| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sukhwinder K Bhullar, Naranjan S Dhall. Angiotensin II-Induced Signal Transduction Mechanisms for Cardiac Hypertrophy. Cells. vol 11. issue 21. 2022-11-11. PMID:36359731. |
it is now evident that the hypertrophic response is mediated by the activation of ang type 1 receptors (at |
2022-11-11 |
2023-08-14 |
Not clear |
| Siyuan Shen, Gaojun Wu, Wu Luo, Weixin Li, Xiaobo Li, Chengyi Dai, Weijian Huang, Guang Lian. Leonurine attenuates angiotensin II-induced cardiac injury and dysfunction via inhibiting MAPK and NF-κB pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 108. 2022-11-04. PMID:36332391. |
hypertension is a common risk factor for heart failure, and excessive angiotensin ii (ang ii) leads to hypertensive cardiac alterations such as hypertrophy, cardiac fibrosis, remodeling, and dysfunction. |
2022-11-04 |
2023-08-14 |
Not clear |
| Jionghong He, Guiling Xia, Long Yang, Zhi Jiang, Ying Yang, Zhaomei Huo, Chuxian Gu. Crim1 inhibits angiotensin II-induced hypertrophy and preserves Kv4.2 expression in cardiomyocytes. Iranian journal of basic medical sciences. vol 25. issue 10. 2022-10-31. PMID:36311192. |
angiotensin ii (ang ii) plays a key role in the regulation of myocardial hypertrophy via downstream cysteine-rich transmembrane bone morphogenetic protein regulator 1 (crim1). |
2022-10-31 |
2023-08-14 |
Not clear |
| Hind Albadrani, T Ammar, Rashida Rajgara, Michael Bader, Nadine Wiper-Bergeron, Jean-Marc Renau. Angiotensin 1-7 increases fiber cross sectional area and force in juvenile mouse skeletal muscle. American journal of physiology. Cell physiology. 2022-10-24. PMID:36280388. |
the objectives of this study were to document i) the extent of the ang 1-7's hypertrophic effect in terms of muscle mass and muscle fiber cross sectional area (csa), ii) how ang 1-7 affects muscle contractile function in terms of twitch and tetanic force, force-frequency relationship, and iii) whether the effect involves masr. |
2022-10-24 |
2023-08-14 |
mouse |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
inhibition of intermittent calcium-activated potassium channel (sk4) attenuates ang ii-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting ras-raf-mek1/2-erk1/2 and cn-nfat signaling pathways. |
2022-10-23 |
2023-08-14 |
Not clear |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
cardiac hypertrophy caused by angiotensin ii (ang ii) is essential for the pathological process of heart failure. |
2022-10-23 |
2023-08-14 |
Not clear |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
however, the role of sk4 in cardiac hypertrophy has not been elucidated. cardiac hypertrophy in human-induced pluripotent stem cells-derived cardiomyocytes (hipsc-cms) was induced by ang ii. |
2022-10-23 |
2023-08-14 |
Not clear |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
the downregulation of sk4 by a specific inhibitor tram-34 markedly ameliorated cardiac hypertrophy (reflected by the mrna levels of atrial natriuretic peptide, brain natriuretic peptide, and β-myosin heavy chain) and apoptosis (reflected by the level of caspase 3, bax, and bcl-2) induced by ang ii treatment. |
2022-10-23 |
2023-08-14 |
Not clear |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
our studies demonstrated that inhibition of sk4 significantly alleviated cardiac hypertrophy induced by ang ii in hipsc-cms by targeting ras-raf-mek1/2-erk1/2 signaling and cn-nfat signaling pathway. |
2022-10-23 |
2023-08-14 |
Not clear |
| Yang Gu, Ying Ding, Xin Zhang, Yong Li, Zhenglu Shan. Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice. European journal of pharmacology. 2022-09-29. PMID:36174667. |
ang ii-induced hypertrophy and fibrosis of heart in mice were attenuated by upregulation of sfrp3, and were further deteriorated by downregulation of sfrp3. |
