| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| In Su Kim, Dong-Kug Choi, Hun Jong Jun. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules (Basel, Switzerland). vol 16. issue 7. 2011-10-24. PMID:21705974. |
these results indicate that vanillyl alcohol protected dopaminergic mn9d cells against mpp+-induced apoptosis by relieving oxidative stress and modulating the apoptotic process and is therefore a potential candidate for treatment of neurodegenerative diseases such as parkinson's disease. |
2011-10-24 |
2023-08-12 |
Not clear |
| Ling-Fei Wu, Yan-Qing Ye, Guan-You Huang, Hong-Biao Li, Guo-Ping Li, Ze-Jin Pu, Bi-Liu Wei, Jia-Lin Fen. Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis. Oncology reports. vol 26. issue 1. 2011-10-21. PMID:21479362. |
endoplasmic reticulum stress (ers)-mediated cell apoptosis has been implicated in the development of multiple diseases such as cancer, neurodegenerative diseases and ischemic reperfusion damage. |
2011-10-21 |
2023-08-12 |
human |
| Gonzalo Arboleda, Yolanda Cárdenas, Yeldy Rodríguez, Luis Carlos Morales, Luisa Matheus, Humberto Arboled. Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. Neurotoxicology. vol 31. issue 6. 2011-09-29. PMID:20696185. |
evidence has implicated apoptosis as a mechanism underlying cell demise in diverse neurodegenerative diseases including parkinson's disease (pd). |
2011-09-29 |
2023-08-12 |
Not clear |
| Virve Cavallucci, Marcello D'Ameli. Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348825. |
neurodegenerative diseases that include amyotrophic lateral sclerosis, huntington's disease, alzheimer's disease, parkinson's disease, stroke, brain trauma and spinal cord injury, are associated with the inappropriate activation of a neuronal cell-suicide program called apoptosis. |
2011-09-29 |
2023-08-12 |
Not clear |
| Tommy Seaborn, Olfa Masmoudi-Kouli, Alain Fournier, Hubert Vaudry, David Vaudr. Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348830. |
apoptosis is a regulated process leading to cell death, which is implicated both in normal development and in various pathologies including heart failure, stroke and neurodegenerative diseases. |
2011-09-29 |
2023-08-12 |
Not clear |
| Francesc X Sureda, Felix Junyent, Ester Verdaguer, Carme Auladell, Carme Pelegri, Jordi Vilaplana, Jaume Folch, Anna Maria Canudas, Carlos Beas Zarate, Merc Pallès, Antoni Camin. Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348832. |
the purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegenerative diseases, highlighting current pharmacological drug targets in neuronal apoptosis prevention. |
2011-09-29 |
2023-08-12 |
Not clear |
| Francesc X Sureda, Felix Junyent, Ester Verdaguer, Carme Auladell, Carme Pelegri, Jordi Vilaplana, Jaume Folch, Anna Maria Canudas, Carlos Beas Zarate, Merc Pallès, Antoni Camin. Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348832. |
in the present study we discuss in depth the pathways involved in apoptosis and neuronal death in neurodegenerative diseases. |
2011-09-29 |
2023-08-12 |
Not clear |
| Francesc X Sureda, Felix Junyent, Ester Verdaguer, Carme Auladell, Carme Pelegri, Jordi Vilaplana, Jaume Folch, Anna Maria Canudas, Carlos Beas Zarate, Merc Pallès, Antoni Camin. Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348832. |
this research contributes to the development of new methods in the field of apoptosis inhibitors that could provide the future tools for the treatment of alzheimer's and parkinson's disease, as well as other neurodegenerative diseases. |
2011-09-29 |
2023-08-12 |
Not clear |
| Domagoj Vucic, Vishva M Dixit, Ingrid E Wert. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nature reviews. Molecular cell biology. vol 12. issue 7. 2011-09-28. PMID:21697901. |
furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia and graft rejection, and diminished apoptosis can lead to autoimmune diseases and cancer. |
2011-09-28 |
2023-08-12 |
Not clear |
