| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa M Smits, Stefano Magni, Kaoru Kinugawa, Kamil Grzyb, Joachim Luginbühl, Sonia Sabate-Soler, Silvia Bolognin, Jay W Shin, Eiichiro Mori, Alexander Skupin, Jens C Schwambor. Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and tissue research. vol 382. issue 3. 2021-08-10. PMID:32737576. |
human midbrain organoids (hmos) have been described to contain midbrain-specific dopaminergic neurons that release the neurotransmitter dopamine. |
2021-08-10 |
2023-08-13 |
human |
| Ana Martínez, Ponciano García-Gutiérrez, Rafael A Zubillaga, Jorge Garza, Rubicelia Varga. Main interactions of dopamine and risperidone with the dopamine D2 receptor. Physical chemistry chemical physics : PCCP. vol 23. issue 26. 2021-08-10. PMID:34159983. |
psychosis is one of the psychiatric disorders that is controlled by dopaminergic drugs such as antipsychotics that have affinity for the dopamine d2 receptor (drd2). |
2021-08-10 |
2023-08-13 |
Not clear |
| Hussein Ibrahim, Zoe Woodward, Jennifer Pooley, Edward William Richfiel. Rotigotine patch prescription in inpatients with Parkinson's disease: evaluating prescription accuracy, delirium and end-of-life use. Age and ageing. vol 50. issue 4. 2021-08-06. PMID:33264385. |
rotigotine patch, a trans-dermal dopamine agonist, is used acutely to replace oral dopaminergic medications for inpatients with parkinson's disease where enteral routes are no longer available, and is also an option in end-of-life care where patients can no longer swallow. |
2021-08-06 |
2023-08-13 |
Not clear |
| Jolanta Dorszewska, Marta Kowalska, Michał Prendecki, Thomas Piekut, Joanna Kozłowska, Wojciech Kozubsk. Oxidative stress factors in Parkinson's disease. Neural regeneration research. vol 16. issue 7. 2021-08-04. PMID:33318422. |
the first step in managing progressive pd is to optimize dopaminergic therapy by increasing the doses of dopamine agonists and l-dopa. |
2021-08-04 |
2023-08-13 |
Not clear |
| Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Gokhan Zengin, Adrian Gheorghe Bumbu, Felicia Liana Andronie-Cioara, Aurelia Cristina Nechifor, Daniela Gitea, Alexa Florina Bungau, Mirela Marioara Toma, Simona Gabriela Bunga. The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson's Disorder and Therapeutic Implications. International journal of molecular sciences. vol 22. issue 13. 2021-08-04. PMID:34201647. |
progressive degeneration of neurons and aggravation of dopaminergic neurons in the substantia nigra pars compacta results in the loss of dopamine in the brain of parkinson's disease (pd) patients. |
2021-08-04 |
2023-08-13 |
Not clear |
| Jianhua Su, Junhua Zhang, Rui Bao, Changbo Xia, Yu Zhang, Zhujun Zhu, Qi Lv, Yingjie Qi, Jianqin Xu. Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3β/PP2A pathway in Parkinson's disease. European journal of pharmacology. vol 907. 2021-08-03. PMID:34048739. |
parkinson's disease (pd) is a common neurological disorder worldwide, characterized by loss of dopaminergic neurons and decrease of dopamine content. |
2021-08-03 |
2023-08-13 |
mouse |
| Kouhei Oonuma, Takehiro G Kusakab. The complete cell lineage and MAPK- and Otx-dependent specification of the dopaminergic cells in the Ciona brain. Development (Cambridge, England). vol 148. issue 12. 2021-08-02. PMID:34121117. |
a recent study suggested that the transcription factors fer2 and meis directly regulate the dopamine synthesis genes in ciona, but the dopaminergic cell lineage and the gene regulatory networks that control the development of dopaminergic cells have not been fully elucidated. |
2021-08-02 |
2023-08-13 |
Not clear |
| Katarzyna Z Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczn. Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299176. |
locomotor activity, neuron count, dopaminergic terminal density, dopamine level, and turnover were analyzed at three time-points post-lesion, up to 4 weeks after the operation. |
2021-07-30 |
2023-08-13 |
human |
| Hexin Yan, Hui Zhao, Yunxiao Kang, Xiaoming Ji, Tianyun Zhang, Yu Wang, Rui Cui, Guoliang Zhang, Geming Sh. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Neuropharmacology. vol 194. 2021-07-28. PMID:34089729. |
we found that parecoxib administration to aged rats for 10 weeks decreased cox-2/pge2 expression, increased tyrosine hydroxylase and dopamine transporter expression in nigrostriatal dopaminergic neurons, and alleviated motor behavioral decline. |
2021-07-28 |
2023-08-13 |
rat |
| Francesca V Lopez, Brittany Y Rohl, Aparna Wagle-Shukla, Dawn Bower. Sniffing Out Cognitive Decline in Patients with and without Evidence of Dopaminergic Deficit. Clinical parkinsonism & related disorders. vol 1. 2021-07-27. PMID:33969286. |
depletion of dopamine is a major neuropathological feature of parkinson's disease; however, 15% of patients with parkinsonian motor symptoms have neuroimaging evidence of intact dopaminergic function. |
2021-07-27 |
2023-08-13 |
Not clear |
