| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K E Vogt, R A Nicol. Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 3. 1999-03-05. PMID:9927703. |
glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. |
1999-03-05 |
2023-08-12 |
Not clear |
| A C Almeida, V M Fernandes de Lima, A F Infantos. Mathematical model of the CA1 region of the rat hippocampus. Physics in medicine and biology. vol 43. issue 9. 1998-12-11. PMID:9755950. |
the results suggest that the depression of the second pulse, often interpreted in the literature as resulting from gaba(a) inhibition, can also be due to 'shunting' effects on the ca1 pyramids' membrane. |
1998-12-11 |
2023-08-12 |
rat |
| K KRNJEVIC, J W PHILLI. Actions of certain amines on cerebral cortical neurones. British journal of pharmacology and chemotherapy. vol 20. 1998-11-01. PMID:14035890. |
catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of gamma-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. |
1998-11-01 |
2023-08-12 |
Not clear |
| M RUSCA. Changes in the level of gamma-aminobutyric acid (GABA) in the ischaemic brain of rats following application of some stimuli evoking spreading EEG depression. Physiologia bohemoslovenica. vol 11. 1998-11-01. PMID:14495334. |
changes in the level of gamma-aminobutyric acid (gaba) in the ischaemic brain of rats following application of some stimuli evoking spreading eeg depression. |
1998-11-01 |
2023-08-12 |
rat |
| T C Dumas, T C Foste. GABA(b) receptors differentially regulate hippocampal CA1 excitatory synaptic transmission across postnatal development in the rat. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654362. |
depression of excitatory postsynaptic potentials (epsps) by the gaba(b) agonist, baclofen, was compared in hippocampal slices from juvenile (postnatal day (p) 15-21) and young adult (p28-35) rats. |
1998-08-17 |
2023-08-12 |
rat |
| A Chabli, D Y Ruan, S Molotchnikof. Influences of area 17 on neuronal activity of simple and complex cells of area 18 in cats. Neuroscience. vol 84. issue 3. 1998-07-01. PMID:9579776. |
in contrast to simple cells, gaba depression enhanced the responses in the majority of complex cells with like orientations in both areas. |
1998-07-01 |
2023-08-12 |
Not clear |
| A Arata, H Onimaru, I Homm. The adrenergic modulation of firings of respiratory rhythm-generating neurons in medulla-spinal cord preparation from newborn rat. Experimental brain research. vol 119. issue 4. 1998-06-26. PMID:9588774. |
the present results suggest that: (1) respiratory rhythm generation is more sensitive to adrenaline than na through alpha-adrenergic action of adrenaline; (2) the activity of pre-i neurons could be directly regulated by excitation via alpha1-receptors and inhibition via alpha2-receptors; and (3) the depression of the respiratory rhythm by adrenaline is partly mediated by gaba(a)ergic neurons. |
1998-06-26 |
2023-08-12 |
rat |
| J L Black, E M Barth, D E Williams, J A Tinsle. Stiff-man syndrome. Results of interviews and psychologic testing. Psychosomatics. vol 39. issue 1. 1998-05-06. PMID:9538674. |
the authors hypothesize that sms patients have a gamma-aminobutyric acid deficiency or gabaergic neuron dysfunction that leads to psychiatric symptoms, including depression and chemical abuse. |
1998-05-06 |
2023-08-12 |
Not clear |
| M A King, J S Thinschmidt, D W Walke. Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 11-12. 1998-04-29. PMID:9503264. |
the gamma-aminobutyric acid b-receptor (gaba-b) agonist baclofen also depressed the efp, but even maximally effective concentrations of the gaba-b antagonist 2-hydroxy-saclofen (800 microm) could not completely block the ghb-induced efp depression. |
1998-04-29 |
2023-08-12 |
rat |
| K J Gingrich, P M Burka. Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit. The Journal of physiology. vol 506 ( Pt 3). 1998-04-29. PMID:9503325. |
zn2+ (500 microm) depression of previously activated current amplitudes (% control) for alpha 1 beta 2 gamma 2 receptors was independent of gaba concentration (5 microm, 13.2 +/- 0.72%; 100 microm, 12.2 +/- 2.9%, p < 0.8, n = 5). |
1998-04-29 |
2023-08-12 |
Not clear |
| K J Gingrich, P M Burka. Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunit. The Journal of physiology. vol 506 ( Pt 3). 1998-04-29. PMID:9503325. |
