| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Herridge, M S Gol. Pharmacological adjuncts in the treatment of opioid and cocaine addicts. Journal of psychoactive drugs. vol 20. issue 3. 1989-05-03. PMID:3069983. |
these agents potentiate dopaminergic transmission and in so doing tend to counter the dopamine depletion effect of prolonged cocaine use. |
1989-05-03 |
2023-08-11 |
Not clear |
| S Iyengar, A Hausler, H S Kim, M Marien, C A Altar, P L Woo. The dopamine autoreceptor agonist, (+/-)-trans-1,3,4,4a5,10b-hexahydro-4-propyl-2H [1]benzopyrano [3,4-b] pyridin-9-ol hydrochloride (CGS 15855A), modulates striatal dopamine metabolism and prolactin release. Neuropharmacology. vol 28. issue 1. 1989-04-28. PMID:2522597. |
these data suggest that cgs 15855a is a selective dopamine autoreceptor agonist which preferentially stimulates d2 receptors on lactotrophs and dopaminergic neurons as compared to d2 receptors on cholinergic interneurons in the striatum. |
1989-04-28 |
2023-08-11 |
Not clear |
| M Diana, S J Young, P M Grove. Modulation of dopaminergic terminal excitability by D1 selective agents. Neuropharmacology. vol 28. issue 1. 1989-04-28. PMID:2522599. |
the results suggest that the terminal excitability of antidromically identified nigro-striatal dopaminergic neurons can be modified with specific dopamine d1 receptor agents via a receptor mediated mechanism. |
1989-04-28 |
2023-08-11 |
Not clear |
| M Diana, S J Young, P M Grove. Modulation of dopaminergic terminal excitability by D1 selective agents. Neuropharmacology. vol 28. issue 1. 1989-04-28. PMID:2522599. |
previous studies from this laboratory have demonstrated that the electrical excitability of nigro-striatal dopaminergic terminals is reduced by the dopaminomimetics apomorphine and amphetamine and is increased by the dopamine antagonists haloperidol, fluphenazine and sulpiride (groves, fenster, tepper, nakamura, and young 1981; tepper, nakamura, young and groves 1984). |
1989-04-28 |
2023-08-11 |
Not clear |
| J F Lipinski, P E Keck, S L McElro. Beta-adrenergic antagonists in psychosis: is improvement due to treatment of neuroleptic-induced akathisia? Journal of clinical psychopharmacology. vol 8. issue 6. 1989-04-26. PMID:2906947. |
it is possible that the mechanism of action for the anti-akathisia and antipsychotic effects of beta-adrenergic antagonists may be due to enhancement of the firing rate of dopamine neurons in the ventral tegmental area, with subsequent increased release of dopamine and decreased interference with dopaminergic neurotransmission. |
1989-04-26 |
2023-08-11 |
Not clear |
| B M Snape, E Pileblad, A Ekman, T Magnusson, A Carlsson, J Enge. The effects of 1-methyl-4-phenylpyridinium ion (MPP+) on the efflux and metabolism of endogenous dopamine in rat striatal slices. The Journal of pharmacy and pharmacology. vol 40. issue 9. 1989-04-26. PMID:2907028. |
the accumulation of mpp+ was reduced in the presence of 10 microm of the selective dopamine uptake inhibitor gbr 12909 (-50%) or by destruction of the dopaminergic terminals by complete hemisection of the forebrain 4 days before the experiments (-75%). |
1989-04-26 |
2023-08-11 |
rat |
| R A Wise, P P Rompr. Brain dopamine and reward. Annual review of psychology. vol 40. 1989-04-24. PMID:2648975. |
one thing is clear: dopamine is not the only reward transmitter, and dopaminergic neurons are not the final common path for all rewards. |
1989-04-24 |
2023-08-11 |
Not clear |
| R A Wise, P P Rompr. Brain dopamine and reward. Annual review of psychology. vol 40. 1989-04-24. PMID:2648975. |
it is not consistent with the dopamine hypothesis that dopamine-independent reward sites should exist in these areas, since any reward signals carried to nucleus accumbens or frontal cortex by dopamine fibers would-unless we are to believe that reward "happens" at these sites-have to be carried to the next stage of the circuit by nondopaminergic fibers (there are no dopaminergic cell bodies in any of the dopamine terminal areas). |
1989-04-24 |
2023-08-11 |
Not clear |
| M Sakai, K Kani, M Yoshida, I Nagats. Dopaminergic cells in the superior cervical ganglion of the rat: light and electron microscopic study using an antibody against dopamine. Neuroscience letters. vol 96. issue 2. 1989-04-24. PMID:2927719. |
dopaminergic cells in the superior cervical ganglion of the rat: light and electron microscopic study using an antibody against dopamine. |
1989-04-24 |
2023-08-11 |
rat |
| H Nissbrandt, E Sundström, G Jonsson, S Hjorth, A Carlsso. Synthesis and release of dopamine in rat brain: comparison between substantia nigra pars compacts, pars reticulata, and striatum. Journal of neurochemistry. vol 52. issue 4. 1989-04-21. PMID:2564423. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic neuronal pathway, but also from the dendrites in the substantia nigra. |
1989-04-21 |
2023-08-11 |
rat |
| O Serri, H Beauregard, M Somma, R Comtois, N Jilwan, J Hard. Defective dopaminergic regulation of prolactin secretion in patients with hyperprolactinemia. Clinical and investigative medicine. Medecine clinique et experimentale. vol 11. issue 6. 1989-04-13. PMID:3229037. |
