Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Bo Lei, Li Lv, Shiqiang Hu, Yikai Tang, Yi Zhon. Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-04. PMID:35377811. |
here, we show that social experiences stimulated switching between latent and silent engrams to achieve flexible memory accessibility and also reveal the basic molecular mechanism of: 1) social reward turning silent engram to latent via suppression of rac1 activity in ca1 neurons of the hippocampus; and 2) social stress switching latent memory engram into silent through activating rac1. |
2022-04-04 |
2023-08-13 |
human |
Cibele Canal Castro, Aline de Souza Pagnussat, Carolina Demarchi Munhoz, Carlos Alexandre Nett. Coumestrol pre-treatment improves spatial learning and memory deficits following transient cerebral ischemia recruiting hippocampal GluR2 AMPA receptors. Hippocampus. 2022-03-29. PMID:35347795. |
transient global ischemia is a leading cause of learning and memory dysfunction and induces a pattern of delayed neuronal death in the ca1 subfield of the hippocampus by down-regulating glur2 mrna ampa receptors in this cerebral area. |
2022-03-29 |
2023-08-13 |
mouse |
Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. |
in the subclinical depression group, verbal learning was positively correlated with the volumes of the ca1, gc-ml-dg, molecular layer, and whole hippocampus in the right hemisphere. |
2022-03-25 |
2023-08-13 |
human |
Saptarnab Naskar, Siddhartha Datta, Sumantra Chattarj. Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala. Neurobiology of stress. vol 18. 2022-03-25. PMID:35330860. |
hence, we tested the impact of riluzole, which potentiates glutamate clearance by astrocytic glutamate transporters, on principal neurons and astrocytes in the basal amygdala (ba) and hippocampal area ca1. |
2022-03-25 |
2023-08-13 |
rat |
Scheila Daiane Schmidt, Eduarda Godfried Nachtigall, Lucas Aschidamini Marcondes, André Zanluchi, Cristiane R G Furini, Maria Beatrice Passani, Claudiu T Supuran, Patrizio Blandina, Ivan Izquierdo, Gustavo Provensi, Jociane de Carvalho Myski. Modulation of carbonic anhydrases activity in the hippocampus or prefrontal cortex differentially affects social recognition memory in rats. Neuroscience. 2022-03-25. PMID:35331846. |
male adult wistar rats were submitted to a social discrimination task and, immediately after the sample phase, received bilateral infusions of vehicle, the cas activator d-phenylalanine (d-phen, 10 nmols/side), the cas inhibitor acetazolamide (actz; 10 nmols/side) or the combination of d-phen and actz directly in the ca1 region of the dorsal hippocampus or in the medial prefrontal cortex (mpfc). |
2022-03-25 |
2023-08-13 |
rat |
Matthew R Herbst, Robert C Twining, Marieke R Gilmarti. Ventral hippocampal shock encoding modulates the expression of trace cued fear. Neurobiology of learning and memory. 2022-03-18. PMID:35302040. |
we first recorded neuronal activity in the ventral hippocampus during trace fear conditioning and found that ventral ca1 predominantly encoded the shock reinforcer. |
2022-03-18 |
2023-08-13 |
human |
Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
however, the subregional deterioration pattern of the hippocampus differs between ad and dlb with the ca1 subfield being more severely affected in ad. |
2022-03-17 |
2023-08-13 |
Not clear |
Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
to this purpose, we employed an automated pipeline for analysis of 3d confocal microscopy images to assess ca1, ca3 and dg/ca4 subfields microglia responses in post-mortem hippocampal samples from late-onset ad (n = 10), dlb (n = 8) and age-matched control (ctl) (n = 11) individuals. |
2022-03-17 |
2023-08-13 |
Not clear |
Hang Xing, Xiong Han, Sihan Xu, Zhongyu Sun, Shijun Yan. Brivaracetam Modulates Short-Term Synaptic Activity and Low-Frequency Spontaneous Brain Activity by Delaying Synaptic Vesicle Recycling in Two Distinct Rodent Models of Epileptic Seizures. Journal of molecular neuroscience : MN. 2022-03-12. PMID:35278193. |
in our study, the electrophysiological field excitatory post-synaptic potential (fepsp) recordings were performed in rat hippocampal brain slices from the ca1 region by stimulation of the schaffer collateral/commissural pathway with or without brv (30 μm for 3 h) in control or epileptic seizure (induced by pilocarpine (pilo) or high potassium (h-k |
2022-03-12 |
2023-08-13 |
rat |
Hongxuan Kuang, Wenji Zhou, Yingwei Zeng, Da Xu, Wanqi Zhu, Shengjie Lin, Ruifang Fa. Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs. Chemosphere. 2022-03-08. PMID:35257710. |
compared with the control mice, only those exposed to 50 μg/kg/day pahs had significantly lower ltp in hippocampal ca1 region and dendritic spine density in hippocampal dg region (p < 0.05). |
2022-03-08 |
2023-08-13 |
