| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
considering that the ventral tegmental area (vta) and substantia nigra (sn) in the midbrain are the primary dopamine producers, creating reliable anatomical templates of the vta and sn through neuroimaging studies would be useful for achieving a detailed understanding of this dopaminergic system. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fatemeh N Emamzadeh, Andrei Surgucho. Parkinson's Disease: Biomarkers, Treatment, and Risk Factors. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30214392. |
dopamine is a neurotransmitter involved in movement, motivation, memory, and other functions; its level is decreased in pd brain as a result of dopaminergic cell death. |
2020-09-30 |
2023-08-13 |
Not clear |
| Haitao Wang, Jiangping Xu, Philip Lazarovici, Remi Quirion, Wenhua Zhen. cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30214393. |
the dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is hyperactive. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yu Zhou, Yukio Yamamura, Masatoshi Ogawa, Ryosuke Tsuji, Koichiro Tsuchiya, Jiro Kasahara, Satoshi Got. c-Abl Inhibition Exerts Symptomatic Antiparkinsonian Effects Through a Striatal Postsynaptic Mechanism. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30505273. |
parkinson's disease (pd) is caused by a progressive degeneration of nigral dopaminergic cells leading to striatal dopamine deficiency. |
2020-09-30 |
2023-08-13 |
mouse |
| Mei-Fang Liu, Yan Xue, Cui Liu, Yun-Hai Liu, Hui-Ling Diao, Ying Wang, Yi-Peng Pan, Lei Che. Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30524223. |
the results from animal experiments demonstrated that orexin-a attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (th) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. |
2020-09-30 |
2023-08-13 |
mouse |
| Rafaela Carneiro Cordeiro, Adriano José Maia Chaves Filho, Nayana Soares Gomes, Viviane de Sousa Tomaz, Camila Dantas Medeiros, Ana Isabelle de Góis Queiroz, Michael Maes, Danielle S Macedo, Andre F Carvalh. Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors. Frontiers in psychiatry. vol 10. 2020-09-30. PMID:30949073. |
to evaluate the involvement of dopamine receptors, different experimental groups were pretreated with either the dopaminergic antagonist sch23390, for d1 receptors or raclopride, for d2/d3 receptors, prior to leptin injection. |
2020-09-30 |
2023-08-13 |
mouse |
| Lisa M Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S Monzel, Nancy Stanslowsky, Marcelo D Rosato-Siri, Alessandra Zanon, Paul M Antony, Jessica Bellmann, Sarah M Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A Hicks, Florian Wegner, Jared L Sterneckert, Jens C Schwambor. Modeling Parkinson's disease in midbrain-like organoids. NPJ Parkinson's disease. vol 5. 2020-09-30. PMID:30963107. |
these organoids are composed of midbrain dopaminergic neurons (mdans), which produce and secrete dopamine. |
2020-09-30 |
2023-08-13 |
human |
| Victoria B Velásquez, Gabriel A Zamorano, Jonathan Martínez-Pinto, Christian Bonansco, Pablo Jara, Gonzalo E Torres, Georgina M Renard, Ramón Sotomayor-Zárat. Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones: Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:30971928. |
programming of dopaminergic neurons by early exposure to sex hormones: effects on morphine-induced accumbens dopamine release, reward, and locomotor behavior in male and female rats. |
2020-09-30 |
2023-08-13 |
rat |
| Aimée I Vester, Merry Chen, Carmen J Marsit, W Michael Caudl. A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure. Toxics. vol 7. issue 2. 2020-09-30. PMID:31052489. |
midbrain rna expression as well as striatal and cortical protein expression of key dopaminergic components were investigated, in addition to adhd-like behavioral tasks and electrochemical dopamine dynamics via fast-scan cyclic voltammetry. |
2020-09-30 |
2023-08-13 |
Not clear |
| Valentina Bassareo, Giuseppe Talani, Roberto Frau, Simona Porru, Michela Rosas, Sanjay B Kasture, Alessandra T Peana, Eleonora Loi, Enrico Sanna, Elio Acqua. Inhibition of Morphine- and Ethanol-Mediated Stimulation of Mesolimbic Dopamine Neurons by Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31275092. |
