| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung-Ju Yang, Jong Eun Lee, Kwan Ho Lee, Jae-Wan Huh, Soo Young Choi, Sung-Woo Ch. Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. Brain research. Molecular brain research. vol 127. issue 1-2. 2004-12-22. PMID:15306132. |
co-administration of glial cell line-derived neurotrophic factor (gdnf) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (bdnf) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors. |
2004-12-22 |
2023-08-12 |
rat |
| Takeshi Yabe, J Taylor Herbert, Asako Takanohashi, Joan P Schwart. Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines. Journal of neuroscience research. vol 77. issue 5. 2004-12-22. PMID:15352210. |
brain-derived neurotrophic factor (bdnf) seemed capable of inducing apoptosis, because a blocking antibody enhanced the protective effect of pedf. |
2004-12-22 |
2023-08-12 |
Not clear |
| Hyun Kim, Qi Li, Barbara L Hempstead, Joseph A Madr. Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. The Journal of biological chemistry. vol 279. issue 32. 2004-10-25. PMID:15169782. |
exogenous bdnf elicits robust angiogenesis and survival in three-dimensional cultures of these endothelial cells, while sequestration of endogenous bdnf caused significant apoptosis. |
2004-10-25 |
2023-08-12 |
Not clear |
| W Ukai, H Ozawa, M Tateno, E Hashimoto, T Sait. Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 6. 2004-09-14. PMID:15168214. |
moreover, brain-derived neurotrophic factor (bdnf) reduced the caspase-3 activity and protected neurons from haloperidol-induced apoptosis. |
2004-09-14 |
2023-08-12 |
rat |
| Jian-Ye Chen, Ji Liu, Ruo-Han Wang, Wen-Zhen Peng, Zhi-Min Liu, Xiao-Ming Wang, Hai-Yan Chen, Jun-Jie Che. [Suppressive effect of brain derived neurotrophic factor on H2O2-induced apoptosis in human lung cancer cell YTMLC-90]. Ai zheng = Aizheng = Chinese journal of cancer. vol 22. issue 9. 2004-08-19. PMID:12969525. |
the aim of this experiment was to investigate the effect of bdnf on hydrogen peroxide (h2o2)-induced apoptosis in the human lung cancer cell line ytmlc-90. |
2004-08-19 |
2023-08-12 |
human |
| Jianye Chen, Ji Liu, Ruohan Wang, Zhimin Liu, Ji Li, Junjie Che. [Effects of brain-derived neurotrophic factor on H2O2-induced apoptosis of human arterial smooth muscle cell]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 34. issue 2. 2004-07-15. PMID:12947703. |
to investigate the protective effects of brain-derived neurotrophic factor (bdnf) on hydrogen peroxide (h2o2) induced apoptosis of human arterial smooth muscle cells (smc). |
2004-07-15 |
2023-08-12 |
human |
| Mutsumi Ueda, Ryousuke Fujita, Takehiko Koji, Hiroshi Ued. The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 309. issue 1. 2004-05-04. PMID:14718588. |
nefiracetam inhibited both necrosis and apoptosis, whereas brain-derived neurotrophic factor (bdnf) inhibited only apoptosis. |
2004-05-04 |
2023-08-12 |
mouse |
| Wen-wen Liu, Ping Xu, Qian Huan. [Effect of neurotrophic factors and growth factors on adult human retinal cells in vitro]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 39. issue 9. 2004-02-26. PMID:14766086. |
to examine whether adult human retinal cells can be maintained in vitro over long time periods and to study the effects of brain-derived neurotrophic factor (bdnf),neurotrophin-4 (nt-4), epidermal growth factor (egf), fibroblast growth factor (fgf), and retinoic acid (ra) on growth, proliferation, and apoptosis of the cultured adult human retinal cells. |
2004-02-26 |
2023-08-12 |
human |
| Satoru Yamagishi, Tomoya Matsumoto, Daisaku Yokomaku, Hiroshi Hatanaka, Koji Shimoke, Masashi Yamada, Toshihiko Ikeuch. Comparison of inhibitory effects of brain-derived neurotrophic factor and insulin-like growth factor on low potassium-induced apoptosis and activation of p38 MAPK and c-Jun in cultured cerebellar granule neurons. Brain research. Molecular brain research. vol 119. issue 2. 2004-02-20. PMID:14625085. |
these results suggest that the greater inhibitory effects of igf-1 than bdnf, on activation of p38 and c-jun and apoptosis, are caused by the higher level of pi3-k activation during lk-induced apoptosis of cultured cerebellar granule neurons. |
2004-02-20 |
2023-08-12 |
rat |
