| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ulrich Fo Luhmann, Scott J Robbie, James Wb Bainbridge, Robin R Al. The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664727. |
systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis and are key regulator and effector cells of the local immune response to acute and chronic tissue injury.two major signalling pathways that differentially define trafficking behaviour and activation of systemic and local myeloid cell populations in response to exogenous and endogenous inflammatory stimuli are the ccl2-ccr2 and the cx3cl1-cx3cr1 chemokine pathways.alterations in these pathways have been implicated in controlling myeloid cell activation during normal ageing and in age-related retinal degenerations, including age-related macular degeneration (amd).we review the evidence for how altered chemokine signalling in acute and chronic inflammatory conditions regulate local and systemic myeloid cell responses in the retina and how this may contribute to or attenuate pathology in inherited and age-related retinal diseases. |
2014-07-24 |
2023-08-12 |
human |
| Rosa M Ferrer-Martín, David Martín-Oliva, Ana Sierra, Maria-Carmen Carrasco, María Martín-Estebané, Ruth Calvente, José L Marín-Teva, Julio Navascués, Miguel A Cuadro. Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death. Experimental eye research. vol 121. 2014-06-27. PMID:24582572. |
flow cytometry using cd68-labeling revealed that the percentage of cd68-positive microglial cells was much higher in developing than in adult retina explants, despite the activation of microglia in both types of explants, indicating that cd68-labeling was more closely related to the maturity degree of microglia than to their activation. |
2014-06-27 |
2023-08-12 |
mouse |
| Rosa M Ferrer-Martín, David Martín-Oliva, Ana Sierra, Maria-Carmen Carrasco, María Martín-Estebané, Ruth Calvente, José L Marín-Teva, Julio Navascués, Miguel A Cuadro. Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death. Experimental eye research. vol 121. 2014-06-27. PMID:24582572. |
this engulfment activity of microglia mimicked that observed in degenerative pathologies of the retina. |
2014-06-27 |
2023-08-12 |
mouse |
| Minhua Wang, Xu Wang, Lian Zhao, Wenxin Ma, Ignacio R Rodriguez, Robert N Fariss, Wai T Won. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 10. 2014-04-29. PMID:24599476. |
chronic retinal inflammation in the form of activated microglia and macrophages are implicated in the etiology of neurodegenerative diseases of the retina, including age-related macular degeneration, diabetic retinopathy, and glaucoma. |
2014-04-29 |
2023-08-12 |
mouse |
| Nan-Kai Wang, Chi-Chun Lai, Chi-Hsiu Liu, Lung-Kun Yeh, Chai Lin Chou, Jian Kong, Takayuki Nagasaki, Stephen H Tsang, Chung-Liang Chie. Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. Disease models & mechanisms. vol 6. issue 5. 2014-04-22. PMID:23828046. |
we demonstrated that more than 80% of the egfp+ cells in retinas from rd7/rd7;tg/tg mice express iba-1 (a microglial marker), and resident microglia are still present in the retina because ap20187 does not cross the blood-brain barrier. |
2014-04-22 |
2023-08-12 |
mouse |
| Claudia A McCarthy, Robert E Widdop, Devy Deliyanti, Jennifer L Wilkinson-Berk. Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system. Clinical and experimental pharmacology & physiology. vol 40. issue 8. 2014-02-19. PMID:23601050. |
microglia are the resident immune cells within the brain and retina, commonly known as the macrophages of the central nervous system (cns). |
2014-02-19 |
2023-08-12 |
Not clear |
| Jelena M Kezic, Paul G McMenami. The effects of CX3CR1 deficiency and irradiation on the homing of monocyte-derived cell populations in the mouse eye. PloS one. vol 8. issue 7. 2014-02-07. PMID:23844223. |
additionally, mhc class ii expression was upregulated on hyalocytes and gfp(+) cells in the peripheral retina and the repopulation of microglia appeared to be more rapid in c57bl/6j mice compared to balb/c mice. |
2014-02-07 |
2023-08-12 |
mouse |
| Xiangting Chen, Jelena Kezic, Claude Bernard, Paul G McMenami. Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retina. Journal of neuropathology and experimental neurology. vol 72. issue 8. 2013-09-23. PMID:23860032. |
immunophenotypic analysis revealed that cd11c-positive cells in the neural retina of these mice had the characteristic profile of activated microglia and not dcs. |
2013-09-23 |
2023-08-12 |
mouse |
| Charanjit Kaur, Gurugirijha Rathnasamy, Eng-Ang Lin. Roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 1. 2013-08-16. PMID:22367679. |
roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina. |
2013-08-16 |
2023-08-12 |
Not clear |
| Martin S Zinkernagel, Holly R Chinnery, Monique L Ong, Claire Petitjean, Valentina Voigt, Samuel McLenachan, Paul G McMenamin, Geoffrey R Hill, John V Forrester, Matthew E Wikstrom, Mariapia A Degli-Espost. Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection. The American journal of pathology. vol 182. issue 3. 2013-08-08. PMID:23313136. |
