| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyun Huang, Lin Chen, Paul Sanber. Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era. Cell medicine. vol 1. issue 1. 2021-10-20. PMID:21359168. |
up to now, the cells successfully used in preclinical experiments and/or clinical trial/treatment include fetal/embryonic brain and spinal cord tissue, stem cells (embryonic stem cells, neural stem/progenitor cells, hematopoietic stem cells, adipose-derived adult stem/precursor cells, skin-derived precursor, induced pluripotent stem cells), glial cells (schwann cells, oligodendrocyte, olfactory ensheathing cells, astrocytes, microglia, tanycytes), neuronal cells (various phenotypic neurons and purkinje cells), mesenchymal stromal cells originating from bone marrow, umbilical cord, and umbilical cord blood, epithelial cells derived from the layer of retina and amnion, menstrual blood-derived stem cells, sertoli cells, and active macrophages, etc. |
2021-10-20 |
2023-08-12 |
Not clear |
| Honglian Wu, Mengqi Wang, Xiaorong Li, Yan Sha. The Metaflammatory and Immunometabolic Role of Macrophages and Microglia in Diabetic Retinopathy. Human cell. vol 34. issue 6. 2021-10-05. PMID:34324139. |
through the pathogenesis of dr, macrophages or microglia play a critical role in the inflammation, neovascularization, and neurodegeneration of the retina. |
2021-10-05 |
2023-08-13 |
Not clear |
| Huimin Zhong, Huan Yu, Jun Sun, Junjue Chen, Shouyue Huang, Ping Huang, Xiaohong Liu, Yisheng Zhon. Isolation of microglia from retinas of chronic ocular hypertensive rats. Open life sciences. vol 16. issue 1. 2021-10-05. PMID:34604533. |
microglia are the principal glial cells involved in the processes of immune inflammation within both retina and optic nerve, especially under the context of glaucomatous neuropathy. |
2021-10-05 |
2023-08-13 |
rat |
| Huimin Zhong, Huan Yu, Jun Sun, Junjue Chen, Shouyue Huang, Ping Huang, Xiaohong Liu, Yisheng Zhon. Isolation of microglia from retinas of chronic ocular hypertensive rats. Open life sciences. vol 16. issue 1. 2021-10-05. PMID:34604533. |
additionally, the proportion of microglia in the whole retina cells was identified by flow cytometry. |
2021-10-05 |
2023-08-13 |
rat |
| Pia Grotegut, Natarajan Perumal, Sandra Kuehn, Andreas Smit, H Burkhard Dick, Franz H Grus, Stephanie C Joachi. Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model. Journal of neuroinflammation. vol 17. issue 1. 2021-09-30. PMID:33317557. |
previous studies noted that intravitreal injection of s100b triggered a glaucoma-like degeneration of retina and optic nerve as well as microglia activation after 14 days. |
2021-09-30 |
2023-08-13 |
Not clear |
| Kan Zhang, Lei Wu, Kana Lin, Mazhong Zhang, Weiguang Li, Xiaoping Tong, Jijian Zhen. Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development. Experimental neurology. vol 340. 2021-09-27. PMID:33640375. |
remodeling of the extracellular matrix (ecm) by matrix metalloproteinases (mmps) plays a pivotal role for microglia in developing retina. |
2021-09-27 |
2023-08-13 |
rat |
| Peipei Zhang, Anja Schlecht, Julian Wolf, Stefaniya Boneva, Yannik Laich, Jana Koch, Franziska Ludwig, Myriam Boeck, Adrian Thien, Carmen Härdtner, Katrin Kierdorf, Hansjürgen Agostini, Günther Schlunck, Marco Prinz, Ingo Hilgendorf, Peter Wieghofer, Clemens Lang. The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation. Journal of neuroinflammation. vol 18. issue 1. 2021-09-24. PMID:34544421. |
microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. |
2021-09-24 |
2023-08-13 |
Not clear |
| Peipei Zhang, Anja Schlecht, Julian Wolf, Stefaniya Boneva, Yannik Laich, Jana Koch, Franziska Ludwig, Myriam Boeck, Adrian Thien, Carmen Härdtner, Katrin Kierdorf, Hansjürgen Agostini, Günther Schlunck, Marco Prinz, Ingo Hilgendorf, Peter Wieghofer, Clemens Lang. The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation. Journal of neuroinflammation. vol 18. issue 1. 2021-09-24. PMID:34544421. |
however, dysfunctional microglia can have a negative impact on the structural and functional integrity of the retina under native and pathological conditions. |
2021-09-24 |
2023-08-13 |
Not clear |
| Hongkwan Cho, Siva P Kambhampati, Michael J Lai, Lingli Zhou, Grace Lee, Yangyiran Xie, Qiaoyan Hui, Rangaramanujam M Kannan, Elia J Du. Dendrimer-Triamcinolone Acetonide Reduces Neuroinflammation, Pathological Angiogenesis, and Neuroretinal Dysfunction in Ischemic Retinopathy. Advanced therapeutics. vol 4. issue 2. 2021-09-21. PMID:34527806. |