in order to evaluate the dopaminergic control of the lactotroph, we examined the plasma prolactin response to metoclopramide (a dopamine receptor blocker, 10 mg iv bolus) and to dopamine (1 microgram/kg/min iv infusion for 120 min) in 52 hyperprolactinemic female patients and 19 healthy volunteer women. |
1989-04-13 |
2023-08-11 |
human |
| Y K Gupta, Anita Chugh, S D Set. Opposing effect of apomorphine on antinociceptive activity of morphine: a dose-dependent phenomenon. Pain. vol 36. issue 2. 1989-04-05. PMID:2919107. |
the attenuation of morphine antinociception thus appears to be due to decreased dopaminergic activity as a result of preferential dopamine autoreceptor stimulation by a low dose of apomorphine, whereas potentiation with a high dose of apomorphine is caused by enhanced dopaminergic activity via postsynaptic receptor stimulation. |
1989-04-05 |
2023-08-11 |
rat |
| J Knol. The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl. Mechanisms of ageing and development. vol 46. issue 1-3. 1989-04-05. PMID:3147347. |
it was established by the aid of (-)deprenyl, a highly specific chemical tool, which increases superoxide dismutase activity in the striatum, facilitates the activity of the nigrostriatal dopaminergic neurons with utmost selectivity, and protects these neurons from their age-related decay, that the efficiency of a male rat in behavioral tests, as well as the duration of its life are striatal dopamine dependent functions. |
1989-04-05 |
2023-08-11 |
rat |
| M D Schechter, J W Boj. CGS 10746B is able to attenuate the effects of amphetamine: further evidence for dopaminergic mediation. Pharmacology, biochemistry, and behavior. vol 30. issue 4. 1989-04-04. PMID:2906435. |
this antagonism was shown to be dose-responsive and constitutes a third mechanism, i.e., dopamine release inhibition, that evidences the dopaminergic mediation of amphetamine in the discriminative paradigm. |
1989-04-04 |
2023-08-11 |
rat |
| I Leroux-Nicollet, J Costenti. In vivo and in vitro autoradiographic labelling of central dopaminergic systems with [3H]GBR12783 in rodents. Neuroscience letters. vol 95. issue 1-3. 1989-03-29. PMID:2976132. |
labelling of central dopaminergic systems with the dopamine uptake inhibitor [3h]gbr12783 was performed in vivo in mice by i.v. |
1989-03-29 |
2023-08-11 |
mouse |
| M K Si. Tuberoinfundibular transport of intrahypothalamic-administered dopamine in normo- and hypertensive rats. Clinical and experimental hypertension. Part A, Theory and practice. vol 10. issue 6. 1989-03-28. PMID:3224434. |
these findings suggest that hypertension and the alleged reduced central dopaminergic activity in the shr is not related to the transport of dopamine in the tuberoinfundibular tract. |
1989-03-28 |
2023-08-11 |
rat |
| S J O'Dell, J F Marshal. Transport of [3H]mazindol binding sites in mesostriatal dopamine axons. Brain research. vol 460. issue 2. 1989-03-27. PMID:3147121. |
such lesions produce accumulations of high-affinity dopamine uptake sites (as measured by [3h]mazindol binding) and acetylcholinesterase proximal to the injection, suggesting that at least a portion of the [3h]mazindol binding and acetylcholinesterase activity seen in the striatum is located presynaptically on the mesostriatal dopaminergic fibers. |
1989-03-27 |
2023-08-11 |
Not clear |
| L Pierot, C Desnos, J Blin, R Raisman, D Scherman, F Javoy-Agid, M Ruberg, Y Agi. D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy. Journal of the neurological sciences. vol 86. issue 2-3. 1989-03-22. PMID:2975699. |
the densities of d1- and d2-type dopamine receptors were measured with [3h]sch23390 and [3h]spiperone, in the caudate nucleus and putamen of a large series of patients with parkinson's disease or progressive supranuclear palsy, in relation to markers of dopaminergic and cholinergic innervation of the striatum ([3h]dihydrotetrabenazine binding and choline acetyltransferase activity). |
1989-03-22 |
2023-08-11 |
Not clear |
| M Takahashi, Y Miura, N Sano, T Ohzeki, T Sugawara, T Noshiro, Y Meguro, H Watanabe, K Shimizu, K Hane. [Effects of high sodium diet on dopaminergic mechanism in normal and hypertensive subjects]. Nihon Naibunpi Gakkai zasshi. vol 64. issue 11. 1989-03-21. PMID:3065095. |
to investigate the effects of dietary sodium on the peripheral dopaminergic mechanism, changes of unconjugated plasma dopamine(da) and its related humoral factors were studied in 8 patients with essential hypertension(eh) and 8 age-matched normal controls(n) while they were receiving ordinary meals (na, 130-180 meq daily) followed by higher sodium (250-300 meq daily) diets for a week. |
1989-03-21 |
2023-08-11 |
human |
| M Hirai, N Kitamura, T Hashimoto, T Nakai, T Mita, O Shirakawa, T Yamadori, T Amano, S A Noguchi-Kuno, C Tanak. [3H]GBR-12935 binding sites in human striatal membranes: binding characteristics and changes in parkinsonians and schizophrenics. Japanese journal of pharmacology. vol 47. issue 3. 1989-03-21. PMID:3221529. |
one site is partially sodium-dependent and appears to be associated with a high-affinity dopamine uptake system on dopaminergic nerve terminals. |
1989-03-21 |
2023-08-11 |
mouse |