| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Mo, Juliang He, Zhenchao Yuan, Zhenjie Wu, Bin Liu, Xiang Lin, Jian Gua. PLK1 contributes to autophagy by regulating MYC stabilization in osteosarcoma cells. OncoTargets and therapy. vol 12. 2020-10-01. PMID:31571905. |
myc modulates the transcription of thousands of genes that required to coordinate a series of cellular processes, including those essential for growth, proliferation, differentiation, self-renewal and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Dandan Jiang, Yuhua Song, Weihong Cao, Xingang Wang, Danni Jiang, Zhidong Lv, Zhaochuan Yang, Funian L. p53-independent role of MYC mutant T58A in the proliferation and apoptosis of breast cancer cells. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655867. |
p53-independent role of myc mutant t58a in the proliferation and apoptosis of breast cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dandan Jiang, Yuhua Song, Weihong Cao, Xingang Wang, Danni Jiang, Zhidong Lv, Zhaochuan Yang, Funian L. p53-independent role of MYC mutant T58A in the proliferation and apoptosis of breast cancer cells. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655867. |
myc proto-oncogene (myc) is an oncoprotein that promotes proliferation and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zhen Guo, Youhong Wang, Yu Zhao, Yi Jin, Liang An, Heng Xu, Zhaoqian Liu, Xiaoping Chen, Honghao Zhou, Hui Wang, Wei Zhan. A Functional 5'-UTR Polymorphism of MYC Contributes to Nasopharyngeal Carcinoma Susceptibility and Chemoradiotherapy Induced Toxicities. Journal of Cancer. vol 10. issue 1. 2020-09-30. PMID:30662535. |
myc is a transcription factor acting as a pivotal regulator of genes involved in cell cycle progression, apoptosis, differentiation and metabolism. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yinfei Tan, Eleonora Sementino, Jonathan Chernoff, Joseph R Test. Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. American journal of cancer research. vol 7. issue 8. 2020-09-29. PMID:28861328. |
a myc inhibitor 10058-f4 reduced mm cell proliferation via down regulation of cyclin d. under serum starvation conditions, mm cells became quiescent, and the addition of myc inhibitors triggered apoptosis in the resting mm cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yinfei Tan, Eleonora Sementino, Jonathan Chernoff, Joseph R Test. Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. American journal of cancer research. vol 7. issue 8. 2020-09-29. PMID:28861328. |
these quiescent cells underwent apoptosis upon pharmacological inhibition of myc. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jiande Wu, Tarun Karthik Kumar Mamidi, Lu Zhang, Chindo Hick. Deconvolution of the Genomic and Epigenomic Interaction Landscape of Triple-Negative Breast Cancer. Cancers. vol 11. issue 11. 2020-09-28. PMID:31683572. |
network and pathway analysis revealed molecule networks and signaling pathways enriched for germline, somatic and epigenomic variation, among them: role of brca1 in dna damage response, hereditary breast cancer signaling, molecular mechanisms of cancer, estrogen-dependent breast cancer, p53, myc mediated apoptosis, and pten signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |
| Guangyao He, Anzhou Tang, Mao Xie, Wei Xia, Pengcheng Zhao, Jianglian Wei, Yongjing Lai, Xianglong Tang, Yi Ming Zou, Heng Li. Blood Gene Expression Profile Study Revealed the Activation of Apoptosis and p53 Signaling Pathway May Be the Potential Molecular Mechanisms of Ionizing Radiation Damage and Radiation-Induced Bystander Effects. Dose-response : a publication of International Hormesis Society. vol 18. issue 1. 2020-09-28. PMID:32284698. |
the analysis showed that the positively correlated modules were significantly involved in apoptosis and p53 signaling pathway, and esr1, atm, and myc were potential transcription factors regulating these modules. |
2020-09-28 |
2023-08-13 |
human |
| Guangyao He, Anzhou Tang, Mao Xie, Wei Xia, Pengcheng Zhao, Jianglian Wei, Yongjing Lai, Xianglong Tang, Yi Ming Zou, Heng Li. Blood Gene Expression Profile Study Revealed the Activation of Apoptosis and p53 Signaling Pathway May Be the Potential Molecular Mechanisms of Ionizing Radiation Damage and Radiation-Induced Bystander Effects. Dose-response : a publication of International Hormesis Society. vol 18. issue 1. 2020-09-28. PMID:32284698. |
thus, the study suggested that apoptosis and p53 signaling pathway may be the potential molecular mechanisms of ir damage and ribe, which could be driven by esr1, atm, and myc. |
2020-09-28 |
2023-08-13 |
human |
| Bhaskar C Kolla, Emilian Racila, Manish R Pate. Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review. Case reports in oncological medicine. vol 2020. 2020-09-28. PMID:32318301. |
