| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R King, F F Rommerts, S L Ford, J C Hutson, J Orly, D M Stocc. Ethane dimethane sulfonate and NNN'N'-tetrakis-(2-pyridylmethyl)ethylenediamine inhibit steroidogenic acute regulatory (StAR) protein expression in MA-10 Leydig cells and rat Sertoli cells. Endocrine research. vol 24. issue 3-4. 1999-04-13. PMID:9888527. |
we conclude 1) steroidogenesis and accumulation of mature star protein are inhibited as a consequence of the induction of apoptosis; 2) reduced levels of star may be partially attributed to inhibition of import because of the loss of delta psi; 3) loss of steroidogenesis is probably due to loss of star synthesis and disruption of delta psi. |
1999-04-13 |
2023-08-12 |
mouse |
| C Merkle, M Fritsche, M Mundt, R Jähne, B Grone. Transcriptional regulation and induction of apoptosis: implications for the use of monomeric p53 variants in gene therapy. Gene therapy. vol 5. issue 12. 1999-03-09. PMID:10023442. |
upon induction, wild-type p53 expressing cells, but not p53 delta 326 expressing cells underwent apoptosis. |
1999-03-09 |
2023-08-12 |
human |
| H Kitagawa, E Tani, H Ikemoto, I Ozaki, A Nakano, S Omur. Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells. FEBS letters. vol 443. issue 2. 1999-03-02. PMID:9989601. |
nonetheless, there were no significant alterations in levels of immunoreactive bcl-2, bcl-x(l), bax, bad, and bak, nor any evidence of cytochrome c release into cytosol and dissipation of delta(psi)m. thus, the proteasome inhibitor-induced apoptosis is mediated by a mitochondria-independent mechanism, and the once activated caspase-3 does not cause the cytochrome c release and the delta(psi)m disruption. |
1999-03-02 |
2023-08-12 |
human |
| J Zhuang, G M Cohe. Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumour cells. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022243. |
apoptosis, induced in human monocytic thp.1 cells by etoposide and n-tosyl-l-phenylalanyl chloromethyl ketone, was accompanied by the processing/activation of caspases, externalisation of phosphatidylserine (ps) and reduction in mitochondrial membrane potential (delta psi(m)). |
1999-02-25 |
2023-08-12 |
human |
| J Zhuang, G M Cohe. Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumour cells. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022243. |
the caspase inhibitor, benzyloxycarbonyl-val-ala-asp (ome) fluoromethyl ketone (z-vad.fmk) blocked the activation of caspases, ps exposure and the reduction in delta psi(m) as well as the morphological changes associated with apoptosis but it did not inhibit the release of mitochondrial cytochrome c. these results suggest that the execution phase of chemical-induced apoptosis in thp.1 cells may be initiated following mitochondrial damage resulting in release of cytochrome c leading to activation of caspase-9 and then activation of effector caspases-3 and -7. |
1999-02-25 |
2023-08-12 |
human |
| S Tada-Oikawa, S Oikawa, M Kawanishi, M Yamada, S Kawanish. Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation-induced apoptosis. FEBS letters. vol 442. issue 1. 1999-02-11. PMID:9923606. |
these findings suggest that dna damage by duocarmycin a induces h2o2 generation, which causes delta psi m loss and subsequently caspase-3 activation, resulting in apoptosis. |
1999-02-11 |
2023-08-12 |
human |
| V P Dave, R Keefe, M A Berger, K Drbal, J A Punt, D L Wiest, B Alarcon, D J Kappe. Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement. International immunology. vol 10. issue 10. 1999-02-03. PMID:9796915. |
here we explore the capacity of tcr-cd3 signaling complexes expressed on delta degrees thymocytes to mediate the following functional outcomes in response to antibody cross-linking: (i) the transition from the cd4-cd8- to cd4+cd8+ stage, (ii) the transition from the cd4+cd8+ to cd4+cd8- or cd4-cd8+ stages and (iii) the induction of apoptosis. |
1999-02-03 |
2023-08-12 |
mouse |
| V P Dave, R Keefe, M A Berger, K Drbal, J A Punt, D L Wiest, B Alarcon, D J Kappe. Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement. International immunology. vol 10. issue 10. 1999-02-03. PMID:9796915. |
depending on the nature of the secondary stimulus, delta degrees thymocytes can be induced to undergo apoptosis or preferential maturation to the cd4-cd8+ stage. |
1999-02-03 |
2023-08-12 |
mouse |
| J Zhuang, D Dinsdale, G M Cohe. Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential. Cell death and differentiation. vol 5. issue 11. 1998-12-30. PMID:9846182. |
