| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
plk1 and stat3 were able to directly regulate the expression of myc and induce apoptosis of glioma cells through the regulation of myc. |
2021-03-18 |
2023-08-13 |
Not clear |
| Jennifer Edelmann, Arran D Dokal, Emma Vilventhraraja, Karlheinz Holzmann, David Britton, Tetyana Klymenko, Hartmut Döhner, Mark Cragg, Andrejs Braun, Pedro Cutillas, John G Gribbe. Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways. iScience. vol 24. issue 2. 2021-02-24. PMID:33615197. |
although both antibodies induce strong erk and myc activation sufficient to promote cell-cycle arrest and b cell death, obinutuzumab exceeds rituximab in supporting apoptosis induction by means of aberrant syk phosphorylation. |
2021-02-24 |
2023-08-13 |
Not clear |
| Eleonora Vecchio, Giuseppe Fiume, Serena Correnti, Salvatore Romano, Enrico Iaccino, Selena Mimmi, Domenico Maisano, Nancy Nisticò, Ileana Quint. Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models. International journal of molecular sciences. vol 21. issue 12. 2021-02-17. PMID:32549409. |
insights about myc and apoptosis in b-lymphomagenesis: an update from murine models. |
2021-02-17 |
2023-08-13 |
mouse |
| Eleonora Vecchio, Giuseppe Fiume, Serena Correnti, Salvatore Romano, Enrico Iaccino, Selena Mimmi, Domenico Maisano, Nancy Nisticò, Ileana Quint. Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models. International journal of molecular sciences. vol 21. issue 12. 2021-02-17. PMID:32549409. |
key features of myc-induced apoptosis will be discussed here along with more recent studies on myc direct and indirect interactors, including their cooperative action in lymphomagenesis. |
2021-02-17 |
2023-08-13 |
mouse |
| Eleonora Vecchio, Giuseppe Fiume, Serena Correnti, Salvatore Romano, Enrico Iaccino, Selena Mimmi, Domenico Maisano, Nancy Nisticò, Ileana Quint. Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models. International journal of molecular sciences. vol 21. issue 12. 2021-02-17. PMID:32549409. |
we review our current knowledge about the role of myc-induced apoptosis in b-cell malignancies, discussing the transcriptional regulation network of myc and regulatory feedback action of mirs during myc-driven lymphomagenesis. |
2021-02-17 |
2023-08-13 |
mouse |
| Markus Hartl, Kane Puglisi, Andrea Nist, Philipp Raffeiner, Klaus Biste. The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin. Molecular oncology. vol 14. issue 3. 2021-02-02. PMID:31944520. |
the myc protein is a transcription factor with oncogenic potential controlling fundamental cellular processes such as cell proliferation, metabolism, differentiation, and apoptosis. |
2021-02-02 |
2023-08-13 |
human |
| Yongqiang Wang, Zenghong Huang, Christopher Z Chen, Chengfei Liu, Christopher P Evans, Allen C Gao, Fangjian Zhou, Hong-Wu Che. Therapeutic Targeting of MDR1 Expression by RORγ Antagonists Resensitizes Cross-Resistant CRPC to Taxane via Coordinated Induction of Cell Death Programs. Molecular cancer therapeutics. vol 19. issue 2. 2021-01-11. PMID:31712394. |
our mechanistic analyses revealed that combined treatment with rorγ antagonists and taxane elicited a robust synergy in killing the resistant cells, which involves a coordinated alteration of p53, myc, and e2f-controlled programs critical for both intrinsic and extrinsic apoptosis, survival, and cell growth. |
2021-01-11 |
2023-08-13 |
Not clear |
| Kamonwan Fish, Federico Comoglio, Arthur L Shaffer, Yanlong Ji, Kuan-Ting Pan, Sebastian Scheich, Angelika Oellerich, Carmen Doebele, Masato Ikeda, Samantha J Schaller, Hang Nguyen, Jagan Muppidi, George W Wright, Henning Urlaub, Hubert Serve, Louis M Staudt, Richard Longnecker, Thomas Oelleric. Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 42. 2021-01-04. PMID:33020271. |
lmp2a cooperated with myc and mutant cyclin d3, two oncogenic drivers of burkitt lymphoma, to promote proliferation and survival of primary human b cells by counteracting myc-induced apoptosis and by inhibiting rb1 function, thereby promoting cell-cycle progression. |
2021-01-04 |
2023-08-13 |
human |
| Yun Jeong Lee, Eun-Young Lee, Bo Hee Choi, Hyonchol Jang, Jae-Kyung Myung, Hye Jin Yo. The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability. Molecules and cells. vol 43. issue 5. 2020-11-11. PMID:32299194. |
moreover, nr1h4 ko enhanced the anti-cancer effects of doxorubicin and cisplatin, supporting the role of myc in the enhanced apoptosis observed in nr1h4 ko cells. |
2020-11-11 |
2023-08-13 |
Not clear |
