| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xueting Li, Jianan Li, Peng Li, Yujia Jiang, Yanping Wu, Baixiang L. Injury to dopaminergic neurons development via the Lmx1a/Wnt1 autoregulatory loop induced by simazine. Toxicology letters. vol 333. 2020-11-02. PMID:32822773. |
we detected the protein and mrna levels of development-related genes of dopaminergic neurons and intracellular dopamine levels in different treatment groups. |
2020-11-02 |
2023-08-13 |
mouse |
| Xueting Li, Jianan Li, Peng Li, Yujia Jiang, Yanping Wu, Baixiang L. Injury to dopaminergic neurons development via the Lmx1a/Wnt1 autoregulatory loop induced by simazine. Toxicology letters. vol 333. 2020-11-02. PMID:32822773. |
based on our experiments' results, we demonstrated an acute response to 24 h-600 μm simazine treatment, the simazine-induced injury to dopaminergic neuronal which leads to abnormal dopamine levels and dopaminergic impairment is via the activation of the lmx1a/wnt1 autoregulatory loop. |
2020-11-02 |
2023-08-13 |
mouse |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
synchronized pauses in the activity of striatal cholinergic interneurons (chins) are correlated with elevated activity of midbrain dopaminergic neurons, whereas synchronous firing of chins induces local release of dopamine. |
2020-11-02 |
2023-08-13 |
Not clear |
| Simona Coviello, Yaiza Gramuntell, Esther Castillo-Gomez, Juan Nache. Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Frontiers in neuroscience. vol 14. 2020-10-31. PMID:33122993. |
in order to evaluate the hypothetical effects of pharmacological modulation of dopaminergic neurotransmission on the differentiation of immature neurons of the adult pcx, we studied dopamine d2 receptor (d2r) expression in this region and the relationship between dopaminergic fibers and immature neurons (defined by psa-ncam expression). |
2020-10-31 |
2023-08-13 |
mouse |
| Natalia Ninkina, Tatiana V Tarasova, Kirill D Chaprov, Andrei Yu Roman, Michail S Kukharsky, Larisa G Kolik, Ruslan Ovchinnikov, Aleksey A Ustyugov, Andrey D Durnev, Vladimir L Buchma. Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice. Neurobiology of aging. vol 91. 2020-10-30. PMID:32224067. |
no significant changes of animal balance/coordination, the number of dopaminergic neurons in the snpc and the content of dopamine and its metabolites in the striatum were observed after adult-onset α-synuclein depletion, but in aging (18-month-old) late-onset depleted mice we found a significant reduction of major dopamine metabolites without changes to the content of dopamine itself. |
2020-10-30 |
2023-08-13 |
mouse |
| Johannes Petzold, Annika Kienast, Ying Lee, Shakoor Pooseh, Edythe D London, Thomas Goschke, Michael N Smolk. Baseline impulsivity may moderate L-DOPA effects on value-based decision-making. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:30948756. |
research has indicated a major role of dopamine in decision-making processes, but the underlying mechanisms remain largely unknown due to inconsistency in effects of dopaminergic drugs. |
2020-10-27 |
2023-08-13 |
human |
| Tommaso Nuzzo, Daniela Punzo, Paola Devoto, Elena Rosini, Silvia Paciotti, Silvia Sacchi, Qin Li, Marie-Laure Thiolat, Celine Véga, Massimo Carella, Manolo Carta, Fabrizio Gardoni, Paolo Calabresi, Loredano Pollegioni, Erwan Bezard, Lucilla Parnetti, Francesco Errico, Alessandro Usiell. The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31222058. |
these results further confirm the existence of deep interaction between dopaminergic and glutamatergic neurotransmission in pd and disclose a possible direct influence of d-amino acids variations in the changes of nmdar transmission occurring under dopamine denervation and l-dopa therapy. |
2020-10-27 |
2023-08-13 |
monkey |
| Nagla A El-Sherbeeny, Nema Soliman, Amal M Youssef, Noha M Abd El-Fadeal, Taghrid B El-Abaseri, Abdullah A Hashish, Walid Kamal Abdelbasset, Gaber El-Saber Batiha, Sawsan A Zaiton. The protective effect of biochanin A against rotenone-induced neurotoxicity in mice involves enhancing of PI3K/Akt/mTOR signaling and beclin-1 production. Ecotoxicology and environmental safety. vol 205. 2020-10-21. PMID:32977283. |
rotenone injection resulted in locomotor disturbances in mice, degeneration in dopaminergic neurons [tyrosine hydroxylase-immunoreactive cells], low striatal dopamine, increased malondialdehyde and decreased level of glutathione. |
2020-10-21 |
2023-08-13 |
mouse |
| Andrew F Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parma. hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease. Cell reports. vol 28. issue 13. 2020-10-19. PMID:31553914. |
furthermore, we provide evidence that hesc-derived dopaminergic grafts transplanted in a long-term preclinical rat model of parkinson's disease (pd) receive synaptic input from subtypes of host cortical, striatal, and pallidal neurons that are known to regulate the function of endogenous nigral dopamine neurons. |
