| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Josie J Gray, Amelia E Zommer, Ron J Bouchard, Nathan Duval, Craig Blackstone, Daniel A Linsema. N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress. Brain research. vol 1494. 2013-07-03. PMID:23220553. |
neuronal cell death via apoptosis or necrosis underlies several devastating neurodegenerative diseases associated with aging. |
2013-07-03 |
2023-08-12 |
mouse |
| Hadhemi Kaddour, Yosra Hamdi, David Vaudry, Magalie Basille, Laurence Desrues, Jérôme Leprince, Hélène Castel, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouk. The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23286644. |
oxidative stress, induced by various neurodegenerative diseases, initiates a cascade of events leading to apoptosis, and thus plays a critical role in neuronal injury. |
2013-07-01 |
2023-08-12 |
Not clear |
| Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B Klein, Daret St Clair, D Allan Butterfiel. Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53. PloS one. vol 7. issue 11. 2013-06-11. PMID:23209608. |
although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. |
2013-06-11 |
2023-08-12 |
mouse |
| Eric Thouvenot, Serge Urbach, Oana Vigy, Martial Séveno, Nathalie Galéotti, Geneviève Nguyen, Joël Bockaert, Philippe Mari. Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis. Journal of proteomics. vol 77. 2013-05-23. PMID:23009950. |
an alternative approach consists in comparing proteins secreted by healthy neurons and neurons degenerating by apoptosis, one of the mechanisms underlying neuronal death in neurodegenerative diseases. |
2013-05-23 |
2023-08-12 |
mouse |
| Daniel M Johnstone, Ross M Graham, Debbie Trinder, Carlos Riveros, John K Olynyk, Rodney J Scott, Pablo Moscato, Elizabeth A Milwar. Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22466002. |
the effects appeared relatively specific for ad in that few genes pertaining to other important neurodegenerative diseases, notably parkinson's disease and huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. |
2013-05-15 |
2023-08-12 |
mouse |
| Shang-Der Chen, Jiu-Haw Yin, Chi-Shin Hwang, Ching-Min Tang, Ding-I Yan. Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia. Free radical research. vol 46. issue 8. 2013-05-09. PMID:22583533. |
emerging evidence reveals that sphingomyelinase/ceramide pathway plays a pivotal role in neurodegenerative diseases that involve mitochondrial dysfunction, oxidative stress and apoptosis. |
2013-05-09 |
2023-08-12 |
Not clear |
| Dusan Zencak, Karine Schouwey, Danian Chen, Per Ekström, Ellen Tanger, Rod Bremner, Maarten van Lohuizen, Yvan Arsenijevi. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 7. 2013-04-08. PMID:23359713. |
reexpression of cell cycle proteins such as cyclin-dependent kinases (cdks) is a hallmark of neuronal apoptosis in neurodegenerative diseases. |
2013-04-08 |
2023-08-12 |
mouse |
| Wenzhi Ta. VDAC blockage by phosphorothioate oligonucleotides and its implication in apoptosis. Biochimica et biophysica acta. vol 1818. issue 6. 2013-04-03. PMID:22236836. |
impaired apoptosis contributes to cancer development, while enhanced apoptosis is detrimental in neurodegenerative diseases. |
2013-04-03 |
2023-08-12 |
Not clear |
| Arindam P Ghosh, Barbara J Klocke, Mary E Ballestas, Kevin A Rot. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PloS one. vol 7. issue 6. 2013-03-21. PMID:22761832. |
endoplasmic reticulum (er) stress-induced apoptosis has been implicated in various neurodegenerative diseases including parkinson disease, alzheimer disease and huntington disease. |
2013-03-21 |
2023-08-12 |
Not clear |
| Hamid Reza Momen. Role of calpain in apoptosis. Cell journal. vol 13. issue 2. 2013-03-20. PMID:23507938. |
the activation of calpain has been implicated in neuronal apoptosis following spinal cord injuries and neurodegenerative diseases. |
2013-03-20 |
2023-08-12 |
Not clear |
| Kelly N Holohan, Debomoy K Lahiri, Bryan P Schneider, Tatiana Foroud, Andrew J Sayki. Functional microRNAs in Alzheimer's disease and cancer: differential regulation of common mechanisms and pathways. Frontiers in genetics. vol 3. 2013-01-22. PMID:23335942. |
we propose a pathway-driven model in which some molecular processes show an inverse relationship between cancer and neurodegenerative disease (e.g., proliferation and apoptosis) whereas others are more parallel in their activity (e.g., immune activation and inflammation). |
2013-01-22 |
2023-08-12 |
Not clear |
| Won Ho Kong, Dong Kyung Sung, Ki Su Kim, Ho Sang Jung, Eun Ji Gho, Seok Hyun Yun, Sei Kwang Hah. Self-assembled complex of probe peptide--E. Coli RNA I conjugate and nano graphene oxide for apoptosis diagnosis. Biomaterials. vol 33. issue 30. 2012-12-18. PMID:22818651. |
