| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keisuke Okuno, Keiichi Torimoto, Stephanie Cicalese, Matthew Sparks, Satoru Eguch. Smooth Muscle At1a Receptor Mediates Perivascular Fibrosis in Angiotensin II-infused Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560912. |
it is conceivable that ang ii signaling in vsmcs specifically initiates cardiovascular remodeling, such as hypertrophy and fibrosis. |
2022-05-13 |
2023-08-13 |
mouse |
| Keisuke Okuno, Keiichi Torimoto, Stephanie Cicalese, Matthew Sparks, Satoru Eguch. Smooth Muscle At1a Receptor Mediates Perivascular Fibrosis in Angiotensin II-infused Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560912. |
in a recent study, deficiency of smooth muscle at1a receptors results in diminished hypertension and protection from cardiac hypertrophy induced by ang ii. |
2022-05-13 |
2023-08-13 |
mouse |
| Keisuke Okuno, Keiichi Torimoto, Stephanie Cicalese, Matthew Sparks, Satoru Eguch. Smooth Muscle At1a Receptor Mediates Perivascular Fibrosis in Angiotensin II-infused Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560912. |
in control mice, ang ii infusion for 2 weeks induced cardiac hypertrophy indicated by heart-to-body weight ratio and echocardiogram. |
2022-05-13 |
2023-08-13 |
mouse |
| Keisuke Okuno, Keiichi Torimoto, Stephanie Cicalese, Matthew Sparks, Satoru Eguch. Smooth Muscle At1a Receptor Mediates Perivascular Fibrosis in Angiotensin II-infused Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560912. |
cardiac wall hypertrophy was seen in control mice after 2 weeks of ang ii infusion, which was attenuated in at1a smko mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Keisuke Okuno, Keiichi Torimoto, Stephanie Cicalese, Matthew Sparks, Satoru Eguch. Smooth Muscle At1a Receptor Mediates Perivascular Fibrosis in Angiotensin II-infused Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560912. |
in conclusion, at1a receptors expressed in vsmc could mediate ang ii-induced cardiovascular hypertrophy and perivascular fibrosis. |
2022-05-13 |
2023-08-13 |
mouse |
| Chen Chen, Xiyu Zhang, Cuiting Zheng, Zhenqiang Gao, Xi Jiang, Yunfei Bai, Yan Men. Sulfasalazine exacerbates Angiotensin II induced cardiac remodeling by activating Akt signal pathway. Clinical and experimental pharmacology & physiology. 2022-05-11. PMID:35538895. |
angiotensin ii (ang ii) results in cardiac fibrosis and hypertrophy partly through activation of inflammation, which increases the fibroblasts and promotes extracellular matrix production. |
2022-05-11 |
2023-08-13 |
mouse |
| Chen Chen, Xiyu Zhang, Cuiting Zheng, Zhenqiang Gao, Xi Jiang, Yunfei Bai, Yan Men. Sulfasalazine exacerbates Angiotensin II induced cardiac remodeling by activating Akt signal pathway. Clinical and experimental pharmacology & physiology. 2022-05-11. PMID:35538895. |
in this study, we found that sasp aggravated cardiac dysfunction, hypertrophy and fibrosis after ang ii infusion. |
2022-05-11 |
2023-08-13 |
mouse |
| Lan Cheng, Rene Nfornah Maboh, Huan Wang, Gao-Wei Mao, Xiao-Ying Wu, Hui Che. Naoxintong capsule activates the Nrf2/HO-1 signaling pathway and suppresses the p38α signaling pathway via estrogen receptors to ameliorate heart remodeling in female mice with postmenopausal hypertension. Journal of cardiovascular pharmacology. 2022-05-02. PMID:35500215. |
in vitro, nxt treatment greatly suppressed ang ii-induced cardiac hypertrophy, cardiac fibrosis, and excessive oxidative stress as proven by reducing the diameter of h9c2 cardiomyocytes, expression of hypertrophy and fibrosis markers, intracellular reactive oxygen species, and oxidative enzymes. |
2022-05-02 |
2023-08-13 |
mouse |
| Yuntao Shi, Jialiang Ge, Rui Li, Yong Li, Li Li. Targeting of midkine alleviates cardiac hypertrophy via attenuation of oxidative stress and autophagy. Peptides. 2022-04-15. PMID:35427698. |
the research aimed to investigate the mitigation influence of downregulation of intermediate factors on myocardial hypertrophy induced by angiotensin Ⅱ (ang), and whether downregulation of midkine could attenuate oxidative stress and autophagy. |
2022-04-15 |
2023-08-13 |
mouse |
| Yuntao Shi, Jialiang Ge, Rui Li, Yong Li, Li Li. Targeting of midkine alleviates cardiac hypertrophy via attenuation of oxidative stress and autophagy. Peptides. 2022-04-15. PMID:35427698. |
induced myocardial hypertrophy of the mice model and treated hl-1 cells with ang Ⅱ in vitro. |
2022-04-15 |
2023-08-13 |
mouse |
| Yuntao Shi, Jialiang Ge, Rui Li, Yong Li, Li Li. Targeting of midkine alleviates cardiac hypertrophy via attenuation of oxidative stress and autophagy. Peptides. 2022-04-15. PMID:35427698. |
midkine silence alleviated cardiac hypertrophy induced by ang ii, and inhibited the increases of atrial natriuretic peptide (anp), brain natriuretic peptide (bnp) and beta-myosin heavy chain (β-mhc) in the heart of mice. |
