| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koichi Niwa, Osamu Inanami, Tohru Yamamori, Toshio Ohta, Taku Hamasu, Takeshi Karino, Mikinori Kuwabar. Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. Free radical research. vol 36. issue 11. 2003-04-28. PMID:12592666. |
roles of protein kinase c delta in the accumulation of p53 and the induction of apoptosis in h2o2-treated bovine endothelial cells. |
2003-04-28 |
2023-08-12 |
cattle |
| Koichi Niwa, Osamu Inanami, Tohru Yamamori, Toshio Ohta, Taku Hamasu, Takeshi Karino, Mikinori Kuwabar. Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. Free radical research. vol 36. issue 11. 2003-04-28. PMID:12592666. |
to clarify the signaling pathways of oxidative stress-induced apoptosis in bovine aortic endothelial cells (baec), we treated cells with 1 mm h2o2 and investigated the roles of protein kinase c delta (pkc delta) and ca2+ in the accumulation of p53 associated with apoptosis. |
2003-04-28 |
2023-08-12 |
cattle |
| Koichi Niwa, Osamu Inanami, Tohru Yamamori, Toshio Ohta, Taku Hamasu, Takeshi Karino, Mikinori Kuwabar. Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. Free radical research. vol 36. issue 11. 2003-04-28. PMID:12592666. |
these results suggest that pkc delta contributes to the accumulation of p53 and that ca2+ plays a role in downstream signals of p53 leading to apoptosis in h2o2-treated baec. |
2003-04-28 |
2023-08-12 |
cattle |
| Bo Yang, Nino Keshelava, Clarke P Anderson, C Patrick Reynold. Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine. Cancer research. vol 63. issue 7. 2003-04-22. PMID:12670899. |
we determined in four nb cell lines cytotoxicity using the dimscan digital imaging fluorescence assay, glutathione (gsh) levels by the dtnb-gssg reductase method, apoptosis, reactive oxygen species (ros), and mitochondrial membrane potential (delta psi(m)) by flow cytometry. |
2003-04-22 |
2023-08-12 |
human |
| Bo Yang, Nino Keshelava, Clarke P Anderson, C Patrick Reynold. Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine. Cancer research. vol 63. issue 7. 2003-04-22. PMID:12670899. |
bso increased ros, decreased delta psi(m), and caused apoptosis in 20% o(2) (but not in 2% o(2)). |
2003-04-22 |
2023-08-12 |
human |
| Bo Yang, Nino Keshelava, Clarke P Anderson, C Patrick Reynold. Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine. Cancer research. vol 63. issue 7. 2003-04-22. PMID:12670899. |
in hypoxia, tpz alone or tpz + bso caused an 80% decrease of delta psi(m) at 24 h, preceding apoptosis in 74-86% of cells at 48 h. thus, hypoxia significantly antagonizes bso-mediated cytotoxicity for nb cell lines, but tpz reversed the inhibition of bso-mediated cytotoxicity in hypoxia, causing increased ros, delta psi(m) decrease, gsh depletion, apoptosis, and synergistic cytotoxicity. |
2003-04-22 |
2023-08-12 |
human |
| Frederic Luciano, Magali Herrant, Arnaud Jacquel, Jean-Ehrland Ricci, Patrick Auberge. The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 6. 2003-04-21. PMID:12586738. |
stable expression of the cleaved form of lyn (lyn-delta-n) in ramos b cells impairs bcr-mediated apoptosis as judged by loss of delta(psi)m, caspase activation and parp cleavage. |
2003-04-21 |
2023-08-12 |
Not clear |
| Timothy L Cover, Uma S Krishna, Dawn A Israel, Richard M Pee. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer research. vol 63. issue 5. 2003-04-01. PMID:12615708. |
in contrast, apoptosis was not induced after incubation with a chimeric s2/m1 toxin (in which the s1 sequence at the nh(2) terminus of vaca from strain 60190 was replaced with the s2 sequence from the nontoxigenic strain tx30a) or a vaca mutant protein (vaca delta 6-27) that lacks a unique strongly hydrophobic region near the vaca nh(2) terminus. |
2003-04-01 |
2023-08-12 |
Not clear |
| Amelia Cataldi, Sebastiano Miscia, Lucia Centurione, Monica Rapino, Domenico Bosco, Giovanna Grifone, Valentina Di Valerio, Francesco Garaci, Rosalba Ran. Role of nuclear PKC delta in mediating caspase-3-upregulation in Jurkat T leukemic cells exposed to ionizing radiation. Journal of cellular biochemistry. vol 86. issue 3. 2003-03-12. PMID:12210761. |
attention has been focused on the connections between nuclear pkc delta activation and the expression of cell death regulators (bcl-2 family proteins bad, bax and bcl-2) and cell death effector caspase-3 (cpp32) which lead to the cleavage of cytoskeletal and nuclear proteins and induction of apoptosis. |
2003-03-12 |
2023-08-12 |
Not clear |
| Priscilla Biswas, Marina Ferrarini, Barbara Mantelli, Claudio Fortis, Guido Poli, Adriano Lazzarin, Angelo A Manfred. Double-edged effect of Vgamma9/Vdelta2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection. European journal of immunology. vol 33. issue 1. 2003-03-12. PMID:12594854. |