caspase-3 plays an important role in the initiation and propagation of apoptosis which is involved in various kinds of diseases including neurodegenerative diseases and inflammatory diseases. |
2012-12-18 |
2023-08-12 |
Not clear |
| Jae-Kyo Jeong, Jae-Suk Seo, Myung-Hee Moon, You-Jin Lee, Jae-Won Seol, Sang-Youel Par. Hypoxia-inducible factor-1 α regulates prion protein expression to protect against neuron cell damage. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:22036844. |
based on our previous findings that hypoxia protects neuronal cells from prp (106-126)-induced apoptosis and increases cellular prion protein (prp(c)) expression, we hypothesized that hypoxia-related genes, including hypoxia-inducible factor-1 alpha (hif-1α), may regulate prp(c) expression and that these genes may be involved in prion-related neurodegenerative diseases. |
2012-11-23 |
2023-08-12 |
human |
| Simona Esposito, Andrea Pristerà, Giovanna Maresca, Sebastiano Cavallaro, Armando Felsani, Fulvio Florenzano, Luigi Manni, Maria T Ciotti, Loredano Pollegioni, Tiziana Borsello, Nadia Can. Contribution of serine racemase/d-serine pathway to neuronal apoptosis. Aging cell. vol 11. issue 4. 2012-11-13. PMID:22507034. |
these findings are relevant to our understanding of neuronal apoptosis and nmdar activity regulation, raising further questions as to the role of sr/d-serine in those neuro-pathophysiological processes, such as aging and neurodegenerative diseases characterized by a convergence of apoptotic mechanisms and nmdar dysfunction. |
2012-11-13 |
2023-08-12 |
Not clear |
| T F Oo, R E Burk. Animal models of induced apoptotic death in the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318770. |
in recent years, there has been a tremendous growth of interest in apoptosis as a mechanism of disease in a wide range of human disorders including the neurodegenerative diseases, such as parkinson's disease (pd) (1). |
2012-10-02 |
2023-08-12 |
human |
| Jane Bayani, Eleftherios P Diamandi. The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6). Clinical chemistry and laboratory medicine. vol 50. issue 2. 2012-10-02. PMID:22047144. |
the observed dysregulated expression in cancers, neurodegenerative diseases and skin conditions has led to the discovery that klk6 participates in other cellular pathways including inflammation, receptor activation and regulation of apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Guangyu Li, Fei Cai, Wei Yan, Cairong Li, Jianghua Wan. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 127. issue 2. 2012-09-24. PMID:22430071. |
mclr-treated hippocampi showed alterations in proteins involved in cytoskeleton, neurodegenerative disease, oxidative stress, apoptosis, and energy metabolism. |
2012-09-24 |
2023-08-12 |
rat |
| John J Mieyal, P Boon Choc. Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation. Antioxidants & redox signaling. vol 16. issue 6. 2012-09-17. PMID:22136616. |
the forum review articles consider the role of s-glutationylation in regulation of the peroxiredoxin enzymes, the special redox environment of the mitochondria, redox regulation pertinent to the function of the cardiovascular system, mechanisms of redox-activated apoptosis in the pulmonary system, and the role of glutathionylation in the initiation, propagation, and treatment of neurodegenerative diseases. |
2012-09-17 |
2023-08-12 |
Not clear |
| Gomathi Chan, Muhamad Noor Alfarizal Kamarudin, Daniel Zin Hua Wong, Nor Hadiani Ismail, Faizuri Abdul Latif, Aurengzeb Hasan, Khalijah Awang, Habsah Abdul Kadi. Mitigation of H(2)O(2)-Induced Mitochondrial-Mediated Apoptosis in NG108-15 Cells by Novel Mesuagenin C from Mesua kunstleri (King) Kosterm. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-09-10. PMID:22956972. |
these findings confirmed the involvement of intrinsic apoptotic pathway in h(2)o(2)-induced apoptosis and suggested that mesuagenin c 3 may have potential therapeutic properties for neurodegenerative diseases. |
2012-09-10 |
2023-08-12 |
Not clear |
| Hiroyuki Uchino, Morika Suzuki, Ayano Okita, Yohko Yuhnaiyama, Mariko Shibuya, Daiki Usui, Ryoichi Miyashita, Kiyoshi Hatakeyam. [Organ protective effects of volatile anesthetics and perioperative outcomes]. Masui. The Japanese journal of anesthesiology. vol 61. issue 5. 2012-08-29. PMID:22702090. |
massive release of ca2+ from er induces ca2+ overload leading to mitochondria permeability transition (mpt) and induces apoptosis in the brain or aggravates the neurodegenerative disease. |
2012-08-29 |
2023-08-12 |
human |