| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alejandra Bosco, Cesar O Romero, Balamurali K Ambati, Monica L Vette. In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. Journal of visualized experiments : JoVE. issue 99. 2015-12-15. PMID:25992962. |
the retina, a cns organ amenable to non-invasive live imaging, offers a powerful system to visualize and characterize the dynamics of microglia activation during chronic disorders. |
2015-12-15 |
2023-08-13 |
mouse |
| Alejandra Bosco, Cesar O Romero, Balamurali K Ambati, Monica L Vette. In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. Journal of visualized experiments : JoVE. issue 99. 2015-12-15. PMID:25992962. |
this approach should be useful to investigate the contributions of microglia to neuronal and axonal decline in chronic cns disorders that affect the retina and optic nerve. |
2015-12-15 |
2023-08-13 |
mouse |
| Lulu Yan, Sangmi Lee, Douglas R Lazzaro, Jacob Aranda, Maria B Grant, Brahim Chaqou. Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia. The Journal of biological chemistry. vol 290. issue 38. 2015-12-15. PMID:26242736. |
single and compound knock-outs of microrna (mirna)-155 and its angiogenic gene target ccn1 in mice alter vascular and neovascular growth in the retina via resident microglia. |
2015-12-15 |
2023-08-13 |
mouse |
| Maanasa Indaram, Wenxin Ma, Lian Zhao, Robert N Fariss, Ignacio R Rodriguez, Wai T Won. 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. Scientific reports. vol 5. 2015-12-04. PMID:25775051. |
to explore the potential relationship between 7kch and microglial activation, we localized 7kch and microglia to the outer retina of aged mice and investigated 7kch effects on retinal microglia in both in vitro and in vivo systems. |
2015-12-04 |
2023-08-13 |
mouse |
| Maanasa Indaram, Wenxin Ma, Lian Zhao, Robert N Fariss, Ignacio R Rodriguez, Wai T Won. 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. Scientific reports. vol 5. 2015-12-04. PMID:25775051. |
the interaction of retinal microglia with 7kch in the aged retina may thus underlie how outer retinal lipid accumulation in intermediate amd results in neuroinflammation that ultimately drives progression towards advanced amd. |
2015-12-04 |
2023-08-13 |
mouse |
| Hans Peter Iseli, Nicole Körber, Anett Karl, Christian Koch, Carsten Schuldt, Anja Penk, Qing Liu, Daniel Huster, Josef Käs, Andreas Reichenbach, Peter Wiedemann, Mike Franck. Damage threshold in adult rabbit eyes after scleral cross-linking by riboflavin/blue light application. Experimental eye research. vol 139. 2015-12-03. PMID:26208440. |
additionally, photoreceptor degenerations associated with microglia activation and macroglia cell reactivity in the retina were detected. |
2015-12-03 |
2023-08-13 |
rabbit |
| Sergio Crespo-Garcia, Nadine Reichhart, Carlos Hernandez-Matas, Xenophon Zabulis, Norbert Kociok, Claudia Brockmann, Antonia M Joussen, Olaf Straus. In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization. Experimental eye research. vol 139. 2015-12-03. PMID:26213305. |
in vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization. |
2015-12-03 |
2023-08-13 |
mouse |
| Sergio Crespo-Garcia, Nadine Reichhart, Carlos Hernandez-Matas, Xenophon Zabulis, Norbert Kociok, Claudia Brockmann, Antonia M Joussen, Olaf Straus. In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization. Experimental eye research. vol 139. 2015-12-03. PMID:26213305. |
this surprisingly revealed that laser damage at the outer retina led to more reactive microglia in the inner retina, shedding light upon a new perspective to approach the immune response in the retina in vivo. |
2015-12-03 |
2023-08-13 |
mouse |
| Jong-Jer Lee, Pei-Wen Wang, I-Hui Yang, Hsiu-Mei Huang, Chia-Shiang Chang, Chia-Lin Wu, Jiin-Haur Chuan. High-fat diet induces toll-like receptor 4-dependent macrophage/microglial cell activation and retinal impairment. Investigative ophthalmology & visual science. vol 56. issue 5. 2015-10-15. PMID:26024088. |
in the present study, a model of high-fat diet (hfd) feeding of mice was used to investigate the role of tlr4 in overnutrition- and obesity-associated inflammation and infiltration of macrophages and microglia in the retina. |
2015-10-15 |
2023-08-13 |
mouse |
| Mei Du, Laura Otalora, Ashley A Martin, Gennadiy Moiseyev, Phillip Vanlandingham, Qilong Wang, Rafal Farjo, Alexander Yeganeh, Alexander Quiambao, Krysten M Farj. Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Molecular and cellular biology. vol 35. issue 16. 2015-10-05. PMID:26055327. |
