| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert S Eisinger, Adolfo Ramirez-Zamora, Samuel Carbunaru, Brandon Ptak, Zhongxing Peng-Chen, Michael S Okun, Aysegul Gundu. Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30863353. |
although it is now well-recognized that dopaminergic treatments and especially dopamine agonists underpin many icds, medications alone are not the sole cause. |
2020-10-01 |
2023-08-13 |
Not clear |
| Robert S Eisinger, Adolfo Ramirez-Zamora, Samuel Carbunaru, Brandon Ptak, Zhongxing Peng-Chen, Michael S Okun, Aysegul Gundu. Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30863353. |
beyond dopamine, other icd associations have been described but remain difficult to explain, including deep brain stimulation surgery, especially in the setting of a reduction in dopaminergic medication use. |
2020-10-01 |
2023-08-13 |
Not clear |
| Krista Farrell, Roger A Barke. Stem cells and regenerative therapies for Parkinson's disease. Degenerative neurological and neuromuscular disease. vol 2. 2020-10-01. PMID:30890881. |
currently the mainstay of parkinson's disease (pd) therapy is the pharmacological replacement of the loss of the dopaminergic nigrostriatal pathway using drugs such as dopamine agonists and levodopa. |
2020-10-01 |
2023-08-13 |
Not clear |
| Krista Farrell, Roger A Barke. Stem cells and regenerative therapies for Parkinson's disease. Degenerative neurological and neuromuscular disease. vol 2. 2020-10-01. PMID:30890881. |
indeed all these studies have provided evidence that following the transplantation of fetal vm tissue, dopaminergic cells can survive long term, produce dopamine, and bring about clinical improvements in younger patients over many years. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hui Dong, Juan Wang, Yan-Fei Yang, Yan Shen, Wei-Min Qu, Zhi-Li Huan. Dorsal Striatum Dopamine Levels Fluctuate Across the Sleep-Wake Cycle and Respond to Salient Stimuli in Mice. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30949023. |
here, we employed an intensity-based genetically encoded dopamine indicator, dlight1.1, to track striatal dopamine levels across the spontaneous sleep-wake cycle and the dopaminergic response to external stimuli. |
2020-10-01 |
2023-08-13 |
mouse |
| Nicholas G Norwitz, Michele T Hu, Kieran Clark. The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease. Frontiers in nutrition. vol 6. 2020-10-01. PMID:31139630. |
although dopamine replacement therapy temporarily helps patients manage their motor symptoms, this current standard of care fails to address the underlying network of pathologies that contribute to the persistent death of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Erika Coletto, John S Dolan, Sara Pritchard, Alex Gant, Atsuko Hikima, Michael J Jackson, Christopher D Benham, K Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M Iravan. Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson's disease. NPJ Parkinson's disease. vol 5. 2020-10-01. PMID:31231674. |
the absence of the relaxation and the inefficacy of l-name in the mptp tissues suggests that central dopaminergic loss dopamine may eventually lead to the impairment of no signal coupling that affects bowel function, and this may be the result of a complex dysregulation at the level of the neuroeffector junction. |
2020-10-01 |
2023-08-13 |
marmoset |
| Ashley L Green, Aseel Eid, Le Zhan, Helmut Zarbl, Grace L Guo, Jason R Richardso. Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter. Frontiers in genetics. vol 10. 2020-10-01. PMID:31749842. |
the dopamine transporter (dat) is a plasma membrane transport protein responsible for regulating the duration and intensity of dopaminergic signaling. |
2020-10-01 |
2023-08-13 |
rat |
| Miguel A Pieron. Investigation of apomorphine during sleep in Parkinson's: Improvement in UPDRS Scores. Neurology international. vol 11. issue 4. 2020-10-01. PMID:31871600. |
this study proposes that dopaminergic deficit may be responsible for the circadian dysregulation that occur with neurodegeneration and therefore a restitution of rem sleep and an improvement in parkinson disease's symptoms can be achieved with the controlled use of dopamine agonists during the night. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