2020-10-19 |
2023-08-13 |
human |
| Namrata Mittra, Amit Kumar Chauhan, Garima Singh, Devendra Kumar Patel, Chetna Sing. Postnatal zinc or paraquat administration increases paraquat or zinc-induced loss of dopaminergic neurons: insight into augmented neurodegeneration. Molecular and cellular biochemistry. vol 467. issue 1-2. 2020-10-19. PMID:32060784. |
exposure of zn or pq during adulthood alone exhibited marked reduction in motor activities, striatal dopamine and metabolites, glutathione content and number of dopaminergic neurons. |
2020-10-19 |
2023-08-13 |
rat |
| Xingyun Xu, Rui Wang, Zongbing Hao, Guanghui Wang, Chenchen Mu, Jianqing Ding, Wanping Sun, Haigang Re. DJ-1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31232473. |
lack of dopamine production and neurodegeneration of dopaminergic neurons in the substantia nigra are considered as the major characteristics of parkinson's disease, a prevalent movement disorder worldwide. |
2020-10-13 |
2023-08-13 |
Not clear |
| Funda Akkus, Sylvia Terbeck, Connor J Haggarty, Valerie Treyer, Janan J Dietrich, Stefanie Hornschuh, Gregor Hasle. The role of the metabotropic glutamate receptor 5 in nicotine addiction. CNS spectrums. 2020-10-07. PMID:32713396. |
previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has provided strong evidence for the involvement of dopaminergic neuronal circuitry in nicotine addiction. |
2020-10-07 |
2023-08-13 |
human |
| Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalep. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Scientific reports. vol 9. issue 1. 2020-10-05. PMID:30918302. |
the results showed that reboxetine improved the parkinsonian phenotype associated with delayed progression of sn/vta dopaminergic neurodegeneration and higher dopamine content in the striatum. |
2020-10-05 |
2023-08-13 |
mouse |
| Eric Uwimana, Brianna Cagle, Coby Yeung, Xueshu Li, Eric V Patterson, Jonathan A Doorn, Hans-Joachim Lehmle. Atropselective Oxidation of 2,2',3,3',4,6'-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2020-10-02. PMID:31268529. |
reactive oxygen species and levels of dopamine and its metabolites were not significantly altered after a 24 h exposure of dopaminergic cells to pure pcb 132 atropisomers. |
2020-10-02 |
2023-08-13 |
human |
| Dimitri Ryczko, Réjean Dubu. Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28603482. |
in pathological conditions where dopamine cells are lost, such as in parkinson's disease, locomotor deficits are traditionally associated with the reduced ascending dopaminergic input to the basal ganglia. |
2020-10-01 |
2023-08-13 |
human |
| Franz Marxreiter, Jürgen Winkler, Martin Uhl, Dominik Madža. A Case Report of Severe Delirium after Amantadine Withdrawal. Case reports in neurology. vol 9. issue 1. 2020-10-01. PMID:28611642. |
amantadine is frequently used in addition to dopaminergic substances like dopamine agonists or l-dopa in advanced parkinson disease (pd). |
2020-10-01 |
2023-08-13 |
Not clear |
| Rui Cui, Yunxiao Kang, Li Wang, Shuangcheng Li, Xiaoming Ji, Wensheng Yan, Guoliang Zhang, Huixian Cui, Geming Sh. Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28620296. |
to determine the efficacy of testosterone supplements in different status of oxidative stress, the present studies analyzed the dopamine (da)-related behaviors and neurochemical indices, as well as markers of nigrostriatal dopaminergic (nsda) system in reserpine-treated aged male rats followed by testosterone propionate (tp) supplements. |
2020-10-01 |
2023-08-13 |
rat |
| Fabrizio Sanna, Jessica Bratzu, Maria A Piludu, Maria G Corda, Maria R Melis, Osvaldo Giorgi, Antonio Argiola. Dopamine, Noradrenaline and Differences in Sexual Behavior between Roman High and Low Avoidance Male Rats: A Microdialysis Study in the Medial Prefrontal Cortex. Frontiers in behavioral neuroscience. vol 11. 2020-10-01. PMID:28638325. |
these differences have been correlated to a higher tone of the mesolimbic dopaminergic system of rha rats vs. rla rats, revealed by the higher increase of dopamine found in the dialysate obtained from the nucleus accumbens of rha than rla rats during sexual activity. |
2020-10-01 |
2023-08-13 |
rat |
| Sudhakar R Subramaniam, Howard J Federof. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28642697. |
parkinson's disease (pd) is a chronic and progressive disorder characterized neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular proteinaceous inclusions, reduction of dopaminergic terminals in the striatum, and increased neuroinflammatory cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Alejandra Boronat-García, Magdalena Guerra-Crespo, René Drucker-Colí. Historical perspective of cell transplantation in Parkinson's disease. World journal of transplantation. vol 7. issue 3. 2020-10-01. PMID:28698835. |
the classical motor symptoms of pd are caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrement in dopamine release in the striatum. |
2020-10-01 |
2023-08-13 |
human |