| A Mantelas, A Stamatakis, I Kazanis, H Philippidis, F Stylianopoulo. Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex. Brain research. Developmental brain research. vol 145. issue 2. 2004-02-19. PMID:14604759. |
and brain-derived neurotrophic factor (bdnf), both of which are involved in the control of synaptic plasticity and apoptosis. |
2004-02-19 |
2023-08-12 |
rat |
| Rosario Garrido, Joe E Springer, Bernhard Hennig, Michal Tobore. Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors. Journal of neurotrauma. vol 20. issue 11. 2004-01-16. PMID:14651807. |
in addition, nicotine, bdnf and fgf-2 fully protected against arachidonic acid-induced apoptosis of spinal cord neurons. |
2004-01-16 |
2023-08-12 |
Not clear |
| Alessia Bachis, Eugene O Major, Italo Mocchett. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843275. |
because brain-derived neurotrophic factor (bdnf) prevents caspase-3-mediated neuronal cell death, we examined whether bdnf could prevent gp120-mediated apoptosis. |
2003-08-14 |
2023-08-12 |
human |
| Alessia Bachis, Eugene O Major, Italo Mocchett. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843275. |
preincubation of neurons with bdnf before the addition of gp120 reduced caspase-3 activation, and consequently rescued 80% of neurons from apoptosis. |
2003-08-14 |
2023-08-12 |
human |
| Alessia Bachis, Eugene O Major, Italo Mocchett. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843275. |
most importantly, bdnf reduced the levels of cxc chemokine receptor-4 (cxcr4), a receptor that mediates hiv-1 gp120-induced apoptosis. |
2003-08-14 |
2023-08-12 |
human |
| Alessia Bachis, Eugene O Major, Italo Mocchett. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843275. |
this effect correlated with the ability of bdnf to reduce gp120 internalization and apoptosis. |
2003-08-14 |
2023-08-12 |
human |
| Steven Poser, Soren Impey, Zhengui Xia, Daniel R Stor. Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 11. 2003-07-01. PMID:12805282. |
here we report the surprising observation that camp attenuates the ability of bdnf to rescue cortical neurons from apoptosis after serum deprivation, a process mediated via the phosphatidylinositol 3 (pi3)-kinase signal transduction cascade. |
2003-07-01 |
2023-08-12 |
Not clear |
| Akiko Tabuchi, Kouhei Funaji, Jun Nakatsubo, Mamoru Fukuchi, Tomofusa Tsuchiya, Masaaki Tsud. Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548706. |
suppression of the apoptosis of cgcs mediated by the ca(2+) influx or neurotrophic factors such as brain-derived neurotrophic factor (bdnf) and adenylate cyclase activating polypeptide-38 (pacap-38) attenuated the aconitase inactivation as well as the lactate dehydrogenase (ldh)-release and the decrease in mtt reduction. |
2003-04-01 |
2023-08-12 |
mouse |
| Michal Hetman, Shih-Ling Hsuan, Agata Habas, Matthew J Higgins, Zhengui Xi. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. The Journal of biological chemistry. vol 277. issue 51. 2003-02-12. PMID:12393899. |
activation of both endogenous erk1/2 and pi3k signaling pathways was required for bdnf to block apoptosis induced by expression of recombinant gsk3beta. |
2003-02-12 |
2023-08-12 |
Not clear |
| Michal Hetman, Shih-Ling Hsuan, Agata Habas, Matthew J Higgins, Zhengui Xi. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. The Journal of biological chemistry. vol 277. issue 51. 2003-02-12. PMID:12393899. |
furthermore, cortical neuron apoptosis induced by ly294002-mediated activation of endogenous gsk3beta was blocked by expression of constitutively active mkk1 or by bdnf via stimulation of the endogenous erk1/2 pathway. |
2003-02-12 |
2023-08-12 |
Not clear |
| Sun H Kim, Seok J Won, Seonghyang Sohn, Hyuk J Kwon, Jee Y Lee, Jong H Park, Byoung J Gwa. Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase. The Journal of cell biology. vol 159. issue 5. 2003-01-23. PMID:12460985. |
since nts enhance survival and differentiation of cultured neurons in serum or defined media containing antioxidants, we set out experiments to delineate the patterns and underlying mechanisms of brain-derived neurotrophic factor (bdnf)-induced neuronal injury in mixed cortical cell cultures containing glia and neurons in serum-free media without antioxidants, where the three major routes of neuronal cell death, oxidative stress, excitotoxicity, and apoptosis, have been extensively studied. |
2003-01-23 |
2023-08-12 |
rat |