| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Zilberter, K M Kaiser, B Sakman. Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex. Neuron. vol 24. issue 4. 2000-01-27. PMID:10624960. |
because synaptic depression was prevented by loading bitufted neurons with gdp-beta-s, it is likely to be caused by exocytotic gaba release from dendrites. |
2000-01-27 |
2023-08-12 |
rat |
| S R Cobb, N A Manuel, R A Morton, C H Gill, G L Collingridge, C H Davie. Regulation of depolarizing GABA(A) receptor-mediated synaptic potentials by synaptic activation of GABA(B) autoreceptors in the rat hippocampus. Neuropharmacology. vol 38. issue 11. 1999-12-20. PMID:10587088. |
this activity-dependent depression was eliminated by the gaba(b) receptor antagonist cgp 35348 (1 mm). |
1999-12-20 |
2023-08-12 |
rat |
| R A Deis. GABA(B) receptor-mediated effects in human and rat neocortical neurones in vitro. Neuropharmacology. vol 38. issue 11. 1999-12-20. PMID:10587091. |
the consequences of gaba receptor-mediated paired-pulse depression on neuronal synchronisation are discussed towards the different cellular mechanisms of focal and bilateral synchronous epilepsies. |
1999-12-20 |
2023-08-12 |
human |
| M Frerking, C C Petersen, R A Nicol. Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 22. 1999-12-10. PMID:10536023. |
bath application of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (ampa)/ka receptor agonist ka in the presence of the ampa receptor antagonist gyki 53655 caused a large increase in spontaneous gaba release and a coincident depression of the evoked ipsc. |
1999-12-10 |
2023-08-12 |
Not clear |
| M Frerking, C C Petersen, R A Nicol. Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 22. 1999-12-10. PMID:10536023. |
ka also caused a reduction in the size of responses to iontophoretically applied gaba, which was indistinguishable from the sch 50911-resistant, residual depression of the evoked ipsc. |
1999-12-10 |
2023-08-12 |
Not clear |
| R A Deis. The GABA(B) receptor antagonist CGP 55845A reduces presynaptic GABA(B) actions in neocortical neurons of the rat in vitro. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501448. |
application of the gaba(b) receptor antagonist cgp 55845a in the presence of cnqx and (-)-2-amino-5-phosphonovaleric acid abolished the inhibitory postsynaptic potential-b and paired-pulse depression. |
1999-12-09 |
2023-08-12 |
rat |
| R A Deis. The GABA(B) receptor antagonist CGP 55845A reduces presynaptic GABA(B) actions in neocortical neurons of the rat in vitro. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501448. |
it is concluded that paired-pulse depression of cortical inhibition is predominantly mediated by presynaptic gaba(b) receptors of gabaergic interneurons. |
1999-12-09 |
2023-08-12 |
rat |
| G Sanacora, G F Mason, D L Rothman, K L Behar, F Hyder, O A Petroff, R M Berman, D S Charney, J H Krysta. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of general psychiatry. vol 56. issue 11. 1999-11-23. PMID:10565505. |
several lines of emerging evidence suggest that dysfunction of gamma-aminobutyric acid (gaba) systems is associated with major depression. |
1999-11-23 |
2023-08-12 |
Not clear |
| G Sanacora, G F Mason, D L Rothman, K L Behar, F Hyder, O A Petroff, R M Berman, D S Charney, J H Krysta. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of general psychiatry. vol 56. issue 11. 1999-11-23. PMID:10565505. |
in this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the gaba neurotransmitter system are associated with the neurobiologic processes of depression. |
1999-11-23 |
2023-08-12 |
Not clear |
| P Monin, J Aranda, R Bansal, T Trippenbac. Effect of increased brain GABA concentrations on breathing in unanesthetized newborn rabbits. Biology of the neonate. vol 76. issue 3. 1999-10-29. PMID:10460954. |
evidence suggests that gamma-aminobutyric acid (gaba) is involved in control of breathing and in the hypoxia-related ventilatory depression in newborns. |
1999-10-29 |
2023-08-12 |
Not clear |
| P G Osborne, Y Hu, D N Covey, B N Barnes, Z Katz, K L Dre. Determination of striatal extracellular gamma-aminobutyric acid in non-hibernating and hibernating arctic ground squirrels using quantitative microdialysis. Brain research. vol 839. issue 1. 1999-10-20. PMID:10482793. |
this study determined extracellular concentrations of gamma-aminobutyric acid ([gaba](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to test the hypothesis that an increase in [gaba](ecf) was associated with profound cns depression during hibernation. |
1999-10-20 |
2023-08-12 |
Not clear |
| P G Osborne, Y Hu, D N Covey, B N Barnes, Z Katz, K L Dre. Determination of striatal extracellular gamma-aminobutyric acid in non-hibernating and hibernating arctic ground squirrels using quantitative microdialysis. Brain research. vol 839. issue 1. 1999-10-20. PMID:10482793. |
