| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anilkumar Pillai, Krishnan M Dhandapani, Bindu A Pillai, Alvin V Terry, Sahebarao P Mahadi. Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 8. 2008-09-02. PMID:17805306. |
such observations provided the impetus for us to investigate in the present study whether co-treatment of rhepo with haloperidol could sustain the normal levels of bdnf in vivo in rats and in vitro in cortical neuronal cultures and further, whether bdnf could prevent haloperidol-induced apoptosis through the regulation of key apoptotic/antiapoptotic markers. |
2008-09-02 |
2023-08-12 |
human |
| Rui Wang, Ying-Bo Li, Yu-Hua Li, Ying Xu, Hong-Li Wu, Xue-Jun L. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain research. vol 1210. 2008-08-26. PMID:18420184. |
exposure of rat cortical neurons to 10 microm glutamate for 24 h caused a significant decrease in bdnf level, accompanied with reduced cell viability and enhanced cell apoptosis. |
2008-08-26 |
2023-08-12 |
rat |
| Zuomin Chen, Micah S Simmons, Rodney T Perry, Howard W Wiener, Lindy E Harrell, Rodney C P G. Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147. issue 3. 2008-08-08. PMID:17918233. |
brain-derived neurotrophic factor (bdnf)/tyrosine receptor kinase (trk) signaling pathway activates a wide range of downstream intracellular cascades, regulating neuronal development and plasticity, long-term potentiation, and apoptosis. |
2008-08-08 |
2023-08-12 |
Not clear |
| Zhaohui Liu, Dongliang Ma, Gaifeng Feng, Yanbing Ma, Haitao H. Recombinant AAV-mediated expression of human BDNF protects neurons against cell apoptosis in Abeta-induced neuronal damage model. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 3. 2008-07-02. PMID:17641830. |
recombinant aav-mediated expression of human bdnf protects neurons against cell apoptosis in abeta-induced neuronal damage model. |
2008-07-02 |
2023-08-12 |
human |
| Zhaohui Liu, Dongliang Ma, Gaifeng Feng, Yanbing Ma, Haitao H. Recombinant AAV-mediated expression of human BDNF protects neurons against cell apoptosis in Abeta-induced neuronal damage model. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 3. 2008-07-02. PMID:17641830. |
the bdnf may reduce neuron apoptosis through increasing the expression of the bcl-2 anti-apoptosis protein and inhibiting intracellular calcium overload. |
2008-07-02 |
2023-08-12 |
human |
| Chi-Hsien Peng, Shih-Hwa Chiou, Shih-Jen Chen, Yueh-Ching Chou, Hung-Hai Ku, Cheng-Kuo Cheng, Chih-Ju Yen, Tung-Hu Tsai, Yuh-Lih Chang, Chun-Lan Ka. Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 2. 2008-04-18. PMID:17566715. |
neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of bdnf and the mapk pathway. |
2008-04-18 |
2023-08-12 |
rat |
| Chi-Hsien Peng, Shih-Hwa Chiou, Shih-Jen Chen, Yueh-Ching Chou, Hung-Hai Ku, Cheng-Kuo Cheng, Chih-Ju Yen, Tung-Hu Tsai, Yuh-Lih Chang, Chun-Lan Ka. Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 2. 2008-04-18. PMID:17566715. |
inhibition of bdnf expression with small interfering rna (sirna), or blocking the mapk pathway with u0126 further significantly decreased bcl-2 protein levels and abrogated the neuroprotective effects of im against lps-induced apoptosis in nscs. |
2008-04-18 |
2023-08-12 |
rat |
| S Giraud, C Lautrette, B Bessette, C Decourt, M Mathonnet, M-O Jaubertea. Modulation of Fas-induced apoptosis by p75 neurotrophin receptor in a human neuroblastoma cell line. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215672. |
fas and p75 neurotrophin receptors (p75(ntr)) are death receptors that alone induce apoptosis of sh-sy5y neuroblastoma cell line respectively by fas ligand or brain-derived neurotrophic factor (bdnf, a p75(ntr) ligand). |
2008-03-25 |
2023-08-12 |
human |
| Robert P Ostrowski, Gerhart Graupner, Elena Titova, Jennifer Zhang, Jeffrey Chiu, Neal Dach, Dalia Corleone, Jiping Tang, John H Zhan. The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia. Neurobiology of disease. vol 29. issue 1. 2008-03-14. PMID:17822911. |
we conclude that hbo preconditioning may be neuroprotective by reducing early apoptosis and inhibition of the conversion of early to late apoptosis, possibly through an increase in brain bdnf level and the suppression of p38 activation. |
2008-03-14 |
2023-08-12 |
rat |