| Ishnoor Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Lotfi Aleya, Simona Bunga. Connecting the dots between mitochondrial dysfunction and Parkinson's disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity. Environmental science and pollution research international. vol 28. issue 28. 2021-07-27. PMID:34053042. |
multiple neurological disorders occur as a consequence of impaired mitochondrial functioning, with greater sensitivity of dopaminergic (da) neurons to mitochondrial dysfunction, due to oxidative nature and low mitochondrial mass, thus supporting the contribution of mitochondrial impairment in parkinson's disorder (neuronal damage due to curbed dopamine levels). |
2021-07-27 |
2023-08-13 |
Not clear |
| Giulia Gaggi, Andrea Di Credico, Pascal Izzicupo, Giovanni Iannetti, Angela Di Baldassarre, Barbara Ghinass. Chemical and Biological Molecules Involved in Differentiation, Maturation, and Survival of Dopaminergic Neurons in Health and Parkinson's Disease: Physiological Aspects and Clinical Implications. Biomedicines. vol 9. issue 7. 2021-07-27. PMID:34209807. |
parkinson's disease (pd) is one of the most common neurodegenerative disease characterized by a specific and progressive loss of dopaminergic (da) neurons and dopamine, causing motor dysfunctions and impaired movements. |
2021-07-27 |
2023-08-13 |
human |
| Abhinaba Ghosh, Faghihe Massaeli, Kyron D Power, Tamunotonye Omoluabi, Sarah E Torraville, Julia B Pritchett, Tayebeh Sepahvand, Vanessa D Strong, Camila Reinhardt, Xihua Chen, Gerard M Martin, Carolyn W Harley, Qi Yua. Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats. Cerebral cortex communications. vol 2. issue 2. 2021-07-24. PMID:34296171. |
however, 10-hz phasic light-mediated learning facilitation was prevented by a dopaminergic antagonist in the pc, or by ventral tegmental area (vta) silencing with lidocaine, suggesting a lc-vta-pc dopamine circuitry involvement. |
2021-07-24 |
2023-08-13 |
rat |
| Yong Wang, Lu Yao, Shasha Gao, Gejuan Zhang, Qiongchi Zhang, Wanyuan Liu, Yingqiong Zhou, Yina Sun, Jie Feng, Jian Li. Inhibition of striatal dopamine D Brain research. vol 1754. 2021-07-22. PMID:33422541. |
striatal dopaminergic signaling plays a critical role in the pathogenesis of lid through its interactions with dopamine receptors. |
2021-07-22 |
2023-08-13 |
Not clear |
| Mutsuo Nuriya, Yosuke Ashikari, Takanori Iino, Takuya Asai, Jingwen Shou, Keiko Karasawa, Kaho Nakamura, Yasuyuki Ozeki, Yukari Fujimoto, Masato Yasu. Alkyne-Tagged Dopamines as Versatile Analogue Probes for Dopaminergic System Analysis. Analytical chemistry. vol 93. issue 27. 2021-07-21. PMID:34210142. |
however, the lack of probes that mimic dopamine in living tissues, owing to the neurotransmitter's small size, has hampered analysis of the dopaminergic system. |
2021-07-21 |
2023-08-13 |
Not clear |
| Debapriya Garabadu, Nidhi Agrawa. Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31916219. |
parkinson's disease (pd) is a neurodegenerative disease that is accompanied with the loss of dopaminergic neurons in the substantia nigra pars compacta which subsequently leads to a reduction in the dopamine level in the striatum. |
2021-07-19 |
2023-08-13 |
rat |
| Luke J Ney, Jane Akhurst, Raimondo Bruno, Patrick A F Laing, Allison Matthews, Kim L Felmingha. Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:32991952. |
here we review the dopamine literature and incorporate it with a growing field of research that describes both the contribution of endocannabinoids to fear extinction and ptsd, as well as the interactions between dopaminergic and endocannabinoid systems underlying this disorder. |
2021-07-19 |
2023-08-13 |
Not clear |
| Yanyun Sun, Xiao-Jun Lu, Xinghui Fu, Ye Zhang, Yan Zhan, Jiabing Liu, Lingxia Zhao, Chun-Lin Xi. Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-19. PMID:33070275. |
parkinson's disease (pd) is a disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra and a depletion of the neurotransmitter dopamine in the striatum. |
2021-07-19 |
2023-08-13 |
rat |
| Diego Luis-Ravelo, Felipe Fumagallo-Reading, Javier Castro-Hernandez, Pedro Barroso-Chinea, Domingo Afonso-Oramas, Alejandro Febles-Casquero, Ignacio Cruz-Muros, Josmar Salas-Hernandez, Virginia Mesa-Infante, Julia Rodriguez-Nuñez, Tomas Gonzalez-Hernande. Prolonged dopamine D Pharmacological research. vol 165. 2021-07-16. PMID:33484816. |
prolonged dopamine d the dopamine transporter (dat) is a membrane glycoprotein in dopaminergic neurons, which modulates extracellular and intracellular dopamine levels. |
2021-07-16 |
2023-08-13 |
Not clear |
| Sharonda Harris, Renee Afram, Takashi Shimano, Bozena Fyk-Kolodziej, Paul D Walker, Rod D Braun, Avril Genene Hol. Dopamine in Auditory Nuclei and Lemniscal Projections is Poised to Influence Acoustic Integration in the Inferior Colliculus. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:33746717. |
these results suggest that several auditory nuclei that project to the inferior colliculus contain dopamine, dopaminergic neurons in the lateral lemniscus project to the inferior colliculus and that dopaminergic neurotransmission is poised to play a pivotal role in the function of the inferior colliculus. |
2021-07-16 |
2023-08-13 |
rat |