the results show that [gaba](ecf) in non-hibernating squirrels was 73 nm and this level was decreased by approximately 50% during hibernation thereby suggesting that an increase in [gaba](ecf) does not play a major role in cns depression during hibernation. |
1999-10-20 |
2023-08-12 |
Not clear |
| P R Patrylo, J S Schweitzer, F E Dude. Abnormal responses to perforant path stimulation in the dentate gyrus of slices from rats with kainate-induced epilepsy and mossy fiber reorganization. Epilepsy research. vol 36. issue 1. 1999-09-28. PMID:10463848. |
furthermore, pharmacological depression of inhibition by adding the gaba(a) receptor antagonist bicuculline unmasked hilar-evoked prolonged negative field-potential shifts in most slices from kainate-treated rats 3-13 months following treatment, and these slices had robust timm's staining in the inner molecular layer. |
1999-09-28 |
2023-08-12 |
rat |
| U Stäubli, J Scafidi, D Chu. GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 11. 1999-06-16. PMID:10341258. |
tbs produced a dose-dependent facilitation of potentiation that turned into depression at the highest concentration tested, a result reflecting the dose-dependent balance between the drug's postsynaptic disinhibitory effect and its action on presynaptic autoreceptors regulating the release of gaba. |
1999-06-16 |
2023-08-12 |
Not clear |
| A Ströhle, E Romeo, B Hermann, A Pasini, G Spalletta, F di Michele, F Holsboer, R Rupprech. Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery. Biological psychiatry. vol 45. issue 3. 1999-05-07. PMID:10023501. |
however, no data are available on the concentrations of 3 alpha,21-dihydroxy-5 alpha-pregnan-20-one (3 alpha,5 alpha-tetrahydrodeoxycorticosterone; 3 alpha,5 alpha-thdoc), another gaba ergic neuroactive steroid, in depression. |
1999-05-07 |
2023-08-12 |
Not clear |
| X J Zeng, E I Tiet. Benzodiazepine tolerance at GABAergic synapses on hippocampal CA1 pyramidal cells. Synapse (New York, N.Y.). vol 31. issue 4. 1999-05-07. PMID:10051107. |
the lack of change in the paired-pulse depression of gaba(b)-mediated ipsps suggested that autoreceptor function was also not impaired following chronic fzp treatment. |
1999-05-07 |
2023-08-12 |
rat |
| J H Ye, J Ren, K Krnjević, P L Liu, J J McArdl. Cocaine and lidocaine have additive inhibitory effects on the GABAA current of acutely dissociated hippocampal pyramidal neurons. Brain research. vol 821. issue 1. 1999-04-22. PMID:10064784. |
the significantly greater depression by the combined agents (p<0.05) indicates additive effects on the gaba receptor/channel complex, which are likely to contribute to the additive convulsant effects noted when these drugs are abused in combination. |
1999-04-22 |
2023-08-12 |
rat |
| E A Jones, A S Basil. Does ammonia contribute to increased GABA-ergic neurotransmission in liver failure? Metabolic brain disease. vol 13. issue 4. 1999-04-14. PMID:10206826. |
observations in animal models of fulminant hepatic failure, that are consistent with increased gabaergic inhibitory neurotransmission contributing to the manifestations of he, include: (i) abnormal visual evoked potential waveforms that resemble those induced by gaba(a)/benzodiazepine (bz) receptor complex agonists; (ii) gaba(a)/bz receptor complex antagonist-induced ameliorations of encephalopathy; (iii) increased resistance to drugs which decrease gabaergic tone; and (iv) hypersensitivity of cns neurons to depression by gaba(a)/bz receptor complex agonists. |
1999-04-14 |
2023-08-12 |
Not clear |
| J Ong, D I Kerr, H Bittiger, P C Waldmeier, P A Baumann, N G Cooke, S J Mickel, W Froest. Morpholin-2-yl-phosphinic acids are potent GABA(B) receptor antagonists in rat brain. European journal of pharmacology. vol 362. issue 1. 1999-04-13. PMID:9865526. |
in rat neocortical slices maintained in mg2+-free krebs medium, baclofen, a gaba(b) receptor agonist, produced a concentration-dependent depression of the frequency of spontaneous discharges with an ec50 of 14 +/- 5.5 microm, which was antagonised reversibly by the morpholin-2-yl-phosphinic derivatives. |
1999-04-13 |
2023-08-12 |
rat |
| J Ong, V Marino, D A Parker, D I Kerr, D J Blythi. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. European journal of pharmacology. vol 362. issue 1. 1999-04-13. PMID:9865527. |
the gaba(b) receptor agonist, baclofen, produced a concentration-dependent depression of the frequency of spontaneous discharges in slices maintained in mg2+-free krebs medium with an ec50 of 6 microm, reversibly antagonised by sch 50911 (5, 10 and 25 microm) with an apparent pa2 of 6.0 +/- 0.1. |
1999-04-13 |
2023-08-12 |
rat |