| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Axel Goerke, Norio Sakai, Elisabeth Gutjahr, Walter A Schlapkohl, J Frederic Mushinski, Hermann Haller, Walter Kolch, Naoaki Saito, Harald Mischa. Induction of apoptosis by protein kinase C delta is independent of its kinase activity. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12055197. |
in addition, a kinase-negative mutant of protein kinase c delta also induced apoptosis to the same extent as the wild type enzyme. |
2002-10-17 |
2023-08-12 |
Not clear |
| Hai-Tao Wang, Xiang-Liang Yang, Zhi-Hong Zhang, Jing-Ling Lu, Hui-Bi X. Reactive oxygen species from mitochondria mediate SW480 cells apoptosis induced by Na2SeO3. Biological trace element research. vol 85. issue 3. 2002-09-27. PMID:11934248. |
na2seo3 also caused the disruption of delta(psi)m. the intracellular ros increase and apoptosis induced by na2seo3 were significantly decreased by superoxide dismutase (sod), catalase. |
2002-09-27 |
2023-08-12 |
human |
| Céline Candé, Isabelle Cohen, Eric Daugas, Luigi Ravagnan, Nathanael Larochette, Naoufal Zamzami, Guido Kroeme. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie. vol 84. issue 2-3. 2002-09-26. PMID:12022952. |
intriguingly, hsp70 lacking abd (hsp70 delta abd) inhibits apoptosis induced by serum withdrawal, staurosporin, and menadione, three models of apoptosis which are also affected by micro-injection of anti-aif antibody or genetic ablation of aif. |
2002-09-26 |
2023-08-12 |
mouse |
| Robert J McKallip, Catherine Lombard, Billy R Martin, Mitzi Nagarkatti, Prakash S Nagarkatt. Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 302. issue 2. 2002-08-29. PMID:12130702. |
delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. |
2002-08-29 |
2023-08-12 |
mouse |
| Jürgen Bock, Ildikò Szabó, Andreas Jekle, Erich Gulbin. Actinomycin D-induced apoptosis involves the potassium channel Kv1.3. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150982. |
here, we demonstrate that cells genetically deficient for the potassium channel kv1.3 are resistant to apoptosis initiated by the cytostatic drug actinomycin d. retransfection of kv1.3 restores sensitivity of the cells to actinomycin d. cells lacking kv1.3 fail to respond to actinomycin d with dna fragmentation, release of cytochrome c, and loss of mitochondrial membrane potential (delta psi(m)), while cells functionally expressing kv1.3 rapidly undergo those changes indicative for apoptosis. |
2002-08-29 |
2023-08-12 |
Not clear |
| Chiharu Kawamura, Masahiro Kizaki, Yumi Fukuchi, Yasuo Iked. A metal chelator, diphenylthiocarbazone, induces apoptosis in acute promyelocytic leukemia (APL) cells mediated by a caspase-dependent pathway without a modulation of retinoic acid signaling pathways. Leukemia research. vol 26. issue 7. 2002-08-08. PMID:12008084. |
treatment of nb4 cells with dithizone markedly-induced apoptosis, which was associated with the loss of mitochondrial transmembrane potentials (delta psi(m)) and activation of caspase-3 and -9. |
2002-08-08 |
2023-08-12 |
human |
| Chiharu Kawamura, Masahiro Kizaki, Yumi Fukuchi, Yasuo Iked. A metal chelator, diphenylthiocarbazone, induces apoptosis in acute promyelocytic leukemia (APL) cells mediated by a caspase-dependent pathway without a modulation of retinoic acid signaling pathways. Leukemia research. vol 26. issue 7. 2002-08-08. PMID:12008084. |
we conclude that dithizone, a metal chelator, induced apoptosis without differentiation in apl cells in association with delta psi(m) collapse and caspase-3 and -9 activation. |
2002-08-08 |
2023-08-12 |
human |
| Sophie Derenne, Brett Monia, Nicholas M Dean, Jennifer K Taylor, Marie-Josée Rapp, Jean-Luc Harousseau, Régis Bataille, Martine Amio. Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. Blood. vol 100. issue 1. 2002-07-26. PMID:12070027. |
the decrease of cell viability induced by mcl-1 aso treatment was associated with an induction of apoptosis that occurred through the disruption of mitochondrial membrane potential delta psi m and the activation of executioner caspase-3. |
2002-07-26 |
2023-08-12 |
human |
| Carol Ward, Ian Dransfield, Joanna Murray, Stuart N Farrow, Christopher Haslett, Adriano G Ross. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055237. |
intriguingly, the sequential metabolites delta(12)pgj(2) and 15-deoxy-delta(12,) delta(14)-pgj(2) (15dpgj(2)) induced caspase-dependent apoptosis in both granulocytes, an effect that did not involve de novo protein synthesis. |
2002-07-16 |
2023-08-12 |
Not clear |
| Carol Ward, Ian Dransfield, Joanna Murray, Stuart N Farrow, Christopher Haslett, Adriano G Ross. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055237. |
