| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcus Karlstetter, Thomas Langman. Microglia in the aging retina. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664700. |
microglia in the aging retina. |
2014-07-24 |
2023-08-12 |
human |
| Marcus Karlstetter, Thomas Langman. Microglia in the aging retina. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664700. |
thus, work in the aging rodent and human retina suggests that long-lived and genetically predisposed microglia transform into a dystrophic state, with loss of neuroprotective functions. |
2014-07-24 |
2023-08-12 |
human |
| Minhua Wang, Wai T Won. Microglia-Müller cell interactions in the retina. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664715. |
microglia and müller cells are cell types that feature prominently in responses to disease and injury in the retina. |
2014-07-24 |
2023-08-12 |
Not clear |
| Sem Genini, William A Beltran, Veronika M Stein, Gustavo D Aguirr. Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664716. |
microglia are the primary resident immune cells of the retina and are involved in the pathogenesis of various retinal diseases. |
2014-07-24 |
2023-08-12 |
dog |
| Sem Genini, William A Beltran, Veronika M Stein, Gustavo D Aguirr. Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664716. |
the most prevalent microglia population in the normal canine retina is cd11b(high)cd45(low). |
2014-07-24 |
2023-08-12 |
dog |
| Roswitha Seitz, Ernst R Tam. Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664717. |
müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection. |
2014-07-24 |
2023-08-12 |
mouse |
| Roswitha Seitz, Ernst R Tam. Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664717. |
herein we report that the procedure of an intravitreal injection alone is sufficient to cause substantial reactive changes in müller cells and microglia throughout the entire retina. |
2014-07-24 |
2023-08-12 |
mouse |
| Ulrich Fo Luhmann, Scott J Robbie, James Wb Bainbridge, Robin R Al. The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664727. |
systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis and are key regulator and effector cells of the local immune response to acute and chronic tissue injury.two major signalling pathways that differentially define trafficking behaviour and activation of systemic and local myeloid cell populations in response to exogenous and endogenous inflammatory stimuli are the ccl2-ccr2 and the cx3cl1-cx3cr1 chemokine pathways.alterations in these pathways have been implicated in controlling myeloid cell activation during normal ageing and in age-related retinal degenerations, including age-related macular degeneration (amd).we review the evidence for how altered chemokine signalling in acute and chronic inflammatory conditions regulate local and systemic myeloid cell responses in the retina and how this may contribute to or attenuate pathology in inherited and age-related retinal diseases. |
2014-07-24 |
2023-08-12 |
human |
| Rosa M Ferrer-Martín, David Martín-Oliva, Ana Sierra, Maria-Carmen Carrasco, María Martín-Estebané, Ruth Calvente, José L Marín-Teva, Julio Navascués, Miguel A Cuadro. Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death. Experimental eye research. vol 121. 2014-06-27. PMID:24582572. |
flow cytometry using cd68-labeling revealed that the percentage of cd68-positive microglial cells was much higher in developing than in adult retina explants, despite the activation of microglia in both types of explants, indicating that cd68-labeling was more closely related to the maturity degree of microglia than to their activation. |
2014-06-27 |
2023-08-12 |
mouse |
| Rosa M Ferrer-Martín, David Martín-Oliva, Ana Sierra, Maria-Carmen Carrasco, María Martín-Estebané, Ruth Calvente, José L Marín-Teva, Julio Navascués, Miguel A Cuadro. Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death. Experimental eye research. vol 121. 2014-06-27. PMID:24582572. |
this engulfment activity of microglia mimicked that observed in degenerative pathologies of the retina. |
2014-06-27 |
2023-08-12 |
mouse |
| Minhua Wang, Xu Wang, Lian Zhao, Wenxin Ma, Ignacio R Rodriguez, Robert N Fariss, Wai T Won. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 10. 2014-04-29. PMID:24599476. |
