| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valeria Gabriela Antico Arciuch, María Eugenia Elguero, Juan José Poderoso, María Cecilia Carrera. Mitochondrial regulation of cell cycle and proliferation. Antioxidants & redox signaling. vol 16. issue 10. 2012-07-25. PMID:21967640. |
in this process, many functions were transferred to the host cells, but mitochondria gained a central role in the regulation of cell proliferation and apoptosis, and in the modulation of metabolism; accordingly, defective organelles contribute to cell transformation and cancer, diabetes, and neurodegenerative diseases. |
2012-07-25 |
2023-08-12 |
Not clear |
| Matthew J Hart, Marcie Glicksman, Min Liu, Mohit K Sharma, Greg Cuny, Veronica Galva. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Analytical biochemistry. vol 421. issue 2. 2012-06-19. PMID:22178911. |
caspases, effectors of apoptosis, are key mediators of neuronal death in several neurodegenerative diseases. |
2012-06-19 |
2023-08-12 |
mouse |
| Joseph D Jebelli, Claudie Hooper, Gwenn A Garden, Jennifer M Pococ. Emerging roles of p53 in glial cell function in health and disease. Glia. vol 60. issue 4. 2012-06-12. PMID:22105777. |
although neurodegenerative diseases each display a distinct and diverse molecular pathology, apoptosis is a widespread hallmark feature and the multimodal capacity of the p53 system to orchestrate apoptosis and glial cell behavior highlights p53 as a potential unifying target for therapeutic intervention in neurodegeneration. |
2012-06-12 |
2023-08-12 |
Not clear |
| Joanna Tucka, Martin Bennett, Trevor Littlewoo. Cell death and survival signalling in the cardiovascular system. Frontiers in bioscience (Landmark edition). vol 17. 2012-05-24. PMID:22201742. |
apoptosis of neurons that fail to make appropriate connections is essential for the selection of correct neural signalling in the developing embryo, but its appearance in adults is often associated with neurodegenerative disease. |
2012-05-24 |
2023-08-12 |
Not clear |
| B Caballero, A Coto-Monte. An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain. Histology and histopathology. vol 27. issue 3. 2012-05-08. PMID:22237704. |
apoptosis is one of processes implicated in aging and neurodegenerative pathologies, and for the last decade, has been one of the most studied processes due to its essential role, not only in aging, but also in many neurodegenerative diseases, including parkinson's, alzheimer's and huntington's. |
2012-05-08 |
2023-08-12 |
Not clear |
| Petra Steinacker, Alastair Aitken, Markus Ott. 14-3-3 proteins in neurodegeneration. Seminars in cell & developmental biology. vol 22. issue 7. 2012-04-25. PMID:21920445. |
the reported function of 14-3-3 proteins in this context are as diverse as the mechanism involved in neurodegeneration, reaching from basal cellular processes like apoptosis, over involvement in features common to many neurodegenerative diseases, like protein stabilization and aggregation, to very specific processes responsible for the selective vulnerability of cellular populations in single neurodegenerative diseases. |
2012-04-25 |
2023-08-12 |
Not clear |
| Namiko Suematsu, Miki Hosoda, Ko Fujimor. Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells. Neuroscience letters. vol 504. issue 3. 2012-03-15. PMID:21964380. |
thus, quercetin might potentially serve as an agent for prevention of neurodegenerative diseases caused by oxidative stress and apoptosis. |
2012-03-15 |
2023-08-12 |
human |
| Shuping Li, Wenhao Yu, Guo-Fu H. Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner. Journal of cellular physiology. vol 227. issue 4. 2012-03-05. PMID:21678416. |
here we report that ang inhibits nuclear translocation of apoptosis inducing factor (aif), an important cell death-executing molecule known to play a dominant role in neurodegenerative diseases. |
2012-03-05 |
2023-08-12 |
Not clear |
| Qi Wang, Sinisa D Grozdanic, Matthew M Harper, Nicolas Hamouche, Helga Kecova, Tatjana Lazic, Chenxu Y. Exploring Raman spectroscopy for the evaluation of glaucomatous retinal changes. Journal of biomedical optics. vol 16. issue 10. 2012-03-05. PMID:22029368. |
glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cells and subsequent loss of visual function. |
2012-03-05 |
2023-08-12 |
Not clear |
| Alexandre Chenal, Charlotte Vendrely, Heidi Vitrac, Johanna C Karst, Alexis Gonneaud, Clément E Blanchet, Sylvain Pichard, Elisabeth Garcia, Bénédicte Salin, Patrice Catty, Daniel Gillet, Nicolas Hussy, Christel Marquette, Christine Almunia, Vincent Forg. Amyloid fibrils formed by the programmed cell death regulator Bcl-xL. Journal of molecular biology. vol 415. issue 3. 2012-02-29. PMID:22119486. |
the potential causality between the accumulation of bcl-xl into amyloid deposits and abnormal apoptosis during neurodegenerative diseases is discussed. |
