| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingyue Ji, Zhi Zuo, Mengyuan Zhang, Zhen Xu, Guoxin H. Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides. 2022-02-26. PMID:35218795. |
experiments were carried out in mice receiving angiotensin (ang) ii to induce cardiac hypertrophy, and in neonatal rat cardiomyocytes (nrcms) or human cardiac ac16 cells with ang ii-induced cardiomyocytes hypertrophy. |
2022-02-26 |
2023-08-13 |
mouse |
| Mingyue Ji, Zhi Zuo, Mengyuan Zhang, Zhen Xu, Guoxin H. Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides. 2022-02-26. PMID:35218795. |
ostn overexpression attenuated the hypertrophy and fibrosis of heart in mice induced by ang ii. |
2022-02-26 |
2023-08-13 |
mouse |
| Mingyue Ji, Zhi Zuo, Mengyuan Zhang, Zhen Xu, Guoxin H. Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides. 2022-02-26. PMID:35218795. |
overexpression of ostn inhibited hypertrophy of nrcms and ac16 cells induced by ang ii. |
2022-02-26 |
2023-08-13 |
mouse |
| Mingyue Ji, Zhi Zuo, Mengyuan Zhang, Zhen Xu, Guoxin H. Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides. 2022-02-26. PMID:35218795. |
overexpression of nadph oxidase 1 (nox1) reversed the attenuating effects of ostn on the ang ii-induced hypertrophic cardiomyocytes. |
2022-02-26 |
2023-08-13 |
mouse |
| Mingyue Ji, Zhi Zuo, Mengyuan Zhang, Zhen Xu, Guoxin H. Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides. 2022-02-26. PMID:35218795. |
treatment with nadph oxidase inhibitor apocynin (apo) suppressed the hypertrophy of nrcms and ac16 cells induced by ang ii. |
2022-02-26 |
2023-08-13 |
mouse |
| Dongjian Han, Fuhang Wang, Bo Wang, Zhentao Qiao, Xinyue Cui, Yi Zhang, Qingjiao Jiang, Miaomiao Liu, Jiahong Shangguan, Xiaohui Zheng, Yajun Bai, Chunyan Du, Deliang She. A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway. Frontiers in pharmacology. vol 13. 2022-02-21. PMID:35185583. |
a hypertrophic model was established in rats using transverse-aortic constriction (tac) surgery and in neonatal rat cardiomyocytes (nrcms) using angiotensin ii (ang ii). |
2022-02-21 |
2023-08-13 |
rat |
| Zhenzhou Zhang, Jianqiong Tang, Jiawei Song, Mengshi Xie, Ying Liu, Zhaojie Dong, Xiaoyan Liu, Xueting Li, Miwen Zhang, Yihang Chen, Hongyu Shi, Jiuchang Zhon. Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling. Free radical biology & medicine. 2022-02-05. PMID:35122997. |
ang ii infusion led to marked increases in systolic blood pressure levels and reduction of elabela levels in hypertensive mice with augmented myocardial hypertrophy and fibrosis. |
2022-02-05 |
2023-08-13 |
mouse |
| David Mondaca-Ruff, Clara Quiroga, Ignacio Norambuena-Soto, Jaime A Riquelme, Alejandra San Martin, Mario Bustamante, Sergio Lavandero, Mario Chion. Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells. Journal of cellular and molecular medicine. 2022-02-04. PMID:35118791. |
we have reported that autophagy regulates ang ii-induced vascular smooth muscle cell (vsmc) hypertrophy, but the mechanism mediating this effect is still unknown. |
2022-02-04 |
2023-08-13 |
rat |
| Juan Wang, Hongjian Li, Zhongying Lv, Xiaomei Luo, Wei Deng, Ting Zou, Yue Zhang, Wanyue Sang, Xuehua Wan. The miR-214-3p/c-Ski axis modulates endothelial-mesenchymal transition in human coronary artery endothelial cells in vitro and in mice model in vivo. Human cell. 2022-01-03. PMID:34978047. |
in the ang ii-induced mouse cardiac hypertrophic model, ang ii-caused increase of cellular cross-sectional area and cardiac fibrosis were partially ameliorated by lv-c-ski; when mice were co-treated with lv-c-ski and agomir-214-3p, the beneficial effects of lv-c-ski were reversed. |
2022-01-03 |
2023-08-13 |
mouse |
| Juan Wang, Hongjian Li, Zhongying Lv, Xiaomei Luo, Wei Deng, Ting Zou, Yue Zhang, Wanyue Sang, Xuehua Wan. The miR-214-3p/c-Ski axis modulates endothelial-mesenchymal transition in human coronary artery endothelial cells in vitro and in mice model in vivo. Human cell. 2022-01-03. PMID:34978047. |
in conclusion, the mir-214-3p/c-ski axis modulated ang ii-induced end-mt in hcaecs and cardiac hypertrophy and fibrosis in the mice model. |
2022-01-03 |
2023-08-13 |
