| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengfei Liu, Joy C Yang, Cameron M Armstrong, Wei Lou, Liangren Liu, Xiaomin Qiu, Binhao Zou, Alan P Lombard, Leandro S D'Abronzo, Christopher P Evans, Allen C Ga. AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer. Molecular cancer therapeutics. vol 18. issue 10. 2020-06-09. PMID:31308078. |
in addition, bioinformatical analysis of indomethacin-treated resistant cells revealed that indomethacin significantly activates the unfolded protein response, p53, and apoptosis pathways, and suppresses cell-cycle, myc, and ar/arv7 pathways. |
2020-06-09 |
2023-08-13 |
Not clear |
| b' Clara Recasens-Zorzo, Teresa Cardesa-Salzmann, Paolo Petazzi, Laia Ros-Blanco, Anna Esteve-Arenys, Guillem Clot, Martina Guerrero-Hern\\xc3\\xa1ndez, Vanina Rodr\\xc3\\xadguez, Davide Soldini, Alexandra Valera, Alexandra Moros, Fina Climent, Eva Gonz\\xc3\\xa1lez-Barca, Santiago Mercadal, Leonor Arenillas, Xavier Calvo, Jos\\xc3\\xa9 Lu\\xc3\\xads Mate, Gonzalo Guti\\xc3\\xa9rrez-Garc\\xc3\\xada, Isolda Casanova, Ram\\xc3\\xb3n Mangues, Alejandra Sanjuan-Pla, Clara Bueno, Pablo Men\\xc3\\xa9ndez, Antonio Mart\\xc3\\xadnez, Dolors Colomer, Roger Estrada Tejedor, Jordi Teixid\\xc3\\xb3, Elias Campo, Armando L\\xc3\\xb3pez-Guillermo, Jos\\xc3\\xa9 Ignacio Borrell, Luis Colomo, Patricia P\\xc3\\xa9rez-Gal\\xc3\\xa1n, Ga\\xc3\\xabl Rou\\xc3\\xa. Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma. Haematologica. vol 104. issue 4. 2020-05-06. PMID:29954928.' |
in a xenotransplant model of diffuse large b-cell lymphoma, the combination of iqs-01.01rs and cpi203 decreased tumor burden through myc and p-akt downregulation, and enhanced the induction of apoptosis. |
2020-05-06 |
2023-08-13 |
Not clear |
| Samantha Littler, Olivia Sloss, Bethany Geary, Andrew Pierce, Anthony D Whetton, Stephen S Taylo. Oncogenic MYC amplifies mitotic perturbations. Open biology. vol 9. issue 8. 2020-04-30. PMID:31455158. |
the oncogenic transcription factor myc modulates vast arrays of genes, thereby influencing numerous biological pathways including biogenesis, metabolism, proliferation, apoptosis and pluripotency. |
2020-04-30 |
2023-08-13 |
Not clear |
| Yangle Li, Xiongbing Zu, Xiheng Hu, Long Wang, Wei H. Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-04-06. PMID:31761897. |
cell survival, clone formation, cell cycle, and cell apoptosis were assessed, and the myc pathway was verified. |
2020-04-06 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
dznep-mediated apoptosis in b-cell lymphoma is independent of the lymphoma type, ezh2 mutation status and myc, bcl2 or bcl6 translocations. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
we aimed to address the impact of the lymphoma type, ezh2 mutation status, as well as myc, bcl2 and bcl6 translocations on the sensitivity of the lymphoma cell lines to dznep-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
we show that dznep inhibits proliferation and induces apoptosis of these cell lines independent of the type of lymphoma, the ezh2 mutation status and the myc, bcl2 and bcl6 rearrangement status. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
although ezh2, myc, bcl2 and bcl6 are important prognostic biomarkers for lymphomas, our study shows that they poorly influence the sensitivity of lymphoma cell lines to dznep-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Jennifer Hüllein, Mikołaj Słabicki, Maciej Rosolowski, Alexander Jethwa, Stefan Habringer, Katarzyna Tomska, Roma Kurilov, Junyan Lu, Sebastian Scheinost, Rabea Wagener, Zhiqin Huang, Marina Lukas, Olena Yavorska, Hanne Helfrich, René Scholtysik, Kyle Bonneau, Donato Tedesco, Ralf Küppers, Wolfram Klapper, Christiane Pott, Stephan Stilgenbauer, Birgit Burkhardt, Markus Löffler, Lorenz H Trümper, Michael Hummel, Benedikt Brors, Marc Zapatka, Reiner Siebert, Markus Kreuz, Ulrich Keller, Wolfgang Huber, Thorsten Zen. MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma. Cancer research. vol 79. issue 12. 2020-03-11. PMID:31000522. |
oncogenic myc activation promotes proliferation in burkitt lymphoma, but also induces cell-cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of burkitt lymphoma cases. |
2020-03-11 |
2023-08-13 |
Not clear |
| Stefanie Schmidt, David Gay, Friedrich Wilhelm Uthe, Sarah Denk, Madelon Paauwe, Niels Matthes, Markus Elmar Diefenbacher, Sheila Bryson, Fiona Clare Warrander, Florian Erhard, Carsten Patrick Ade, Apoorva Baluapuri, Susanne Walz, Rene Jackstadt, Catriona Ford, Georgios Vlachogiannis, Nicola Valeri, Christoph Otto, Christina Schülein-Völk, Katja Maurus, Werner Schmitz, John Raymond Philip Knight, Elmar Wolf, Douglas Strathdee, Almut Schulze, Christoph-Thomas Germer, Andreas Rosenwald, Owen James Sansom, Martin Eilers, Armin Wiegerin. A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature cell biology. vol 21. issue 11. 2020-02-19. PMID:31685988. |