2012-02-29 |
2023-08-12 |
human |
| Ko Fujimori, Ayano Fukuhara, Takashi Inui, Maria Allhor. Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. Journal of neurochemistry. vol 120. issue 2. 2012-02-09. PMID:22043816. |
thus, l-pgds might potentially serve as an agent for prevention of human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2012-02-09 |
2023-08-12 |
human |
| Ting-Fang Kuo, Hideki Tatsukawa, Soichi Kojim. New insights into the functions and localization of nuclear transglutaminase 2. The FEBS journal. vol 278. issue 24. 2012-01-23. PMID:22051117. |
through this mechanism, tg2 controls cell growth or survival, differentiation and apoptosis, and is involved in the pathogenesis and/or treatment of neurodegenerative diseases, liver diseases and cancers. |
2012-01-23 |
2023-08-12 |
Not clear |
| Clivia Pazin Miwa, Maria Noêmia Martins de Lima, Felipe Scalco, Gustavo Vedana, Raquel Mattos, Liana Lisboa Fernandez, Arlete Hilbig, Nadja Schröder, Monica R M Viann. Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats. Neurotoxicity research. vol 19. issue 4. 2012-01-20. PMID:20369315. |
oxidative stress, cellular damage, and neuronal apoptosis are believed to underlie the progressive cognitive decline that accompanies natural aging and to be exacerbated in neurodegenerative diseases. |
2012-01-20 |
2023-08-12 |
rat |
| Evgeny V Mymrikov, Alim S Seit-Nebi, Nikolai B Guse. Large potentials of small heat shock proteins. Physiological reviews. vol 91. issue 4. 2011-12-13. PMID:22013208. |
hspb8 also seems to be directly or indirectly involved in regulation of apoptosis and carcinogenesis, contributes to cardiac cell hypertrophy and survival and, when mutated, might be involved in development of neurodegenerative diseases. |
2011-12-13 |
2023-08-12 |
human |
| Jhih-Bin Chen, Eric Minwei Liu, Ting-Rong Chern, Chieh-Wen Yang, Chia-I Lin, Nai-Kuei Huang, Yun-Lian Lin, Yijuang Chern, Jung-Hsin Lin, Jim-Min Fan. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. vol 6. issue 8. 2011-11-28. PMID:21692183. |
in agreement with competitive ligand binding assay results, these compounds also prevent apoptosis in serum-deprived pc12 cells, rendering a crucial function in neuroprotection and potential utility in the treatment of neurodegenerative diseases. |
2011-11-28 |
2023-08-12 |
Not clear |
| Raquel Gómez-Sintes, Félix Hernández, José J Lucas, Jesús Avil. GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration. Frontiers in molecular neuroscience. vol 4. 2011-11-23. PMID:22110426. |
it is important to dissect this duality since, among the diseases in which gsk-3 is involved, excessive cell death is crucial in some illnesses like neurodegenerative diseases, while a deficient apoptosis is occurring in others such as cancer or autoimmune diseases. |
2011-11-23 |
2023-08-12 |
mouse |
| Cecília da Silva Ferreira, Carla Cristina Maganhin, Ricardo dos Santos Simões, Manoel João Batista Castello Girão, Edmund Chada Baracat, José Maria Soare. [Melatonin: cell death modulator]. Revista da Associacao Medica Brasileira (1992). vol 56. issue 6. 2011-11-14. PMID:21271142. |
when apoptosis is out of control, it contributes to the emergence of several neoplastic, autoimmune and neurodegenerative diseases. |
2011-11-14 |
2023-08-12 |
Not clear |
| Carlotta Giorgi, Mariusz R Wieckowski, Pier Paolo Pandolfi, Paolo Pinto. Mitochondria associated membranes (MAMs) as critical hubs for apoptosis. Communicative & integrative biology. vol 4. issue 3. 2011-11-10. PMID:21980573. |
apoptosis is a process of major biomedical interest, since its deregulation is involved in the pathogenesis of a broad variety of disorders (neoplasia, autoimmune disorders, viral and neurodegenerative diseases, to name a few). |
2011-11-10 |
2023-08-12 |
Not clear |
| Parco M Si. Muscle apoptotic response to denervation, disuse, and aging. Medicine and science in sports and exercise. vol 41. issue 10. 2011-11-08. PMID:19727026. |
the pathological consequences of aberrant regulation of apoptosis have been widely demonstrated in carcinogenesis, neurodegenerative diseases, autoimmune diseases, viral infections, and acquired immunodeficiency syndrome. |
2011-11-08 |
2023-08-12 |
Not clear |
| Dongmei Li, Hui Chen, Abigail Florentino, Deepu Alex, Patricia Sikorski, William A Fonzi, Richard Calderon. Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death. Eukaryotic cell. vol 10. issue 5. 2011-10-31. PMID:21398508. |
our observation of increased ros production associated with a defective ci and pcd is reminiscent of mitochondrial studies of patients with some types of neurodegenerative diseases where ci and/or ciii dysfunctions lead to increased ros and apoptosis. |
2011-10-31 |
2023-08-12 |
human |