| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Mapelli, Paola Rossi, Thierry Nieus, Egidio D'Angel. Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus. Journal of neurophysiology. vol 101. issue 6. 2009-08-03. PMID:19339456. |
blocking gaba(b) receptors with cgp55845 enhanced the first inhibitory postsynaptic current (ipsc) and short-term depression in a train while reducing trial-to-trial variability and failures. |
2009-08-03 |
2023-08-12 |
Not clear |
| Yugi Inaba, Margherita D'Antuono, Giuliano Bertazzoni, Giuseppe Biagini, Massimo Avol. Diminished presynaptic GABA(B) receptor function in the neocortex of a genetic model of absence epilepsy. Neuro-Signals. vol 17. issue 2. 2009-07-15. PMID:19176980. |
these alterations may lead to hyperexcitability by downregulating the function of presynaptic gaba(b) receptors in neocortical networks as suggested by a reduction in paired-pulse depression. |
2009-07-15 |
2023-08-12 |
rat |
| Graziano Pinna, Erminio Costa, Alessandro Guidott. SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Current opinion in pharmacology. vol 9. issue 1. 2009-07-14. PMID:19157982. |
thus, fluoxetine and related congeners facilitate gaba(a) receptor neurotransmission and effectively ameliorate emotional and anxiety disorders and depression by acting as selective brain steroidogenic stimulants (sbsss). |
2009-07-14 |
2023-08-12 |
mouse |
| Yuval Silberman, Olusegun J Ariwodola, Jeff L Weine. Differential effects of GABAB autoreceptor activation on ethanol potentiation of local and lateral paracapsular GABAergic synapses in the rat basolateral amygdala. Neuropharmacology. vol 56. issue 5. 2009-07-02. PMID:19371578. |
at local synapses, we found significant paired-pulse depression (ppd, 250 ms inter-pulse interval) which was abated by sch-50911 (gaba(b)-r antagonist). |
2009-07-02 |
2023-08-12 |
human |
| Tomonori Takazawa, Hidemasa Furue, Koichi Nishikawa, Daisuke Uta, Kaori Takeshima, Fumio Goto, Megumu Yoshimur. Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings. The European journal of neuroscience. vol 29. issue 3. 2009-06-12. PMID:19222560. |
this depression may have been caused by interactions of propofol with gaba(a) receptors, as decay time of gabaergic sipscs was prolonged after propofol injection (128 +/- 11% of control, n = 5) with minimal effect on epscs. |
2009-06-12 |
2023-08-12 |
rat |
| Phillip Larimer, Ben W Strowbridg. Nonrandom local circuits in the dentate gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 47. 2009-06-09. PMID:19020015. |
hilar ipsps have low failure rates, are blocked by the gaba(a) receptor antagonist gabazine, and exhibit short-term depression when tested at 17 hz. |
2009-06-09 |
2023-08-12 |
rat |
| Z Shao, A C Puche, E Kiyokage, G Szabo, M T Shiple. Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals. Journal of neurophysiology. vol 101. issue 4. 2009-05-26. PMID:19225171. |
in response to on stimulation, on-driven pg cells exhibit paired-pulse depression (ppd), which is partially reversed by gaba(b) receptor antagonists. |
2009-05-26 |
2023-08-12 |
mouse |
| E Engin, J Stellbrink, D Treit, C T Dickso. Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: behavioral and neurophysiological evidence. Neuroscience. vol 157. issue 3. 2009-04-14. PMID:18940236. |
however, despite its extensive expression in limbic areas, and its co-localization with gaba, a neurotransmitter previously implicated in emotion, the effects of sst on anxiety and depression have not been investigated. |
2009-04-14 |
2023-08-12 |
rat |
| Pan-Yue Deng, Saobo Le. Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels. Molecular and cellular neurosciences. vol 39. issue 2. 2009-04-08. PMID:18687403. |
application of 5-ht inhibited low-mg(2+)-induced seizure activity in slices via 5-ht(1a) and 5-ht(2a) receptors suggesting that 5-ht-mediated depression of neuronal excitability and increase in gaba release contribute to its anti-epileptic effects in the ec. |
2009-04-08 |
2023-08-12 |
rat |
| Chun Xu, Man-xia Zhao, Mu-ming Poo, Xiao-hui Zhan. GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses. Nature neuroscience. vol 11. issue 12. 2009-04-08. PMID:18953347. |
the potentiation was abolished by blocking gaba(b) receptors (gaba(b)rs), whereas the depression was independent of gaba(b)r activation and could be converted to potentiation by elevating gaba(b)r activity. |
2009-04-08 |
2023-08-12 |
rat |