both effects were mainly mediated by release of tnf-alpha and ifn-gamma from activated gamma delta lymphocytes, although fas-fasl interaction also contributed to u1 apoptosis. |
2003-03-12 |
2023-08-12 |
Not clear |
| David W Kamp, Vij ayalakshmi Panduri, Sigmund A Weitzman, Navdeep Chande. Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Molecular and cellular biochemistry. vol 234-235. issue 1-2. 2003-02-14. PMID:12162428. |
further, the delta(psi)m after 4 h was inversely proportional to the levels of apoptosis noted at 24 h as assessed by nuclear morphology as well as by dna nucleosome formation. |
2003-02-14 |
2023-08-12 |
Not clear |
| David W Kamp, Vij ayalakshmi Panduri, Sigmund A Weitzman, Navdeep Chande. Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Molecular and cellular biochemistry. vol 234-235. issue 1-2. 2003-02-14. PMID:12162428. |
a role for iron-derived ros was suggested by the finding that phytic acid, an iron chelator, blocked asbestos-induced reductions in a549 cell delta(psi)m and attenuated apoptosis. |
2003-02-14 |
2023-08-12 |
Not clear |
| David W Kamp, Vij ayalakshmi Panduri, Sigmund A Weitzman, Navdeep Chande. Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Molecular and cellular biochemistry. vol 234-235. issue 1-2. 2003-02-14. PMID:12162428. |
finally, overexpression of bcl-xl, an anti-apoptotic protein that localizes to the mitochondria, prevented asbestos-induced decreases in a549 cell delta(psi)m after 4 h and diminished apoptosis. |
2003-02-14 |
2023-08-12 |
Not clear |
| Yun Dai, Paul Dent, Steven Gran. Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A. Cell cycle (Georgetown, Tex.). vol 1. issue 2. 2003-01-07. PMID:12429924. |
an 18-hr exposure to 5 microm cgp74514a induced mitochondrial damage (i.e., loss of delta psi(m)) and apoptosis in multiple human leukemia cell lines (e.g., u937, hl-60, kg-1, ccrf-cem, raji, and thp; range 30-95%). |
2003-01-07 |
2023-08-12 |
human |
| Andrew P Garner, Claire R Weston, Daniel E Todd, Kathryn Balmanno, Simon J Coo. Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint. Oncogene. vol 21. issue 53. 2002-12-23. PMID:12444545. |
activation of delta mekk3:er* inhibited cell proliferation through a combination of an initial g1 and g2 cell cycle arrest, followed by a delayed onset of apoptosis. |
2002-12-23 |
2023-08-12 |
rat |
| Ismael Galve-Roperh, Daniel Rueda, Teresa Gómez del Pulgar, Guillermo Velasco, Manuel Guzmá. Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Molecular pharmacology. vol 62. issue 6. 2002-12-09. PMID:12435806. |
here, we show that in u373 mg human astrocytoma cells, cb(1) receptor activation with the cannabinoid agonist delta(8)-tetrahydrocannabinol dimethyl heptyl (hu-210) was coupled to erk activation and protection from ceramide-induced apoptosis. |
2002-12-09 |
2023-08-12 |
human |
| Rina Recchioni, Fiorella Marcheselli, Fausto Moroni, Carlo Pier. Apoptosis in human aortic endothelial cells induced by hyperglycemic condition involves mitochondrial depolarization and is prevented by N-acetyl-L-cysteine. Metabolism: clinical and experimental. vol 51. issue 11. 2002-11-27. PMID:12404184. |
we investigated whether the dissipation of mitochondrial transmembrane potential (delta(psi)(m)) was involved in apoptosis of cultured human aortic endothelial cells (haecs) exposed to hyperglycemic conditions (30 mmol/l glucose). |
2002-11-27 |
2023-08-12 |
human |
| Carla V Finkielstein, Lin G Chen, James L Malle. A role for G1/S cyclin-dependent protein kinases in the apoptotic response to ionizing radiation. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12176996. |
consistent with a role for cyclin a2 in apoptosis, the addition of delta n-cyclin a2-cdk2, but not full-length cyclin a2-cdk2, to xenopus egg extracts triggers apoptotic dna fragmentation even when caspases are not activated. |
2002-11-25 |
2023-08-12 |
xenopus_laevis |
| Axel Goerke, Norio Sakai, Elisabeth Gutjahr, Walter A Schlapkohl, J Frederic Mushinski, Hermann Haller, Walter Kolch, Naoaki Saito, Harald Mischa. Induction of apoptosis by protein kinase C delta is independent of its kinase activity. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12055197. |
induction of apoptosis by protein kinase c delta is independent of its kinase activity. |
2002-10-17 |
2023-08-12 |
Not clear |
| Axel Goerke, Norio Sakai, Elisabeth Gutjahr, Walter A Schlapkohl, J Frederic Mushinski, Hermann Haller, Walter Kolch, Naoaki Saito, Harald Mischa. Induction of apoptosis by protein kinase C delta is independent of its kinase activity. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12055197. |
here we show that at least one protein kinase c function, the induction of apoptosis by protein kinase c delta, is independent of the kinase activity. |
2002-10-17 |
2023-08-12 |
Not clear |