| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian Brugger, Roberto Erro, Bettina Balint, Georg Kägi, Paolo Barone, Kailash P Bhati. Why is there motor deterioration in Parkinson's disease during systemic infections-a hypothetical view. NPJ Parkinson's disease. vol 1. 2020-10-01. PMID:28725683. |
possible explanations encompass changes in the pharmacodynamics of the dopaminergic drugs, altered dopamine metabolism in the brain, alterations in the dopaminergic transmission in the striatum or an enhancement of neurodegeneration due to remote effects of peripheral inflammatory processes or circulating bacterial toxins. |
2020-10-01 |
2023-08-13 |
Not clear |
| Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storc. Early Postnatal but Not Late Adult Neurogenesis Is Impaired in the Pitx3-Mutant Animal Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28883785. |
as dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (sn) in pd may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (svz) and dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
mouse |
| Min Ki Kim, Nan Young Kim, Sangkyoon Hong, Hyeo-Il Ma, Yun Joong Ki. Presynaptic Dopaminergic Degeneration in a Patient with Beta-Propeller Protein-Associated Neurodegeneration Documented by Dopamine Transporter Positron Emission Tomography Images: A Case Report. Journal of movement disorders. vol 10. issue 3. 2020-10-01. PMID:28889720. |
presynaptic dopaminergic degeneration in a patient with beta-propeller protein-associated neurodegeneration documented by dopamine transporter positron emission tomography images: a case report. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jackalina M Van Kampen, Harold A Robertso. The BSSG rat model of Parkinson's disease: progressing towards a valid, predictive model of disease. The EPMA journal. vol 8. issue 3. 2020-10-01. PMID:29021837. |
our understanding of the role of dopamine in pd has led to the development of effective pharmacological treatments of the motor symptoms in the form of dopamine replacement therapy using levodopa and dopaminergic agonists. |
2020-10-01 |
2023-08-13 |
rat |
| Satoshi Got. Striatal Gα Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:29201000. |
striatal gα the motor symptoms of parkinson's disease (pd) result from striatal dopamine (da) deficiency due to a progressive degeneration of nigral dopaminergic cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Clément Bourguignon, Kai-Florian Storc. Control of Rest:Activity by a Dopaminergic Ultradian Oscillator and the Circadian Clock. Frontiers in neurology. vol 8. 2020-10-01. PMID:29230188. |
the cellular substrate and mechanism of ultradian rhythm generation have remained elusive so far, however recent findings-the subject of this review-now indicate that ultradian locomotor rhythms rely on an oscillator based on dopamine, dubbed the dopaminergic ultradian oscillator (duo). |
2020-10-01 |
2023-08-13 |
human |
| Rafał Muda, Mariusz Kicia, Małgorzata Michalak-Wojnowska, Michał Ginszt, Agata Filip, Piotr Gawda, Piotr Majche. The Dopamine Receptor D4 Gene ( Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:29551965. |
the most prominent explanation for this effect is the fact that 7r+ individuals are less sensitive to dopamine and thus seek more stimulation to generate "normal" dopaminergic activity and feel pleasure. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yannick Vermeiren, Jana Janssens, Debby Van Dam, Peter P De Dey. Serotonergic Dysfunction in Amyotrophic Lateral Sclerosis and Parkinson's Disease: Similar Mechanisms, Dissimilar Outcomes. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29615862. |
levodopa (l-dopa) therapy in pd largely seems to confirm the influential role of 5-ht, since serotonergic rather than dopaminergic projections release l-dopa-derived dopamine, particularly in extrastriatal regions, emphasizing the strongly interwoven interactions between both monoamine systems. |
2020-10-01 |
2023-08-13 |
Not clear |
| Michael Kirsch, Wolfgang Merten. On the Drive Specificity of Freudian Drives for the Generation of SEEKING Activities: The Importance of the Underestimated Imperative Motor Factor. Frontiers in psychology. vol 9. 2020-10-01. PMID:29774002. |
most importantly, all of these imperative motor factors can both activate a drive-specific brain area and release dopamine from dopaminergic neurons, i.e., they can achieve the so-called drive specificity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ambra Lanzo, Bryan D Safratowich, Sirisha R Kudumala, Ivan Gallotta, Giuseppina Zampi, Elia Di Schiavi, Lucia Carvell. Silencing of Frontiers in physiology. vol 9. 2020-10-01. PMID:29872404. |