myc family genes are master regulators of several cellular pathways including proliferation, differentiation, and apoptosis and recently have been shown to be involved in tumor immune evasion. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yin Li, C Hengqi Kong, Lei Feng, Wenliang Tang, Mengwei Chen, Zhiyuan Zhen. MYC Participates in Lipopolysaccharide-Induced Sepsis via Promoting Cell Proliferation and Inhibiting Apoptosis. Cell journal. vol 22. issue Suppl 1. 2020-09-28. PMID:32779435. |
myc participates in lipopolysaccharide-induced sepsis via promoting cell proliferation and inhibiting apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Tao Liang, Xuxiao Ye, Dongliang Yan, Chao Deng, Zuowei Li, Binqiang Tia. FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis. OncoTargets and therapy. vol 13. 2020-09-28. PMID:32943883. |
this study was designed to examine critical glycolysis components including transcription factor myc and its downstream target lactate dehydrogenase a (ldha), potential upstream regulators of glycolysis such as family with sequence similarity 46 member b (fam46b), and the impact of the abundance of these proteins on apoptosis and glycolysis in prostate cancer. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ruimin Li, Hongjian Zhou, Chaolong Jia, Ping Jin, Fei M. Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2. PLoS genetics. vol 16. issue 8. 2020-09-23. PMID:32810129. |
drosophila myc (dmyc), as a broad-spectrum transcription factor, can regulate the expression of a large number of genes to control diverse cellular processes, such as cell cycle progression, cell growth, proliferation and apoptosis. |
2020-09-23 |
2023-08-13 |
drosophila_melanogaster |
| Cuiting Peng, Changzhen Sun, Ningyu Wang, Yuanmin He, Jixiang Xu, Yongqiong Deng, Lanyang Gao, Jianqiao Zhong, Xia Xiong, Li Li. A novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31527063. |
taken together, these results revealed that brd4 inhibitor ylt-ll-11 can down-regulate growth-associated transcription factors myc in dlbcl thus resulted in cell growth inhibition and apoptosis. |
2020-09-15 |
2023-08-13 |
human |
| Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake, Edward McDonald, Paul A Clarke, Paul Workman, David Blake, Daniella Zhelev. Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer. PloS one. vol 15. issue 7. 2020-09-14. PMID:32645016. |
we show that the mechanism of action of fadraciclib is consistent with potent inhibition of cdk9-mediated transcription, decreasing levels of rna polymerase ii c-terminal domain serine 2 phosphorylation, the pro-survival protein myeloid cell leukemia 1 (mcl1) and myc oncoprotein, and inducing rapid apoptosis in cancer cells. |
2020-09-14 |
2023-08-13 |
mouse |
| Dennis Özcelik, John Paul Pezack. Small Molecule Inhibition of Protein Disulfide Isomerase in Neuroblastoma Cells Induces an Oxidative Stress Response and Apoptosis Pathways. ACS chemical neuroscience. vol 10. issue 9. 2020-09-10. PMID:31343165. |
induction of the p53 signaling pathway and downregulation of myc are known to affect processes such as cell cycle, cellular repair, and apoptosis. |
2020-09-10 |
2023-08-13 |
Not clear |
| Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y Zaytseva, Charles E Schwartz, Eun Y Lee, B Mark Evers, Andrew J Morris, Side Liu, Qing-Bai Sh. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32591507. |
pharmacological or genetic inhibition of myc activity in sms-depleted crc cells dramatically induces bim expression and apoptosis and causes tumor regression, but these effects are profoundly attenuated by silencing bim. |
2020-08-31 |
2023-08-13 |
Not clear |
| Christopher Letson, Eric Padro. Non-canonical transcriptional consequences of BET inhibition in cancer. Pharmacological research. vol 150. 2020-08-24. PMID:31698067. |
downregulation of the myc oncogene, cdk6, bcl2 and fosl1 are just a few examples of the effects of bet inhibitors that can lead to cell cycle arrest and apoptosis in cancer cells. |
2020-08-24 |
2023-08-13 |
Not clear |
| Andreas Herrmann, Toshikage Nagao, Chunyan Zhang, Christoph Lahtz, Yi-Jia Li, Chanyu Yue, Ronja Mülfarth, Hua Y. An effective cell-penetrating antibody delivery platform. JCI insight. vol 4. issue 14. 2020-08-21. PMID:31341104. |
both local and systemic administrations of low doses of modified antibodies effectively inhibited intracellular targets, such as transcription factors myc, interferon regulatory factor 4, and tyrosine-protein kinase src, and expression of their downstream genes in tumors, resulting in tumor cell apoptosis and tumor growth inhibition. |
2020-08-21 |
2023-08-13 |
Not clear |
| Yuanhui Liu, Nancy G Azizian, Yaling Dou, Lan V Pham, Yulin L. Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma. Journal of hematology & oncology. vol 12. issue 1. 2020-07-06. PMID:31752970. |
here, we demonstrate that xpo1 inhibition abrogates myc protein expression and induces massive tumor cell apoptosis. |
2020-07-06 |
2023-08-13 |
mouse |