| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Böhler, J Waiser, H Hepburn, J Gaedeke, C Lehmann, P Hambach, K Budde, H H Neumaye. TNF-alpha and IL-1alpha induce apoptosis in subconfluent rat mesangial cells. Evidence for the involvement of hydrogen peroxide and lipid peroxidation as second messengers. Cytokine. vol 12. issue 7. 2000-09-08. PMID:10880243. |
these results provide evidence that tnf-alpha and il-1alpha induce apoptosis in rat mc with hydrogen peroxide and lipid peroxidation as second messengers. |
2000-09-08 |
2023-08-12 |
rat |
| Y H Lee, S Y Kim, J R Kim, K T Yoh, S H Baek, M J Kim, S H Ryu, P G Suh, J H Ki. Overexpression of phospholipase Cbeta-1 protects NIH3T3 cells from oxidative stress-induced cell death. Life sciences. vol 67. issue 7. 2000-09-07. PMID:10968412. |
oxidative stress has been implicated in a wide range of cellular damage which includes dna oxidation, membrane lipid peroxidation, and apoptosis. |
2000-09-07 |
2023-08-12 |
Not clear |
| S K Manna, A Mukhopadhyay, B B Aggarwa. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 12. 2000-07-20. PMID:10843709. |
resveratrol suppresses tnf-induced activation of nuclear transcription factors nf-kappa b, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. |
2000-07-20 |
2023-08-12 |
Not clear |
| J Li, C Y Huang, R L Zheng, K R Cui, J F L. Hydrogen peroxide induces apoptosis in human hepatoma cells and alters cell redox status. Cell biology international. vol 24. issue 1. 2000-07-10. PMID:10826769. |
the h2o2 downregulation of gsh may be more important for apoptosis than h2o2 induction of lipid peroxidation, and the h2o2 induced changes in redox status of the cell may be among the original events which lead up to other biochemical changes. |
2000-07-10 |
2023-08-12 |
human |
| G Lizard, C Miguet, G Besséde, S Monier, S Gueldry, D Neel, P Gamber. Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. Free radical biology & medicine. vol 28. issue 5. 2000-05-25. PMID:10754270. |
previous investigations of our laboratory have shown that 7-ketocholesterol was a potent inducer of apoptosis involving a release of cytochrome c into the cytosol, and a lipid peroxidation process that could be the consequence of a production of radical oxygen species. |
2000-05-25 |
2023-08-12 |
Not clear |
| P Seth, R Kumari, S Madhavan, A K Singh, H Mani, K K Banaudha, S C Sharma, D K Kulshreshtha, R K Maheshwar. Prevention of renal ischemia-reperfusion-induced injury in rats by picroliv. Biochemical pharmacology. vol 59. issue 10. 2000-05-17. PMID:10736432. |
picroliv-pretreated rats exhibited lower lipid peroxidation, improved antioxidant status, and reduced apoptosis, indicating better viability of renal cells. |
2000-05-17 |
2023-08-12 |
rat |
| M Igarashi, T Miyazaw. Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? Biochemical and biophysical research communications. vol 270. issue 2. 2000-05-08. PMID:10753678. |
do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? |
2000-05-08 |
2023-08-12 |
human |
| M Igarashi, T Miyazaw. Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? Biochemical and biophysical research communications. vol 270. issue 2. 2000-05-08. PMID:10753678. |
cepa and cdha have been demonstrated in cultured cells to cause cell death via lipid peroxidation and apoptosis in the absence of alpha-tocopherol. |
2000-05-08 |
2023-08-12 |
human |
| L J Mi, K M Mak, C S Liebe. Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC). Alcoholism, clinical and experimental research. vol 24. issue 2. 2000-05-02. PMID:10698373. |
this effect appears to be mediated by the induction of hepatic cytochrome p-4502e1(cyp2e1) and its generation of free radicals, which results in an enhanced lipid peroxidation that initiates apoptosis. |
2000-05-02 |
2023-08-12 |
rat |
| T Huang, A G Cheng, H Stupak, W Liu, A Kim, H Staecker, P P Lefebvre, B Malgrange, R Kopke, G Moonen, T R Van De Wate. Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 2-3. 2000-04-28. PMID:10715580. |