2022-09-29 |
2023-08-14 |
mouse |
| Yang Gu, Ying Ding, Xin Zhang, Yong Li, Zhenglu Shan. Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice. European journal of pharmacology. 2022-09-29. PMID:36174667. |
ang ii-induced hypertrophy of nrcm and hl-1 cells were improved by sfrp3 overexpression, and were further deteriorated by sfrp3 knockdown. |
2022-09-29 |
2023-08-14 |
mouse |
| Yong Wang, Yulong Xing, Xiuling Liu, Lu Chen, Gang Zhang, Yong L. G-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in Ang II-treated mice. Peptides. 2022-09-15. PMID:36108979. |
g-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in ang ii-treated mice. |
2022-09-15 |
2023-08-14 |
mouse |
| Yong Wang, Yulong Xing, Xiuling Liu, Lu Chen, Gang Zhang, Yong L. G-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in Ang II-treated mice. Peptides. 2022-09-15. PMID:36108979. |
the model of cardiac hypertrophy was induced by infusion of angiotensin (ang) ii in mice, and was induced by ang ii treatment in neonatal rat cardiomyocyte (nrcm). |
2022-09-15 |
2023-08-14 |
mouse |
| Yong Wang, Yulong Xing, Xiuling Liu, Lu Chen, Gang Zhang, Yong L. G-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in Ang II-treated mice. Peptides. 2022-09-15. PMID:36108979. |
the mouse model of myocardial hypertrophy was induced by angiotensin (ang) Ⅱ, and the neonatal rat cardiomyocyte (nrcm) was induced by ang Ⅱ treatment. |
2022-09-15 |
2023-08-14 |
mouse |
| Yong Wang, Yulong Xing, Xiuling Liu, Lu Chen, Gang Zhang, Yong L. G-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in Ang II-treated mice. Peptides. 2022-09-15. PMID:36108979. |
gpr30 agonist g1 reduced cardiac hypertrophy induced by ang ii in mice, and reduced cardiac atrial natriuretic peptide (anp), brain natriuretic peptide (bnp) and β-myosin heavy chain (β-mhc) induced by ang ii. |
2022-09-15 |
2023-08-14 |
mouse |
| Mingyue Ji, Yong Li, Yun Liu, Genshan M. Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats. Journal of cardiovascular pharmacology. vol 80. issue 3. 2022-09-06. PMID:36067399. |
vaspin attenuates ang ii-induced hypertrophy of nrcms and fibrosis of nrcfs through suppressing pi3k/akt pathway to alleviate oxidative stress. |
2022-09-06 |
2023-08-14 |
rat |
| Ze-Yu Li, Guo-Qing Lu, Jing Lu, Pan-Xia Wang, Xiao-Lei Zhang, Yong Zou, Pei-Qing Li. SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice. Acta pharmacologica Sinica. 2022-08-30. PMID:36042291. |
sirt3 has been proven to be cardioprotective in a model of ang ii-induced cardiac hypertrophy. |
2022-08-30 |
2023-08-14 |
mouse |
| Mingyue Ji, Yun Liu, Zhi Zuo, Cheng Xu, Li Lin, Yong L. Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis. Biology direct. vol 17. issue 1. 2022-08-22. PMID:35996142. |
angiotensin (ang) ii induced cardiac hypertrophy in mice and neonatal rat cardiomyocytes (nrcms) or hl-1 cells in vitro. |
2022-08-22 |
2023-08-14 |
mouse |
| Ming-Yu Liu, Li-Juan Yue, Ying-Chun Luo, Jing Lu, Guo-Dong Wu, Si-Qi Sheng, Yuan-Qi Shi, Zeng-Xiang Don. SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy. European journal of pharmacology. 2022-07-21. PMID:35863508. |
here, angiotensin ii (ang ii) -treated neonatal rat cardiomyocytes and transverse aortic constriction (tac) mice were used to investigate the effect and mechanism of mhrt in cardiac hypertrophy in vitro and in vivo. |
2022-07-21 |
2023-08-14 |
mouse |
| Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhan. ANGPTL8 is a negative regulator in pathological cardiac hypertrophy. Cell death & disease. vol 13. issue 7. 2022-07-19. PMID:35851270. |
we found that serum angptl8 levels were significantly increased in hypertensive patients with cardiac hypertrophy and in mice with cardiac hypertrophy induced by ang ii or tac. |
2022-07-19 |
2023-08-14 |
mouse |