leaky optoelectrical fiber for optogenetic stimulation and electrochemical detection of dopamine exocytosis from human dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
human |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
in parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. |
2020-10-01 |
2023-08-13 |
human |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
transplanting dopaminergic neurons derived from stem cells could restore dopamine levels without additional motor complications. |
2020-10-01 |
2023-08-13 |
human |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
finally, light leaking from the micro-optical windows is used to stimulate the dopaminergic neurons resulting in the release of dopamine that is detected in real-time using chronoamperometry. |
2020-10-01 |
2023-08-13 |
human |
| Mehmet Atilla Uysal, Ülgen Sever, Ayşe Feyda Nursal, Sacide Pehlİva. Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population. Noro psikiyatri arsivi. vol 56. issue 4. 2020-10-01. PMID:31903031. |
dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| E E M Knowles, S R Mathias, D R McKay, E Sprooten, John Blangero, Laura Almasy, D C Glah. Genome-Wide Analyses of Working-Memory Ability: A Review. Current behavioral neuroscience reports. vol 1. issue 4. 2020-10-01. PMID:25729637. |
interestingly, the results of those searches converge on the mediating role of neuronal excitability in working-memory performance, such that the role of each gene highlighted by genome-wide methods plays a part in ion channel formation and/or dopaminergic signaling in the brain, with either direct or indirect influence on dopamine levels in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kenneth Blum, Peter K Thanos, Marlene Oscar-Berman, Marcelo Febo, David Baron, Rajendra D Badgaiyan, Eliot Gardner, Zsolt Demetrovics, Claudia Fahlke, Brett C Haberstick, Kristina Dushaj, Mark S Gol. Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction. Journal of reward deficiency syndrome. vol 1. issue 3. 2020-10-01. PMID:27398406. |
finally, we are cognizant of the differences in dopaminergic function as addiction progresses and argue that relapse may be tied to dopamine deficiency. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xue Qing Yang, Daniel Glizer, Andrew Vo, Ken N Seergobin, Penny A MacDonal. Pramipexole Increases Go Timeouts but Not No-go Errors in Healthy Volunteers. Frontiers in human neuroscience. vol 10. 2020-10-01. PMID:27803657. |
pd patients taking dopaminergic therapy, such as levodopa but especially dopamine agonists (das), evidence an increase in impulse control disorders (icds), suggesting a link between dopaminergic therapy and impulsive pursuit of pleasurable activities. |
2020-10-01 |
2023-08-13 |
human |
| Chiara Volpato, Sami Schiff, Silvia Facchini, Stefano Silvoni, Marianna Cavinato, Francesco Piccione, Angelo Antonini, Niels Birbaume. Dopaminergic Medication Modulates Learning from Feedback and Error-Related Negativity in Parkinson's Disease: A Pilot Study. Frontiers in behavioral neuroscience. vol 10. 2020-10-01. PMID:27822182. |
we hypothesize that high tonic dopaminergic stimulation due to the dopamine agonist medication, combined to the low level of phasic dopamine due to the off-levodopa state, could prevent phasic "dopamine dips" indicated by the ern needed for learning from negative feedback. |
2020-10-01 |
2023-08-13 |
human |
| Haruo Nishijima, Masahiko Tomiyam. What Mechanisms Are Responsible for the Reuptake of Levodopa-Derived Dopamine in Parkinsonian Striatum? Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28018168. |
when dopaminergic neurons are lost and dopamine transporters decreased, serotonin and norepinephrine transporters compensate by increasing uptake of excessive extracellular dopamine in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bernardita Cádiz-Moretti, María Abellán-Álvaro, Cecília Pardo-Bellver, Fernando Martínez-García, Enrique Lanuz. Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice. Frontiers in neuroanatomy. vol 10. 2020-10-01. PMID:28066196. |
double labeling with choline acetyltransferase indicates that the afferent projection from the basal forebrain is the origin of its distinctive cholinergic innervation, and double labeling with dopamine transporter shows that the projection from the vta is the source of dopaminergic innervation. |
2020-10-01 |
2023-08-13 |
mouse |