we present several approaches for the prevention of auditory sensory loss from reactive oxygen species-induced apoptosis: 1) preventing the formation of reactive oxygen species; (2) neutralizing the toxic products of membrane lipid peroxidation; and 3) blocking the damaged sensory cells' apoptotic pathway. |
2000-04-28 |
2023-08-12 |
Not clear |
| P G Fallon, E J Richardson, P Smith, D W Dunn. Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice. European journal of immunology. vol 30. issue 2. 2000-03-14. PMID:10671202. |
the livers of depleted mice had similar levels of apoptosis as control infected mice but had a marked increase in lipid peroxidation indicative of their livers being under oxidative stress. |
2000-03-14 |
2023-08-12 |
mouse |
| S S Biswal, K Datta, S D Shaw, X Feng, J D Robertson, J P Kehre. Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 53. issue 1. 2000-02-15. PMID:10653524. |
this was supported by the findings that glutathione disulfide levels were increased by 4 h following treatment with 10 microm ndga, that pretreatment with n-acetylcysteine completely blocked the ndga-induced loss of membrane potential and apoptosis, and that lipid peroxidation was enhanced in cells treated with ndga. |
2000-02-15 |
2023-08-12 |
Not clear |
| Y Ito, M Arakawa, K Ishige, H Fukud. Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells. Neuroscience research. vol 35. issue 4. 2000-02-07. PMID:10617323. |
the lipid peroxidation product, 4-hydroxynonenal (hne), has been shown to induce apoptosis in pc12 cells and hippocampal neurons. |
2000-02-07 |
2023-08-12 |
Not clear |
| U N Da. Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins, leukotrienes, and essential fatty acids. vol 61. issue 3. 2000-02-04. PMID:10582655. |
essential fatty acids, lipid peroxidation and apoptosis. |
2000-02-04 |
2023-08-12 |
Not clear |
| U N Da. Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins, leukotrienes, and essential fatty acids. vol 61. issue 3. 2000-02-04. PMID:10582655. |
phosphorylation of bcl-2 inhibits its ability to interfere with apoptosis and enhances lipid peroxidation leading to the occurrence of apoptosis. |
2000-02-04 |
2023-08-12 |
Not clear |
| U N Da. Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins, leukotrienes, and essential fatty acids. vol 61. issue 3. 2000-02-04. PMID:10582655. |
based on these results, it is suggested that long-chain fatty acids induce apoptosis by enhancing lipid peroxidation, suppressing bcl-2 expression possibly by phosphorylation and augmentation of p450 activity. |
2000-02-04 |
2023-08-12 |
Not clear |
| H L Borges, R Linde. Gamma irradiation leads to two waves of apoptosis in distinct cell populations of the retina of newborn rats. Journal of cell science. vol 112 ( Pt 23). 2000-02-03. PMID:10564649. |
the antioxidant pyrrolidinedithiocarbamate prevented the early but not the late wave of apoptosis following irradiation, and blocked lipid peroxidation at 6 hours after the insult, suggesting that the two waves of apoptosis are indeed mediated by distinct mechanisms. |
2000-02-03 |
2023-08-12 |
rat |
| F Galli, S Rovidati, S Benedetti, F Canestrari, B Ferraro, A Floridi, U Buoncristian. Lipid peroxidation, leukocyte function and apoptosis in hemodialysis patients treated with vitamin E-modified filters. Contributions to nephrology. vol 127. 2000-01-28. PMID:10629785. |
lipid peroxidation, leukocyte function and apoptosis in hemodialysis patients treated with vitamin e-modified filters. |
2000-01-28 |
2023-08-12 |
Not clear |
| L C Park, N Y Calingasan, K Uchida, H Zhang, G E Gibso. Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617112. |
among the cell types tested, only in neurons did td induce apoptosis and cause the accumulation of 4-hydroxy-2-nonenal, a lipid peroxidation product. |
2000-01-18 |
2023-08-12 |
Not clear |
| S Camandola, G Poli, M P Mattso. The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617117. |
the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal (hne) is increasingly implicated in the disruption of neuronal calcium homeostasis that occurs in various paradigms of neuronal excitotoxicity and apoptosis. |
2000-01-18 |
2023-08-12 |
rat |