| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel A Linseman, Maria L McClure, Ron J Bouchard, Tracey A Laessig, Ferogh A Ahmadi, Kim A Heidenreic. Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism. The Journal of biological chemistry. vol 277. issue 27. 2002-08-27. PMID:11964396. |
neuronal apoptosis contributes to the progression of neurodegenerative disease. |
2002-08-27 |
2023-08-12 |
Not clear |
| J L Mazzola, M A Sirove. Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts. Journal of neurochemistry. vol 76. issue 2. 2002-08-15. PMID:11208907. |
new functions have been identified for glyceraldehyde-3-phosphate dehydrogenase (gapdh) including its role in neurodegenerative disease and in apoptosis. |
2002-08-15 |
2023-08-12 |
Not clear |
| Carol M Troy, Guy S Salvese. Caspases on the brain. Journal of neuroscience research. vol 69. issue 2. 2002-08-14. PMID:12111795. |
there is now evidence that the pathology of several neurodegenerative diseases is due to inappropriate apoptosis. |
2002-08-14 |
2023-08-12 |
Not clear |
| D Perrelet, A Ferri, P Liston, P Muzzin, R G Korneluk, A C Kat. IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo. Nature cell biology. vol 4. issue 2. 2002-08-08. PMID:11813002. |
during embryonic development, and in certain neurodegenerative diseases, neurons die by apoptosis. |
2002-08-08 |
2023-08-12 |
rat |
| [Alzheimer's disease in the year 2000]. Revista panamericana de salud publica = Pan American journal of public health. vol 10. issue 4. 2002-07-15. PMID:11715172. |
in research on the etiology of the disease, key areas of attention have included amyloid, presenilins, apolipoprotein e, and other genetic ties; apoptosis; and protein aggregation in other neurodegenerative disease. |
2002-07-15 |
2023-08-12 |
human |
| K Schindowski, S Leutner, S Kressmann, A Eckert, W E Mülle. Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761). Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 8-9. 2002-04-29. PMID:11716149. |
in addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis in neuronal tissue. |
2002-04-29 |
2023-08-12 |
mouse |
| Kawase, K Sunaga, S Tani, M Niwa, T Uemats. Trifluoromethyl ketone-based inhibitors of apoptosis in cerebellar granule neurons. Biological & pharmaceutical bulletin. vol 24. issue 11. 2002-04-23. PMID:11725976. |
among them, alpha-trifluoromethyl diketone (2) and benzyl trifluoromethyl ketone (11) were found to be apoptosis inhibitors which can prevent a neurodegenerative disease. |
2002-04-23 |
2023-08-12 |
Not clear |
| Sumeer Dhar, Rhonda L Bitting, Svetlana N Rylova, Paul J Jansen, Ellen Lockhart, Dwight D Koeberl, Andrea Amalfitano, Rose-Mary N Boustan. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Annals of neurology. vol 51. issue 4. 2002-04-18. PMID:11921051. |
flupirtine may be useful as a drug capable of halting the progression of neurodegenerative diseases caused by dysregulated apoptosis. |
2002-04-18 |
2023-08-12 |
human |
| S Porat, A Premkumar, R Simanto. Dopamine induces phenotypic differentiation or apoptosis in a dose-dependent fashion: involvement of the dopamine transporter and p53. Developmental neuroscience. vol 23. issue 6. 2002-04-12. PMID:11872944. |
these findings provide an insight into the role of dopamine, dopamine transporters and p53 in the differentiation and apoptosis of dopaminergic neurons, which will further our understanding of neuronal development and neurodegenerative diseases. |
2002-04-12 |
2023-08-12 |
human |
| Allen M Gown, Mark C Willingha. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 50. issue 4. 2002-04-09. PMID:11897797. |
apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases, and development. |
2002-04-09 |
2023-08-12 |
Not clear |
| D Reverter, S Strobl, C Fernandez-Catalan, H Sorimachi, K Suzuki, W Bod. Structural basis for possible calcium-induced activation mechanisms of calpains. Biological chemistry. vol 382. issue 5. 2002-03-12. PMID:11517928. |
the calpains are believed to play important roles in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction, but have also been implicated in muscular dystrophy, ischemia, traumatic brain injury, neurodegenerative diseases, rheumatoid arthritis and cataract formation. |
2002-03-12 |
