| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
using early postnatal mouse retina, a cns region undergoing significant developmental remodeling, we performed scrnaseq on microglia from mice that are wild-type, lack neuronal apoptosis (bax ko), or are treated with csf1r inhibitor (plx3397). |
2022-04-28 |
2023-08-13 |
mouse |
| Dennis-Dominik Rosmus, Clemens Lange, Franziska Ludwig, Bahareh Ajami, Peter Wieghofe. The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453590. |
whereas the cns borders harbor extraparenchymal cns-associated macrophages whose main duty is to build up a defense against invading pathogens and other damaging factors from the periphery, the resident immune cells of the cns parenchyma and the retina, microglia, are highly dynamic cells with a plethora of functions during homeostasis and disease. |
2022-04-23 |
2023-08-13 |
Not clear |
| Whitney A Thiel, Zachary I Blume, Diana M Mitchel. Compensatory engulfment and Müller glia reactivity in the absence of microglia. Glia. 2022-04-22. PMID:35451181. |
microglia are known for important phagocytic functions in the vertebrate retina. |
2022-04-22 |
2023-08-13 |
zebrafish |
| Whitney A Thiel, Zachary I Blume, Diana M Mitchel. Compensatory engulfment and Müller glia reactivity in the absence of microglia. Glia. 2022-04-22. PMID:35451181. |
here, we investigate müller glial engulfment of dying cells in the developing zebrafish retina in the presence and absence of microglia, using a genetic mutant in which microglia do not develop. |
2022-04-22 |
2023-08-13 |
zebrafish |
| Mei-Ling Gao, Xiao Zhang, Fang Han, Jia Xu, Si-Jian Yu, Kangxin Jin, Zi-Bing Ji. Functional microglia derived from human pluripotent stem cells empower retinal organ. Science China. Life sciences. 2022-04-22. PMID:35451725. |
microglia are known to play essential roles in the development, progression and treatment of diverse neurodegenerative diseases in the central nervous system, including the retina, brain and spinal cord. |
2022-04-22 |
2023-08-13 |
human |
| Mei-Ling Gao, Xiao Zhang, Fang Han, Jia Xu, Si-Jian Yu, Kangxin Jin, Zi-Bing Ji. Functional microglia derived from human pluripotent stem cells empower retinal organ. Science China. Life sciences. 2022-04-22. PMID:35451725. |
notably, the resident imgs in the hros formed sparse web-like structures beneath the photoreceptor cell layer, resembling microglia's orientation in human retina. |
2022-04-22 |
2023-08-13 |
human |
| Wei Fan, Weidi Huang, Jiayi Chen, Na Li, Liming Mao, Shengping Ho. Retinal microglia: Functions and diseases. Immunology. 2022-04-11. PMID:35403700. |
microglia, the resident immune cells in the retina and nervous system, make irreplaceable contributions to the maintenance of normal homeostasis and immune surveillance of these systems. |
2022-04-11 |
2023-08-13 |
human |
| Wei Fan, Weidi Huang, Jiayi Chen, Na Li, Liming Mao, Shengping Ho. Retinal microglia: Functions and diseases. Immunology. 2022-04-11. PMID:35403700. |
increasing evidence points towards the dual roles of microglia in the retina and they are regulated by many factors. |
2022-04-11 |
2023-08-13 |
human |
| Fangyuan Hu, Yuting Ma, Zaoxu Xu, Shenghai Zhang, Jiankang Li, Xinghuai Sun, Jihong W. Single-Cell RNA-Seq Reveals the Cellular Diversity and Developmental Characteristics of the Retinas of an Infant and a Young Child. Frontiers in cell and developmental biology. vol 10. 2022-04-07. PMID:35386199. |
here, we performed single-cell rna-seq to analyze 194,967 cells from the donors of infants and young children, resulting in 17 distinct clusters representing major cell types in the retina: rod photoreceptors (prs), cone prs, bipolar cells (bcs), horizontal cells (hcs), amacrine cells (acs), retinal ganglion cells (rgcs), müller glial cells (mgs), microglia, and astrocytes (asts). |
2022-04-07 |
2023-08-13 |
human |
| Li Guo, Soyoung Choi, Priyanka Bikkannavar, M Francesca Cordeir. Microglia: Key Players in Retinal Ageing and Neurodegeneration. Frontiers in cellular neuroscience. vol 16. 2022-04-04. PMID:35370560. |
