| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heba M Mahdy, Mohamed R Mohamed, Manal A Emam, Amr M Karim, Ashraf B Abdel-Naim, Ashraf Abdel-Naim, Amani E Khalif. The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. Canadian journal of physiology and pharmacology. vol 92. issue 3. 2014-05-16. PMID:24593790. |
these results indicate that pur may be a useful preventive approach to various neurodegenerative diseases with underlying apoptosis and neuroinflammation. |
2014-05-16 |
2023-08-12 |
rat |
| Sheng-Quan Hu, Wei Cui, Da-Ping Xu, Shing-Hung Mak, Jing Tang, Chung-Lit Choi, Yuan-Ping Pang, Yi-Fan Ha. Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway. CNS neuroscience & therapeutics. vol 19. issue 10. 2014-05-08. PMID:23826635. |
neuronal loss via apoptosis in cns is the fundamental mechanism underlying various neurodegenerative diseases. |
2014-05-08 |
2023-08-12 |
Not clear |
| Eun-Bum Kang, In-Su Kwon, Jung-Hoon Koo, Eung-Joon Kim, Chul-Hyun Kim, Jin Lee, Choon-Ho Yang, Young-Il Lee, In-Ho Cho, Joon-Yong Ch. Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23907580. |
er stress is involved in neurodegenerative diseases including ad, but the molecular mechanisms of neuronal apoptosis and inflammation by aβ-induced er stress to exercise training are not fully understood. |
2014-05-08 |
2023-08-12 |
mouse |
| Aleksandra Rodack. [Properties and functional diversity of glyceraldehyde-3-phosphate dehydrogenase]. Postepy higieny i medycyny doswiadczalnej (Online). vol 67. 2014-04-29. PMID:24018444. |
furthermore, other studies also indicate a role of gapdh in apoptosis, and age-related neurodegenerative disease e.g. |
2014-04-29 |
2023-08-12 |
Not clear |
| Jianhua Jiang, Juean Jiang, Yuanyi Zuo, Zhenlun G. Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. International journal of molecular medicine. vol 31. issue 4. 2014-04-24. PMID:23426728. |
parkinson's disease (pd) is a neurodegenerative disease, in which oxidative stress and mitochondrial dysfunction are responsible for neuronal apoptosis. |
2014-04-24 |
2023-08-12 |
rat |
| Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Vahid Sheibani, Mehdi Abbasnejad, Anahita Mehdizadeh, Mohammad Mehdi Yaghoob. Inhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropein. Rejuvenation research. vol 16. issue 2. 2014-03-21. PMID:23394606. |
however, some natural herbal products have been shown to rescue neurons from death and apoptosis in some of neurodegenerative diseases. |
2014-03-21 |
2023-08-12 |
rat |
| A J Kole, R P Annis, M Deshmuk. Mature neurons: equipped for survival. Cell death & disease. vol 4. 2014-02-25. PMID:23807218. |
examining the adaptations for inhibiting apoptosis during neuronal maturation is key to comprehending not just how neurons survive long term, but may also provide insight for understanding how neuronal toxicity in various neurodegenerative diseases may ultimately lead to cell death. |
2014-02-25 |
2023-08-12 |
Not clear |
| Guang Ji, Hui Ji, Xiaoye Mo, Ting Li, Yaduo Yu, Zhiping H. The role of GRASPs in morphological alterations of Golgi apparatus: mechanisms and effects. Reviews in the neurosciences. vol 24. issue 5. 2014-02-20. PMID:24002661. |
ga shows various morphological alterations in many neurodegenerative diseases and cell apoptosis induced by biochemical reagents, mechanisms in which oxidative stress is strongly involved. |
2014-02-20 |
2023-08-12 |
Not clear |
| Vishal Jinda. Glaucoma: an extension of various chronic neurodegenerative disorders. Molecular neurobiology. vol 48. issue 1. 2014-02-12. PMID:23397135. |
targets for therapeutic intervention in chronic neurodegenerative diseases and glaucoma include apoptosis, axonal transport, free radical damage, role of polyunsaturated fatty acids, chaperones, gene regulation, etc. |
2014-02-12 |
2023-08-12 |
Not clear |
| Kyoung Joo Cho, Hyun Woo Kim, So Yeong Cheon, Jong Eun Lee, Gyung Whan Ki. Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice. Biochemical and biophysical research communications. vol 441. issue 2. 2014-01-17. PMID:24021285. |
apoptosis signal-regulating kinase-1 (ask1), an early signaling element in the cell death pathway, has been suggested to participate in the pathology of neurodegenerative diseases, which may be associated with environmental factors that impact the diseases. |
2014-01-17 |
2023-08-12 |
mouse |
