| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Ho-Won Lee, Dong-Kug Cho. Lipid-based nanodelivery approaches for dopamine-replacement therapies in Parkinson's disease: From preclinical to translational studies. Biomaterials. vol 232. 2021-04-30. PMID:31901690. |
pd is primarily characterized by the progressive loss of dopaminergic (daergic) neurons and/or associated neuronal networks and the subsequent depletion of dopamine (da) levels in the brain. |
2021-04-30 |
2023-08-13 |
Not clear |
| Siddhartha Sahai, Emaan T Effendi, Emily C Mahoney, Heidi R Tucker, Benjamin J Moolick, Gianna Mamone, Saisree Mikkilineni, Megan Gupta, Alycia Nicholson, Fu Yee Chua, Kainat Akhtar, Zall Hirschstein, Eric S Molho, Julie G Pilitsis, Damian S Shi. Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson's disease. Neuroscience letters. vol 739. 2021-04-30. PMID:33141067. |
the underlying mechanisms contributing to this reduction remain unclear, but studies posit that stn-dbs may increase striatal dopamine levels by exciting remaining dopaminergic cells in the substantia nigra pars compacta (snc). |
2021-04-30 |
2023-08-13 |
rat |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Shameema Bano, Shubha Shukl. Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease. Behavioural brain research. vol 378. 2021-04-29. PMID:31626851. |
dopamine d1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of parkinson's disease. |
2021-04-29 |
2023-08-13 |
rat |
| Lukas Meyerolbersleben, Christine Winter, Nadine Bernhard. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. Behavioural brain research. vol 378. 2021-04-28. PMID:31629834. |
the predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. |
2021-04-28 |
2023-08-13 |
rat |
| Alexandra Perebikovsky, Alexander T Hwu, Andrew R Yale, Maziar Ghazinejad, Marc Mado. Nanofibrous Carbon Multifunctional Smart Scaffolds for Simultaneous Cell Differentiation and Dopamine Detection. ACS biomaterials science & engineering. vol 6. issue 1. 2021-04-28. PMID:33463198. |
carbon mss is used to (1) enhance the morphology and differentiation of mouse neural stem/progenitor cells (mnspcs) derived from different regions of the developing brain and (2) simultaneously detect a neurotransmitter, dopamine, from a model dopaminergic cell line growing on the electrode. |
2021-04-28 |
2023-08-13 |
mouse |
| Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarr. A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-04-28. PMID:33808343. |
at present, anti-pd drugs acting on dopamine receptors are mainly symptomatic and have only very limited neuroprotective effects, whereas drugs slowing down neurodegeneration of dopaminergic neurons and deterioration of clinical symptoms are not yet available. |
2021-04-28 |
2023-08-13 |
human |
| Mariana H G Monje, Javier Blesa, Miguel Ángel García-Cabezas, José A Obeso, Carmen Cavad. Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 3. 2021-04-27. PMID:31800134. |
the primate thalamus is densely and heterogeneously innervated with dopaminergic axons, most of which express the dopamine transporter, as does the nigrostriatal system. |
2021-04-27 |
2023-08-13 |
monkey |
| Zahra Jafari, Bryan E Kolb, Majid H Mohajeran. Auditory Dysfunction in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 4. 2021-04-27. PMID:32052894. |
improvement in auditory responses following dopaminergic therapies also indicates the presence of similar neurotransmitters (i.e., glutamate and dopamine) in the auditory system and basal ganglia. |
2021-04-27 |
2023-08-13 |
Not clear |
| Jodi R Godfrey, Melanie Pincus, Zsofia Kovacs-Balint, Eric Feczko, Eric Earl, Oscar Miranda-Dominguez, Damien A Fair, Sara R Jones, Jason Locke, Mar M Sanchez, Mark E Wilson, Vasiliki Michopoulo. Obesogenic diet-associated C-reactive protein predicts reduced central dopamine and corticostriatal functional connectivity in female rhesus monkeys. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32240763. |
alterations in dopamine (da) signaling and reductions in functional connectivity (fc; a measure of temporal correlations of activity between different brain regions) within dopaminergic reward pathways are implicated in the etiology of psychopathology and have been associated with increased concentrations of inflammatory markers, including c-reactive protein. |
2021-04-27 |
2023-08-13 |
monkey |
| Jian-Fu Liao, Yun-Fang Cheng, Shu-Ting You, Wen-Chun Kuo, Chi-Wei Huang, Jen-Jie Chiou, Chih-Chieh Hsu, Hsiu-Mei Hsieh-Li, Sabrina Wang, Ying-Chieh Tsa. Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32739365. |
here, we report that orally administering ps128 for 4 weeks significantly alleviated the motor deficits, elevation in corticosterone, nigrostriatal dopaminergic neuronal death, and striatal dopamine reduction in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (mptp)-induced pd mouse models. |
2021-04-27 |
2023-08-13 |
mouse |
