| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federica Bono, Veronica Mutti, Paola Devoto, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentin. Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422895. |
impaired dopamine d3 and nicotinic acetylcholine receptor membrane localization in ipscs-derived dopaminergic neurons from two parkinson's disease patients carrying the lrrk2 g2019s mutation. |
2021-09-28 |
2023-08-13 |
Not clear |
| Huimin Zheng, Changhe Shi, Haiyang Luo, Liyuan Fan, Zhihua Yang, Xinchao Hu, Zhongxian Zhang, Shuo Zhang, Zhengwei Hu, Yu Fan, Jing Yang, Chengyuan Mao, Yuming X. α-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 27. issue 4. 2021-09-24. PMID:32729773. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases, defined as motor and non-motor symptoms associated with the loss of dopaminergic neurons and a decreased release of dopamine (da). |
2021-09-24 |
2023-08-13 |
Not clear |
| Ece Bayram, Irene Litvan, Brenton A Wright, Cailey Grembowski, Qian Shen, Deborah L Harringto. Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson's disease. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. vol 28. issue 6. 2021-09-23. PMID:33021874. |
wm is regulated by dopaminergic neurotransmission in the prefrontal cortex, but the effect of dopamine on specific processes supporting visuospatial wm are not well understood. |
2021-09-23 |
2023-08-13 |
human |
| Sanne K Meles, Wolfgang H Oertel, Klaus L Leender. Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-09-23. PMID:34530732. |
studies have focused on radiotracer imaging of the dopaminergic nigrostriatal system, which can be assessed with dopamine transporter (dat) single photon emission computed tomography (spect). |
2021-09-23 |
2023-08-13 |
human |
| José Ángel García-Pedraza, Asunción Morán, María Luisa Martín, Claudia Ollauri-Ibáñez, Alicia Rodríguez-Barbero, Carlos M Villalón, Mónica García-Doming. Dopamine D Pflugers Archiv : European journal of physiology. vol 472. issue 12. 2021-09-22. PMID:32820344. |
dopamine d the dopaminergic system influences the heart rhythm by inhibiting the rat cardiac sympathetic and parasympathetic neurotransmissions through activation of d |
2021-09-22 |
2023-08-13 |
rat |
| Sven R Suwijn, Hamdia Samim, Carsten Eggers, Alberto J Espay, Susan Fox, Anthony E Lang, Mike Samuel, Monty Silverdale, Constant V M Verschuur, Joke M Dijk, Hein J Verberne, Jan Booij, Rob M A de Bi. Value of Clinical Signs in Identifying Patients with Scans without Evidence of Dopaminergic Deficit (SWEDD). Journal of Parkinson's disease. vol 10. issue 4. 2021-09-17. PMID:32597819. |
in clinical trials that recruited patients with early parkinson's disease (pd), 4-15% of the participants with a clinical diagnosis of pd had normal dopamine transporter single photon emission computed tomography (dat spect) scans, also called "scans without evidence of dopaminergic deficit" (swedd). |
2021-09-17 |
2023-08-13 |
human |
| Richard L Jayaraj, Rami Beiram, Sheikh Azimullah, Nagoor Meeran M F, Shreesh K Ojha, Abdu Adem, Fakhreya Yousuf Jala. Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways. Molecules (Basel, Switzerland). vol 26. issue 15. 2021-09-17. PMID:34361780. |
parkinson's disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (snpc) and the resultant loss of dopamine in the striatum. |
2021-09-17 |
2023-08-13 |
rat |
| Rita R Fagan, Patrick J Kearney, Dino Luethi, Nicholas C Bolden, Harald H Sitte, Patrick Emery, Haley E Melikia. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Molecular psychiatry. 2021-09-17. PMID:34471250. |
dopaminergic ric gtpase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in drosophila melanogaster. |
2021-09-17 |
2023-08-13 |
mouse |
| Loredana Leggio, Greta Paternò, Silvia Vivarelli, Giovanna G Falzone, Carmela Giachino, Bianca Marchetti, Nunzio Irac. Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson's Disease. Aging and disease. vol 12. issue 6. 2021-09-17. PMID:34527424. |
pd is characterized by the progressive degeneration of dopaminergic neurons, with consequent dopamine depletion, and the accumulation of misfolded α-synuclein aggregates. |
2021-09-17 |
2023-08-13 |
Not clear |
| Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selen. Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical science. vol 12. issue 33. 2021-09-16. PMID:34522296. |
in this work, we combine molecular dynamics simulations, live-cell biosensor and electrophysiological assays to investigate the action of the neurotransmitter dopamine at the dopaminergic d |
2021-09-16 |
2023-08-13 |
Not clear |