despite the fact that delta(12)pgj(2) and 15dpgj(2) are peroxisome proliferator-activated receptor-gamma (ppar-gamma) activators, apoptosis was not mimicked by synthetic ppar-gamma and ppar-alpha ligands or blocked by an irreversible ppar-gamma antagonist. |
2002-07-16 |
2023-08-12 |
Not clear |
| Carol Ward, Ian Dransfield, Joanna Murray, Stuart N Farrow, Christopher Haslett, Adriano G Ross. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055237. |
furthermore, delta(12)pgj(2) and 15dpgj(2) inhibited lps-induced i kappa b alpha degradation and subsequent inhibition of neutrophil apoptosis, suggesting that apoptosis is mediated via ppar-gamma-independent inhibition of nf-kappa b activation. |
2002-07-16 |
2023-08-12 |
Not clear |
| No Soo Kim, Gyun Min Le. Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression. Journal of biotechnology. vol 95. issue 3. 2002-07-12. PMID:12007864. |
at 522 mosm x kg(-1), sh2-0.32-(delta)bcl-2 cells underwent a gradual cell death mainly through apoptosis due to the cytotoxic effect of hyperosmotic pressure. |
2002-07-12 |
2023-08-12 |
Not clear |
| No Soo Kim, Gyun Min Le. Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression. Journal of biotechnology. vol 95. issue 3. 2002-07-12. PMID:12007864. |
at 580 mosm x kg(-1), acute hyperosmotic pressure induced the rapid loss of viability in both sh2-0.32-(delta)bcl-2 and 14c6-bcl-2 cells through necrosis rather than through apoptosis. |
2002-07-12 |
2023-08-12 |
Not clear |
| Etsuko Yasugi, Isao Uemura, Tsukasa Kumagai, Yoshihisa Nishikawa, Sadao Yasugi, Akira Yu. Disruption of mitochondria is an early event during dolichyl monophosphate-induced apoptosis in U937 cells. Zoological science. vol 19. issue 1. 2002-06-26. PMID:12025407. |
the reduction in delta psi m was not inhibited by cyclosporin a, n-acetyl-l-cysteine and vitamin e. these results indicate that mitochondrial disruption is one of the first triggering events of dol-p-induced apoptosis. |
2002-06-26 |
2023-08-12 |
human |
| S S Smaili, Y T Hsu, R J Youle, J T Russel. Mitochondria in Ca2+ signaling and apoptosis. Journal of bioenergetics and biomembranes. vol 32. issue 1. 2002-06-11. PMID:11768760. |
in apoptosis signaling, collapse of delta(psi)m and cytochrome c release from mitochondria occur followed by activation of caspases, dna fragmentation, and cell death. |
2002-06-11 |
2023-08-12 |
Not clear |
| Vladimir L Gabai, Katsuhide Mabuchi, Dick D Mosser, Michael Y Sherma. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Molecular and cellular biology. vol 22. issue 10. 2002-06-04. PMID:11971973. |
an hsp72 mutant (hsp72 delta eevd) with a deletion of the four c-terminal amino acids, which are essential for the chaperone function, blocked tnf-induced apoptosis in a manner similar to that of normal hsp72 but did not inhibit heat shock-induced death. |
2002-06-04 |
2023-08-12 |
mouse |
| Vladimir L Gabai, Katsuhide Mabuchi, Dick D Mosser, Michael Y Sherma. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Molecular and cellular biology. vol 22. issue 10. 2002-06-04. PMID:11971973. |
in these cells neither normal hsp72 nor hsp72 delta eevd conferred additional protection from apoptosis, suggesting that hsp72 specifically affects bid-dependent but not bid-independent apoptotic pathways. |
2002-06-04 |
2023-08-12 |
mouse |
| C Amsellem, Durieu, M T Chambe, S Peyrol, Y Pachéc. In vitro expression of fas and CD40 and induction of apoptosis in human cystic fibrosis airway epithelial cells. Respiratory medicine. vol 96. issue 4. 2002-06-03. PMID:12000003. |
treatment of interferon gamma-stimulated cells with anti-fas resulted in apoptosis for about 80% of cft-2 (homozygous for delta f508 deletion) cells and for 35-40% of cft-1 (heterozygous) or normal cells. |
2002-06-03 |
2023-08-12 |
human |
| T J Grob, U Novak, C Maisse, D Barcaroli, A U Lüthi, F Pirnia, B Hügli, H U Graber, V De Laurenzi, M F Fey, G Melino, A Toble. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell death and differentiation. vol 8. issue 12. 2002-05-28. PMID:11753569. |
as anticipated, delta np73 is capable of regulating tap73 and p53 function since it is able to block their transactivation activity and their ability to induce apoptosis. |
2002-05-28 |
2023-08-12 |
mouse |
| Teresa Gómez del Pulgar, Guillermo Velasco, Cristina Sánchez, Amador Haro, Manuel Guzmá. De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. The Biochemical journal. vol 363. issue Pt 1. 2002-05-17. PMID:11903061. |
delta(9)-tetrahydrocannabinol (thc) and other cannabinoids have been shown to induce apoptosis of glioma cells via ceramide generation. |
2002-05-17 |
2023-08-12 |
Not clear |