| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohan K Ghanta, P Elango, Bhaskar L V K . Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson's Disease. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32065086. |
treatment of parkinson's disease (pd) through dopamine replacement strategies may provide improvement in early stages and this treatment response is related to dopaminergic neuronal mass which decreases in advanced stages. |
2021-03-19 |
2023-08-13 |
Not clear |
| Taylor A Gee, Nathan C Weintraub, Dong Lu, Caroline E Phelps, Edita Navratilova, Michael L Heien, Frank Porrec. A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens. Pain. vol 161. issue 10. 2021-03-19. PMID:32453137. |
capsaicin treatment in the alternate cornea, however, again produced coincident decreased dopaminergic tone and increased phasic dopamine release. |
2021-03-19 |
2023-08-13 |
rat |
| Taylor A Gee, Nathan C Weintraub, Dong Lu, Caroline E Phelps, Edita Navratilova, Michael L Heien, Frank Porrec. A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens. Pain. vol 161. issue 10. 2021-03-19. PMID:32453137. |
our data show that (1) the mesolimbic dopamine circuit reliably encodes acute noxious stimuli; (2) ongoing pain produces decreases in dopaminergic tone; and (3) pain-induced decreases in tonic dopamine correspond to augmented evoked phasic dopamine release. |
2021-03-19 |
2023-08-13 |
rat |
| Taylor A Gee, Nathan C Weintraub, Dong Lu, Caroline E Phelps, Edita Navratilova, Michael L Heien, Frank Porrec. A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens. Pain. vol 161. issue 10. 2021-03-19. PMID:32453137. |
enhanced phasic dopamine neurotransmission resulting from salient stimuli may contribute to increased impulsivity and cognitive deficits often observed in conditions associated with decreased dopaminergic tone, including parkinson disease and chronic pain. |
2021-03-19 |
2023-08-13 |
rat |
| M V Melnikov, M V Pashenkov, A N Boyk. [The prospect of dopaminergic therapy in multiple sclerosis]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 121. issue 2. 2021-03-18. PMID:33728853. |
dopamine can modulate th17 cells function as well as dendritic cell-mediated th17-immune response that allows considering dopaminergic receptors as a new therapeutic target in multiple sclerosis. |
2021-03-18 |
2023-08-13 |
Not clear |
| Danielle Wasserman, Dorothea Bindman, Alexander D Nesbitt, Diana Cash, Milan Milosevic, Paul T Francis, K Ray Chaudhuri, Guy D Leschziner, Luigi Ferini-Strambi, Clive Ballard, Amy Eccles, Ivana Rosenzwei. Striatal Dopaminergic Deficit and Sleep in Idiopathic Rapid Eye Movement Behaviour Disorder: An Explorative Study. Nature and science of sleep. vol 13. 2021-03-17. PMID:33447113. |
neuroimaging studies of striatal dopamine transporter uptake tracer signaling suggest increasing dopaminergic deficit across the continuum of the alpha-synucleinopathies, with early sleep dysfunction suggestive of early caudate dysfunction. |
2021-03-17 |
2023-08-13 |
Not clear |
| Michael R Kilbour. Biomedicines. vol 9. issue 2. 2021-03-16. PMID:33499179. |
in vivo pet imaging of dopaminergic functions of the central nervous system (cns) including dopamine synthesis, vesicular storage, synaptic release and receptor binding, and reuptake processes, are now routinely used for studies in neurology, psychiatry, drug abuse and addiction, and drug development. |
2021-03-16 |
2023-08-13 |
Not clear |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| P Stepanova, V Srinivasan, D Lindholm, M H Voutilaine. Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington's disease. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33154393. |
cerebral dopamine neurotrophic factor (cdnf) is an endoplasmic reticulum (er) located protein with neurotrophic factor (ntf) properties, protecting and restoring the function of dopaminergic neurons in animal models of pd more effectively than other ntfs. |
2021-03-15 |
2023-08-13 |
rat |
| Yasuhisa Ano, Shiho Kitaoka, Rena Ohya, Keiji Kondo, Tomoyuki Furuyashik. Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress. International journal of molecular sciences. vol 21. issue 24. 2021-03-15. PMID:33348553. |
since acute oral consumption with iaa increases dopamine levels in hippocampus and improves memory impairment via vagal nerve activation, here we investigated the effects of chronic administration of hop bitter acids on the dopaminergic activity associated with emotional disturbance in a mouse model of repeated social defeat stress (r-sds). |
2021-03-15 |
2023-08-13 |
mouse |
| Yasuhisa Ano, Shiho Kitaoka, Rena Ohya, Keiji Kondo, Tomoyuki Furuyashik. Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress. International journal of molecular sciences. vol 21. issue 24. 2021-03-15. PMID:33348553. |
