| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F C Liu, A M Graybiel, S B Dunnett, R W Baughma. Intrastriatal grafts derived from fetal striatal primordia: II. Reconstitution of cholinergic and dopaminergic systems. The Journal of comparative neurology. vol 295. issue 1. 1990-06-27. PMID:1971286. |
for the dopaminergic system, a comparable modular organization was found in the grafts by immunostaining for tyrosine hydroxylase, the catecholamine synthetic enzyme; by autoradiographic [3h]mazindol binding for dopamine uptake sites; and by [3h]sch23390 binding for dopamine d1 receptors and [3h]sulpiride binding for dopamine d2 receptors. |
1990-06-27 |
2023-08-11 |
rat |
| K Racké, B Hering, K Ziegle. Lack of autoreceptor mediated regulation of the spontaneous dopamine turnover in the isolated neurointermediate lobe of the rat pituitary gland in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:1971426. |
it was previously shown that the high rate of spontaneous outflow of dopamine metabolites from the dopaminergic nerves in the neurointermediate lobe reflects largely the immediate catabolism of newly synthesized dopamine. |
1990-06-27 |
2023-08-11 |
rat |
| F R George, M C Rit. Cocaine produces locomotor stimulation in SS but not LS mice: relationship to dopaminergic function. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2188275. |
since striatal dopaminergic neurons influence locomotor activity, we also assessed ligand affinity and receptor density of dopamine transporters and dopaminergic d1 and d2 receptors in striatal tissue obtained from these two selected lines. |
1990-06-27 |
2023-08-11 |
mouse |
| N S Pilotte, L G Sharpe, E M Da. Multiple, but not acute, infusions of cocaine alter the release of prolactin in male rats. Brain research. vol 512. issue 1. 1990-06-21. PMID:2159825. |
repeated administration of cocaine may produce long-term changes in either the tuberoinfundibular dopaminergic neurons or the adenohypophysial dopamine d2-receptors, or both. |
1990-06-21 |
2023-08-11 |
rat |
| P W Kalivas, P Duffy, H Eberhard. Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists. The Journal of pharmacology and experimental therapeutics. vol 253. issue 2. 1990-06-21. PMID:2160011. |
these data support electrophysiological studies suggesting that activation of gamma-aminobutyric acidb receptors on dopamine perikarya inhibits dopaminergic activity, while activation of gamma-aminobutyric acida receptors results in an indirect disinhibition of dopaminergic function. |
1990-06-21 |
2023-08-11 |
rat |
| A L Jadhav, M F Lokhandwal. Dietary sodium-induced changes in renal noradrenergic and dopaminergic responses in rats. Journal of human hypertension. vol 4. issue 2. 1990-06-21. PMID:2338689. |
effects of dietary sodium on plasma, renal cortical, and urinary dopamine and noradrenaline levels were studied in order to examine the noradrenergic and dopaminergic responses to high sodium intake. |
1990-06-21 |
2023-08-11 |
rat |
| A L Jadhav, M F Lokhandwal. Dietary sodium-induced changes in renal noradrenergic and dopaminergic responses in rats. Journal of human hypertension. vol 4. issue 2. 1990-06-21. PMID:2338689. |
these results indicate that high sodium intake affects urinary elimination of dopamine without affecting the sympathetic neural activity, as indicated by the novadrenaline levels in urine, plasma, and renal cortex; and, that excess dietary sodium produces distinctly different dopaminergic and adrenergic responses. |
1990-06-21 |
2023-08-11 |
rat |
| D Pickar, R E Litman, P E Konicki, O M Wolkowitz, A Breie. Neurochemical and neural mechanisms of positive and negative symptoms in schizophrenia. Modern problems of pharmacopsychiatry. vol 24. 1990-06-14. PMID:1970851. |
whereas compelling evidence continues to link the mechanism of action of neuroleptic drugs, including therapeutic effects on negative and positive symptoms, to blockade of d2 receptors, neuroleptic-induced alterations in dopaminergic function are time-dependent and may include reductions in variability as well as in net dopamine activity. |
1990-06-14 |
2023-08-11 |
Not clear |
| P P Michel, B K Dandapani, S M Efange, F Heft. Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: selective toxicity of 1-methyl-4-(4'-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture. Experimental neurology. vol 108. issue 2. 1990-06-12. PMID:2335192. |
some compounds tested were selected to fulfill two criteria believed to underly the selective dopaminergic neurotoxicity of mpp+, i.e., to be a potential substrate for the uptake carrier for dopamine and to possess a strong delocalized positive charge to inhibit the mitochondrial respiratory system. |
1990-06-12 |
2023-08-11 |
Not clear |
| S L Greenspan, A Klibanski, J W Rowe, D Elah. Age alters pulsatile prolactin release: influence of dopaminergic inhibition. The American journal of physiology. vol 258. issue 5 Pt 1. 1990-06-07. PMID:2333989. |
because the major neuroregulator of prolactin is dopamine and because normal aging has been reported to be associated with reductions in hypothalamic dopamine content and effect, we determined whether the mechanism of altered day-night prolactin pulsatile secretion was due to changes in dopaminergic tone. |
