PMID:1971778. |
it is argued that dopaminergic inhibition of basal tsh secretion and tsh pulsatility is predominantly regulated through dopamine d-2 receptors at the pituitary level, and through d-1 receptors at the hypothalamic level, respectively. |
1990-07-06 |
2023-08-11 |
Not clear |