chronic administration of iaa and mhba significantly increased dopaminergic activity based on the dopamine metabolite to dopamine ratio in the hippocampus and medial prefrontal cortex following r-sds. |
2021-03-15 |
2023-08-13 |
mouse |
| Tamriage A Martin, Hilary R Smith, Deborah J Luessen, Rong Chen, Linda J Porrin. Functional brain activity is globally elevated by dopamine D2 receptor knockdown in the ventral tegmental area. Brain research. vol 1727. 2021-03-10. PMID:31726041. |
regulation of dopamine transmission within this system is achieved in part through a negative feedback mechanism via dopamine d2 autoreceptors located on somatodendrites and terminals of vta dopaminergic neurons. |
2021-03-10 |
2023-08-13 |
rat |
| Jose L Labandeira-Garcia, Rita Valenzuela, Maria A Costa-Besada, Begoña Villar-Cheda, Ana I Rodriguez-Pere. The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons. Progress in neurobiology. vol 199. 2021-03-10. PMID:33039415. |
the dopaminergic system is particularly interesting to investigate the ras as important functional interactions between dopamine and ras have been observed in the brain and several peripheral tissues. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ji Ae Lee, Hye Ri Kim, Hyo Jin Son, Nari Shin, Se Hee Han, Chan Seong Cheong, Dong Jin Kim, Onyou Hwan. A novel pyrazolo [3,4-d] pyrimidine, KKC080106, activates the Nrf2 pathway and protects nigral dopaminergic neurons. Experimental neurology. vol 332. 2021-03-09. PMID:32580013. |
in mptp-treated mice that received kkc080106 orally, the compound blocked microglial activation, protected the nigral dopaminergic neurons from degeneration, and prevented development of the dopamine deficiency-related motor deficits. |
2021-03-09 |
2023-08-13 |
mouse |
| Jing Wang, Simin Lai, Guodong Li, Ting Zhou, Biao Wang, Fang Cao, Teng Chen, Xia Zhang, Yanjiong Che. Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31626970. |
we previously demonstrated that the dopamine d3 receptor (d3r) inhibitor, ngb2904, increases susceptibility to depressive-like symptoms, elevates pro-inflammatory cytokine expression, and alters brain-derived neurotrophic factor (bdnf) levels in mesolimbic dopaminergic regions, including the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and ventral tegmental area (vta) in mice. |
2021-03-08 |
2023-08-13 |
mouse |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
dopamine (da) metabolism is a cardinal physiological process in dopaminergic neurons, which is closely related to the loss of dopaminergic neurons in the sn. |
2021-03-08 |
2023-08-13 |
Not clear |
| Haiyun Chen, Jie Cao, Ling Zha, Peile Wang, Zheng Liu, Baojian Guo, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Yuqiang Wan. Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways. Aging. vol 12. issue 14. 2021-03-04. PMID:32710729. |
t-006 was able to improve locomotor behavior, increase survival of nigra dopaminergic neurons and boost striatal dopamine levels in both mptp- and 6-ohda-induced animals. |
2021-03-04 |
2023-08-13 |
rat |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
specifically, using a rodent model of gc exposure in late gestation (approximating human brain development at late second/early third trimester), we demonstrated enduring effects on the shape and volume of the ventral tegmental area (vta) and substantia nigra pars compacta (snc) (origins of the mesocorticolimbic and nigrostriatal dopaminergic pathways) on the topographical organisation and size of the dopaminergic neuronal populations and astrocytes within these nuclei and on target innervation density and neurochemical markers of dopaminergic transmission (receptors, transporters, basal and amphetamine-stimulated dopamine release at striatal and prefrontal cortical sites) that impact on the adult brain. |
2021-03-04 |
2023-08-13 |
human |
| Suzanne O Nolan, Jennifer E Zachry, Amy R Johnson, Lillian J Brady, Cody A Siciliano, Erin S Calipar. Direct dopamine terminal regulation by local striatal microcircuitry. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32356315. |
here we review how these mechanisms work in concert to influence the timing and magnitude of striatal dopamine signaling, independent of action potential activity at the level of dopaminergic cell bodies in the midbrain, thereby providing a parallel pathway by which dopamine can be modulated. |
2021-03-02 |
2023-08-13 |
Not clear |
| Giulia Paparella, Giulia Di Stefano, Alessandra Fasolino, Giuseppe Di Pietro, Donato Colella, Andrea Truini, Giorgio Cruccu, Alfredo Berardelli, Matteo Bologn. Painful stimulation increases spontaneous blink rate in healthy subjects. Scientific reports. vol 10. issue 1. 2021-03-02. PMID:33203984. |
our study provides evidence on the role of dopamine in nociception and suggests that dopaminergic activity may be involved in pain modulation. |
2021-03-02 |
2023-08-13 |
human |