| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessia Bachis, Italo Mocchett. Semisynthetic sphingoglycolipid LIGA20 is neuroprotective against human immunodeficiency virus-gp120-mediated apoptosis. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477610. |
brain-derived neurotrophic factor (bdnf) prevents gp120-mediated apoptosis in cerebellar granule cells. |
2006-06-01 |
2023-08-12 |
human |
| Henry K Teng, Kenneth K Teng, Ramee Lee, Saundrene Wright, Seema Tevar, Ramiro D Almeida, Pouneh Kermani, Risa Torkin, Zhe-Yu Chen, Francis S Lee, Rosemary T Kraemer, Anders Nykjaer, Barbara L Hempstea. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 22. 2006-03-02. PMID:15930396. |
because recent studies suggest that prongf, the precursor form of ngf, is more active than mature ngf in inducing apoptosis after binding to p75ntr and a coreceptor, sortilin, we asked whether the precursor of bdnf (probdnf) is also a proapoptotic ligand in the nervous system. |
2006-03-02 |
2023-08-12 |
Not clear |
| X-F Zhou, W-P Li, F H-H Zhou, J-H Zhong, J-X Mi, L L-Y Wu, C J Xia. Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837121. |
after peripheral nerve injury, axotomized sensory neurons in dorsal root ganglia (drg) undergo apoptosis and up-regulate brain-derived neurotrophic factor (bdnf). |
2005-08-30 |
2023-08-12 |
mouse |
| X-F Zhou, W-P Li, F H-H Zhou, J-H Zhong, J-X Mi, L L-Y Wu, C J Xia. Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837121. |
in the in vitro model, treatment with bdnf antibody significantly reduced apoptosis of sensory neurons in drg explants from both adult and neonate rats and adult mice cultured for 48 h. consistently, exogenous bdnf increased the percentage of apoptotic neurons in the drgs from mice. |
2005-08-30 |
2023-08-12 |
mouse |
| X-F Zhou, W-P Li, F H-H Zhou, J-H Zhong, J-X Mi, L L-Y Wu, C J Xia. Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837121. |
while endogenous bdnf induced apoptosis of axotomized sensory neurons through p75ntr in vitro where more neurons expressed p75ntr, it prevented apoptosis in vivo where fewer neurons expressed p75ntr after sciatic nerve transection. |
2005-08-30 |
2023-08-12 |
mouse |
| Barbara Sitek, Ognjan Apostolov, Kai Stühler, Kathy Pfeiffer, Helmut E Meyer, Angelika Eggert, Alexander Schram. Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry. Molecular & cellular proteomics : MCP. vol 4. issue 3. 2005-07-21. PMID:15654083. |
the trka and trkb tyrosine kinases are members of the neurotrophin receptor family and mediate survival, differentiation, growth, and apoptosis of neurons in response to stimulation by their ligands, ngf and bdnf, respectively. |
2005-07-21 |
2023-08-12 |
human |
| Roger N Pearse, Steven L Swendeman, Ying Li, Dahlia Rafii, Barbara L Hempstea. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. vol 105. issue 11. 2005-07-12. PMID:15657181. |
addition of bdnf protects human mm cell lines (hmcls) from apoptosis induced by dexamethasone or bortezomib and prolongs the survival of primary mm cells cultured alone or with human bone marrow (bm) stroma. |
2005-07-12 |
2023-08-12 |
human |
| E Carden Yeiser, Nancy J Rutkoski, Asuka Naito, Jun-ichiro Inoue, Bruce D Carte. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 46. 2005-06-21. PMID:15548667. |
in sympathetic neurons cultured from traf6+/+ superior cervical ganglia (scgs), there was an increase in jnk activation and apoptosis after bdnf binding to p75; however, traf6-/- neurons did not respond. |
2005-06-21 |
2023-08-12 |
mouse |
| B Fayard, S Loeffler, J Weis, E Vögelin, A Krüttge. The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC. Journal of neuroscience research. vol 80. issue 1. 2005-05-26. PMID:15704182. |
the neurotrophin brain-derived neurotrophic factor (bdnf) binds to two cell surface receptors: trkb receptors that promote neuronal survival and differentiation and p75ntr that induces apoptosis or survival. |
2005-05-26 |
2023-08-12 |
Not clear |
| Kyoko Isoyama, Hiroshi Nagata, Yuji Shino, Naohisa Isegawa, Yukiko Arimoto, Masao Koda, Keiichiro Kumahara, Yoshitaka Okamoto, Hiroshi Shirasaw. Effects of adenoviral vector-mediated BDNF expression on the bulbectomy-induced apoptosis of olfactory receptor neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469885. |
effects of adenoviral vector-mediated bdnf expression on the bulbectomy-induced apoptosis of olfactory receptor neurons. |
2005-04-19 |
2023-08-12 |
mouse |