silencing of the dopamine transporter (dat) is a cell membrane protein whose main function is to reuptake the dopamine (da) released in the synaptic cleft back into the dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Annette Gower, Mario Tiber. The Intersection of Central Dopamine System and Stroke: Potential Avenues Aiming at Enhancement of Motor Recovery. Frontiers in synaptic neuroscience. vol 10. 2020-10-01. PMID:30034335. |
parkinson's disease and schizophrenia are two major human neuropsychiatric disorders typically associated with dysfunctional dopamine activity levels, which can be alleviated through the druggability of the dopaminergic systems. |
2020-10-01 |
2023-08-13 |
human |
| Annette Gower, Mario Tiber. The Intersection of Central Dopamine System and Stroke: Potential Avenues Aiming at Enhancement of Motor Recovery. Frontiers in synaptic neuroscience. vol 10. 2020-10-01. PMID:30034335. |
here, we discuss the state of knowledge regarding the modulation of dopaminergic systems following stroke, and the use of dopamine boosting therapies in animal stroke models to improve stroke recovery. |
2020-10-01 |
2023-08-13 |
human |
| Braulio Muñoz, Gonzalo E Yevenes, Benjamin Förstera, David M Lovinger, Luis G Aguay. Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:30050406. |
it is believed that the rewarding actions of drugs are mediated by dysregulation of the mesolimbic dopaminergic system leading to increased levels of dopamine in the nucleus accumbens (nac). |
2020-10-01 |
2023-08-13 |
Not clear |
| Jonathan Timpka, Tove Henriksen, Per Odi. Non-oral Continuous Drug Delivery Techniques in Parkinson's Disease: For Whom, When, and How? Movement disorders clinical practice. vol 3. issue 3. 2020-10-01. PMID:30363573. |
in pd, the degeneration of dopaminergic neurons leads to a reduced capacity to buffer dopamine, which could increase the vulnerability to a pulsatile administration of drugs. |
2020-10-01 |
2023-08-13 |
Not clear |
| John Liang, Mark Groves, Vicki L Shanke. Clozapine Treatment for Impulse Control Disorders in Parkinson's Disease Patients: A Case Series. Movement disorders clinical practice. vol 2. issue 3. 2020-10-01. PMID:30363600. |
all 4 took dopaminergic medications at the time that icds developed; all received dopamine agonist therapy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Susanna Jakobson Mo, Jan Linder, Lars Forsgren, Katrine Riklun. Accuracy of Visual Assessment of Dopamine Transporter Imaging in Early Parkinsonism. Movement disorders clinical practice. vol 2. issue 1. 2020-10-01. PMID:30363855. |
dopamine transporter (dat) imaging may be supportive in the initial clinical diagnostic workup in patients with suspected parkinsonian diseases, given that the method has the potential to detect dopaminergic degeneration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
after the last pole test, dopaminergic neuronal survival in the striatum and the substantia nigra (sn), cell proliferation in the svz and mrna expression of neurotrophic factors and dopamine receptors in the striatum were evaluated. |
2020-10-01 |
2023-08-13 |
mouse |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
krg administration suppressed dopaminergic neuronal death induced by mptp in the striatum as well as the sn, augmented the number of brdu- and brdu/doublecortin (dcx)-positive cells in the svz and enhanced the expression of proliferation cell nuclear antigen, brain derived neurotrophic factor (bdnf), glial cell derived neurotrophic factor (gdnf), cerebral dopamine neurotrophic factor (cdnf), ciliary neurotrophic factor (cntf), dopamine receptor d3 (drd3) and d5 mrnas. |
2020-10-01 |
2023-08-13 |
mouse |
| Michelino Puopol. The hypothalamic-spinal dopaminergic system: a target for pain modulation. Neural regeneration research. vol 14. issue 6. 2020-10-01. PMID:30761995. |
hypothalamic a11 dopaminergic neurons project to all levels of the spinal cord and provide the main source of spinal dopamine. |
2020-10-01 |
2023-08-13 |
human |
| Elisa Caggiu, Giannina Arru, Sepideh Hosseini, Magdalena Niegowska, GianPietro Sechi, Ignazio Roberto Zarbo, Leonardo A Sech. Inflammation, Infectious Triggers, and Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30837941. |
parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons of the substantia nigra pars compacta with a reduction of dopamine concentration in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |