| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongkwan Cho, Siva P Kambhampati, Michael J Lai, Lingli Zhou, Grace Lee, Yangyiran Xie, Qiaoyan Hui, Rangaramanujam M Kannan, Elia J Du. Dendrimer-Triamcinolone Acetonide Reduces Neuroinflammation, Pathological Angiogenesis, and Neuroretinal Dysfunction in Ischemic Retinopathy. Advanced therapeutics. vol 4. issue 2. 2021-09-21. PMID:34527806. |
following intravitreal injection, dendrimer-conjugated ta (d-ta) exhibits selective localization and sustained retention in activated microglia in disease-associated areas of the retina. |
2021-09-21 |
2023-08-13 |
mouse |
| Yahan Zhang, Anna Lena Erhard, Tanja Plagemann, Nicole Eter, Peter Heiduschk. A modified protocol for isolation of retinal microglia from the pig. Experimental eye research. vol 207. 2021-09-17. PMID:33910034. |
microglia are the resident immune cells in the retina. |
2021-09-17 |
2023-08-13 |
human |
| Amir Saeed Khan, Thomas Langman. Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33143743. |
indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. |
2021-09-16 |
2023-08-13 |
Not clear |
| Amir Saeed Khan, Thomas Langman. Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33143743. |
here, we hypothesized that i3c may inhibit microglia reactivity and exert neuroprotective effects in the light-damaged murine retina mimicking important immunological aspects of retinal degeneration. |
2021-09-16 |
2023-08-13 |
Not clear |
| Hai Xie, Chaoyang Zhang, Dandan Liu, Qian Yang, Lei Tang, Tianqin Wang, Haibin Tian, Lixia Lu, Jing-Ying Xu, Furong Gao, Juan Wang, Caixia Jin, Weiye Li, Guoxu Xu, Guo-Tong Xu, Jingfa Zhan. Erythropoietin protects the inner blood-retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy. Diabetologia. vol 64. issue 1. 2021-08-19. PMID:33104828. |
however, the regulation of microglia in the retina and its relationship to inner blood-retinal barrier (ibrb) maintenance have not been fully characterised. |
2021-08-19 |
2023-08-13 |
Not clear |
| Jeremy C Burns, Richard M Ransohoff, Michaël Minguenea. Isolation of Microglia and Analysis of Protein Expression by Flow Cytometry: Avoiding the Pitfall of Microglia Background Autofluorescence. Bio-protocol. vol 11. issue 14. 2021-08-17. PMID:34395729. |
microglia are a unique type of tissue-resident innate immune cell found within the brain, spinal cord, and retina. |
2021-08-17 |
2023-08-13 |
rat |
| Alexander M Hilla, Dietmar Fische. Studying the Role of Microglia in Neurodegeneration and Axonal Regeneration in the murine Visual System. Bio-protocol. vol 8. issue 16. 2021-08-17. PMID:34395779. |
using this approach, we investigated the role of microglia in neuroprotection in the retina and axon regeneration in the injured optic nerve under different conditions. |
2021-08-17 |
2023-08-13 |
Not clear |
| Chen Yu, Christophe Roubeix, Florian Sennlaub, Daniel R Saba. Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina. Trends in neurosciences. vol 43. issue 6. 2021-07-30. PMID:32459994. |
microglia versus monocytes: distinct roles in degenerative diseases of the retina. |
2021-07-30 |
2023-08-13 |
Not clear |
| Chen Yu, Christophe Roubeix, Florian Sennlaub, Daniel R Saba. Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina. Trends in neurosciences. vol 43. issue 6. 2021-07-30. PMID:32459994. |
unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not solely comprised of microglia but may include monocyte-derived recruits. |
2021-07-30 |
2023-08-13 |
Not clear |
| Zachary I Blume, Jared M Lambert, Anna G Lovel, Diana M Mitchel. Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling. Developmental dynamics : an official publication of the American Association of Anatomists. vol 249. issue 6. 2021-07-26. PMID:32072708. |
microglia in the developing retina couple phagocytosis with the progression of apoptosis via p2ry12 signaling. |
2021-07-26 |
2023-08-13 |
zebrafish |
| Laszlo G Harsing, Gábor Szénási, Tibor Zelles, László Köle. Purinergic-Glycinergic Interaction in Neurodegenerative and Neuroinflammatory Disorders of the Retina. International journal of molecular sciences. vol 22. issue 12. 2021-07-26. PMID:34201404. |
in searching for key factors that contribute to the development of these pathologies, we considered potential interactions among purinergic neuromodulation, glycinergic neurotransmission, and microglia activity in the retina. |
2021-07-26 |
2023-08-13 |
Not clear |
| Laszlo G Harsing, Gábor Szénási, Tibor Zelles, László Köle. Purinergic-Glycinergic Interaction in Neurodegenerative and Neuroinflammatory Disorders of the Retina. International journal of molecular sciences. vol 22. issue 12. 2021-07-26. PMID:34201404. |
second, p2y purinoceptor agonists and glycine transporter 1 inhibitors may indirectly inhibit microglia activity by decreasing neuronal or glial glycine release in energy-compromised retina. |