| Yi Zhang, Yina Shao, Zhimeng Lv, Weiwei Zhang, Xuelin Zhao, Ming Guo, Chenghua L. Molecular cloning and functional characterization of MYC transcription factor in pathogen-challenged Apostichopus japonicus. Developmental and comparative immunology. vol 102. 2020-11-06. PMID:31472172. |
myc inhibitor treatment could not only inhibit the expression of ajmyc and ajcaspase3, but also depress the coelomocyte apoptosis. |
2020-11-06 |
2023-08-13 |
Not clear |
| Fabian V Filipp, Chen Li, Alexander D Boik. CD271 is a molecular switch with divergent roles in melanoma and melanocyte development. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31118427. |
two divergent arms of neurotrophin signaling hold the balance between positive regulators of tumor growth controlled by e2f, myc, srebp1 and akt3 pathways on the one hand, and differentiation, senescence, and apoptosis controlled by traf6/irak-dependent activation of ap1 and tp53 mediated processes on the other hand. |
2020-10-22 |
2023-08-13 |
Not clear |
| Hai Vu Nguyen, Cassandra J Vandenberg, Ashley P Ng, Mikara R Robati, Natasha S Anstee, Joel Rimes, Edwin D Hawkins, Suzanne Cor. Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis. Blood. vol 135. issue 13. 2020-10-20. PMID:31978211. |
development and survival of myc-driven lymphomas require the myc antagonist mnt to curb myc-induced apoptosis. |
2020-10-20 |
2023-08-13 |
mouse |
| Hai Vu Nguyen, Cassandra J Vandenberg, Ashley P Ng, Mikara R Robati, Natasha S Anstee, Joel Rimes, Edwin D Hawkins, Suzanne Cor. Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis. Blood. vol 135. issue 13. 2020-10-20. PMID:31978211. |
myc drives cell growth and proliferation, but also, at high levels, promotes apoptosis. |
2020-10-20 |
2023-08-13 |
mouse |
| Hai Vu Nguyen, Cassandra J Vandenberg, Ashley P Ng, Mikara R Robati, Natasha S Anstee, Joel Rimes, Edwin D Hawkins, Suzanne Cor. Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis. Blood. vol 135. issue 13. 2020-10-20. PMID:31978211. |
our genetic data establish that mnt synergizes with myc by suppressing myc-driven apoptosis, and that it does so primarily by reducing the level of pro-apoptotic bim. |
2020-10-20 |
2023-08-13 |
mouse |
| Xi Qiao, Ying Liu, Maria Llamazares Prada, Aravind K Mohan, Abhishekh Gupta, Alok Jaiswal, Mukund Sharma, Joni Merisaari, Heidi M Haikala, Kati Talvinen, Laxman Yetukuri, Joanna W Pylvänäinen, Juha Klefström, Pauliina Kronqvist, Annika Meinander, Tero Aittokallio, Ville Hietakangas, Martin Eilers, Jukka Westermarc. Cancer research. vol 80. issue 7. 2020-10-14. PMID:32029551. |
for maximal oncogenic activity, cellular myc protein levels need to be tightly controlled so that they do not induce apoptosis. |
2020-10-14 |
2023-08-13 |
drosophila_melanogaster |
| Ekaterina Kim, Elisa Ten Hacken, Mariela Sivina, Astrid Clarke, Philip A Thompson, Nitin Jain, Alessandra Ferrajoli, Zeev Estrov, Michael J Keating, William G Wierda, Kapil N Bhalla, Jan A Burge. The BET inhibitor GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment. Leukemia. vol 34. issue 6. 2020-10-07. PMID:31862959. |
gs-5829 inhibited cll cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as blk, akt, erk1/2, and myc. |
2020-10-07 |
2023-08-13 |
Not clear |
| Yi Zhang, Yina Shao, Zhimeng Lv, Chenghua L. MYC regulates coelomocytes apoptosis by targeting Bax expression in sea cucumber Apostichopus japonicus. Fish & shellfish immunology. vol 97. 2020-10-02. PMID:31843700. |
myc regulates coelomocytes apoptosis by targeting bax expression in sea cucumber apostichopus japonicus. |
2020-10-02 |
2023-08-13 |
Not clear |
| Heidi M Haikala, Johanna M Anttila, Juha Klefströ. MYC and AMPK-Save Energy or Die! Frontiers in cell and developmental biology. vol 5. 2020-10-01. PMID:28443281. |
the ampk-involving metabolic side of myc apoptosis may provide novel avenues for therapeutic development. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lijie Gong, Yingjie Xia, Zhenyuan Qian, Ji Shi, Jungang Luo, Guangyuan Song, Ji Xu, Zaiyuan Y. Overexpression of MYC binding protein promotes invasion and migration in gastric cancer. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552163. |
the myc proto-oncogene protein serves key roles in cellular proliferation, differentiation, transformation and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Shuang Fu, Yu Fu, Fang Chen, Yanping Hu, Bi Quan, Jihong Zhan. Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30283340. |
overexpression of myct1 inhibits proliferation and induces apoptosis in human acute myeloid leukemia hl-60 and kg-1a cells myc target 1 (myct1), a direct target gene of c-myc, is a novel candidate tumor suppressor gene first cloned from laryngeal squamous cell carcinoma. |
2020-10-01 |
2023-08-13 |
human |