| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Se Eun Jang, Lifeng Qiu, Ling Ling Chan, Eng-King Tan, Li Zen. Current Status of Stem Cell-Derived Therapies for Parkinson's Disease: From Cell Assessment and Imaging Modalities to Clinical Trials. Frontiers in neuroscience. vol 14. 2020-11-13. PMID:33177975. |
pd is characterized by the gradual loss of dopaminergic (da) neurons and decreased striatal dopamine levels. |
2020-11-13 |
2023-08-13 |
Not clear |
| Jeremiah Ramos, Ethan J Hardin, Alice H Grant, Grace Flores-Robles, Adrian T Gonzalez, Bryan Cruz, Arantxa K Martinez, Nina M Beltran, Katherine M Serafin. The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D The Journal of pharmacology and experimental therapeutics. vol 374. issue 1. 2020-11-12. PMID:32265322. |
the effects of eating a high fat diet on sensitivity of male and female rats to methamphetamine and dopamine d rats eating high fat chow are more sensitive to the behavioral effects of dopaminergic drugs, including methamphetamine and the dopamine d |
2020-11-12 |
2023-08-13 |
rat |
| Susanna Waters, Clas Sonesson, Peder Svensson, Joakim Tedroff, Manolo Carta, Elisabeth Ljung, Jenny Gunnergren, Malin Edling, Boel Svanberg, Anne Fagerberg, Johan Kullingsjö, Stephan Hjorth, Nicholas Water. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. The Journal of pharmacology and experimental therapeutics. vol 374. issue 1. 2020-11-12. PMID:32358046. |
we hypothesized that such a dopamine antagonist with physicochemical properties similar to agonists would exert antidyskinetic and antipsychotic effects in states of dysregulated dopaminergic signaling while having little negative impact on physiologic dopamine transmission and, hence, minimal liability for side effects related to dopamine-dependent functions. |
2020-11-12 |
2023-08-13 |
Not clear |
| Rafieh Alizadeh, Farnaz Ramezanpour, Amirhossein Mohammadi, Mina Eftekharzadeh, Sara Simorgh, Milad Kazemiha, Fatemeh Morad. Differentiation of human olfactory system-derived stem cells into dopaminergic neuron-like cells: A comparison between olfactory bulb and mucosa as two sources of stem cells. Journal of cellular biochemistry. vol 120. issue 12. 2020-11-05. PMID:31297865. |
quantitative real-time polymerase chain reaction analysis 3 weeks after induction demonstrated that the mrna expression of the dopaminergic activity markers tyrosine hydroxylase (th), dopamine transporter (dat), paired box gene 2 (pax2), and pax5 in the neuron-like cells derived from ob-nscs was significantly higher than those derived from oe-mscs. |
2020-11-05 |
2023-08-13 |
human |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |
| Alfonso Rubino, Claudio D'Addario, Martina Di Bartolomeo, Enrico Michele Salamone, Nicoletta Locuratolo, Francesco Fattapposta, Nicola Vanacore, Esterina Pascal. DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients. Acta neurologica Scandinavica. vol 142. issue 3. 2020-11-05. PMID:32415851. |
among others, we, here, focused the attention on the dopamine transporter (dat) gene playing a critical role in maintaining the integrity of dopaminergic neurons. |
2020-11-05 |
2023-08-13 |
Not clear |
| Anum Maqsood, Salman Akram, Faisal Akra. Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia. Cureus. vol 12. issue 9. 2020-11-05. PMID:33145137. |
a fundamental step in the pathophysiology of ts is the hyperactivity of dopaminergic system leading to increased dopamine release in the cortical-basal ganglia-thalamo-cortical (cbgtc) circuits, thereby providing the rationale for treatment with dopamine receptor, in particular d2, antagonists. |
2020-11-05 |
2023-08-13 |
Not clear |
| Blenda Hyedra de Campos, Lorena de Jager, Gabriela Souza Reginato, Rito Santo Pereira, Carlos César Crestani, Phileno Pinge-Filho, Marli Cardoso Martins-Ping. Cardiovascular evaluation of female rats with 6-OHDA-induced parkinsonism: Possible protection by ovarian hormones and participation of nitric oxide. Life sciences. vol 259. 2020-11-04. PMID:32795538. |
parkinson's disease (pd) is a neurological disorder caused by environmental and genetic factors, characterized by the death of dopaminergic neurons of the substantia nigra pars compacta (snpc), leading to a decrease of dopamine in the striatum. |
2020-11-04 |
2023-08-13 |
rat |
| Francesca Palese, Silvia Pontis, Natalia Realini, Daniele Piomell. A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration. Scientific reports. vol 9. issue 1. 2020-11-03. PMID:31685899. |
nape, but not fae, accumulation is enhanced in mice lacking nape-pld, which display a substantial reduction in 6-ohda-induced neurotoxicity, as shown by increased survival of substantia nigra dopamine neurons, integrity of striatal dopaminergic fibers, and striatal dopamine metabolite content. |
2020-11-03 |
2023-08-13 |
mouse |
| Seoyon Yang, Mathieu Boudier-Revéret, Yoo Jin Choo, Min Cheol Chan. Association between Chronic Pain and Alterations in the Mesolimbic Dopaminergic System. Brain sciences. vol 10. issue 10. 2020-11-03. PMID:33023226. |
studies on administration of dopaminergic drugs to control chronic pain, with a focus on increasing low dopamine levels in the mesolimbic system, show that it is effective in patients with parkinson's disease, restless legs syndrome, fibromyalgia, dry mouth syndrome, lumbar radicular pain, and chronic back pain. |
2020-11-03 |