| Kyoko Isoyama, Hiroshi Nagata, Yuji Shino, Naohisa Isegawa, Yukiko Arimoto, Masao Koda, Keiichiro Kumahara, Yoshitaka Okamoto, Hiroshi Shirasaw. Effects of adenoviral vector-mediated BDNF expression on the bulbectomy-induced apoptosis of olfactory receptor neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469885. |
tunel staining indicated that the exogenous bdnf enhanced the survival of the bulbectomized oe by inhibiting apoptosis. |
2005-04-19 |
2023-08-12 |
mouse |
| Orly Weinreb, Orit Bar-Am, Tamar Amit, Orly Chillag-Talmor, Moussa B H Youdi. Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 12. 2005-04-05. PMID:15247150. |
here, we report that rasagiline (0.1-10 microm) decreased apoptosis via multiple protection mechanisms, including the stimulation of pkc phosphorylation; up-regulation of pkcalpha and pkc mrnas, induction of bcl-xl, bcl-w, and brain-derived neurotrophic factor (bdnf) mrnas; and down-regulation of bad and bax mrnas. |
2005-04-05 |
2023-08-12 |
rat |
| Isabelle Husson, Claire-Marie Rangon, Vincent Lelièvre, Alexis-Pierre Bemelmans, Philippe Sachs, Jacques Mallet, Barry E Kosofsky, Pierre Gressen. BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cerebral cortex (New York, N.Y. : 1991). vol 15. issue 3. 2005-04-05. PMID:15269108. |
bdnf neuroprotection involved trkb receptors, mapk pathway and reduced apoptosis. |
2005-04-05 |
2023-08-12 |
human |
| Isabelle Husson, Claire-Marie Rangon, Vincent Lelièvre, Alexis-Pierre Bemelmans, Philippe Sachs, Jacques Mallet, Barry E Kosofsky, Pierre Gressen. BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cerebral cortex (New York, N.Y. : 1991). vol 15. issue 3. 2005-04-05. PMID:15269108. |
finally, bdnf exacerbated neuronal death produced by ibotenate at p0 through increased apoptosis and p75(ntr) receptors, while bdnf had no detectable effect on lesions induced at p10. |
2005-04-05 |
2023-08-12 |
human |
| Rachel L Nosheny, Alessia Bachis, Elio Acquas, Italo Mocchett. Human immunodeficiency virus type 1 glycoprotein gp120 reduces the levels of brain-derived neurotrophic factor in vivo: potential implication for neuronal cell death. The European journal of neuroscience. vol 20. issue 11. 2005-02-28. PMID:15579139. |
because several neurodegenerative disorders are characterized by lack of trophic support, we tested the hypothesis that gp120 may cause apoptosis by reducing bdnf expression. |
2005-02-28 |
2023-08-12 |
mouse |
| P Leeds, Y Leng, E Chalecka-Franaszek, D-M Chuan. Neurotrophins protect against cytosine arabinoside-induced apoptosis of immature rat cerebellar neurons. Neurochemistry international. vol 46. issue 1. 2005-02-22. PMID:15567516. |
k252a, an inhibitor of the tropomyosin-related kinase (trk) tyrosine kinase receptor family which showed no toxicity by itself, blocked bdnf protection of arac-induced apoptosis in a concentration-dependent manner. |
2005-02-22 |
2023-08-12 |
rat |
| Liqi Tong, Robert Balazs, Phillip L Thornton, Carl W Cotma. Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 30. 2005-02-15. PMID:15282285. |
the functional consequences of abeta interference with signaling are robust, causing increased vulnerability of neurons, abrogating bdnf protection against dna damage- and trophic deprivation-induced apoptosis. |
2005-02-15 |
2023-08-12 |
Not clear |
| Federico Madeddu, Sibel Naska, Yuri Bozz. BDNF down-regulates the caspase 3 pathway in injured geniculo-cortical neurones. Neuroreport. vol 15. issue 13. 2005-01-13. PMID:15486479. |
death of dlgn neurones occurs by apoptosis and is partially prevented (approximately 50%) by intraocular delivery of brain-derived neurotrophic factor (bdnf). |
2005-01-13 |
2023-08-12 |
rat |
| Italo Mocchetti, Alessia Bachi. Brain-derived neurotrophic factor activation of TrkB protects neurons from HIV-1/gp120-induced cell death. Critical reviews in neurobiology. vol 16. issue 1-2. 2005-01-05. PMID:15581399. |
the neurotrophin brain-derived neurotrophic factor (bdnf) has been shown to prevent gp120-mediated apoptosis of cerebellar granule cells by inhibiting caspase-3 activation. |
2005-01-05 |
2023-08-12 |
human |
| Italo Mocchetti, Alessia Bachi. Brain-derived neurotrophic factor activation of TrkB protects neurons from HIV-1/gp120-induced cell death. Critical reviews in neurobiology. vol 16. issue 1-2. 2005-01-05. PMID:15581399. |
pharmacological inhibition of trkb or erk1/2, but not pi3-k, greatly reduced the ability of bdnf to block gp120-mediated apoptosis of cerebellar granule cells. |
2005-01-05 |
2023-08-12 |
human |