mouse |
| Guizhi Jia, Chunguang Liang, Wenhui Li, Hongliang Da. MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7. Bioengineered. vol 13. issue 1. 2021-12-24. PMID:34951337. |
the current work was aimed to determine the role and underlying mechanism of mir-410-3p on angiotensin ii (ang ii) induced cardiac hypertrophy. |
2021-12-24 |
2023-08-13 |
Not clear |
| Guizhi Jia, Chunguang Liang, Wenhui Li, Hongliang Da. MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7. Bioengineered. vol 13. issue 1. 2021-12-24. PMID:34951337. |
mir-410-3p was found significantly up-regulated in ang ii-induced cardiac hypertrophy. |
2021-12-24 |
2023-08-13 |
Not clear |
| Guizhi Jia, Chunguang Liang, Wenhui Li, Hongliang Da. MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7. Bioengineered. vol 13. issue 1. 2021-12-24. PMID:34951337. |
in summary, our findings revealed that mir-410-3p mediated ang ii-induced cardiac hypertrophy via targeting inhibition of smad7. |
2021-12-24 |
2023-08-13 |
Not clear |
| Ge Jin, Lintao Wang, Jun M. Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation. European journal of pharmacology. 2021-12-17. PMID:34919891. |
the findings demonstrated that stat5 inhibitor resulted in a substantial decrease in cardiac hypertrophy in ang ii-induced mice and that this effect is mediated by decreasing inflammation, thus identifying one mechanism of ang ii-induced stat5 activation. |
2021-12-17 |
2023-08-13 |
mouse |
| Zhiyong Sheng, Jianning Xu, Fuxing Li, Ying Yuan, Xiaogang Peng, Shenjian Chen, Rui Zhou, Wei Huan. The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway. Experimental cell research. vol 410. issue 1. 2021-12-11. PMID:34856161. |
in the present work, thoracic transverse aortic constriction (tac) was performed in transgenic mice with rnf146 knockout mice (ko) and wild-type mice, and neonatal rat cardiomyocytes (nrcms) were subjected to angiotensin ii (ang ii) stimulation to induce cardiac hypertrophy in vitro and in vivo. |
2021-12-11 |
2023-08-13 |
mouse |
| Zhiyong Sheng, Jianning Xu, Fuxing Li, Ying Yuan, Xiaogang Peng, Shenjian Chen, Rui Zhou, Wei Huan. The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway. Experimental cell research. vol 410. issue 1. 2021-12-11. PMID:34856161. |
rnf146-ko mice and knockdown of rnf146 nrcms attenuated tac- or ang ii-stimulated cardiac hypertrophy. |
2021-12-11 |
2023-08-13 |
mouse |
| Yao Li, Yanhu Shi, Yaoli He, Xiaoming Li, Junlu Yan. RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-α-dependent lipogenesis pathway. Bioengineered. vol 12. issue 2. 2021-12-02. PMID:34854353. |
liver x receptors (lxr-α) agonists reduce cellular hypertrophy initiated by various hypertrophic stimuli as lipopolysaccharides and ang ii. |
2021-12-02 |
2023-08-13 |
Not clear |
| Si-Lin Lv, Zi-Fan Zeng, Wen-Qiang Gan, Wei-Qi Wang, Tie-Gang Li, Yu-Fang Hou, Zheng Yan, Ri-Xin Zhang, Min Yan. Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation. Acta pharmacologica Sinica. vol 42. issue 12. 2021-12-01. PMID:34226664. |
as expected, darapladib significantly prevented ang ii-induced cardiac fibrosis, ventricular hypertrophy, and cardiac dysfunction, with potent abatement of macrophage infiltration and inflammatory response. |
2021-12-01 |
2023-08-13 |
Not clear |
| Tongtong Shen, Yu Liu, Shuangshuang Dong, Xiaohong Xu, Xinxin Wang, Yong Li, Limin Zho. Alarin moderated myocardial hypertrophy via inhibiting cyclic adenosine monophosphate/protein kinase A signaling pathway to attenuate autophagy. Peptides. vol 146. 2021-11-26. PMID:34624429. |
myocardial hypertrophy was induced by angiotensin (ang) ii infusion in vivo in mice and by ang ii treatment of neonatal rat cardiomyocytes (nrcms) in vitro. |
2021-11-26 |
2023-08-13 |
mouse |
| Tongtong Shen, Yu Liu, Shuangshuang Dong, Xiaohong Xu, Xinxin Wang, Yong Li, Limin Zho. Alarin moderated myocardial hypertrophy via inhibiting cyclic adenosine monophosphate/protein kinase A signaling pathway to attenuate autophagy. Peptides. vol 146. 2021-11-26. PMID:34624429. |
the ang ii-induced hypertrophy and fibrosis of the heart were alleviated after alarin administration in mice. |
2021-11-26 |
2023-08-13 |
mouse |