| Rowan Saloner, Mariana Cherner, David J Grelotti, Emily W Paolillo, David J Moore, Robert K Heaton, Scott L Letendre, Adarsh Kumar, Igor Grant, Ronald J Elli. Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32966871. |
abnormalities in dopaminergic neurotransmission and depression are common in people with hiv (pwh), however the link between dopamine (da) and depression in pwh is poorly characterized. |
2021-04-27 |
2023-08-13 |
Not clear |
| Mykel A Robble, Mary E Bozsik, Daniel S Wheeler, Robert A Wheele. Learned avoidance requires VTA KOR-mediated reductions in dopamine. Neuropharmacology. vol 167. 2021-04-23. PMID:32057802. |
to determine the necessity of vta kor activity in the regulation of dopamine signaling and avoidance, we tested the effects of vta kor blockade on real time dopaminergic responses to aversive stimuli and learned avoidance in male sprague-dawley rats. |
2021-04-23 |
2023-08-13 |
rat |
| C Costas, L R F Far. Do naturally occurring antioxidants protect against neurodegeneration of the dopaminergic system? A systematic revision in animal models of Parkinson's disease. Current neuropharmacology. 2021-04-22. PMID:33882808. |
parkinson's disease (pd) is the second most common neurodegenerative disease and is characterized by a significant decrease in dopamine levels, caused by progressive degeneration of the dopaminergic neurons in the nigrostriatal pathway. |
2021-04-22 |
2023-08-13 |
Not clear |
| Megan A Aumann, Adam J Stark, Shelby B Hughes, Ya-Chen Lin, Hakmook Kang, Elise Bradley, David H Zald, Daniel O Claasse. Self-reported rates of impulsivity in Parkinson's Disease. Annals of clinical and translational neurology. vol 7. issue 4. 2021-04-19. PMID:32227451. |
patients with parkinson's disease (pd) who receive dopaminergic treatment, especially dopamine agonists, are at risk of developing impulsive-compulsive behaviors (icbs). |
2021-04-19 |
2023-08-13 |
Not clear |
| Chunhui Yang, Yiqing Qiu, Yuan Qing, Jinyu Xu, Wei Dai, Xiaowu Hu, Xi W. Synergistic effect of electric stimulation and mesenchymal stem cells against Parkinson's disease. Aging. vol 12. issue 16. 2021-04-19. PMID:32836217. |
mesenchymal stem cells (mscs) can salvage loss of dopamine in pd through their differentiation into dopaminergic neurons. |
2021-04-19 |
2023-08-13 |
mouse |
| Dagmar N van Deursen, Odile A van den Heuvel, Jan Booij, Henk W Berendse, Chris Vrien. Autonomic failure in Parkinson's disease is associated with striatal dopamine deficiencies. Journal of neurology. vol 267. issue 7. 2021-04-12. PMID:32162062. |
dopamine and serotonin are known to play a role in autonomic regulation, and, therefore, pd-related degeneration of serotonergic and dopaminergic neurons in these regions may be associated with autonomic dysfunction. |
2021-04-12 |
2023-08-13 |
Not clear |
| Camilla Hume, Shelley Massey, Maarten van den Buus. The Effect of Chronic Methamphetamine Treatment on Schizophrenia Endophenotypes in Heterozygous Reelin Mice: Implications for Schizophrenia. Biomolecules. vol 10. issue 6. 2021-04-12. PMID:32580454. |
chronic methamphetamine (meth) use may cause dopaminergic sensitisation and psychosis and has been proposed to affect brain dopamine systems similarly to changes seen in schizophrenia. |
2021-04-12 |
2023-08-13 |
mouse |
| Ana Sofia Abrantes Dias, Joana Catarina Amaral Pinto, Mariana Magalhães, Vera M Mendes, Bruno Manada. Analytical methods to monitor dopamine metabolism in plasma: Moving forward with improved diagnosis and treatment of neurological disorders. Journal of pharmaceutical and biomedical analysis. vol 187. 2021-04-09. PMID:32470692. |
since dopamine (da) was discovered as an essential neurotransmitter, with a profound impact on motor control, memory, and behavioral impulses, the pathogenesis of several neurodegenerative and neuropsychiatric disorders have been associated with the dysfunction of the dopaminergic system. |
2021-04-09 |
2023-08-13 |
human |
| Gopi Margabandhu, Arambakkam Janardhanam Vanisre. Dopamine, a key factor of mitochondrial damage and neuronal toxicity on rotenone exposure and also parkinsonic motor dysfunction-Impact of asiaticoside with a probable vesicular involvement. Journal of chemical neuroanatomy. vol 106. 2021-04-06. PMID:32278634. |
persuasive evidence propose that the toxicity of dopamine in parkinsonism and the loss of dopaminergic neurons are the earliest events during the pathogenesis of parkinson's disease (pd). |
2021-04-06 |
2023-08-13 |
rat |
| Yasuo Terao, Motoyasu Honma, Yuki Asahara, Shin-Ichi Tokushige, Toshiaki Furubayashi, Tai Miyazaki, Satomi Inomata-Terada, Ayumi Uchibori, Shinji Miyagawa, Yaeko Ichikawa, Atsuro Chiba, Yoshikazu Ugawa, Masahiko Suzuk. Time Distortion in Parkinsonism. Frontiers in neuroscience. vol 15. 2021-04-06. PMID:33815049. |
although animal studies and studies on parkinson's disease (pd) suggest that dopamine deficiency slows the pace of the internal clock, which is corrected by dopaminergic medication, timing deficits in parkinsonism remain to be characterized with diverse findings. |
2021-04-06 |
2023-08-13 |
human |