| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Wert, H C Palfre. Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. The Biochemical journal. vol 352 Pt 1. 2001-01-25. PMID:11062070. |
a role for pkc delta was confirmed in pc12 cells expressing a dominant-negative pkcdelta fragment, in which reversal of apoptosis by bfgf was partially blocked. |
2001-01-25 |
2023-08-12 |
Not clear |
| N Yanase, K Ohshima, H Ikegami, J Mizuguch. Cytochrome c release, mitochondrial membrane depolarization, caspase-3 activation, and Bax-alpha cleavage during IFN-alpha-induced apoptosis in Daudi B lymphoma cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 20. issue 12. 2001-01-25. PMID:11152579. |
ifn-alpha-induced apoptosis occurred 48 h after stimulation, with a further increase in proportion up to 72 h. pretreatment with pancaspase inhibitor z-vad-fmk substantially inhibited the ifn-alpha-mediated bax-alpha cleavage and apoptosis, but not the decline in delta psi(m), suggesting the possibility that caspase-3 activation is implicated in the bax-alpha cleavage, probably leading to amplification of the apoptotic processes. |
2001-01-25 |
2023-08-12 |
Not clear |
| M Sumitomo, R Shen, J S Goldberg, J Dai, D Navarro, D M Nanu. Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase C delta degradation. Cancer research. vol 60. issue 23. 2001-01-11. PMID:11118039. |
neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase c delta degradation. |
2001-01-11 |
2023-08-12 |
Not clear |
| S Ko, W F Yuen, K P Fung, C Y Lee, Y M Choy, H K Cheng, T T Kwok, S K Kon. Reversal of TNF-alpha resistance by hyperthermia: role of mitochondria. Life sciences. vol 67. issue 25. 2001-01-11. PMID:11125848. |
based on the results from flow cytometry and western blotting, hyperthermia (43 degrees c, 3 h) was found to induce apoptosis, mitochondrial potential (delta psi(m)) depolarization and release of cytochrome c in l929-11e cells. |
2001-01-11 |
2023-08-12 |
Not clear |
| J A Sakoff, S P Acklan. Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells. Cancer chemotherapy and pharmacology. vol 46. issue 6. 2001-01-04. PMID:11138461. |
in conclusion, cell death induced by ts inhibition is mediated via the apoptotic pathway which clearly involves biphasic alterations in delta psi m. in l1210 cells, but not in hl60 cells, caspases function as the final executioner of apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |
| I C Park, M J Park, C S Hwang, C H Rhee, D Y Whang, J J Jang, T B Choe, S I Hong, S H Le. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells. Cancer letters. vol 158. issue 2. 2000-10-31. PMID:10960761. |
protein kinase c (pkc) delta was cleaved to its characteristic 40 kda fragment in a caspase-3-dependent manner; on the other hand pkc zeta was cleaved to approximately 40 kda independently of caspase-3 in the drug-induced apoptosis of the cells. |
2000-10-31 |
2023-08-12 |
human |
| Y Yokoyama, M Saito, T Saito, T Yuguchi, M Sawataishi, T Sakamoto, K Tazawa, K Tsukad. Synergistic antiproliferative effect of delta 12-prostaglandin J2 (delta 12-PGJ2) and hyperthermia on human esophageal cancer cell lines. Human cell. vol 13. issue 1. 2000-10-19. PMID:10937344. |
in this study, the combined effect of delta 12-pgj2 and hyperthermia on six established cell lines of human esophageal carcinoma (sgf series) was analyzed by an in vitro assay, and the degree of apoptosis induced by this combination was examined to clarify the mechanism of supra-additive effects. |
2000-10-19 |
2023-08-12 |
human |
| Y Yokoyama, M Saito, T Saito, T Yuguchi, M Sawataishi, T Sakamoto, K Tazawa, K Tsukad. Synergistic antiproliferative effect of delta 12-prostaglandin J2 (delta 12-PGJ2) and hyperthermia on human esophageal cancer cell lines. Human cell. vol 13. issue 1. 2000-10-19. PMID:10937344. |
the supra-additive combined effect of delta 12-pgj2 and hyperthermia on esophageal cancer cells is attributed to the synergistic induction of apoptosis. |
2000-10-19 |
2023-08-12 |
human |
| Y Yokoyama, M Saito, T Saito, T Yuguchi, M Sawataishi, T Sakamoto, K Tazawa, K Tsukad. Synergistic antiproliferative effect of delta 12-prostaglandin J2 (delta 12-PGJ2) and hyperthermia on human esophageal cancer cell lines. Human cell. vol 13. issue 1. 2000-10-19. PMID:10937344. |
delta 12-pgj2 induced g1 accumulation and apoptosis was induced by delta 12-pgj2 from g1 phase. |
2000-10-19 |
2023-08-12 |
human |
| Y Yokoyama, M Saito, T Saito, T Yuguchi, M Sawataishi, T Sakamoto, K Tazawa, K Tsukad. Synergistic antiproliferative effect of delta 12-prostaglandin J2 (delta 12-PGJ2) and hyperthermia on human esophageal cancer cell lines. Human cell. vol 13. issue 1. 2000-10-19. PMID:10937344. |
