| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Maxwell, S A Acosta, G E Davi. Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line. Apoptosis : an international journal on programmed cell death. vol 4. issue 2. 2003-12-23. PMID:14634288. |
ecv-304 endothelial cells that expressed the bax delta species underwent apoptosis much more rapidly and more extensively after induction of p53, suggesting that the bax delta species enhances p53-mediated apoptosis. |
2003-12-23 |
2023-08-12 |
human |
| Meredith A McCracken, Loren J Miraglia, Robert A McKay, Jeannine S Strob. Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. Molecular cancer therapeutics. vol 2. issue 3. 2003-12-11. PMID:12657722. |
the role of pkc delta in the breast tumor cell lines was of particular interest, because contradictory reports exist in the literature regarding the role of pkc delta in cell survival and apoptosis. |
2003-12-11 |
2023-08-12 |
mouse |
| Siddharth Kaul, Arthi Kanthasamy, Masashi Kitazawa, Vellareddy Anantharam, Anumantha G Kanthasam. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511319. |
in the present study, we demonstrate that caspase-3 mediated proteolytic activation of protein kinase c delta (pkc delta) is critical in mpp+-induced oxidative stress and apoptosis. |
2003-12-05 |
2023-08-12 |
rat |
| Siddharth Kaul, Arthi Kanthasamy, Masashi Kitazawa, Vellareddy Anantharam, Anumantha G Kanthasam. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511319. |
together, we demonstrate for the first time that mpp+-induced oxidative stress proteolytically activates pkc delta in a caspase-3-dependent manner to induce apoptosis and up-regulate the caspase cascade in dopaminergic neuronal cells. |
2003-12-05 |
2023-08-12 |
rat |
| David Holzberg, C Graham Knight, Oliver Dittrich-Breiholz, Heike Schneider, Anneke Dörrie, Elke Hoffmann, Klaus Resch, Michael Krach. Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12832416. |
disruption of the c-jun-jnk complex by a cell-permeable peptide containing the c-jun delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes. |
2003-12-02 |
2023-08-12 |
human |
| Sastry Gollapudi, Michael J McCormick, Sudhir Gupt. Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cells. International journal of oncology. vol 22. issue 3. 2003-11-18. PMID:12579313. |
in this study we demonstrate that anti-cd95-induced apoptosis in t cells is associated with both depolarization of mitochondrial membrane potential (delta(psi)m) and increase in mitochondrial mass and activation of caspase-8 and caspase-3 but without caspase-9 activation. |
2003-11-18 |
2023-08-12 |
Not clear |
| Johan Saldeen, Linda Tillmar, Ella Karlsson, Nils Wels. Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis. Molecular and cellular biochemistry. vol 243. issue 1-2. 2003-11-18. PMID:12619896. |
these treatments also induce disruption of the mitochondrial membrane potential (delta psi(m)), as revealed using the mitochondrial probe jc-1, followed by parp cleavage and apoptosis all of which are inhibited by the anti-apoptotic protein bcl-2. |
2003-11-18 |
2023-08-12 |
mouse |
| Y Zhang, Y Chen, K Zhou, K Ca. [Mitochondrial mechanisms of CPT-induced apoptosis in nasopharyngeal carcinoma cells]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology. vol 15. issue 7. 2003-11-11. PMID:12541789. |
to understand whether cpt-induced apoptosis is related to the alteration of mitochondrial transmembrane potentials (delta psi m). |
2003-11-11 |
2023-08-12 |
Not clear |
| Tatsuji Hanej. [Protein phosphatases and nucleolin in osteoblastic cells: cleavage of nucleolin in apoptotic cells]. Kaibogaku zasshi. Journal of anatomy. vol 78. issue 3. 2003-11-07. PMID:14531277. |
our results indicate that pp1 delta directly binds to nucleolin in the nucleolus and that nucleolin is cleaved during apoptosis. |
2003-11-07 |
2023-08-12 |
human |
| J Wan, D Martinvalet, X Ji, C Lois, S M Kaech, U H Von Andrian, J Lieberman, R Ahmed, N Manjunat. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology. vol 110. issue 1. 2003-10-24. PMID:12941136. |
moreover, similar to bnip3-induced cell death, ctl apoptosis was associated with increased production of reactive oxygen species and decreased delta psi m. finally, retroviral transduction of bnip3 antisense rna diminished aicd in effector ctl. |
2003-10-24 |
2023-08-12 |
mouse |
| Dwayne M Baxa, Fayth K Yoshimur. Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha. Biochemical pharmacology. vol 66. issue 6. 2003-10-16. PMID:12963487. |
generation of the repressive activity of delta i kappa b alpha on nf-kappa b is a novel mechanism for the reduction of this transcription factor by genistein and the possible effect this may have on the ability of genistein to induce apoptosis in tumor cells. |
2003-10-16 |
2023-08-12 |
Not clear |
| Yi-He Ling, Leonard Liebes, Yiyu Zou, Roman Perez-Sole. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12821677. |
in pc-3 prostate carcinoma cells (with overexpression of bcl-2), a reduction of bortezomib-induced ros generation, delta psi m increase was correlated with cellular resistance to bortezomib and the attenuation of drug-induced apoptosis. |
2003-10-07 |
2023-08-12 |
human |
| Yi-He Ling, Leonard Liebes, Yiyu Zou, Roman Perez-Sole. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12821677. |
the transient transfection of wild type p53 in p53 null h358 cells caused stimulation of the bortezomib-induced apoptosis but failed to enhance ros generation and delta psi m increase. |
2003-10-07 |
2023-08-12 |
human |
| Yuichi Tanaka, M Veronica Gavrielides, Yasuhiro Mitsuuchi, Teruhiko Fujii, Marcelo G Kazaniet. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12824193. |
activation of protein kinase c (pkc) by phorbol esters or diacylglycerol mimetics induces apoptosis in androgen-dependent prostate cancer cells, an effect that involves both the activation of the classic pkc alpha and the novel pkc delta isozymes (fujii, t., garcía-bermejo, m. l., bernabó, j. l., caamaño, j., ohba, m., kuroki, t., li, l., yuspa, s. h., and kazanietz, m. g. (2000) j. biol. |
2003-10-07 |
2023-08-12 |
Not clear |
| David M Tillman, Kamel Izeradjene, Kinga Szekely Szucs, Leslie Douglas, Janet A Houghto. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941843. |
rottlerin, an inhibitor of novel isoforms of pkc, specifically pkc delta, sensitized five of six cell lines to trail-induced apoptosis, suggesting that pkc delta may be involved in the mechanism of trail resistance. |
2003-09-24 |
2023-08-12 |
human |
| David M Tillman, Kamel Izeradjene, Kinga Szekely Szucs, Leslie Douglas, Janet A Houghto. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941843. |
however, after 15-min incubation with rottlerin, mitochondrial membrane potential (delta psi m) was dramatically reduced in rko cells, and, in cells subsequently treated with trail, rapid apoptosis was evident within 8 h. calphostin c, but not go6976, also caused a decrease in delta psi m. in rko, rottlerin induced the release of cytochrome c, htra2/omi, smac/diablo, and aif from the mitochondria, potentiated in combination with trail, with concomitant caspase activation and down-regulation of xiap. |
2003-09-24 |
2023-08-12 |
human |
| Daya Upadhyay, Vijayalakshmi Panduri, Andrew Ghio, David W Kam. Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. American journal of respiratory cell and molecular biology. vol 29. issue 2. 2003-09-03. PMID:12600817. |
pm caused dose-dependent aec dna strand break formation, reductions in mitochondrial membrane potential (delta psi m), caspase 9 activation, and apoptosis. |
2003-09-03 |
2023-08-12 |
Not clear |
| Arti Shukla, Maria Stern, Karen M Lounsbury, Trisha Flanders, Brooke T Mossma. Asbestos-induced apoptosis is protein kinase C delta-dependent. American journal of respiratory cell and molecular biology. vol 29. issue 2. 2003-09-03. PMID:12626342. |
here, we report a functional role of protein kinase (pkc)delta in apoptosis by crocidolite asbestos. |
2003-09-03 |
2023-08-12 |
Not clear |
| Arti Shukla, Maria Stern, Karen M Lounsbury, Trisha Flanders, Brooke T Mossma. Asbestos-induced apoptosis is protein kinase C delta-dependent. American journal of respiratory cell and molecular biology. vol 29. issue 2. 2003-09-03. PMID:12626342. |
we first show that asbestos increases the kinase activity of pkc delta in alveolar type ii epithelial cells (c10 line) and causes its translocation to mitochondria, events associated with caspase-9 cleavage and apoptosis as detected by the apostain technique. |
2003-09-03 |
2023-08-12 |
Not clear |
| Arti Shukla, Maria Stern, Karen M Lounsbury, Trisha Flanders, Brooke T Mossma. Asbestos-induced apoptosis is protein kinase C delta-dependent. American journal of respiratory cell and molecular biology. vol 29. issue 2. 2003-09-03. PMID:12626342. |
asbestos-induced apoptosis also was inhibited in cells stably expressing a dominant-negative kinase-deficient mutant of pkc delta (dnpkc delta), but not dnpkc alpha. |
2003-09-03 |
2023-08-12 |
Not clear |