1990-06-07 |
2023-08-11 |
human |
| Y Masuo, D Pélaprat, M N Montagne, D Scherman, W Rostèn. Regulation of neurotensin-containing neurons in the rat striatum and substantia nigra. Effects of unilateral nigral lesion with 6-hydroxydopamine on neurotensin content and its binding site density. Brain research. vol 510. issue 2. 1990-06-04. PMID:1970504. |
tyrosine hydroxylase (t-oh) activity, gamma-aminobutyric acid (gaba) content, binding site densities of dihydrotetrabenazine (tbzoh), a marker of dopaminergic synaptic vesicles, and of iodosulpiride, a ligand for dopamine d2 receptors, were also determined. |
1990-06-04 |
2023-08-11 |
rat |
| E W Thornton, G E Bradbury, A P Wickens, D R Mottram, R McClellan. Intra-habenular injection of 6-hydroxydopamine produces impaired acquisition of DRL operant behavior. Behavioral and neural biology. vol 53. issue 2. 1990-05-31. PMID:2109973. |
while the neurotoxic lesion procedure used does not differentiate noradrenergic and dopaminergic damage, the importance of intact catecholaminergic systems within the habenula for effective drl acquisition is consistent with the suggested importance of the habenula for feedback regulation of dopamine within the ventral tegmental area through ascending dopamine fibers to the habenula. |
1990-05-31 |
2023-08-11 |
rat |
| R M Hagan, B J Jones, C C Jordan, M B Tyer. Effect of 5-HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat. British journal of pharmacology. vol 99. issue 2. 1990-05-30. PMID:1691672. |
the effects of ondansetron on dime-c7-induced changes in dopamine and 5-ht metabolism in discrete areas of rat forebrain were studied in order to investigate further the possible mechanism of action of 5-ht3 antagonists in modifying mesolimbic dopaminergic systems. |
1990-05-30 |
2023-08-11 |
rat |
| R M Hagan, B J Jones, C C Jordan, M B Tyer. Effect of 5-HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat. British journal of pharmacology. vol 99. issue 2. 1990-05-30. PMID:1691672. |
these results are in agreement with the proposed facilitatory role of 5-ht3 receptor activation on mesolimbic dopaminergic transmission, and suggest that 5-ht3 antagonists may have important therapeutic indications for the treatment of cns disorders in which mesolimbic dopamine systems are perturbed. |
1990-05-30 |
2023-08-11 |
rat |
| V Simonneaux, L C Murrin, M Ebad. Characterization of D1 dopamine receptors in the bovine pineal gland with [3H]SCH 23390. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2139469. |
dopaminergic receptor agonists and antagonists inhibited [3h]sch 23390 binding in a concentration-dependent and stereoselective fashion, demonstrating a pharmacology characteristic of d1 dopamine receptors. |
1990-05-30 |
2023-08-11 |
cattle |
| M C Bohn, M Kanuick. Bilateral recovery of striatal dopamine after unilateral adrenal grafting into the striatum of the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP)-treated mouse. Journal of neuroscience research. vol 25. issue 3. 1990-05-24. PMID:1969970. |
in striking contrast to the unilateral recovery of the dopaminergic fibers, striatal dopamine levels were increased bilaterally in all tissue grafted mice. |
1990-05-24 |
2023-08-11 |
mouse |
| A R Crossma. A hypothesis on the pathophysiological mechanisms that underlie levodopa- or dopamine agonist-induced dyskinesia in Parkinson's disease: implications for future strategies in treatment. Movement disorders : official journal of the Movement Disorder Society. vol 5. issue 2. 1990-05-24. PMID:1970120. |
in levodopa- or dopamine agonist-induced dyskinesia, (c) the site of action of dopaminergic agents in causing chorea is the putamen. |
1990-05-24 |
2023-08-11 |
human |
| P Barone, S A Parashos, V Palma, C Marin, G Campanella, T N Chas. Dopamine D1 receptor modulation of pilocarpine-induced convulsions. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2139189. |
the contribution of dopaminergic mechanisms to the generalization of epileptic activity was studied in rats given pilocarpine after pretreatment with selective dopamine agonists. |
1990-05-21 |
2023-08-11 |
rat |
| J J Robert, M Orosco, C Rouch, Y Cohen, C Jacquo. Opposite dopaminergic activity in lateral and median hypothalamic nuclei in relation to the feeding effect of D-Ser2-Leu-Enk-Thr6 (DSLET). Brain research. vol 510. issue 1. 1990-05-21. PMID:2322848. |
the decreased dopaminergic activity in the lh would appear to be the most specifically related to the behavioural effect given the known role of dopamine in this region. |
1990-05-21 |
2023-08-11 |
rat |
| R Kuczenski, D S Segal, L D Manle. Apomorphine does not alter amphetamine-induced dopamine release measured in striatal dialysates. Journal of neurochemistry. vol 54. issue 5. 1990-05-18. PMID:2324735. |
the present experiments were designed to test the extent to which amphetamine-induced dopamine release is dependent on impulse flow and autoreceptor function in dopaminergic neurons. |
1990-05-18 |
2023-08-11 |
rat |