2022-04-15 |
2023-08-13 |
mouse |
| Min Luo, Hui-Cai Lin, Zhao-Qin Wen, Pan-Pan Chen, Wan-Lan Shi, Ying-Ying Li Coll, Yang Gao, Shang-Fu Xu, Rui-Xia Xu, Qi-Hai Gong, Jiang Den. Sodium ferulate inhibits rat cardiomyocyte hypertrophy induced by Ang II through enhancement of eNOS/NO/cGMP signaling pathway. Journal of cardiovascular pharmacology. 2022-04-13. PMID:35416804. |
sodium ferulate inhibits rat cardiomyocyte hypertrophy induced by ang ii through enhancement of enos/no/cgmp signaling pathway. |
2022-04-13 |
2023-08-13 |
rat |
| Min Luo, Hui-Cai Lin, Zhao-Qin Wen, Pan-Pan Chen, Wan-Lan Shi, Ying-Ying Li Coll, Yang Gao, Shang-Fu Xu, Rui-Xia Xu, Qi-Hai Gong, Jiang Den. Sodium ferulate inhibits rat cardiomyocyte hypertrophy induced by Ang II through enhancement of eNOS/NO/cGMP signaling pathway. Journal of cardiovascular pharmacology. 2022-04-13. PMID:35416804. |
in this study, myocardial hypertrophy was induced by angiotensin ii (ang ii) 0.1 μmol/l in neonatal sprague-dawley rat ventricular myocytes. |
2022-04-13 |
2023-08-13 |
rat |
| Min Luo, Hui-Cai Lin, Zhao-Qin Wen, Pan-Pan Chen, Wan-Lan Shi, Ying-Ying Li Coll, Yang Gao, Shang-Fu Xu, Rui-Xia Xu, Qi-Hai Gong, Jiang Den. Sodium ferulate inhibits rat cardiomyocyte hypertrophy induced by Ang II through enhancement of eNOS/NO/cGMP signaling pathway. Journal of cardiovascular pharmacology. 2022-04-13. PMID:35416804. |
overall, these findings reveal that sf can inhibit ang ii-induced myocardial hypertrophy of neonatal rat cardiomyocytes, which is closely related to activation of enos/no/cgmp, and inhibition of pkc and mitogen activated protein kinase signaling pathways. |
2022-04-13 |
2023-08-13 |
rat |
| Kun Zhao, Yong Li, Zihao Zhou, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yonghong Yong, Peng L. Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation. European journal of pharmacology. 2022-04-03. PMID:35367419. |
cardiac remodeling in mice induced by left coronary artery ligation were used in the in vivo model, and angiotensin (ang) ii-induced cardiac fibroblasts (nrcfs) and cardiomyocytes (nrcms) isolated from neonatal rats were used in in vitro fibrosis and hypertrophy models, respectively. |
2022-04-03 |
2023-08-13 |
mouse |
| Shuang Lin, Shanshan Dai, Jiahui Lin, Xiaohe Liang, Weiqi Wang, Weijian Huang, Bozhi Ye, Xia Hon. Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation. Cardiovascular therapeutics. vol 2022. 2022-04-01. PMID:35360548. |
our study investigated that hypertrophy and fibrosis can be induced after being treated with ang ii in cardiomyocytes (h9c2 cells and primary rat cardiomyocytes) and c57bl/6j mice. |
2022-04-01 |
2023-08-13 |
mouse |
| Jiajia Mo, Peng Zhou, Zhaoxing Chu, Yan Zhao, Xiang Wan. Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-28. PMID:35341136. |
to investigate the protective effect and mechanism of liquiritin (liq) on cardiomyocyte hypertrophy induced by angiotensin ii (ang ii). |
2022-03-28 |
2023-08-13 |
Not clear |
| Deanna L Muehleman, Claudia Crocini, Alison R Swearingen, Christopher D Ozeroff, Leslie A Leinwan. Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific. American journal of physiology. Heart and circulatory physiology. 2022-03-18. PMID:35302880. |
two pathological stimuli causing hypertrophy via distinct pathways were administered to male and female mice: angiotensin ii [ang ii] or isoproterenol [iso]. |
2022-03-18 |
2023-08-13 |
mouse |
| Jiayu Lv, Shuqing Shi, Bingxuan Zhang, Xia Xu, Haoran Zheng, Yumeng Li, Xiangning Cui, Huaqin Wu, Qingqiao Son. Role of Puerarin in Pathological Cardiac Remodeling: A Review. Pharmacological research. 2022-03-06. PMID:35248700. |
in recent years, a growing number of studies have shown that puerarin significantly inhibits myocardial hypertrophic growth, myocyte death, fetal gene expression, fibroblast proliferation and activation, improves energy metabolism, promotes post-infarction angiogenesis, and suppresses inflammation and oxidative stress, consequently attenuating or preventing cardiac remodeling in response to multiple stimuli ( e.g., pressure overload, miri, mi, iso, and ang ii stimulation). |
2022-03-06 |
2023-08-13 |
Not clear |
| Yu-Kai Cui, Yi-Xiang Hong, Wei-Yin Wu, Wei-Min Han, Yao Wu, Chan Wu, Gui-Rong Li, Yan Wan. Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway. European journal of pharmacology. 2022-02-27. PMID:35219729. |
in cardiomyocytes from neonatal rat with hypertrophy induced by angiotensin ii (ang ii), acacetin at 0.3, 1, and 3 μm reduced the increased myocyte surface area, brain natriuretic peptide (bnp), and ros production by upregulating anti-oxidative molecules (i.e. |
2022-02-27 |
2023-08-13 |
rat |