| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Radnikow, S Titz, S Mades, J Bäurle, U Misgel. Gamma-aminobutyric acid(B) autoreceptors in substantia nigra and neostriatum of the weaver mutant mouse. Neuroscience letters. vol 299. issue 1-2. 2001-05-03. PMID:11166943. |
we compared the depression of gamma-aminobutyric acid (gaba)(a) synaptic currents by the gaba(b) agonist r-baclofen in pars compacta neurons of weaver mice which were largely spared from cell degeneration and of wild-type mice. |
2001-05-03 |
2023-08-12 |
mouse |
| F Licata, G Li Volsi, M Di Mauro, G Fretto, L Ciranna, F Santangel. Serotonin modifies the neuronal inhibitory responses to gamma-aminobutyric acid in the red nucleus: a microiontophoretic study in the rat. Experimental neurology. vol 167. issue 1. 2001-03-08. PMID:11161597. |
in fact, 5-ht induced an enhancement of the gaba responses in neurons mostly located in the rostral rn and a depression in those in the caudal rn. |
2001-03-08 |
2023-08-12 |
rat |
| K Jensen, J D Lambert, M S Jense. The effect of internal GTPgammaS on GABA-release in cultured hippocampal neurons. Experimental brain research. vol 134. issue 2. 2001-02-15. PMID:11037287. |
presynaptic gtpgammas increased the depression of ipscs by the gaba(b)-receptor-agonist baclofen (10 microm), and the effect of baclofen was poorly reversible after washing. |
2001-02-15 |
2023-08-12 |
Not clear |
| N Doreulee, Y Yanovsky, I Flagmeyer, D R Stevens, H L Haas, R E Brow. Histamine H(3) receptors depress synaptic transmission in the corticostriatal pathway. Neuropharmacology. vol 40. issue 1. 2001-01-09. PMID:11077076. |
the histaminergic depression was probably not mediated indirectly through interneurons since blockade of gaba(a), gaba(b), nicotinic and muscarinic receptors or nitric oxide synthase did not prevent the histamine effect. |
2001-01-09 |
2023-08-12 |
mouse |
| K Jensen, J D Lambert, M S Jense. Tetanus-induced asynchronous GABA release in cultured hippocampal neurons. Brain research. vol 880. issue 1-2. 2000-12-21. PMID:11033007. |
the elevation of [ca(2+)](i) that accompanies presynaptic action potential firing triggers asynchronous release of gaba vesicles, thereby counteracting tetanic depression of synchronous ipscs. |
2000-12-21 |
2023-08-12 |
Not clear |
| Y Tohdoh, E Narimatsu, M Kawamata, A Namik. The involvement of adenosine neuromodulation in pentobarbital-induced field excitatory postsynaptic potentials depression in rat hippocampal slices. Anesthesia and analgesia. vol 91. issue 6. 2000-12-20. PMID:11094014. |
however, the fepsp depression was not affected by pretreatment with 10 microm 8-cyclopentyl-1, 3-dipropylxanthine, an a(2) receptor antagonist, or 10 microm bicuculline, a gamma-aminobutyric acid (gaba) a receptor antagonist. |
2000-12-20 |
2023-08-12 |
rat |
| J Ong, D I Ker. Effects of Ca2+ concentration on GABA(B) receptor function in rat neocortical slices. Canadian journal of physiology and pharmacology. vol 78. issue 6. 2000-11-21. PMID:10914641. |
baclofen, the gaba(b) receptor agonist, produced a concentration-dependent depression of discharge frequency, reversibly antagonised by the antagonist (+)-(s)-5,5-dimethylmorpholinyl-2-acetic acid (sch 50911). |
2000-11-21 |
2023-08-12 |
rat |
| M L Kram, G L Kramer, M Steciuk, P J Ronan, F Pett. Effects of learned helplessness on brain GABA receptors. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000446. |
gaba is involved in both clinical depression and in animal models of depression; however, the roles of gaba(a) and gaba(b) receptors in specific brain regions are not clear. |
2000-11-01 |
2023-08-12 |
rat |
| M L Kram, G L Kramer, M Steciuk, P J Ronan, F Pett. Effects of learned helplessness on brain GABA receptors. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000446. |
changes in densities of both gaba(a) and gaba(b) receptors have been reported with the learned helplessness animal model of depression and with chronic antidepressant drug treatment. |
2000-11-01 |
2023-08-12 |
rat |
| M L Kram, G L Kramer, M Steciuk, P J Ronan, F Pett. Effects of learned helplessness on brain GABA receptors. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000446. |