| I Gross, O Armant, S Benosman, J L G de Aguilar, J-N Freund, M Kedinger, J D Licht, C Gaiddon, J-P Loeffle. Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell death and differentiation. vol 14. issue 10. 2007-12-06. PMID:17599098. |
in mature neurons that exhibit an extensive neurite network, spry2 expression is sustained by bdnf and is downregulated during neuronal apoptosis. |
2007-12-06 |
2023-08-12 |
Not clear |
| Kazuhiro Kawamura, Nanami Kawamura, Jun Fukuda, Jin Kumagai, Aaron J W Hsueh, Toshinobu Tanak. Regulation of preimplantation embryo development by brain-derived neurotrophic factor. Developmental biology. vol 311. issue 1. 2007-12-03. PMID:17880937. |
treatment with bdnf promoted the development of two-cell-stage embryos into blastocysts showing increased proliferation and decreased apoptosis. |
2007-12-03 |
2023-08-12 |
Not clear |
| Erzsebet Szatmari, Katarzyna B Kalita, Giorgi Kharebava, Michal Hetma. Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942733. |
in cultured rat cortical neurons, bdnf activates erk1/2 to enhance neuronal survival by suppressing dna damage- or trophic deprivation-induced apoptosis. |
2007-11-08 |
2023-08-12 |
rat |
| Erzsebet Szatmari, Katarzyna B Kalita, Giorgi Kharebava, Michal Hetma. Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 42. 2007-11-08. PMID:17942733. |
in contrast, bdnf suppression of trophic deprivation-induced apoptosis was unaffected by shksr1 although blocked by sherk1/2. |
2007-11-08 |
2023-08-12 |
rat |
| R Brooks Wilson, Kannan Kunchithapautham, Bärbel Rohre. Paradoxical role of BDNF: BDNF+/- retinas are protected against light damage-mediated stress. Investigative ophthalmology & visual science. vol 48. issue 6. 2007-07-02. PMID:17525224. |
photoreceptors can be prevented from undergoing apoptosis in response to constant light by the application of exogenous neuroprotective agents, including brain-derived neurotrophic factor (bdnf). |
2007-07-02 |
2023-08-12 |
Not clear |
| Rachel L Nosheny, Alessia Bachis, Sadia A Aden, Maria A De Bernardi, Italo Mocchett. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. Journal of neurobiology. vol 66. issue 12. 2006-12-11. PMID:16967504. |
because glial cell line-derived neurotrophic factor (gdnf) and bdnf are neurotrophic factors crucial for the survival of dopaminergic neurons of the sn, we investigated whether gp120 reduces gdnf and bdnf levels concomitantly to induce apoptosis. |
2006-12-11 |
2023-08-12 |
human |
| Andrew P Hibbert, Bianca M R Kramer, Freda D Miller, David R Kapla. The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Molecular and cellular neurosciences. vol 32. issue 4. 2006-10-24. PMID:16843677. |
bdnf, through p75ntr, promotes apoptosis and inhibits axonal growth of sympathetic neurons, antagonizing the pro-survival and axon growth-promoting actions of ngf through trka. |
2006-10-24 |
2023-08-12 |
Not clear |
| Susan G Dorsey, Cynthia L Renn, Laura Carim-Todd, Colleen A Barrick, Linda Bambrick, Bruce K Krueger, Christopher W Ward, Lino Tessaroll. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. vol 51. issue 1. 2006-08-31. PMID:16815329. |
in the trisomy 16 (ts16) mouse there is increased apoptosis in the cortex, and hippocampal neurons undergo accelerated cell death that cannot be rescued by administration of brain-derived neurotrophic factor (bdnf). |
2006-08-31 |
2023-08-12 |
mouse |
| Alessia Bachis, Italo Mocchett. Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179530. |
the neurotrophin brain-derived neurotrophic factor (bdnf) has been shown to block neuronal apoptosis. |
2006-06-06 |
2023-08-12 |
human |
| Alessia Bachis, Italo Mocchett. Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179530. |
preexposure of cerebellar granule cells to bdnf prior to both gp120s decreased apoptosis and consequently enhanced their survival. |
2006-06-06 |
2023-08-12 |
human |
| Orly Weinreb, Tamar Amit, Orit Bar-Am, Orly Chillag-Talmor, Moussa B H Youdi. Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179541. |
in a model of serum withdrawal-induced apoptosis of rat pheochromocytoma pc12 cells, rasagiline and its propargyl moiety, n-propargylamine, decreased cell death via multiple neuroprotective pathways that include the stimulation of pkc phosphorylation; upregulation of pkcepsilon mrna; induction of bcl-x(l), bcl-w, and brain-derived neurotrophic factor (bdnf) mrnas; and downregulation of pkcgamma, bad, and bax mrnas. |
2006-06-06 |
2023-08-12 |
rat |