2021-07-26 |
2023-08-13 |
Not clear |
| Zhen Xu, Xin Zhou, Bo Peng, Yanxia Ra. Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice. STAR protocols. vol 2. issue 3. 2021-07-22. PMID:34286294. |
here, we introduce a potentially clinical-feasible strategy named microglia replacement by bone marrow transplantation that achieves efficient microglia replacement at the whole cns scale, including the brain, spinal cord, and retina in adult mice. |
2021-07-22 |
2023-08-13 |
mouse |
| Ana Catarina Rodrigues-Neves, Rafael Carecho, Sónia Catarina Correia, Cristina Carvalho, Elisa Julião Campos, Filipa Isabel Baptista, Paula Isabel Moreira, António Francisco Ambrósi. Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33606195. |
however, we detected a few differential changes in the retina and brain regions, and particularly a different profile in microglia branching in the retina and hippocampus, only at 4 months, where the number and length of the processes decreased in the retina and increased in the hippocampus. |
2021-07-06 |
2023-08-13 |
mouse |
| Ana I Ramírez, José A Fernández-Albarral, Rosa de Hoz, Inés López-Cuenca, Elena Salobrar-García, Pilar Rojas, Francisco Javier Valiente-Soriano, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Manuel Vidal-Sanz, Alberto Triviño, Juan J Salazar, José M Ramíre. Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. Progress in brain research. vol 256. issue 1. 2021-07-05. PMID:32958210. |
in the eyes of aged naive, aged oht and aged contralateral eyes, microglial changes were observed compared to the young mice, including: (i) aged naive vs young naive: an increased soma size and vertical processes; (ii) aged oht eyes vs young oht eyes: a decrease in the area of the retina occupied by iba-1 cells and in vertical processes; and (iii) aged contralateral vs young contralateral: a decrease in the soma size and arbor area and an increase in the number of microglia in the outer segment layer. |
2021-07-05 |
2023-08-13 |
mouse |
| Yi Li, Shuizhen Shi, Fan Xia, Chao Shan, Yonju Ha, Jing Zou, Awadalkareem Adam, Ming Zhang, Tian Wang, Hua Liu, Pei-Yong Shi, Wenbo Zhan. Zika virus induces neuronal and vascular degeneration in developing mouse retina. Acta neuropathologica communications. vol 9. issue 1. 2021-06-28. PMID:34034828. |
zikv-infected retina exhibited dramatically decreased thickness with loss of neurons, initial neovascular tufts followed by vessel dilation and degeneration, increased microglia and leukocyte recruitment and activation, degeneration of astrocyte network and gliosis. |
2021-06-28 |
2023-08-13 |
mouse |
| Debora Napoli, Martina Biagioni, Federico Billeri, Beatrice Di Marco, Noemi Orsini, Elena Novelli, Enrica Stretto. Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa. International journal of molecular sciences. vol 22. issue 10. 2021-06-17. PMID:34065385. |
inflammation relies on local microglia and recruitment of immune cells, reaching the retina through breakdowns of the inner blood retinal barrier (ibrb). |
2021-06-17 |
2023-08-13 |
mouse |
| Yizhen Tang, Zebin Xiao, Li Pan, Dongli Zhuang, Kin-Sang Cho, Kyle Robert, Xiaoxiao Chen, Lian Shu, Guangxian Tang, Jihong Wu, Xinghuai Sun, Dong F Che. Therapeutic Targeting of Retinal Immune Microenvironment With CSF-1 Receptor Antibody Promotes Visual Function Recovery After Ischemic Optic Neuropathy. Frontiers in immunology. vol 11. 2021-06-14. PMID:33281816. |
here we used rodent models of ri and showed that retinal ischemia induced by acute elevation of intraocular pressure triggered an early activation of microglia and macrophages in the retina within 12 h. |
2021-06-14 |
2023-08-13 |
human |
| Yizhen Tang, Zebin Xiao, Li Pan, Dongli Zhuang, Kin-Sang Cho, Kyle Robert, Xiaoxiao Chen, Lian Shu, Guangxian Tang, Jihong Wu, Xinghuai Sun, Dong F Che. Therapeutic Targeting of Retinal Immune Microenvironment With CSF-1 Receptor Antibody Promotes Visual Function Recovery After Ischemic Optic Neuropathy. Frontiers in immunology. vol 11. 2021-06-14. PMID:33281816. |
these results, together with the existing clinical safety profiles, support that csf-1rab may present a promising therapeutic avenue for ri, a currently untreatable condition, by targeting microglia and the immune microenvironment in the retina to facilitate neural survival and visual function recovery. |
2021-06-14 |
2023-08-13 |
human |
| Kenichi Makabe, Sunao Sugita, Yoko Futatsugi, Masayo Takahash. Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases. International journal of molecular sciences. vol 22. issue 7. 2021-06-11. PMID:33806238. |
in an intraocular inflammatory state, microglia residing in the retina become active and migrate inside the retina. |
2021-06-11 |
2023-08-13 |
mouse |