microglia in the outer layers of the retina and the subretinal space are thought to be involved in retinal diseases where low-grade chronic inflammation and oxidative stress play a role. |
2013-08-08 |
2023-08-12 |
mouse |
| Beatriz I Gallego, Juan J Salazar, Rosa de Hoz, Blanca Rojas, Ana I Ramírez, Manuel Salinas-Navarro, Arturo Ortín-Martínez, Francisco J Valiente-Soriano, Marcelino Avilés-Trigueros, Maria P Villegas-Perez, Manuel Vidal-Sanz, Alberto Triviño, Jose M Ramíre. IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma. Journal of neuroinflammation. vol 9. 2013-06-10. PMID:22583833. |
iop induces upregulation of gfap and mhc-ii and microglia reactivity in mice retina contralateral to experimental glaucoma. |
2013-06-10 |
2023-08-12 |
mouse |
| Wenxin Ma, Steven Coon, Lian Zhao, Robert N Fariss, Wai T Won. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819137. |
in the aging retina, microglia aggregate in the outer retina and acquire intracellular autofluorescent lipofuscin deposits. |
2013-05-24 |
2023-08-12 |
Not clear |
| Wenxin Ma, Steven Coon, Lian Zhao, Robert N Fariss, Wai T Won. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819137. |
taken together, our findings highlight the role of microglia in the local control of complement activation in the retina and present the age-related accumulation of ocular lipofuscin in subretinal microglia as a cellular mechanism capable of driving outer retinal immune dysregulation in age-related macular degeneration pathogenesis. |
2013-05-24 |
2023-08-12 |
Not clear |
| Debra A Carter, Balini Balasubramaniam, Andrew D Dic. Functional analysis of retinal microglia and their effects on progenitors. Methods in molecular biology (Clifton, N.J.). vol 935. 2013-04-17. PMID:23150375. |
utilizing human postmortem retina, we have created a research platform to isolate, culture, and characterize adult retinal microglia as well as analyze their effect on retinal progenitors. |
2013-04-17 |
2023-08-12 |
human |
| Ruth Bejarano-Escobar, Manuel Blasco, Gervasio Martín-Partido, Javier Francisco-Morcill. Light-induced degeneration and microglial response in the retina of an epibenthonic pigmented teleost: age-dependent photoreceptor susceptibility to cell death. The Journal of experimental biology. vol 215. issue Pt 21. 2013-04-15. PMID:22811246. |
specific labelling of microglial cells with griffonia simplicifolia lectin (gsl) histochemistry revealed that photoreceptor cell death alerts microglia in the degenerating retina, leading to local proliferation, migration towards the injured outer nuclear layer (onl), and enhanced phagocytosis of photoreceptor debris. |
2013-04-15 |
2023-08-12 |
Not clear |
| Ulrich F O Luhmann, Livia S Carvalho, Scott J Robbie, Jill A Cowing, Yanai Duran, Peter M G Munro, James W B Bainbridge, Robin R Al. Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Experimental eye research. vol 107. 2013-03-27. PMID:23232206. |
in conclusion, ccl2-ccr2 and/or cx3cl1-cx3cr1 signalling defects may differentially affect the trafficking of microglia and macrophages in the retina during ageing, but do not appear to cause age-related retinal degeneration in mice. |
2013-03-27 |
2023-08-12 |
mouse |
| Congrong Guo, Atsushi Otani, Akio Oishi, Hiroshi Kojima, Yukiko Makiyama, Satoko Nakagawa, Nagahisa Yoshimur. Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa. Experimental eye research. vol 104. 2013-01-25. PMID:23022404. |
photoreceptor apoptosis (tunel staining) and the number of microglia (positive for the f4/80 antibody) in the retina were examined. |
2013-01-25 |
2023-08-12 |
mouse |
| Qing-ling Fu, Yu Zhang, Yi-hua Su, Yue-qi Sun, Shu-juan Sun, Jian-bo Sh. [Increasing expression of microglia in the retina after optic nerve transection in rats]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 47. issue 12. 2013-01-07. PMID:22336117. |
[increasing expression of microglia in the retina after optic nerve transection in rats]. |
2013-01-07 |
2023-08-12 |
rat |
| Mei Chen, Jiawu Zhao, Chang Luo, Sudha Priya Soundara Pandi, Rosana G Penalva, Denise C Fitzgerald, Heping X. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent. Glia. vol 60. issue 5. 2012-11-19. PMID:22362506. |
both resident microglia and bm-derived phagocytes displayed mild activation in the neuronal retina following irradiation. |
2012-11-19 |
2023-08-12 |
mouse |
| Holly R Chinnery, Samuel McLenachan, Timothy Humphries, Jelena M Kezic, Xiangting Chen, Marc J Ruitenberg, Paul G McMenami. Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1. Neurobiology of aging. vol 33. issue 8. 2012-10-24. PMID:21570740. |
we investigated the effects of age, pigmentation and cx(3)cr1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old cx(3)cr1(gfp/gfp) (cx(3)cr1-deficient) or cx(3)cr1(gfp/+) mice on either a pigmented (c57bl/6) or albino (balb/c) background. |
2012-10-24 |
2023-08-12 |
mouse |