induction of apoptosis in human monocytic thp.1 cells by etoposide or n-tosyl-l-phenylalanyl chloromethyl ketone resulted in release of mitochondrial cytochrome c, formation of ultracondensed mitochondria, development of outer mitochondrial membrane discontinuities and a reduction in mitochondrial membrane potential (delta psi m), as well as externalisation of phosphatidylserine, caspase-3 and -7 activation, proteolysis of poly(adp-ribose) polymerase and lamin b1. |
1998-12-30 |
2023-08-12 |
human |
| J Zhuang, D Dinsdale, G M Cohe. Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential. Cell death and differentiation. vol 5. issue 11. 1998-12-30. PMID:9846182. |
thus apoptosis is characterised by release of mitochondrial cytochrome c prior to formation of ultracondensed mitochondria and a reduction in delta psi m and by a mechanism independent of rupture of the outer mitochondrial membrane. |
1998-12-30 |
2023-08-12 |
human |
| H W Sohn, E Y Choi, S H Kim, I S Lee, D H Chung, U A Sung, D H Hwang, S S Cho, B H Jun, J J Jang, J G Chi, S H Par. Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells. The American journal of pathology. vol 153. issue 6. 1998-12-29. PMID:9846983. |
these results suggest that cd99 engagement induce csa-inhibitable mitochondrial permeability transition pore opening, followed by a reduction of delta psi m and caspase activation, thereby leading to apoptosis. |
1998-12-29 |
2023-08-12 |
Not clear |
| J M Le. Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation. Oncogene. vol 17. issue 13. 1998-11-17. PMID:9796694. |
in this report we find that p53-dependent apoptosis proceeds through a pathway involving depolarization of the mitochondrial electropotential gradient (delta(psi)m) and the generation of reactive oxygen species (ros). |
1998-11-17 |
2023-08-12 |
mouse |
| J M Le. Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation. Oncogene. vol 17. issue 13. 1998-11-17. PMID:9796694. |
kit activation suppresses p53-induced apoptosis in the mouse dp16 friend erythroleukemia cell line by preventing delta(psi)m depolarization and ros generation. |
1998-11-17 |
2023-08-12 |
mouse |
| S Fulda, S A Susin, G Kroemer, K M Debati. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer research. vol 58. issue 19. 1998-11-03. PMID:9766678. |
in contrast to caspase-8, cleavage of caspase-3 or poly(adp-ribose)polymerase was always restricted to delta psi(m)low cells, downstream of the bcl-2- or bcl-x(l)-controlled checkpoint of apoptosis. |
1998-11-03 |
2023-08-12 |
Not clear |
| I Marzo, C Brenner, G Kroeme. The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 52. issue 6. 1998-10-21. PMID:9755823. |
first, in intact cells, apoptosis is accompanied by an early dissipation of the mitochondrial transmembrane potential (delta psi m). |
1998-10-21 |
2023-08-12 |
Not clear |
| I Marzo, C Brenner, G Kroeme. The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 52. issue 6. 1998-10-21. PMID:9755823. |
in several models of apoptosis, specific agents inhibiting the mitochondrial megachannels prevent this delta psi m dissipation and simultaneously abolish the manifestations of caspase- and endonuclease activation, indicating that megachannel opening is a critical event of the apoptotic process. |
1998-10-21 |
2023-08-12 |
Not clear |
| M Villalb. A possible role for PKC delta in cerebellar granule cells apoptosis. Neuroreport. vol 9. issue 10. 1998-10-14. PMID:9694232. |
a possible role for pkc delta in cerebellar granule cells apoptosis. |
1998-10-14 |
2023-08-12 |
rat |
| M Villalb. A possible role for PKC delta in cerebellar granule cells apoptosis. Neuroreport. vol 9. issue 10. 1998-10-14. PMID:9694232. |
here i show that pkc delta, which has been involved in apoptosis in different cell lines, is constitutively cleaved in cgc, suggesting that its catalytic subunit is active per se. |
1998-10-14 |
2023-08-12 |
rat |
| M Villalb. A possible role for PKC delta in cerebellar granule cells apoptosis. Neuroreport. vol 9. issue 10. 1998-10-14. PMID:9694232. |
a model is proposed where, in the absence of survival signals, activated pkc delta induces cyclin d1 expression and accumulation in the nucleus, which subsequently, would lead to an aborted cell cycle and apoptosis. |
1998-10-14 |
2023-08-12 |
rat |
| W G Tatton, R M Chalmers-Redma. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749585. |
a decrease in mitochondrial membrane potential (delta psim) causing opening of the permeability transition pore (ptp) in mitochondrial membranes has been implicated as a critical effector of apoptosis in a variety of non-neural cells. |
1998-10-07 |
2023-08-12 |
Not clear |