inhibition of morphine- and ethanol-mediated stimulation of mesolimbic dopamine neurons by morphine- and ethanol-induced stimulation of neuronal firing of ventral tegmental area (vta) dopaminergic neurons and of dopamine (da) transmission in the shell of the nucleus accumbens (acbsh) represents a crucial electrophysiological and neurochemical response underlying the ability of these compounds to elicit motivated behaviors and trigger a cascade of plasticity-related biochemical events. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ashish Kumar Gupta, Ruchika Pokhriyal, Uddipan Das, Mohd Imran Khan, Domada Ratna Kumar, Rishab Gupta, Rakesh Kumar Chadda, Rashmi Ramachandran, Vinay Goyal, Manjari Tripathi, Gururao Hariprasa. Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson's disease and schizophrenia. Neuropsychiatric disease and treatment. vol 15. 2020-09-30. PMID:31410011. |
these two neuropsychiatric disorders represent disease end points of the dopaminergic spectrum where parkinson's disease represents dopamine deficit and schizophrenia represents dopamine hyperactivity in the mid-brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ali Farzam, Karan Chohan, Miroslava Strmiskova, Sarah J Hewitt, David S Park, John P Pezacki, Dennis Özceli. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox biology. vol 28. 2020-09-30. PMID:31760358. |
here, we compare 6-hydroxydopamine (6-ohda), a product of dopamine oxidation that commonly induces dopaminergic neurodegeneration in laboratory animals, with a synthetic alkyne-functionalized 6-ohda variant. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ali Farzam, Karan Chohan, Miroslava Strmiskova, Sarah J Hewitt, David S Park, John P Pezacki, Dennis Özceli. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox biology. vol 28. 2020-09-30. PMID:31760358. |
our study links dopamine oxidation to protein modification and protein folding in dopaminergic neurons and the pd model. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kohei Ueno, Johannes Morstein, Kyoko Ofusa, Shintaro Naganos, Ema Suzuki-Sawano, Saika Minegishi, Samir P Rezgui, Hiroaki Kitagishi, Brian W Michel, Christopher J Chang, Junjiro Horiuchi, Minoru Saito. Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 18. 2020-09-30. PMID:32253360. |
dopaminergic neurons innervate extensive areas of the brain and release dopamine (da) onto a wide range of target neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Henin. Restless Legs Syndrome. Current treatment options in neurology. vol 1. issue 4. 2020-09-30. PMID:11096718. |
the optimal initial approach to rls in the general patient is usually the use of a dopaminergic agent: low-dose levodopa in milder cases, a dopamine agonist in more severe ones. |
2020-09-30 |
2023-08-12 |
Not clear |
| David M White, Nina V Kraguljac, Meredith A Reid, Adrienne C Laht. Contribution of substantia nigra glutamate to prediction error signals in schizophrenia: a combined magnetic resonance spectroscopy/functional imaging study. NPJ schizophrenia. vol 1. 2020-09-30. PMID:26878032. |
because dopamine neurons signal a mismatch between expected and actual reward called prediction error (pe), aberrant pe signals in schizophrenia have been attributed to known dopaminergic abnormalities. |
2020-09-30 |
2023-08-13 |
Not clear |
| Katsuhiro Nagatomo, Sechiko Suga, Masato Saitoh, Masahito Kogawa, Kazuto Kobayashi, Yoshio Yamamoto, Katsuya Yamad. Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28203148. |
substantia nigra pars reticulata (snr), the major output nucleus of the basal ganglia, receives dopamine from dendrites extending from dopaminergic neurons of the adjacent nucleus pars compacta (snc), which is known for its selective degeneration in parkinson's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Lachlan Ferguson, Alice Petty, Chelsie Rohrscheib, Michael Troup, Leonie Kirszenblat, Darryl W Eyles, Bruno van Swindere. Transient Dysregulation of Dopamine Signaling in a Developing Frontiers in psychiatry. vol 8. 2020-09-30. PMID:28243212. |
transient dysregulation of dopamine signaling in a developing the dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. |
2020-09-30 |
2023-08-13 |
drosophila_melanogaster |
| Jia-Ming Mei, Chao-Shi Ni. How does conserved dopamine neurotrophic factor protect against and rescue neurodegeneration of PC12 cells? Neural regeneration research. vol 12. issue 7. 2020-09-29. PMID:28852398. |
conserved dopamine neurotrophic factor protects and rescues dopaminergic neurodegeneration induced by 6-hydroxydopamine |
2020-09-29 |
2023-08-13 |
Not clear |
| Elena Pretegiani, Lance M Optica. Eye Movements in Parkinson's Disease and Inherited Parkinsonian Syndromes. Frontiers in neurology. vol 8. 2020-09-29. PMID:29170650. |
pd is a progressive, neurodegenerative disorder caused by dopaminergic cell loss within the substantia nigra pars compacta, resulting in depletion of striatal dopamine and subsequent increased inhibitory bg output from the internal globus pallidus and the substantia nigra pars reticulata. |
2020-09-29 |
2023-08-13 |
Not clear |