eif2b5 limits myc expression and prevents apoptosis in apc-deficient murine and patient-derived organoids and in apc-deficient murine intestinal epithelia in vivo. |
2020-02-19 |
2023-08-13 |
Not clear |
| Colleen T Harrington, Elena Sotillo, Aude Robert, Katharina E Hayer, Agata M Bogusz, James Psathas, Duonan Yu, Deanne Taylor, Chi V Dang, Peter S Klein, Michael D Hogarty, Birgit Geoerger, Wafik S El-Deiry, Joëlle Wiels, Andrei Thomas-Tikhonenk. Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma. Leukemia. vol 33. issue 10. 2020-02-03. PMID:30914792. |
transient stabilization, rather than inhibition, of myc amplifies extrinsic apoptosis and therapeutic responses in refractory b-cell lymphoma. |
2020-02-03 |
2023-08-13 |
human |
| Qingfeng Yu, Ping Wang, Linlin Yang, Zhaoxing Wu, Shu Li, Ying Xu, Bowen Wu, An Ma, Xiaoxian Gan, Rongzhen X. Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 117. 2020-01-22. PMID:31247466. |
mechanistically, tcb potently reduced myc protein by inhibiting camkiiγ, a critical enzyme that stabilizes myc protein, and induces apoptosis of myc-positive leukemia cells. |
2020-01-22 |
2023-08-13 |
mouse |
| Scott Best, Taylor Hashiguchi, Adam Kittai, Nur Bruss, Cody Paiva, Craig Okada, Tingting Liu, Allison Berger, Alexey V Danilo. Targeting ubiquitin-activating enzyme induces ER stress-mediated apoptosis in B-cell lymphoma cells. Blood advances. vol 3. issue 1. 2020-01-09. PMID:30617217. |
myc oncoprotein sensitized dlbcl cells to uae inhibition; engineered expression of myc enhanced while genetic myc knockdown protected from tak-243-induced apoptosis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Lucía García-Gutiérrez, María Dolores Delgado, Javier Leó. MYC Oncogene Contributions to Release of Cell Cycle Brakes. Genes. vol 10. issue 3. 2020-01-09. PMID:30909496. |
in contrast, myc activates arf, which contributes to the apoptosis induced by high myc levels. |
2020-01-09 |
2023-08-13 |
Not clear |
| Warren Fiskus, Tianyu Cai, Courtney D DiNardo, Steven M Kornblau, Gautam Borthakur, Tapan M Kadia, Naveen Pemmaraju, Prithviraj Bose, Lucia Masarova, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Christopher P Mill, Dyana T Saenz, David N Saenz, Baohua Sun, Joseph D Khoury, Yu Shen, Marina Konopleva, Kapil N Bhall. Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood cancer journal. vol 9. issue 2. 2019-12-30. PMID:30647404. |
beti treatment is shown here to perturb accessible chromatin and activity of enhancers/promoters, attenuating myc, cdk6, mcl1 and bcl2, while inducing bim, hexim1, cdkn1a expressions and apoptosis of aml cells. |
2019-12-30 |
2023-08-13 |
mouse |
| Andrea Bisso, Arianna Sabò, Bruno Amat. MYC in Germinal Center-derived lymphomas: Mechanisms and therapeutic opportunities. Immunological reviews. vol 288. issue 1. 2019-12-30. PMID:30874346. |
myc, in particular, is a transcription factor that contributes to cell activation, growth and proliferation, while concomitantly sensitizing cells to apoptosis, the latter being blocked by bcl2. |
2019-12-30 |
2023-08-13 |
Not clear |
| Simone Di Giacomo, Manuela Sollazzo, Simona Paglia, Daniela Grifon. MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad. Genes. vol 8. issue 4. 2019-11-20. PMID:28420161. |
it is well known that myc upregulation triggers cell-autonomous apoptosis in normal tissues, while frankly malignant cells develop resistance to apoptotic stimuli, partly resulting from myc addiction. |
2019-11-20 |
2023-08-13 |
Not clear |
| Simone Di Giacomo, Manuela Sollazzo, Simona Paglia, Daniela Grifon. MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad. Genes. vol 8. issue 4. 2019-11-20. PMID:28420161. |
as well as inducing cell-autonomous apoptosis, myc upregulation is able to trigger non cell-autonomous apoptotic death through an evolutionarily conserved mechanism known as "cell competition". |
2019-11-20 |
2023-08-13 |
Not clear |
| Qin Zhang, Kimberly West-Osterfield, Erick Spears, Zhaoliang Li, Alexander Panaccione, Stephen R Han. MB0 and MBI Are Independent and Distinct Transactivation Domains in MYC that Are Essential for Transformation. Genes. vol 8. issue 5. 2019-11-20. PMID:28481271. |
deregulation of myc can also induce apoptosis through activation of p53 and/or arf tumor suppressors as a safeguard to prevent tumorigenesis. |
2019-11-20 |
2023-08-13 |
mouse |
| Qin Zhang, Kimberly West-Osterfield, Erick Spears, Zhaoliang Li, Alexander Panaccione, Stephen R Han. MB0 and MBI Are Independent and Distinct Transactivation Domains in MYC that Are Essential for Transformation. Genes. vol 8. issue 5. 2019-11-20. PMID:28481271. |
in addition, both mb0 and mbi are essential for myc transformation of primary fibroblasts in cooperation with activated ras, while mb0 is necessary for efficient myc-induced p53-independent apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |