| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Norihiro Tada, Nobutaka Hattor. Aging-related motor function and dopaminergic neuronal loss in C57BL/6 mice. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32293495. |
thus, dopamine levels are affected by the loss of dopaminergic neurons. |
2021-02-03 |
2023-08-13 |
mouse |
| María-de-Los-Angeles Andrade-Oliva, Juan Escamilla-Sánchez, Yazmín Debray-García, Russell A Morales-Rubio, Raúl González-Pantoja, Marisela Uribe-Ramírez, Omar Amador-Muñoz, Raúl V Díaz-Godoy, Andrea De Vizcaya-Ruiz, José-Antonio Arias-Montañ. In vitro exposure to ambient fine and ultrafine particles alters dopamine uptake and release, and D Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942001. |
in vitro exposure to ambient fine and ultrafine particles alters dopamine uptake and release, and d the exposure to environmental pollutants, such as fine and ultrafine particles (fp and ufp), has been associated with increased risk for parkinson's disease, depression and schizophrenia, disorders related to altered dopaminergic transmission. |
2021-02-03 |
2023-08-13 |
Not clear |
| María-de-Los-Angeles Andrade-Oliva, Juan Escamilla-Sánchez, Yazmín Debray-García, Russell A Morales-Rubio, Raúl González-Pantoja, Marisela Uribe-Ramírez, Omar Amador-Muñoz, Raúl V Díaz-Godoy, Andrea De Vizcaya-Ruiz, José-Antonio Arias-Montañ. In vitro exposure to ambient fine and ultrafine particles alters dopamine uptake and release, and D Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942001. |
the striatum, a neuronal nucleus with extensive dopaminergic afferents, is a target site for particle toxicity, which results in oxidative stress, inflammation, astrocyte activation and modifications in dopamine content and d |
2021-02-03 |
2023-08-13 |
Not clear |
| R N Lippert, S Hess, P Klemm, L M Burgeno, T Jahans-Price, M E Walton, P Kloppenburg, J C Brünin. Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. The Journal of clinical investigation. vol 130. issue 7. 2021-02-02. PMID:32510473. |
this translated into silencing of dopaminergic midbrain neurons, reduced connectivity to their downstream targets, and reduced stimulus-evoked dopamine (da) release in the striatum. |
2021-02-02 |
2023-08-13 |
mouse |
| Kathleen Wiencke, Annette Horstmann, David Mathar, Arno Villringer, Jane Neuman. Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission. PLoS computational biology. vol 16. issue 11. 2021-01-29. PMID:33253315. |
signal variability in target areas of dopaminergic neurons (striatum, cortex) may arise from dopamine concentration variability. |
2021-01-29 |
2023-08-13 |
Not clear |
| Kathleen Wiencke, Annette Horstmann, David Mathar, Arno Villringer, Jane Neuman. Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission. PLoS computational biology. vol 16. issue 11. 2021-01-29. PMID:33253315. |
specifically, dopaminergic tone is assumed to impact on phasic dopamine and hence on the integration of reward-related signals. |
2021-01-29 |
2023-08-13 |
Not clear |
| Agnese Gugliandolo, Federica Pollastro, Placido Bramanti, Emanuela Mazzo. Cannabidiol exerts protective effects in an in vitro model of Parkinson's disease activating AKT/mTOR pathway. Fitoterapia. vol 143. 2021-01-27. PMID:32184097. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of the nigrostriatal dopaminergic pathway with loss of substantia nigra pars compacta neurons and dopamine depletion. |
2021-01-27 |
2023-08-13 |
Not clear |
| T S Pronina, A A Kolacheva, L K Dil'muhametova, Yu O Nikishina, K K Suhinich, M V Ugrumo. Characteristic of Dopamine-Producing System and Dopamine Receptors in the Suprachiasmatic Nucleus in Rats in Ontogenesis. Doklady. Biochemistry and biophysics. vol 490. issue 1. 2021-01-26. PMID:32342310. |
one of the features of the developing suprachiasmatic nucleus (scn), the "biological clock" of the body, is the early expression of dopamine (da) receptors in the absence of dopaminergic neurons as a source of da. |
2021-01-26 |
2023-08-13 |
rat |
| Patrycja Kupnicka, Klaudyna Kojder, Emilia Metryka, Patrycja Kapczuk, Dariusz Jeżewski, Izabela Gutowska, Marta Goschorska, Dariusz Chlubek, Irena Baranowska-Bosiack. Morphine-element interactions - The influence of selected chemical elements on neural pathways associated with addiction. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 60. 2021-01-25. PMID:32179426. |
mesolimbic and mesocortical dopaminergic pathways play an important role in modulation of cognitive processes and decision making and, therefore, changes in dopamine metabolism are considered the central basis for the development of dependence. |
2021-01-25 |
2023-08-13 |
Not clear |
| Fangmiao Sun, Jingheng Zhou, Bing Dai, Tongrui Qian, Jianzhi Zeng, Xuelin Li, Yizhou Zhuo, Yajun Zhang, Yipan Wang, Cheng Qian, Ke Tan, Jiesi Feng, Hui Dong, Dayu Lin, Guohong Cui, Yulong L. Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature methods. vol 17. issue 11. 2021-01-25. PMID:33087905. |
dopamine (da) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. |
2021-01-25 |
2023-08-13 |
Not clear |
| Wen-Wen Liu, Shi-Zhuang Wei, Guo-Dong Huang, Lu-Bing Liu, Chao Gu, Yun Shen, Xian-Hui Wang, Shu-Ting Xia, An-Mu Xie, Li-Fang Hu, Fen Wang, Chun-Feng Li. BMAL1 regulation of microglia-mediated neuroinflammation in MPTP-induced Parkinson's disease mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32246801. |
we here showed that inactivation of brain and muscle arnt-like 1 (bmal1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (mptp)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (dans) in the substantia nigra pars compacta (snpc), decrease of dopamine (da) transmitter, and increased activation of microglia and astrocytes in the striatum. |
2021-01-22 |
2023-08-13 |
mouse |
| Joseph Jankovic, Eng King Ta. Parkinson's disease: etiopathogenesis and treatment. Journal of neurology, neurosurgery, and psychiatry. vol 91. issue 8. 2021-01-19. PMID:32576618. |
the involvement of dopaminergic as well as noradrenergic, glutamatergic, serotonergic and adenosine pathways provide insights into the rich and variable clinical phenomenology associated with pd and the possibility of alternative therapeutic approaches beyond traditional dopamine replacement therapies.one of the biggest challenges in the development of potential neuroprotective therapies has been the lack of reliable and sensitive biomarkers of progression. |
2021-01-19 |
2023-08-13 |
Not clear |
| Bianca L B Marino, Lucilene R de Souza, Kessia P A Sousa, Jaderson V Ferreira, Elias C Padilha, Carlos H T P da Silva, Carlton A Taft, Lorane I S Hage-Meli. Parkinson's Disease: A Review from Pathophysiology to Treatment. Mini reviews in medicinal chemistry. vol 20. issue 9. 2021-01-15. PMID:31686637. |
pd is caused by the necrosis of dopaminergic neurons in the substantia nigra, which is the brain region responsible for the synthesis of the neurotransmitter dopamine (da), resulting in its decrease in the synaptic cleft. |
2021-01-15 |
2023-08-13 |
Not clear |
| Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizaw. Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32847967. |
to investigate how dopamine signaling modulates stress-coping behavior, we measured the subsecond fluctuation of extracellular dopamine concentration and ph using fast scanning cyclic voltammetry (fscv) in the nac, a postsynaptic target of midbrain dopaminergic neurons, in male mice engaged in a tail suspension test (tst). |
2021-01-15 |
2023-08-13 |
mouse |
| Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizaw. Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32847967. |
we then addressed the causal relationship of such a dopaminergic transmission with behavioral alterations by knocking out both the dopamine receptors, i.e., d1 and d2, in the nac using viral vector-mediated genome editing. |
2021-01-15 |
2023-08-13 |
mouse |
| Maria Lindahl, Alcmène Chalazonitis, Erik Palm, Emmi Pakarinen, Tatiana Danilova, Tuan D Pham, Wanda Setlik, Meenakshi Rao, Vootele Võikar, Jatta Huotari, Jaakko Kopra, Jaan-Olle Andressoo, Petteri T Piepponen, Mikko Airavaara, Anne Panhelainen, Michael D Gershon, Mart Saarm. Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiology of disease. vol 134. 2021-01-13. PMID:31783118. |
cerebral dopamine neurotrophic factor (cdnf) is neuroprotective for nigrostriatal dopamine neurons and restores dopaminergic function in animal models of parkinson's disease (pd). |
2021-01-13 |
2023-08-13 |
mouse |
| Carlos Juri, Vasko Kramer, Patrick J Riss, Cristian Soza-Ried, Arlette Haeger, Rossana Pruzzo, Frank Rösch, Horacio Amaral, Pedro Chana-Cueva. [18F]PR04.MZ PET/CT Imaging for Evaluation of Nigrostriatal Neuron Integrity in Patients With Parkinson Disease. Clinical nuclear medicine. vol 46. issue 2. 2021-01-13. PMID:33323728. |
degeneration of dopaminergic, nigrostriatal neurons is the hallmark of parkinson disease (pd), and pet quantification of dopamine transporters is a widely accepted method for differential diagnosis between idiopathic pd and essential tremor. |
2021-01-13 |
2023-08-13 |
Not clear |
| M Angela Cenci, Anders Björklun. Animal models for preclinical Parkinson's research: An update and critical appraisal. Progress in brain research. vol 252. 2021-01-11. PMID:32247366. |
a substantial loss of nigrostriatal dopamine neurons is necessary for the animal to exhibit a hypokinetic motor phenotype responsive to dopaminergic agents, thus resembling clinical pd. |
2021-01-11 |
2023-08-13 |
mouse |
| Hirotaka Sekiguchi, Geoff Pavey, Brian Dea. Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia. NPJ schizophrenia. vol 5. issue 1. 2021-01-10. PMID:31792225. |
we postulated that the dopamine transporter (dat), which regulates intra-synaptic dopamine concentrations by transporting dopamine from the synaptic cleft into the pre-synaptic neuron, could be involved in dopaminergic dysfunction in schizophrenia. |
2021-01-10 |
2023-08-13 |
human |
| Fabin Han, Baoyang H. Stem Cell Therapy for Parkinson's Disease. Advances in experimental medicine and biology. vol 1266. 2021-01-08. PMID:33105493. |
here, we summarize the research advance in experimental and clinical studies to transplant these cells into animal models and clinical patients, and specifically highlight the studies to use hescs /ipscs-derived dopaminergic precursor cells and dopamine neurons for the treatment of pd, at last propose future challenges for developing clinical-grade dopaminergic cells for treating the pd. |
2021-01-08 |
2023-08-13 |
human |