both augmented g1 arrest followed by g1 phase-selective induction of apoptosis and increased apoptotic induction without cell-cycle specificity are responsible for the synergism of combined treatment with delta 12-pgj2 and hyperthermia. |
2000-10-19 |
2023-08-12 |
human |
| T Tanaka, I Tsujio, T Nishikawa, K Shinosaki, T Kudo, M Taked. Significance of tau phosphorylation and protein kinase regulation in the pathogenesis of Alzheimer disease. Alzheimer disease and associated disorders. vol 14 Suppl 1. 2000-10-17. PMID:10850726. |
it is suggested that fragmentation of protein kinase c delta during the process of apoptosis results in the phosphorylation and the inactivation of gsk-3. |
2000-10-17 |
2023-08-12 |
human |
| G Kroeme. Mitochondrial control of apoptosis: an overview. Biochemical Society symposium. vol 66. 2000-09-26. PMID:10989652. |
first, in intact cells, apoptosis is accompanied by an early dissipation of the mitochondrial transmembrane potential, delta psi m. in several models of apoptosis, specific agents inhibiting the mitochondrial pt pore abolish this dissipation of the delta psi m and simultaneously prevent activation of downstream caspases and endonucleases, indicating that pt pore opening can be a critical event of the apoptotic process. |
2000-09-26 |
2023-08-12 |
Not clear |
| H M Shapir. Membrane potential estimation by flow cytometry. Methods (San Diego, Calif.). vol 21. issue 3. 2000-09-21. PMID:10873481. |
mitochondrial delta psi is reduced when energy metabolism is disrupted, notably in apoptosis. |
2000-09-21 |
2023-08-12 |
Not clear |
| S Salvioli, J Dobrucki, L Moretti, L Troiano, M G Fernandez, M Pinti, J Pedrazzi, C Franceschi, A Cossarizz. Mitochondrial heterogeneity during staurosporine-induced apoptosis in HL60 cells: analysis at the single cell and single organelle level. Cytometry. vol 40. issue 3. 2000-08-25. PMID:10878561. |
the responsibility of modifications in mitochondrial membrane potential (delta psi) in triggering apoptosis is under investigation. |
2000-08-25 |
2023-08-12 |
Not clear |
| P K Majumder, P Pandey, X Sun, K Cheng, R Datta, S Saxena, S Kharbanda, D Kuf. Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. The Journal of biological chemistry. vol 275. issue 29. 2000-08-24. PMID:10818086. |
mitochondrial translocation of protein kinase c delta in phorbol ester-induced cytochrome c release and apoptosis. |
2000-08-24 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, P Pérez-Galán, P Lasierra, D Johnson, A Piñeiro, J Nava. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Experimental cell research. vol 258. issue 1. 2000-08-08. PMID:10912804. |
cotreatment of cells with the caspase inhibitors ac-devd-cho, z-vdvad-fmk, z-ietd-fmk, and z-lehd-fmk alone or in combination, or overexpression of crma, prevented many morphological features of apoptosis but not loss of mitochondrial membrane potential (delta(psi)m), phospatidilserine exposure, and cell death. |
2000-08-08 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, P Pérez-Galán, P Lasierra, D Johnson, A Piñeiro, J Nava. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Experimental cell research. vol 258. issue 1. 2000-08-08. PMID:10912804. |
these results, taken together, suggest that the key mediator of doxorubicin-induced apoptosis in jurkat cells may be an inducible, z-vad-sensitive caspase (caspase-x), which would cause delta(psi)m loss, release of apoptogenic factors from mitochondria, and cell death. |
2000-08-08 |
2023-08-12 |
Not clear |
| H Walczak, A Bouchon, H Stahl, P H Kramme. Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells. Cancer research. vol 60. issue 11. 2000-06-30. PMID:10850456. |
we show here that trail-induced apoptosis involves late dissipation of mitochondrial membrane potential (delta psi(m)) and cytochrome c release. |
2000-06-30 |
2023-08-12 |
Not clear |
| R B Evans-Storms, J A Cidlowsk. Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: the role of nuclear factor-kappaB. Endocrinology. vol 141. issue 5. 2000-05-23. PMID:10803596. |
dexamethasone treatment blocked a decrease in this potential (delta psi(m)) during serum deprivation induced apoptosis in htc cells, indicating an action of this hormone upstream of mitochondria. |
2000-05-23 |
2023-08-12 |
rat |
| I Dal Pra, J F Whitfield, A Chiarini, U Armat. Increased activity of the protein kinase C-delta holoenzyme in the cytoplasmic particulate fraction precedes the activation of caspases in polyomavirus-transformed pyF111 rat fibroblasts exposed to calphostin C or topoisomerase-II inhibitors. Experimental cell research. vol 255. issue 2. 2000-04-24. PMID:10694433. |
a caspase-mediated release of the 40-kda catalytic fragment of the delta isoform (cf-delta) of protein kinase c (pkc-delta) is involved in apoptosis, but its actual role in apoptosis development is still unknown. |
2000-04-24 |
2023-08-12 |
rat |