2023-08-13 |
Not clear |
| E Maruthi Prasad, Shih-Ya Hun. Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 9. issue 10. 2020-11-03. PMID:33081318. |
in pd, continuous loss of dopaminergic neurons in the substantia nigra causes dopamine depletion in the striatum, promotes the primary motor symptoms of resting tremor, bradykinesia, muscle rigidity, and postural instability. |
2020-11-03 |
2023-08-13 |
Not clear |
| Xueting Li, Jianan Li, Peng Li, Yujia Jiang, Yanping Wu, Baixiang L. Injury to dopaminergic neurons development via the Lmx1a/Wnt1 autoregulatory loop induced by simazine. Toxicology letters. vol 333. 2020-11-02. PMID:32822773. |
we detected the protein and mrna levels of development-related genes of dopaminergic neurons and intracellular dopamine levels in different treatment groups. |
2020-11-02 |
2023-08-13 |
mouse |
| Xueting Li, Jianan Li, Peng Li, Yujia Jiang, Yanping Wu, Baixiang L. Injury to dopaminergic neurons development via the Lmx1a/Wnt1 autoregulatory loop induced by simazine. Toxicology letters. vol 333. 2020-11-02. PMID:32822773. |
based on our experiments' results, we demonstrated an acute response to 24 h-600 μm simazine treatment, the simazine-induced injury to dopaminergic neuronal which leads to abnormal dopamine levels and dopaminergic impairment is via the activation of the lmx1a/wnt1 autoregulatory loop. |
2020-11-02 |
2023-08-13 |
mouse |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
synchronized pauses in the activity of striatal cholinergic interneurons (chins) are correlated with elevated activity of midbrain dopaminergic neurons, whereas synchronous firing of chins induces local release of dopamine. |
2020-11-02 |
2023-08-13 |
Not clear |
| Simona Coviello, Yaiza Gramuntell, Esther Castillo-Gomez, Juan Nache. Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Frontiers in neuroscience. vol 14. 2020-10-31. PMID:33122993. |
in order to evaluate the hypothetical effects of pharmacological modulation of dopaminergic neurotransmission on the differentiation of immature neurons of the adult pcx, we studied dopamine d2 receptor (d2r) expression in this region and the relationship between dopaminergic fibers and immature neurons (defined by psa-ncam expression). |
2020-10-31 |
2023-08-13 |
mouse |
| Natalia Ninkina, Tatiana V Tarasova, Kirill D Chaprov, Andrei Yu Roman, Michail S Kukharsky, Larisa G Kolik, Ruslan Ovchinnikov, Aleksey A Ustyugov, Andrey D Durnev, Vladimir L Buchma. Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice. Neurobiology of aging. vol 91. 2020-10-30. PMID:32224067. |
no significant changes of animal balance/coordination, the number of dopaminergic neurons in the snpc and the content of dopamine and its metabolites in the striatum were observed after adult-onset α-synuclein depletion, but in aging (18-month-old) late-onset depleted mice we found a significant reduction of major dopamine metabolites without changes to the content of dopamine itself. |
2020-10-30 |
2023-08-13 |
mouse |
| Johannes Petzold, Annika Kienast, Ying Lee, Shakoor Pooseh, Edythe D London, Thomas Goschke, Michael N Smolk. Baseline impulsivity may moderate L-DOPA effects on value-based decision-making. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:30948756. |
research has indicated a major role of dopamine in decision-making processes, but the underlying mechanisms remain largely unknown due to inconsistency in effects of dopaminergic drugs. |
2020-10-27 |
2023-08-13 |
human |
| Tommaso Nuzzo, Daniela Punzo, Paola Devoto, Elena Rosini, Silvia Paciotti, Silvia Sacchi, Qin Li, Marie-Laure Thiolat, Celine Véga, Massimo Carella, Manolo Carta, Fabrizio Gardoni, Paolo Calabresi, Loredano Pollegioni, Erwan Bezard, Lucilla Parnetti, Francesco Errico, Alessandro Usiell. The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31222058. |
these results further confirm the existence of deep interaction between dopaminergic and glutamatergic neurotransmission in pd and disclose a possible direct influence of d-amino acids variations in the changes of nmdar transmission occurring under dopamine denervation and l-dopa therapy. |
2020-10-27 |
2023-08-13 |
monkey |
| Nagla A El-Sherbeeny, Nema Soliman, Amal M Youssef, Noha M Abd El-Fadeal, Taghrid B El-Abaseri, Abdullah A Hashish, Walid Kamal Abdelbasset, Gaber El-Saber Batiha, Sawsan A Zaiton. The protective effect of biochanin A against rotenone-induced neurotoxicity in mice involves enhancing of PI3K/Akt/mTOR signaling and beclin-1 production. Ecotoxicology and environmental safety. vol 205. 2020-10-21. PMID:32977283. |
rotenone injection resulted in locomotor disturbances in mice, degeneration in dopaminergic neurons [tyrosine hydroxylase-immunoreactive cells], low striatal dopamine, increased malondialdehyde and decreased level of glutathione. |
2020-10-21 |
2023-08-13 |
mouse |
| Andrew F Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parma. hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease. Cell reports. vol 28. issue 13. 2020-10-19. PMID:31553914. |
furthermore, we provide evidence that hesc-derived dopaminergic grafts transplanted in a long-term preclinical rat model of parkinson's disease (pd) receive synaptic input from subtypes of host cortical, striatal, and pallidal neurons that are known to regulate the function of endogenous nigral dopamine neurons. |
2020-10-19 |
2023-08-13 |
human |