2023-08-12 |
human |
| Shigeko Uryu, Jun Harada, Marie Hisamoto, Tomiichiro Od. Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain research. vol 924. issue 2. 2002-03-05. PMID:11750908. |
both excitotoxicity and apoptosis contribute to neuronal loss in various neurodegenerative diseases such as alzheimer's disease as well as stroke, and a drug inhibiting both types of cell death may lead to practical treatment for these diseases. |
2002-03-05 |
2023-08-12 |
Not clear |
| Shigeko Uryu, Jun Harada, Marie Hisamoto, Tomiichiro Od. Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain research. vol 924. issue 2. 2002-03-05. PMID:11750908. |
in conclusion, although the mechanisms of troglitazone's neuroprotective effects are unknown, the post-treatment-neuroprotective effect and the dual-inhibitory-activity against both excitotoxicity and apoptosis may provide a novel therapy for various neurodegenerative diseases. |
2002-03-05 |
2023-08-12 |
Not clear |
| X H Liu, R J Collier, R J Youl. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11574549. |
bcl-2 and bcl-xl prevent neuronal apoptosis during development, neurodegenerative disease, and trauma. |
2002-01-10 |
2023-08-12 |
rat |
| D Reverter, H Sorimachi, W Bod. The structure of calcium-free human m-calpain: implications for calcium activation and function. Trends in cardiovascular medicine. vol 11. issue 6. 2001-12-05. PMID:11673052. |
the calpains are believed to play important roles in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction, but are also implicated in muscular dystrophy, cardiac and cerebral ischemia, platelet aggregation, restenosis, neurodegenerative diseases, rheumatoid arthritis and cataract formation. |
2001-12-05 |
2023-08-12 |
human |
| Iu A Chelyshev, G V Cherepnev, K I Saĭtkulo. [Apoptosis in the nervous system]. Ontogenez. vol 32. issue 2. 2001-10-18. PMID:11544763. |
various disturbances in the control of apoptosis underlie various neurodegenerative diseases, the formation of malignant tumors, autoimmune disturbances, and developmental abnormalities. |
2001-10-18 |
2023-08-12 |
Not clear |
| b' R Neuwirtov\\xc3\\xa. [Will knowledge of the mechanisms of apoptosis lead to new therapeutic procedures?]. Casopis lekaru ceskych. vol 140. issue 15. 2001-10-18. PMID:11569166.' |
conversely a delay of premature apoptosis gives hope for hitherto untreatable neurodegenerative diseases, myelodysplastic syndromes, ischaemic events and some severe infections. |
2001-10-18 |
2023-08-12 |
human |
| S Sathasivam, P G Ince, P J Sha. Apoptosis in amyotrophic lateral sclerosis: a review of the evidence. Neuropathology and applied neurobiology. vol 27. issue 4. 2001-10-04. PMID:11532157. |
in a chronic neurodegenerative disease such as als, conclusive evidence of apoptosis is likely to be difficult to detect, given the rapidity of the apoptotic cell death process in relation to the relatively slow time course of the disease. |
2001-10-04 |
2023-08-12 |
human |
| E B Stuart, J M Thompson, R W Rhees, E D Lephar. Steroid hormone influence on brain calbindin-D(28K) in male prepubertal and ovariectomized rats. Brain research. Developmental brain research. vol 129. issue 2. 2001-09-27. PMID:11506857. |
calbindin-d(28k) (calb), a calcium-binding protein, is thought to buffer intracellular calcium levels in neurons playing several important roles during central nervous system development such as, protecting against apoptosis (programmed cell death), neurodegenerative diseases and influencing sexually dimorphic brain structures. |
2001-09-27 |
2023-08-12 |
rat |
| S Gökhan, M F Mehle. Basic and clinical neuroscience applications of embryonic stem cells. The Anatomical record. vol 265. issue 3. 2001-09-13. PMID:11458329. |
in addition, recent experimental observations suggest that neurodegenerative disease pathology may involve alterations in a range of progressive neural inductive and neurodevelopmental events through novel biological mechanisms that result in sublethal impairments in cellular homeostasis within evolving regional neuronal precursor populations containing the mutant proteins, culminating in increased vulnerability of their differentiated neuronal progeny to late-onset apoptosis. |
2001-09-13 |
2023-08-12 |
Not clear |