| Mark J Milla. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 6. issue 1. 2009-04-02. PMID:19110199. |
dual neurokinin(1) antagonists/5-ht reuptake inhibitors (sris) and melanocortin(4) antagonists/sris should display advantages over their selective counterparts, and histamine h(3) antagonists/sris, gaba(b) antagonists/sris, glutamatergic/sris, and cholinergic agents/sris may counter the compromised cognitive function of depression. |
2009-04-02 |
2023-08-12 |
Not clear |
| Rotem Genud, Avia Merenlender, Iris Gispan-Herman, Rachel Maayan, Abraham Weizman, Gal Yadi. DHEA lessens depressive-like behavior via GABA-ergic modulation of the mesolimbic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 3. 2009-03-30. PMID:18496525. |
our results imply that alterations in dhea are involved in the pathophysiology of depression and that the antidepressant action of dhea is mediated via gaba(a)rs in the nac and vta. |
2009-03-30 |
2023-08-12 |
rat |
| J-Y Xu, B Yang, B R Sastr. The involvement of GABA-C receptors in paired-pulse depression of inhibitory postsynaptic currents in rat hippocampal CA1 pyramidal neurons. Experimental neurology. vol 216. issue 1. 2009-03-20. PMID:19100735. |
in rat hippocampal ca1 pyramidal neurons, gamma-aminobutyric acid (gaba) a receptor-mediated inhibitory postsynaptic currents (ipscs) undergo a paired-pulse depression (ppd) by the second of two pulses, with inter-pulse intervals of 100-2000 ms, applied to the stratum radiatum. |
2009-03-20 |
2023-08-12 |
rat |
| Nicole Guetg, Riad Seddik, Réjan Vigot, Rostislav Turecek, Martin Gassmann, Kaspar E Vogt, Hans Bräuner-Osborne, Ryuichi Shigemoto, Oliver Kretz, Michael Frotscher, Akos Kulik, Bernhard Bettle. The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 5. 2009-02-24. PMID:19193888. |
specifically, we demonstrate that selectively gaba(b(1a,2)) receptors mediate heterosynaptic depression of mf transmission, a physiological phenomenon involving transsynaptic inhibition of glutamate release via presynaptic gaba(b) receptors. |
2009-02-24 |
2023-08-12 |
mouse |
| Barbara Zieba, Małgorzata Grzegorzewska, Piotr Brański, Helena Domin, Joanna M Wierońska, Grzegorz Hess, Maria Smiałowsk. The behavioural and electrophysiological effects of CRF in rat frontal cortex. Neuropeptides. vol 42. issue 5-6. 2009-02-19. PMID:18617263. |
electrophysiological experiments showed that crf-induced a transient depression of field potentials in slices partly disinhibited by gaba(a) and gaba(b) receptors antagonists. |
2009-02-19 |
2023-08-12 |
rat |
| Mark C Bieda, Henry Su, M Bruce Macive. Anesthetics discriminate between tonic and phasic gamma-aminobutyric acid receptors on hippocampal CA1 neurons. Anesthesia and analgesia. vol 108. issue 2. 2009-02-09. PMID:19151276. |
in the present study, we compared and contrasted the involvement of tonic versus synaptic gaba(a) receptors in the functional depression of cns neurons produced by isoflurane and thiopental. |
2009-02-09 |
2023-08-12 |
Not clear |
| Jamin M Mulvey, Gillian M C Rensha. GABA is not elevated during neuroprotective neuronal depression in the hypoxic epaulette shark (Hemiscyllium ocellatum). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 152. issue 2. 2009-01-29. PMID:19010436. |
gaba is not elevated during neuroprotective neuronal depression in the hypoxic epaulette shark (hemiscyllium ocellatum). |
2009-01-29 |
2023-08-12 |
Not clear |
| Ertugrul Esel, Kader Kose, Yunus Hacimusalar, Saliha Ozsoy, Mustafa Kula, Zaliha Candan, Tayfun Tura. The effects of electroconvulsive therapy on GABAergic function in major depressive patients. The journal of ECT. vol 24. issue 3. 2009-01-22. PMID:18562944. |
it has been proposed that major depression is associated with a dysfunction of the gamma-aminobutyric acid (gaba) system. |
2009-01-22 |
2023-08-12 |
Not clear |
| C Grasshoff, N Netzhammer, J Schweizer, B Antkowiak, H Hentschk. Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18619475. |
depression of spinal network activity by thiopental: shift from phasic to tonic gaba(a) receptor-mediated inhibition. |
2009-01-15 |
2023-08-12 |
mouse |
| Corinne G Jolivalt, Corinne A Lee, Khara M Ramos, Nigel A Calcut. Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain. vol 140. issue 1. 2009-01-13. PMID:18755547. |
gaba(a) receptor-mediated rate-dependent depression of the spinal h reflex was absent in the spinal cord of diabetic rats. |
2009-01-13 |
2023-08-12 |
human |