| Andres Klein, Carola Maldonado, Lina M Vargas, Marcela Gonzalez, Fermín Robledo, Karen Perez de Arce, Francisco J Muñoz, Claudio Hetz, Alejandra R Alvarez, Silvana Zanlung. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20883783. |
niemann-pick type c (npc) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. |
2011-09-27 |
2023-08-12 |
mouse |
| Majid Assadi, Reza Nemati, Iraj Nabipour, Hooman Salimipour, Abdullatif Amin. Radiolabeled annexin V imaging: a useful technique for determining apoptosis in multiple sclerosis. Medical hypotheses. vol 77. issue 1. 2011-09-26. PMID:21440374. |
however, they are unable to detect apoptosis in neurodegenerative diseases. |
2011-09-26 |
2023-08-12 |
Not clear |
| Sanjay L Dholakiya, Kenza E Benzeroua. Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-α expression. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 5. 2011-09-26. PMID:21477647. |
several studies have demonstrated a link between increased pro-inflammatory mediators and apoptosis in neurodegenerative diseases. |
2011-09-26 |
2023-08-12 |
Not clear |
| Donald Raymond Daudt, Thomas Yori. FKBP51 protects 661w cell culture from staurosporine-induced apoptosis. Molecular vision. vol 17. 2011-09-20. PMID:21617754. |
neurodegenerative diseases and neurotraumas typically result in apoptosis of specific neurons leading to the pathology observed during the disease state. |
2011-09-20 |
2023-08-12 |
Not clear |
| Niloufar Ansari, Fariba Khodagholi, Mohsen Amini, Fatemeh Shaerzade. Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative. Biochimie. vol 93. issue 5. 2011-09-15. PMID:21295107. |
neuronal cell death due to apoptosis is a common characteristic of neurodegenerative diseases. |
2011-09-15 |
2023-08-12 |
rat |
| Mohammad Shamsul Ola, Mohd Nawaz, Haseeb Ahsa. Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Molecular and cellular biochemistry. vol 351. issue 1-2. 2011-08-26. PMID:21210296. |
apoptosis is a highly regulated form of cell death, and dysregulation of apoptosis results in pathological conditions including cancer, autoimmune and neurodegenerative diseases. |
2011-08-26 |
2023-08-12 |
Not clear |
| Kyoji Iked. [Mitochondrial function in bone resorption and formation]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 7. 2011-08-16. PMID:21774358. |
mitochondria are involved in diverse biological processes through energy production, ros generation and apoptosis, and mitochondrial dysfunction causes metabolic disorders, neurodegenerative disease, cancer and aging. |
2011-08-16 |
2023-08-12 |
Not clear |
| Tomasz M Stępkowski, Marcin K Kruszewsk. Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis. Free radical biology & medicine. vol 50. issue 9. 2011-08-08. PMID:21295136. |
the roles of keap1 molecular binding partners in apoptosis regulation during carcinogenesis and in neurodegenerative diseases are also discussed. |
2011-08-08 |
2023-08-12 |
Not clear |
| Kumar Sapkota, Seung Kim, Se-Eun Park, Sung-Jun Ki. Detoxified extract of Rhus verniciflua stokes inhibits rotenone-induced apoptosis in human dopaminergic cells, SH-SY5Y. Cellular and molecular neurobiology. vol 31. issue 2. 2011-07-18. PMID:21061154. |
these results suggest that rvs may protect dopaminergic neurons against rotenone-induced apoptosis by multiple functions and contribute to neuroprotection in neurodegenerative diseases, such as pd. |
2011-07-18 |
2023-08-12 |
human |
| Hongwen He, Weiguo Dong, Fang Huan. Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease. Current neuropharmacology. vol 8. issue 3. 2011-07-14. PMID:21358971. |
it is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in ad. |
2011-07-14 |
2023-08-12 |
Not clear |
| Mark L Dallas, John P Boyle, Carol J Milligan, Rachael Sayer, Talitha L Kerrigan, Connor McKinstry, Peiyuan Lu, Jamel Mankouri, Mark Harris, Jason L Scragg, Hugh A Pearson, Chris Peer. Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21248240. |
oxidative stress induces neuronal apoptosis and is implicated in cerebral ischemia, head trauma, and age-related neurodegenerative diseases. |
2011-06-28 |
2023-08-12 |
Not clear |