these results suggest a unique role for the septum in modulating gaba in the learned helplessness animal model of depression. |
2000-11-01 |
2023-08-12 |
rat |
| H M Prakash, K Suman. The biology of depression. Journal of the Indian Medical Association. vol 98. issue 5. 2000-10-27. PMID:11203058. |
other neurotransmitters like gamma amino butyric acid (gaba) and dopamine are also considered to have some role in depression. |
2000-10-27 |
2023-08-12 |
Not clear |
| R Gomez, H M Barro. Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880686. |
it is possible that decreased gaba function is involved in depression associated with diabetes, because a benzodiazepine partially counteracts these changes without modifying blood glucose and glycogen parameters. |
2000-08-28 |
2023-08-12 |
rat |
| J E Coelho, A de Mendonça, J A Ribeir. Presynaptic inhibitory receptors mediate the depression of synaptic transmission upon hypoxia in rat hippocampal slices. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865070. |
we tested the hypothesis that activation of heterosynaptic inhibitory receptors localized in glutamatergic presynaptic terminals in the hippocampus, namely gamma-aminobutyric acid subtype b (gaba(b)) receptors, alpha(2)-adrenergic receptors, and muscarinic receptors might contribute to the hypoxia-induced depression of synaptic transmission. |
2000-08-25 |
2023-08-12 |
rat |
| Q Xiao, C Suguihara, D Hehre, C Devia, J Huang, E Bancalar. Effects of GABA receptor blockade on the ventilatory response to hypoxia in hypothermic newborn piglets. Pediatric research. vol 47. issue 5. 2000-07-07. PMID:10813594. |
these data suggest that the depression in hypoxic ventilatory response produced by ht is in part modulated by an increased cns gaba concentration. |
2000-07-07 |
2023-08-12 |
Not clear |
| Z Ziakopoulos, M W Brown, Z I Bashi. GABAB receptors mediate frequency-dependent depression of excitatory potentials in rat perirhinal cortex in vitro. The European journal of neuroscience. vol 12. issue 3. 2000-05-22. PMID:10762309. |
we establish that this frequency-dependent depression relies on the activation of gabab (gamma-aminobutyric acid) receptors. |
2000-05-22 |
2023-08-12 |
rat |
| Z Ziakopoulos, M W Brown, Z I Bashi. GABAB receptors mediate frequency-dependent depression of excitatory potentials in rat perirhinal cortex in vitro. The European journal of neuroscience. vol 12. issue 3. 2000-05-22. PMID:10762309. |
moreover, ppd increases with stimulus strength and the depression is enhanced by short trains of stimuli, consistent with stronger stimulation resulting in more gaba reaching gabab receptors on excitatory glutamatergic synapses. |
2000-05-22 |
2023-08-12 |
rat |
| Y M Lu, I M Mansuy, E R Kandel, J Rode. Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. Neuron. vol 26. issue 1. 2000-05-18. PMID:10798404. |
calcineurin produces its effect on e-s coupling by inducing a long-lasting depression (ltd) of the gaba(a)-mediated inhibitory postsynaptic potentials (ipsps). |
2000-05-18 |
2023-08-12 |
Not clear |
| A Semyanov, D M Kullman. Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors. Neuron. vol 25. issue 3. 2000-05-02. PMID:10774733. |
this depression persists when gaba(b) receptors are blocked, is enhanced by blocking glutamate uptake, and is abolished by the group iii metabotropic receptor antagonist (alpha-methylserine-o-phosphate (msop). |
2000-05-02 |
2023-08-12 |
Not clear |
| P Molnár, J V Nadle. gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus. European journal of pharmacology. vol 391. issue 3. 2000-04-21. PMID:10729366. |
the effect of cgaba was not mediated by depression of gaba release through activation of presynaptic gaba(b) receptors. |
2000-04-21 |
2023-08-12 |
rat |
| S Wang, Q Cheng, S Malik, J Yan. Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640285. |
the il-1beta depression of gaba current was inhibited by high concentrations of nonspecific kinase inhibitors staurosporine (500 nm) and 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine (h-7; 50 microm), but not by a protein kinase c selective inhibitor calphostin c (5 microm). |
2000-02-22 |
2023-08-12 |
Not clear |