| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang-Hun Lee, Ivan Soltes. Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells. The Journal of physiology. vol 589. issue Pt 4. 2012-03-06. PMID:21173082. |
our present data from paired recording experiments from presynaptic basket cells and postsynaptic ca1 pyramidal cells in acute rat brain slices show that the p/q ca2+ channel antagonist agatoxin tk (250 nm) abolished gaba release from pv+ basket cells, but it had no effect on the cck-induced depression of gaba release from cck+ basket cells. |
2012-03-06 |
2023-08-12 |
rat |
| Jhimly Sarkar, Seth Wakefield, Georgina MacKenzie, Stephen J Moss, Jamie Maguir. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 50. 2012-02-09. PMID:22171026. |
further, gaba(a)r δ subunit-containing receptors and phosphorylation of kcc2 residue ser940 may be novel targets for control of the stress response, which has therapeutic potential for numerous disorders associated with hyperexcitability of the hpa axis, including cushing's syndrome, epilepsy, and major depression. |
2012-02-09 |
2023-08-12 |
mouse |
| C Schüle, D Eser, T C Baghai, C Nothdurfter, J S Kessler, R Rupprech. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience. vol 191. 2012-01-10. PMID:21439354. |
in particular, 3α-reduced neuroactive steroids such as allopregnanolone or allotetrahydrodeoxycorticosterone have been shown to act as positive allosteric modulators of the gaba(a) receptor and to play an important role in the pathophysiology of depression and anxiety. |
2012-01-10 |
2023-08-12 |
human |
| Hatsuo Hayashi, Yukihiro Nonak. Cooperation and competition between lateral and medial perforant path synapses in the dentate gyrus. Neural networks : the official journal of the International Neural Network Society. vol 24. issue 3. 2011-12-23. PMID:21269806. |
the feed-forward gaba(b) inhibition suppressed unusual high-frequency firing of the granule cell, and consequently prevented excessive synaptic depression due to synaptic competition through stdp. |
2011-12-23 |
2023-08-12 |
human |
| John G Mielke, Tarun K Ahuja, Tanya Comas, Geoffrey A R Mealin. Choline-mediated depression of hippocampal synaptic transmission. Nutritional neuroscience. vol 14. issue 5. 2011-12-20. PMID:22005282. |
the ability of choline to increase paired-pulse facilitation, and the inability of applied gamma-aminobutyric acid (gaba) to mediate further depression of fepsps, suggests that the principal mechanism of choline's action was on the facilitation of neurotransmitter release. |
2011-12-20 |
2023-08-12 |
Not clear |
| Ling-ling Yu, Ru-peng Liu, Xin-yan Gao, Kun Liu, Liang Li, Hui Ben, Pei-jing Ron. [Development of studies on neurochemical mechanism of acupuncture underlying improvement of depression]. Zhen ci yan jiu = Acupuncture research. vol 36. issue 5. 2011-12-20. PMID:22073894. |
in the present review, the authors summarize the progress of experimental researches on acupuncture treatment of depression from (1) monoamines neurotransmitters and their receptors, (2) gamma-aminobutyric acid and glutamate, (3) neuropeptide y, (4) hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-throid axis activities, and (5) brain-derived neurotrophic factor. |
2011-12-20 |
2023-08-12 |
Not clear |
| Robert L Gannon, Mark J Milla. Positive allosteric modulators at GABAB receptors exert intrinsic actions and enhance the influence of baclofen on light-induced phase shifts of hamster circadian activity rhythms. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21756929. |
gaba(b) receptors clearly warrant further investigation as agents for modulation of circadian dysfunction associated with cns disorders such as depression. |
2011-12-09 |
2023-08-12 |
Not clear |
| Botir T Sagdullaev, Erika D Eggers, Robert Purgert, Peter D Lukasiewic. Nonlinear interactions between excitatory and inhibitory retinal synapses control visual output. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 42. 2011-12-08. PMID:22016544. |
this depression was relieved by amacrine cell inhibitory feedback that activated presynaptic gaba(c) receptors. |
2011-12-08 |
2023-08-12 |
mouse |
| Caroline Le Duigou, Thomas Holden, Dimitri M Kullman. Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation. Neuropharmacology. vol 60. issue 5. 2011-10-03. PMID:21185314. |
the dhpg-evoked depression was unaffected by antagonists of cb1 and gaba(b) receptors but was occluded when presynaptic p/q-type ca(2+) channels were blocked. |
2011-10-03 |
2023-08-12 |
rat |
| Mai Marie Holm, Jose Luis Nieto-Gonzalez, Irina Vardya, Kim Henningsen, Magdalena Niepsuj Jayatissa, Ove Wiborg, Kimmo Jense. Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087886. |
in summary, we have revealed a hippocampal dysfunction in the gabaergic system in the chronic mild stress model of depression in rats, caused by a reduction in action potential-dependent gaba release. |