increased expression of pro-interleukin-18 (pro-il-18) mrna and activated il-18 protein and early-onset microglia activation in the retina suggest that retinal degeneration is driven by a proinflammatory mechanism. |
2015-10-05 |
2023-08-13 |
mouse |
| Lu Li, Nicole Eter, Peter Heiduschk. The microglia in healthy and diseased retina. Experimental eye research. vol 136. 2015-08-28. PMID:25952657. |
the microglia in healthy and diseased retina. |
2015-08-28 |
2023-08-13 |
Not clear |
| Lu Li, Nicole Eter, Peter Heiduschk. The microglia in healthy and diseased retina. Experimental eye research. vol 136. 2015-08-28. PMID:25952657. |
the microglia are the immune cells of the central nervous system and, also the retina. |
2015-08-28 |
2023-08-13 |
Not clear |
| A Trost, K Motloch, D Bruckner, F Schroedl, B Bogner, A Kaser-Eichberger, C Runge, C Strohmaier, B Klein, L Aigner, H A Reitsame. Time-dependent retinal ganglion cell loss, microglial activation and blood-retina-barrier tightness in an acute model of ocular hypertension. Experimental eye research. vol 136. 2015-08-28. PMID:26001526. |
in an acute short-term ocular hypertension model in rat, we characterize rgc loss, but also microglial cell activation and vascular alterations of the retina at certain time points. |
2015-08-28 |
2023-08-13 |
rat |
| Julia Preissler, Antje Grosche, Vera Lede, Diana Le Duc, Katja Krügel, Vitali Matyash, Frank Szulzewsky, Sonja Kallendrusch, Kerstin Immig, Helmut Kettenmann, Ingo Bechmann, Torsten Schöneberg, Angela Schul. Altered microglial phagocytosis in GPR34-deficient mice. Glia. vol 63. issue 2. 2015-08-19. PMID:25142016. |
however, gpr34-deficient microglia showed reduced phagocytosis activity in both retina and acutely isolated cortical slices. |
2015-08-19 |
2023-08-13 |
mouse |
| Agustina Noailles, Laura Fernández-Sánchez, Pedro Lax, Nicolás Cuenc. Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects. Journal of neuroinflammation. vol 11. 2015-08-07. PMID:25359524. |
the objective of this study was to quantify microglia activation in the retina of p23h rats, an animal model of retinitis pigmentosa, and to evaluate the therapeutic effects of tudca (tauroursodeoxycholic acid), which has been described as a neuroprotective compound. |
2015-08-07 |
2023-08-13 |
rat |
| Marcus Karlstetter, Rebecca Scholz, Matt Rutar, Wai T Wong, Jan M Provis, Thomas Langman. Retinal microglia: just bystander or target for therapy? Progress in retinal and eye research. vol 45. 2015-08-03. PMID:25476242. |
in addition, we present the concept that microglia play a key role in local regulation of complement in the retina and specify aspects of microglial aging relevant for chronic inflammatory processes in the retina. |
2015-08-03 |
2023-08-13 |
human |
| Ana Sierra, Julio Navascués, Miguel A Cuadros, Ruth Calvente, David Martín-Oliva, Rosa M Ferrer-Martín, María Martín-Estebané, María-Carmen Carrasco, José L Marín-Tev. Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina. PloS one. vol 9. issue 8. 2015-06-26. PMID:25170849. |
expression of inducible nitric oxide synthase (inos) in microglia of the developing quail retina. |
2015-06-26 |
2023-08-13 |
Not clear |
| Ana Sierra, Julio Navascués, Miguel A Cuadros, Ruth Calvente, David Martín-Oliva, Rosa M Ferrer-Martín, María Martín-Estebané, María-Carmen Carrasco, José L Marín-Tev. Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina. PloS one. vol 9. issue 8. 2015-06-26. PMID:25170849. |
inos expression and no production in lps-treated microglial cells were investigated by an in vitro approach based on organotypic cultures of e8 retinas, in which microglial cell behavior is similar to that of the in situ retina, as previously demonstrated in our laboratory. |
2015-06-26 |
2023-08-13 |
Not clear |
| Ana Sierra, Julio Navascués, Miguel A Cuadros, Ruth Calvente, David Martín-Oliva, Rosa M Ferrer-Martín, María Martín-Estebané, María-Carmen Carrasco, José L Marín-Tev. Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina. PloS one. vol 9. issue 8. 2015-06-26. PMID:25170849. |
we show here that amoeboid microglia in the quail retina express inos during normal development. |
2015-06-26 |
2023-08-13 |
Not clear |
| Ana Sierra, Julio Navascués, Miguel A Cuadros, Ruth Calvente, David Martín-Oliva, Rosa M Ferrer-Martín, María Martín-Estebané, María-Carmen Carrasco, José L Marín-Tev. Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina. PloS one. vol 9. issue 8. 2015-06-26. PMID:25170849. |
this expression is stronger in microglial cells migrating tangentially in the vitreal part of the retina and is downregulated, albeit maintained, when microglia differentiate and become ramified. |
2015-06-26 |
2023-08-13 |
Not clear |