| Seok Jong Chung, Sangwon Lee, Han Soo Yoo, Yang Hyun Lee, Hye Sun Lee, Yonghoon Choi, Phil Hyu Lee, Mijin Yun, Young H Soh. Association of the Non-Motor Burden with Patterns of Striatal Dopamine Loss in de novo Parkinson's Disease. Journal of Parkinson's disease. vol 10. issue 4. 2021-09-15. PMID:32925098. |
striatal dopamine deficits play a key role in the pathogenesis of parkinson's disease (pd), and several non-motor symptoms (nmss) have a dopaminergic component. |
2021-09-15 |
2023-08-13 |
Not clear |
| Yue Yu, Richard P S de Campos, Seolim Hong, Dimitar L Krastev, Siddharth Sadanand, Yen Leung, Aaron R Wheele. A microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. Microsystems & nanoengineering. vol 5. 2021-09-14. PMID:31057937. |
a microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. |
2021-09-14 |
2023-08-13 |
Not clear |
| Yue Yu, Richard P S de Campos, Seolim Hong, Dimitar L Krastev, Siddharth Sadanand, Yen Leung, Aaron R Wheele. A microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. Microsystems & nanoengineering. vol 5. 2021-09-14. PMID:31057937. |
in response to this challenge, we introduce an integrated microfluidic system that combines dopaminergic cell culture and differentiation with electroanalytical measurements of extracellular dopamine in real |
2021-09-14 |
2023-08-13 |
Not clear |
| Peter A Kempster, Laura Perju-Dumbrav. The Thermodynamic Consequences of Parkinson's Disease. Frontiers in neurology. vol 12. 2021-09-14. PMID:34512508. |
that the dopaminergic deficit of pd creates a problem with energy efficiency highlights the role played by the basal ganglia, and by dopamine, in thermodynamic governance. |
2021-09-14 |
2023-08-13 |
Not clear |
| Tobias Morville, Kristoffer H Madsen, Hartwig R Siebner, Oliver J Hulm. Reward signalling in brainstem nuclei under fluctuating blood glucose. PloS one. vol 16. issue 4. 2021-09-13. PMID:33826633. |
phasic dopamine release from mid-brain dopaminergic neurons is thought to signal errors of reward prediction (rpe). |
2021-09-13 |
2023-08-13 |
human |
| Oleg Kovtun, Ruben Torres, Riley S Ferguson, Travis Josephs, Sandra J Rosentha. Single Quantum Dot Tracking Unravels Agonist Effects on the Dopamine Receptor Dynamics. Biochemistry. vol 60. issue 13. 2021-09-10. PMID:32584548. |
d2 dopamine receptors (drd2s) belong to a family of g protein-coupled receptors that modulate synaptic dopaminergic tone via regulation of dopamine synthesis, storage, and synaptic release. |
2021-09-10 |
2023-08-13 |
Not clear |
| Amy Hauck Newman, Therese Ku, Chloe J Jordan, Alessandro Bonifazi, Zheng-Xiong X. New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders. Annual review of pharmacology and toxicology. vol 61. 2021-09-09. PMID:33411583. |
as both cocaine and methamphetamine rapidly increase dopamine (da) levels in mesolimbic brain regions, leading to euphoria that in some can lead to addiction, targets in which this increased dopaminergic tone may be mitigated have been explored. |
2021-09-09 |
2023-08-13 |
Not clear |
| Conner W Wallace, Nari S Beatty, Sarah A Hutcherson, Heather A Emmons, Madison C Loudermilt, Steve C Fordah. Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine. Nutrients. vol 13. issue 7. 2021-09-08. PMID:34371851. |
diet-induced obesity reduces dopaminergic neurotransmission in the nucleus accumbens (nac), and stressful weight loss interventions could promote cravings for palatable foods high in fat and sugar that stimulate dopamine. |
2021-09-08 |
2023-08-13 |
mouse |
| Yang Feng, Tao Li, Changyang Xing, Chen Wang, Yunyou Duan, Lijun Yuan, Yajun Zhan. Effective inhibition of miR-330/SHIP1/NF-κB signaling pathway via miR-330 sponge repolarizes microglia differentiation. Cell biology international. vol 45. issue 4. 2021-09-06. PMID:33325083. |
in the lps-induced pd mice, administration of raav-sponge-gfp suppressed activation of microglia, downregulated proinflammatory cytokines, resumed the secretion of dopamine, rescued the dopaminergic neurons, and alleviated motor dysfunction. |
2021-09-06 |
2023-08-13 |
mouse |
| Abeer Dagra, Douglas R Miller, Min Lin, Adithya Gopinath, Fatemeh Shaerzadeh, Sharonda Harris, Zachary A Sorrentino, Jonatan Fullerton Støier, Sophia Velasco, Janelle Azar, Adetola R Alonge, Joseph J Lebowitz, Brittany Ulm, Mengfei Bu, Carissa A Hansen, Nikhil Urs, Benoit I Giasson, Habibeh Khoshboue. α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. NPJ Parkinson's disease. vol 7. issue 1. 2021-09-04. PMID:34408150. |
we employed molecular biology, electrophysiology, and live-cell imaging to investigate how excessive α-synuclein expression alters multiple characteristics of dopaminergic neuronal dynamics and dopamine transmission in cultured dopamine neurons conditionally expressing gcamp6f. |
2021-09-04 |
2023-08-13 |
mouse |