chronic retinal inflammation in the form of activated microglia and macrophages are implicated in the etiology of neurodegenerative diseases of the retina, including age-related macular degeneration, diabetic retinopathy, and glaucoma. |
2014-04-29 |
2023-08-12 |
mouse |
| Nan-Kai Wang, Chi-Chun Lai, Chi-Hsiu Liu, Lung-Kun Yeh, Chai Lin Chou, Jian Kong, Takayuki Nagasaki, Stephen H Tsang, Chung-Liang Chie. Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. Disease models & mechanisms. vol 6. issue 5. 2014-04-22. PMID:23828046. |
we demonstrated that more than 80% of the egfp+ cells in retinas from rd7/rd7;tg/tg mice express iba-1 (a microglial marker), and resident microglia are still present in the retina because ap20187 does not cross the blood-brain barrier. |
2014-04-22 |
2023-08-12 |
mouse |
| Claudia A McCarthy, Robert E Widdop, Devy Deliyanti, Jennifer L Wilkinson-Berk. Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system. Clinical and experimental pharmacology & physiology. vol 40. issue 8. 2014-02-19. PMID:23601050. |
microglia are the resident immune cells within the brain and retina, commonly known as the macrophages of the central nervous system (cns). |
2014-02-19 |
2023-08-12 |
Not clear |
| Jelena M Kezic, Paul G McMenami. The effects of CX3CR1 deficiency and irradiation on the homing of monocyte-derived cell populations in the mouse eye. PloS one. vol 8. issue 7. 2014-02-07. PMID:23844223. |
additionally, mhc class ii expression was upregulated on hyalocytes and gfp(+) cells in the peripheral retina and the repopulation of microglia appeared to be more rapid in c57bl/6j mice compared to balb/c mice. |
2014-02-07 |
2023-08-12 |
mouse |
| Xiangting Chen, Jelena Kezic, Claude Bernard, Paul G McMenami. Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retina. Journal of neuropathology and experimental neurology. vol 72. issue 8. 2013-09-23. PMID:23860032. |
immunophenotypic analysis revealed that cd11c-positive cells in the neural retina of these mice had the characteristic profile of activated microglia and not dcs. |
2013-09-23 |
2023-08-12 |
mouse |
| Charanjit Kaur, Gurugirijha Rathnasamy, Eng-Ang Lin. Roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 1. 2013-08-16. PMID:22367679. |
roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina. |
2013-08-16 |
2023-08-12 |
Not clear |
| Martin S Zinkernagel, Holly R Chinnery, Monique L Ong, Claire Petitjean, Valentina Voigt, Samuel McLenachan, Paul G McMenamin, Geoffrey R Hill, John V Forrester, Matthew E Wikstrom, Mariapia A Degli-Espost. Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection. The American journal of pathology. vol 182. issue 3. 2013-08-08. PMID:23313136. |
microglia in the outer layers of the retina and the subretinal space are thought to be involved in retinal diseases where low-grade chronic inflammation and oxidative stress play a role. |
2013-08-08 |
2023-08-12 |
mouse |
| Beatriz I Gallego, Juan J Salazar, Rosa de Hoz, Blanca Rojas, Ana I Ramírez, Manuel Salinas-Navarro, Arturo Ortín-Martínez, Francisco J Valiente-Soriano, Marcelino Avilés-Trigueros, Maria P Villegas-Perez, Manuel Vidal-Sanz, Alberto Triviño, Jose M Ramíre. IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma. Journal of neuroinflammation. vol 9. 2013-06-10. PMID:22583833. |
iop induces upregulation of gfap and mhc-ii and microglia reactivity in mice retina contralateral to experimental glaucoma. |
2013-06-10 |
2023-08-12 |
mouse |
| Wenxin Ma, Steven Coon, Lian Zhao, Robert N Fariss, Wai T Won. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819137. |
in the aging retina, microglia aggregate in the outer retina and acquire intracellular autofluorescent lipofuscin deposits. |
2013-05-24 |
2023-08-12 |
Not clear |
| Wenxin Ma, Steven Coon, Lian Zhao, Robert N Fariss, Wai T Won. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819137. |
taken together, our findings highlight the role of microglia in the local control of complement activation in the retina and present the age-related accumulation of ocular lipofuscin in subretinal microglia as a cellular mechanism capable of driving outer retinal immune dysregulation in age-related macular degeneration pathogenesis. |
2013-05-24 |
2023-08-12 |
Not clear |