inhibition onset was also biexponential for preactivated alpha 1 beta 2 receptors with current depression more than fourfold less sensitive (5 microm gaba, ic50 = 3.8 microm, s = 0.84) relative to that in constant zn2+. |
1998-04-29 |
2023-08-12 |
Not clear |
| A Markou, T R Kosten, G F Koo. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 3. 1998-04-02. PMID:9471114. |
finally, the neurotransmitter systems whose function appears to be altered in depression (i.e., serotonin, norepinephrine, acetylcholine, dopamine, gamma-aminobutyric acid, corticotropin releasing factor, neuropeptide y, and somatostatin), as revealed primarily by animal studies, are discussed. |
1998-04-02 |
2023-08-12 |
Not clear |
| C T Lai, V A Tanay, G J Charrois, G B Baker, A N Bateso. Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic acid decarboxylase (GAD67 and GAD65), the GABA transporter GAT-1 and GABA transaminase in rat cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 1. 1998-03-11. PMID:9459570. |
phenelzine and imipramine are efficacious in the treatment of depression and panic disorder and phenelzine has been reported to elevate gaba levels while imipramine enhances gaba release in rat brains. |
1998-03-11 |
2023-08-12 |
rat |
| G Chen, A N van den Po. Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 5. 1998-03-04. PMID:9465016. |
the depression of gaba release by gabab autoreceptors appeared to be mediated primarily through a modulation of presynaptic calcium channels. |
1998-03-04 |
2023-08-12 |
rat |
| H Katsuki, C Nakanishi, H Saito, N Matsuk. Biphasic effect of hydrogen peroxide on field potentials in rat hippocampal slices. European journal of pharmacology. vol 337. issue 2-3. 1998-03-03. PMID:9430416. |
an n-methyl-d-aspartate receptor antagonist dl-2-amino-5-phosphonovaleric acid had no influence on the effect of h2o2, whereas a gamma-aminobutyric acid type a receptor channel blocker picrotoxin attenuated long-lasting depression, indicating that gamma-aminobutyric acid-mediated inhibition is altered during the depression phase. |
1998-03-03 |
2023-08-12 |
rat |
| K Z Shen, S W Johnso. Presynaptic GABAB and adenosine A1 receptors regulate synaptic transmission to rat substantia nigra reticulata neurones. The Journal of physiology. vol 505 ( Pt 1). 1998-02-03. PMID:9409479. |
both baclofen and adenosine reduced the magnitude of paired-pulse depression of ipscs, and neither blocked currents evoked by gaba, which was pressure-ejected from micropipettes. |
1998-02-03 |
2023-08-12 |
rat |
| M D Edwards, G Lee. Modulation of a recombinant invertebrate gamma-aminobutyric acid receptor-chloride channel complex by isoflurane: effects of a point mutation in the M2 domain. British journal of pharmacology. vol 122. issue 4. 1998-01-02. PMID:9375970. |
the depression of gaba response at high isoflurane concentrations, in wt receptors, (typical of a variety of anaesthetic agents) may reflect low affinity channel block via the ptx site. |
1998-01-02 |
2023-08-12 |
xenopus_laevis |
| J S Dittman, W G Regeh. Mechanism and kinetics of heterosynaptic depression at a cerebellar synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 23. 1997-12-15. PMID:9364051. |
brief tetanic stimulation of granule cell parallel fibers activated inhibitory neurons, leading to a transient elevation of extracellular gaba, which in turn caused a short-lived heterosynaptic depression of the parallel fiber to purkinje cell epsc. |
1997-12-15 |
2023-08-12 |
rat |
| J S Dittman, W G Regeh. Mechanism and kinetics of heterosynaptic depression at a cerebellar synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 23. 1997-12-15. PMID:9364051. |
the magnitude and time course of the depression of calcium influx were mimicked by the rapid release of an estimated 10 microm gaba using the technique of flash photolysis. |
1997-12-15 |
2023-08-12 |
rat |
| B D Bennett, J R Huguenard, D A Princ. Adrenoceptor-mediated elevation of ambient GABA levels activates presynaptic GABA(B) receptors in rat sensorimotor cortex. Journal of neurophysiology. vol 78. issue 1. 1997-12-02. PMID:9242307. |
blockade of gaba(b) receptors prevented the depression of evoked ipsc amplitude by epinephrine but did not affect the increase in spontaneous ipsc frequency. |
1997-12-02 |
2023-08-12 |
rat |