microglia, the resident immune cells of the retina, have emerged as a potentially important regulator of pathologic retinal angiogenesis. |
2021-09-21 |
2023-08-13 |
mouse |
| Hongkwan Cho, Siva P Kambhampati, Michael J Lai, Lingli Zhou, Grace Lee, Yangyiran Xie, Qiaoyan Hui, Rangaramanujam M Kannan, Elia J Du. Dendrimer-Triamcinolone Acetonide Reduces Neuroinflammation, Pathological Angiogenesis, and Neuroretinal Dysfunction in Ischemic Retinopathy. Advanced therapeutics. vol 4. issue 2. 2021-09-21. PMID:34527806. |
generation-4 hydroxyl polyamidoamine dendrimer nanoparticles are utilized to deliver ta to activated microglia in the ischemic retina in a mouse model of oxygen-induced retinopathy (oir). |
2021-09-21 |
2023-08-13 |
mouse |
| Hongkwan Cho, Siva P Kambhampati, Michael J Lai, Lingli Zhou, Grace Lee, Yangyiran Xie, Qiaoyan Hui, Rangaramanujam M Kannan, Elia J Du. Dendrimer-Triamcinolone Acetonide Reduces Neuroinflammation, Pathological Angiogenesis, and Neuroretinal Dysfunction in Ischemic Retinopathy. Advanced therapeutics. vol 4. issue 2. 2021-09-21. PMID:34527806. |
following intravitreal injection, dendrimer-conjugated ta (d-ta) exhibits selective localization and sustained retention in activated microglia in disease-associated areas of the retina. |
2021-09-21 |
2023-08-13 |
mouse |
| Yahan Zhang, Anna Lena Erhard, Tanja Plagemann, Nicole Eter, Peter Heiduschk. A modified protocol for isolation of retinal microglia from the pig. Experimental eye research. vol 207. 2021-09-17. PMID:33910034. |
microglia are the resident immune cells in the retina. |
2021-09-17 |
2023-08-13 |
human |
| Amir Saeed Khan, Thomas Langman. Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33143743. |
indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. |
2021-09-16 |
2023-08-13 |
Not clear |
| Amir Saeed Khan, Thomas Langman. Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33143743. |
here, we hypothesized that i3c may inhibit microglia reactivity and exert neuroprotective effects in the light-damaged murine retina mimicking important immunological aspects of retinal degeneration. |
2021-09-16 |
2023-08-13 |
Not clear |
| Hai Xie, Chaoyang Zhang, Dandan Liu, Qian Yang, Lei Tang, Tianqin Wang, Haibin Tian, Lixia Lu, Jing-Ying Xu, Furong Gao, Juan Wang, Caixia Jin, Weiye Li, Guoxu Xu, Guo-Tong Xu, Jingfa Zhan. Erythropoietin protects the inner blood-retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy. Diabetologia. vol 64. issue 1. 2021-08-19. PMID:33104828. |
however, the regulation of microglia in the retina and its relationship to inner blood-retinal barrier (ibrb) maintenance have not been fully characterised. |
2021-08-19 |
2023-08-13 |
Not clear |
| Jeremy C Burns, Richard M Ransohoff, Michaël Minguenea. Isolation of Microglia and Analysis of Protein Expression by Flow Cytometry: Avoiding the Pitfall of Microglia Background Autofluorescence. Bio-protocol. vol 11. issue 14. 2021-08-17. PMID:34395729. |
microglia are a unique type of tissue-resident innate immune cell found within the brain, spinal cord, and retina. |
2021-08-17 |
2023-08-13 |
rat |
| Alexander M Hilla, Dietmar Fische. Studying the Role of Microglia in Neurodegeneration and Axonal Regeneration in the murine Visual System. Bio-protocol. vol 8. issue 16. 2021-08-17. PMID:34395779. |
using this approach, we investigated the role of microglia in neuroprotection in the retina and axon regeneration in the injured optic nerve under different conditions. |
2021-08-17 |
2023-08-13 |
Not clear |
| Chen Yu, Christophe Roubeix, Florian Sennlaub, Daniel R Saba. Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina. Trends in neurosciences. vol 43. issue 6. 2021-07-30. PMID:32459994. |
microglia versus monocytes: distinct roles in degenerative diseases of the retina. |
2021-07-30 |
2023-08-13 |
Not clear |
| Chen Yu, Christophe Roubeix, Florian Sennlaub, Daniel R Saba. Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina. Trends in neurosciences. vol 43. issue 6. 2021-07-30. PMID:32459994. |
unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not solely comprised of microglia but may include monocyte-derived recruits. |
2021-07-30 |
2023-08-13 |
Not clear |
| Zachary I Blume, Jared M Lambert, Anna G Lovel, Diana M Mitchel. Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling. Developmental dynamics : an official publication of the American Association of Anatomists. vol 249. issue 6. 2021-07-26. PMID:32072708. |
microglia in the developing retina couple phagocytosis with the progression of apoptosis via p2ry12 signaling. |
2021-07-26 |
2023-08-13 |
zebrafish |