mouse |
Zhu-Qing He, Peng-Fei Huan, Li Wang, Jian-Cheng H. Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling. Metabolic brain disease. 2022-03-01. PMID:35230626. |
additionally, pf improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the ca1 and ca3, and upregulating psd-95 as well as syn protein levels. |
2022-03-01 |
2023-08-13 |
mouse |
Tatyana Strekalova, Dmitrii Pavlov, Alexander Trofimov, Daniel C Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespugli. Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216176. |
anhedonic (susceptible) but not non-anhedonic (resilient) animals exhibited elevated cox-2 mrna levels, increased numbers of cox-2 and iba-1-positive cells in the dentate gyrus and the ca1 area, and decreased numbers of ki67-positive cells in the subgranular zone of the hippocampus. |
2022-02-26 |
2023-08-13 |
mouse |
Hannah Twarkowksi, Victor Steininger, Min Jae Kim, Amar Saha. A dentate gyrus- CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation. eLife. vol 11. 2022-02-22. PMID:35191834. |
memories encoded in the dentate gyrus (dg) - ca3 circuit of the hippocampus are routed from ca1 to anterior cingulate cortex (acc) for consolidation. |
2022-02-22 |
2023-08-13 |
Not clear |
Behzad Dehqanizadeh, Ziya Fallah Mohammadi, Abdol Hossein Taheri Kalani, Seyed Javad Mirghan. Effect of Early Exercise on Inflammatory Parameters and Apoptosis in CA1 Area of the Hippocampus Following Cerebral Ischemia-reperfusion in Rats. Brain research bulletin. 2022-02-21. PMID:35189318. |
effect of early exercise on inflammatory parameters and apoptosis in ca1 area of the hippocampus following cerebral ischemia-reperfusion in rats. |
2022-02-21 |
2023-08-13 |
rat |
Behzad Dehqanizadeh, Ziya Fallah Mohammadi, Abdol Hossein Taheri Kalani, Seyed Javad Mirghan. Effect of Early Exercise on Inflammatory Parameters and Apoptosis in CA1 Area of the Hippocampus Following Cerebral Ischemia-reperfusion in Rats. Brain research bulletin. 2022-02-21. PMID:35189318. |
the purpose of this study was to evaluate the effect of early exercise on inflammatory parameters and apoptosis in the ca1 area of the hippocampus following cerebral i/r in adult male rats. |
2022-02-21 |
2023-08-13 |
rat |
Yu Zhang, Qi Wu, Yu Ren, Ye Zhang, Linyin Fen. A53T α-synuclein induces neurogenesis impairment and cognitive dysfunction in line M83 transgenic mice and reduces the proliferation of embryonic neural stem cells. Brain research bulletin. 2022-02-19. PMID:35182691. |
golgi staining indicated that the apical neuronal dendritic spines of hippocampal ca1 neurons were significantly reduced in 6-month-old homozygotes and heterozygotes, although map2 protein expression revealed no significant difference in the hippocampus among wild-type mice, homozygotes and heterozygotes. |
2022-02-19 |
2023-08-13 |
mouse |
Ying Hao Yu, Yeou San Lim, Chen Yin Ou, Kai Chieh Chang, Arthur C Tsai, Fang Chih Chang, Andrew Chih Wei Huan. The Medial Prefrontal Cortex, Nucleus Accumbens, Basolateral Amygdala, and Hippocampus Regulate the Amelioration of Environmental Enrichment and Cue in Fear Behavior in the Animal Model of PTSD. Behavioural neurology. vol 2022. 2022-02-18. PMID:35178125. |
the present study addressed this issue and examined whether the medial prefrontal cortex (mpfc, including the cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), the nucleus accumbens (nac), the basolateral amygdala (bla), and the hippocampus (e.g., ca1, ca3, and dentate gyrus (dg)) regulated the amelioration of the ee, cue, or the combination of ee and cue. |
2022-02-18 |
2023-08-13 |
Not clear |
Ying Hao Yu, Yeou San Lim, Chen Yin Ou, Kai Chieh Chang, Arthur C Tsai, Fang Chih Chang, Andrew Chih Wei Huan. The Medial Prefrontal Cortex, Nucleus Accumbens, Basolateral Amygdala, and Hippocampus Regulate the Amelioration of Environmental Enrichment and Cue in Fear Behavior in the Animal Model of PTSD. Behavioural neurology. vol 2022. 2022-02-18. PMID:35178125. |
the mpfc (i.e., the cg1, prl, and il) and the hippocampus (i.e., the ca1, ca3, and dg) downregulated the c-fos expression in the suppression of the cue in fear behavior. |
2022-02-18 |
2023-08-13 |
Not clear |
Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
hypoxia/ischemia-induced rod microglia phenotype in ca1 hippocampal slices. |
2022-02-15 |
2023-08-13 |
rat |
Ya-Fei Zhao, Wen-Jing Ren, Ying Zhang, Jin-Rong He, Hai-Yan Yin, Yang Liao, Patrizia Rubini, Jan M Deussing, Alexei Verkhratsky, Zeng-Qiang Yuan, Peter Illes, Yong Tan. High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163829. |
in hippocampal slices of mice and rats, only foot shock increased the current responses to locally applied dibenzoyl-atp (bz-atp) in ca1 astrocytes; in contrast, tst and restraint depressed these responses. |
2022-02-15 |
2023-08-13 |
mouse |