microglia are the resident immune cells of the central nervous system (cns) and play a key role in maintaining the normal function of the retina and brain. |
2022-04-04 |
2023-08-13 |
Not clear |
| Li Guo, Soyoung Choi, Priyanka Bikkannavar, M Francesca Cordeir. Microglia: Key Players in Retinal Ageing and Neurodegeneration. Frontiers in cellular neuroscience. vol 16. 2022-04-04. PMID:35370560. |
during early development, microglia migrate into the retina, transform into a highly ramified phenotype, and scan their environment constantly. |
2022-04-04 |
2023-08-13 |
Not clear |
| Li Guo, Soyoung Choi, Priyanka Bikkannavar, M Francesca Cordeir. Microglia: Key Players in Retinal Ageing and Neurodegeneration. Frontiers in cellular neuroscience. vol 16. 2022-04-04. PMID:35370560. |
as the professional phagocytes in the retina, microglia are responsible for the clearance of pathogens, dead cells, and protein aggregates. |
2022-04-04 |
2023-08-13 |
Not clear |
| Lei Tang, Chaoyang Zhang, Lixia Lu, Haibin Tian, Kun Liu, Dawei Luo, Qinghua Qiu, Guo-Tong Xu, Jingfa Zhan. Melatonin Maintains Inner Blood-Retinal Barrier by Regulating Microglia Frontiers in immunology. vol 13. 2022-04-04. PMID:35371022. |
in diabetic rat retinas, activated microglia proliferated and migrated from the inner retina to the outer retina, accompanied by the obvious morphological changes. |
2022-04-04 |
2023-08-13 |
rat |
| Julian Wolf, Stefaniya Boneva, Dennis-Dominik Rosmus, Hansjürgen Agostini, Günther Schlunck, Peter Wieghofer, Anja Schlecht, Clemens Lang. In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity. Frontiers in immunology. vol 13. 2022-04-04. PMID:35371110. |
microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage. |
2022-04-04 |
2023-08-13 |
human |
| Guoqing Wang, Xingran Li, Na Li, Xiaotang Wang, Siyuan He, Wanqian Li, Wei Fan, Ruonan Li, Jiangyi Liu, Shengping Ho. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox biology. vol 52. 2022-03-25. PMID:35334248. |
further results showed the proinflammatory m1 microglia could be transferred to anti-inflammatory m2 microglia by ica in the retina and hmc3 cells. |
2022-03-25 |
2023-08-13 |
Not clear |
| Sohair A Eltony, Heba S Mohaseb, Amel A Ahmed, Manal M Saye. Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa? Tissue & cell. vol 76. 2022-03-24. PMID:35325673. |
in enu treated group, the retina revealed vacuolations and morphological changes in the glia (müller cells and microglia) and blood capillaries. |
2022-03-24 |
2023-08-13 |
rat |
| Mario Bonillo, Julia Pfromm, M Dominik Fische. Challenges to Gene Editing Approaches in the Retina. Klinische Monatsblatter fur Augenheilkunde. vol 239. issue 3. 2022-03-22. PMID:35316854. |
immune responses to gene editing in the retina may be humoral or cell mediated, with immunologically active cells, including microglia, implicated in facilitating possible immune responses to gene editing. |
2022-03-22 |
2023-08-13 |
Not clear |
| Ngan Pan Bennett Au, Chi Him Eddie M. Neuroinflammation, Microglia and Implications for Retinal Ganglion Cell Survival and Axon Regeneration in Traumatic Optic Neuropathy. Frontiers in immunology. vol 13. 2022-03-21. PMID:35309305. |
retinal microglia are immune-competent cells residing in the retina. |
2022-03-21 |
2023-08-13 |
Not clear |
| Antolín Canto, Javier Martínez-González, María Miranda, Teresa Olivar, Inma Almansa, Vicente Hernández-Rabaz. Sulforaphane Modulates the Inflammation and Delays Neurodegeneration on a Retinitis Pigmentosa Mice Model. Frontiers in pharmacology. vol 13. 2022-03-18. PMID:35300301. |
histological retina samples were used to assess cellular degeneration, müller cells, and microglia activation. |
2022-03-18 |
2023-08-13 |
mouse |
| Antolín Canto, Javier Martínez-González, María Miranda, Teresa Olivar, Inma Almansa, Vicente Hernández-Rabaz. Sulforaphane Modulates the Inflammation and Delays Neurodegeneration on a Retinitis Pigmentosa Mice Model. Frontiers in pharmacology. vol 13. 2022-03-18. PMID:35300301. |
moreover, sulforaphane treatment regulated the microglia activation state, inducing changes in the microglia morphology, migration, and expression through the retina. |
2022-03-18 |
2023-08-13 |
mouse |