2011-09-28 |
2023-08-12 |
rat |
| S Desmyter, C van Heeringen, K Audenaer. Structural and functional neuroimaging studies of the suicidal brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21216267. |
several reports have suggested abnormalities of gaba neurotransmission in depression. |
2011-09-13 |
2023-08-12 |
human |
| Matthew J Taylor, Zola N Mannie, Ray Norbury, Jamie Near, Philip J Cowe. Elevated cortical glutamate in young people at increased familial risk of depression. The international journal of neuropsychopharmacology. vol 14. issue 2. 2011-09-02. PMID:20846462. |
we used mrs to measure gaba and glutamate in parieto-occipital cortex in young people (ages 16-21 yr) with a family history of parental depression (n=24) but no personal history of illness and a control group without a history of depression in any first-degree relative (n=28). |
2011-09-02 |
2023-08-12 |
human |
| Chao-Yang Gu, Shu-Cheng A. [Rat orbital frontal (orbital frontal cortex, OFC) GABA B receptor mechanisms in stress and depression]. Dong wu xue yan jiu = Zoological research. vol 32. issue 3. 2011-08-25. PMID:21698801. |
[rat orbital frontal (orbital frontal cortex, ofc) gaba b receptor mechanisms in stress and depression]. |
2011-08-25 |
2023-08-12 |
rat |
| S Hossein Fatemi, Timothy D Folsom, Paul D Thura. Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study. Schizophrenia research. vol 128. issue 1-3. 2011-08-24. PMID:21303731. |
in the current study, we examined protein levels of the two gaba(b) receptor subunits gabbr1 and gabbr2 in lateral cerebella from a well-characterized cohort of subjects with schizophrenia (n=15), bipolar disorder (n=14), major depression (n=13) and healthy controls (n=12). |
2011-08-24 |
2023-08-12 |
human |
| Ahmad Khundakar, Christopher Morris, Alan J Thoma. The immunohistochemical examination of GABAergic interneuron markers in the dorsolateral prefrontal cortex of patients with late-life depression. International psychogeriatrics. vol 23. issue 4. 2011-08-17. PMID:21044398. |
gamma-aminobutyric acid (gaba) is thought to play a major role in the neurobiology of depression. |
2011-08-17 |
2023-08-12 |
Not clear |
| Jane Skov, Mogens Andreasen, John J Hablitz, Steen Nedergaar. Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K+ channel blockade. Cellular and molecular neurobiology. vol 31. issue 4. 2011-08-16. PMID:21274618. |
we propose that these novel effects of ba(2+) and cs(+) are exerted through blockade of inwardly rectifying k(+) channels in glial cells, which are functionally interacting with the gaba(b) receptor-dependent glutamate release that generates heterosynaptic depression. |
2011-08-16 |
2023-08-12 |
rat |
| Louise Adermark, Rhona B C Clarke, Bo Söderpalm, Mia Ericso. Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons. Neurochemistry international. vol 58. issue 6. 2011-08-16. PMID:21333709. |
this depression of synaptic output is insensitive to the n-methyl-d-aspartic acid (nmda) receptor inhibitor dl-2-amino-5-phosphonopentanoic acid (ap-5, 50μm), but is blocked in slices treated with glycine receptor antagonists (strychnine, 1μm; pmba, 50μm), nicotinic acetylcholine receptor antagonists (mecamylamine, 10μm; methyllycaconitine citrate (mla), 40nm), or gaba(a) receptor inhibitors (picrotoxin, 100μm; bicuculline, 2μm, 20μm). |
2011-08-16 |
2023-08-12 |
rat |
| S B Kombian, O A Phillip. In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons. Neuroscience. vol 180. 2011-08-04. PMID:21296129. |
the synaptic depression by ph084 was without effect on the resting membrane conductance at resting or relatively hyperpolarized voltage and could be blocked by gaba(b), dopamine d1-like and α-adrenergic receptor antagonists but not by an adenosine a1 receptor antagonist. |
2011-08-04 |
2023-08-12 |
rat |
| Young-Hwan Jo, Emmanuelle Donier, Audrey Martinez, Maurice Garret, Estelle Toulmé, Eric Boué-Grabo. Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse. The Journal of biological chemistry. vol 286. issue 22. 2011-08-01. PMID:21482824. |
moreover, disruption of the physical coupling using competitive peptides containing the identified motif abolishes current inhibition between p2x4 and gaba(a) receptors in recombinant system and p2x4 receptor-mediated gabaergic depression in sf-1 gfp-positive neurons. |
2011-08-01 |
2023-08-12 |
Not clear |
| Louiza B Thomsen, Henrik Jörntell, Jens Midtgaar. Presynaptic calcium signalling in cerebellar mossy fibres. Frontiers in neural circuits. vol 4. 2011-07-14. PMID:20162034. |
a paired-pulse depression of the calcium signal lasting more than 1 s affected burst firing in mossy fibres; this paired-pulse depression was reduced by gaba b antagonists. |
2011-07-14 |
2023-08-12 |
Not clear |