| M Jahanshahi, E G Nickmahzar, F Babakord. Effect of Gingko biloba extract on scopolamine-induced apoptosis in the hippocampus of rats. Anatomical science international. vol 88. issue 4. 2014-01-16. PMID:23828103. |
apoptosis is also involved in neurodegenerative diseases such as alzheimer's disease. |
2014-01-16 |
2023-08-12 |
rat |
| Meera Soundararajan, Annette K Roos, Pavel Savitsky, Panagis Filippakopoulos, Arminja N Kettenbach, Jesper V Olsen, Scott A Gerber, Jeyanthy Eswaran, Stefan Knapp, Jonathan M Elkin. Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition. Structure (London, England : 1993). vol 21. issue 6. 2014-01-02. PMID:23665168. |
dual-specificity tyrosine-(y)-phosphorylation-regulated kinases (dyrks) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. |
2014-01-02 |
2023-08-12 |
Not clear |
| Chun-Ming Wang, Ming-Yan Liu, Fang Wang, Min-Jie Wei, Shuang Wang, Chun-Fu Wu, Jing-Yu Yan. Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease. Pharmacology, biochemistry, and behavior. vol 106. 2013-12-26. PMID:23541491. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by amyloid β (aβ) deposits, elevated oxidative stress, and apoptosis of the neurons. |
2013-12-26 |
2023-08-12 |
mouse |
| Gye Sun Jeon, Jee-Eun Kim, Suk-Won Ahn, Kyung-Seok Park, Yoon-Ho Hong, In-Hae Ye, Ji-Seon Park, Seung Hyun Kim, Kwang-Woo Lee, Sung-Min Kim, Jung-Joon Sun. Effect of JGK-263 as a new glycogen synthase kinase-3β inhibitor on extrinsic apoptosis pathway in motor neuronal cells. Biochemical and biophysical research communications. vol 439. issue 2. 2013-11-26. PMID:23899525. |
gsk-3β inhibitor has been investigated as a modulator of apoptosis and has been shown to confer significant protective effects on cell death in neurodegenerative diseases. |
2013-11-26 |
2023-08-12 |
Not clear |
| Marco Fiocchetti, Elisabetta De Marinis, Paolo Ascenzi, Maria Marin. Neuroglobin and neuronal cell survival. Biochimica et biophysica acta. vol 1834. issue 9. 2013-09-26. PMID:23357651. |
the balance between neuronal apoptosis and survival sculpts the developing brain and has an important role in neurodegenerative diseases. |
2013-09-26 |
2023-08-12 |
Not clear |
| N N Besednova, L M Somova, S A Guliaev, T S Zaporozhet. [Neuroprotective effects of sulfated polysaccharides from seaweed]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 5. 2013-09-26. PMID:24000668. |
consequently, sps can arrest a number of secondary pathological effects observed in neurodegenerative diseases (oxidative stress, inflammation, the phenomenon of increased neuronal apoptosis, toxic effects etc.). |
2013-09-26 |
2023-08-12 |
human |
| Mingming Ma, Xuejing Wang, Xuebing Ding, Jing Jing, Yaohua Ma, Junfang Ten. Protective effect of BAG5 on MPP+-induced apoptosis in PC12 cells. Neurological research. vol 34. issue 10. 2013-08-26. PMID:23146300. |
parkinson's disease (pd) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of pd. |
2013-08-26 |
2023-08-12 |
Not clear |
| Janett Eckmann, Schamim H Eckert, Kristina Leuner, Walter E Muller, Gunter P Ecker. Mitochondria: mitochondrial membranes in brain ageing and neurodegeneration. The international journal of biochemistry & cell biology. vol 45. issue 1. 2013-08-20. PMID:22743330. |
in addition to atp synthesis mitochondria are key regulators of calcium homeostasis, free radical production, steroid synthesis and apoptosis, each of these factors could also be associated with essential mechanisms involved in neurodegenerative diseases. |
2013-08-20 |
2023-08-12 |
mouse |
| Ling Ye, Yunlong Huang, Lixia Zhao, Yuju Li, Lijun Sun, You Zhou, Guanxiang Qian, Jialin C Zhen. IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23578284. |
using primary rat and human neuronal cultures, we confirmed that interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α), two pro-inflammatory cytokines that are typically elevated in neurodegenerative disease states, induced neuronal death and apoptosis in vitro. |
2013-08-06 |
2023-08-12 |
human |
| M E Breuer, W J Koopman, S Koene, M Nooteboom, R J Rodenburg, P H Willems, J A M Smeitin. The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases. Neurobiology of disease. vol 51. 2013-07-24. PMID:22426394. |
malfunctions in mitochondrial respiration and atp production may prove disastrous for our cells and neurons, ultimately resulting in apoptosis, neurodegeneration and consequently, neurodegenerative diseases. |
2013-07-24 |
2023-08-12 |
Not clear |