| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Mazzolai, J Nussberger, J F Aubert, D B Brunner, G Gabbiani, H R Brunner, T Pedrazzin. Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension (Dallas, Tex. : 1979). vol 31. issue 6. 1998-06-19. PMID:9622149. |
these mice develop myocardial hypertrophy without signs of fibrosis independently from the presence of hypertension, demonstrating that local ang ii production is important in mediating the hypertrophic response in vivo. |
1998-06-19 |
2023-08-12 |
mouse |
| K Harada, I Komuro, I Shiojima, D Hayashi, S Kudoh, T Mizuno, K Kijima, H Matsubara, T Sugaya, K Murakami, Y Yazak. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation. vol 97. issue 19. 1998-06-18. PMID:9609089. |
moreover, it has been reported that pressure overload-induced cardiac hypertrophy is completely prevented by ace inhibitors in vivo and that the stored angiotensin ii (ang ii) is released from cardiac myocytes in response to mechanical stretch and induces cardiomyocyte hypertrophy through the ang ii type 1 receptor (at1) in vitro. |
1998-06-18 |
2023-08-12 |
mouse |
| N J Brown, D E Vaugha. Angiotensin-converting enzyme inhibitors. Circulation. vol 97. issue 14. 1998-05-27. PMID:9577953. |
ace inhibitors alter the balance between the vasoconstrictive, salt-retentive, and hypertrophic properties of angiotensin ii (ang ii) and the vasodilatory and natriuretic properties of bradykinin and alter the metabolism of a number of other vasoactive substances. |
1998-05-27 |
2023-08-12 |
Not clear |
| C Heymes, J S Silvestre, C Llorens-Cortes, B Chevalier, F Marotte, B I Levy, B Swynghedauw, J L Samue. Cardiac senescence is associated with enhanced expression of angiotensin II receptor subtypes. Endocrinology. vol 139. issue 5. 1998-05-08. PMID:9564874. |
recent studies have pointed out the differential role of angiotensin ii (ang ii) receptor subtypes, at1 and at2, in cardiac hypertrophy and fibrosis during pathological cardiac growth. |
1998-05-08 |
2023-08-12 |
rat |
| K Harada, I Komuro, Y Zou, S Kudoh, K Kijima, H Matsubara, T Sugaya, K Murakami, Y Yazak. Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice. Circulation research. vol 82. issue 7. 1998-05-05. PMID:9562437. |
increasing evidence has suggested that locally produced angiotensin ii (ang ii) plays an important role in the development of cardiac hypertrophy through the ang ii type 1 receptor (at1). |
1998-05-05 |
2023-08-12 |
mouse |
| K Harada, I Komuro, Y Zou, S Kudoh, K Kijima, H Matsubara, T Sugaya, K Murakami, Y Yazak. Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice. Circulation research. vol 82. issue 7. 1998-05-05. PMID:9562437. |
we and others have recently reported that ang ii is critical for mechanical stress-induced hypertrophic responses in vitro. |
1998-05-05 |
2023-08-12 |
mouse |
| K Harada, I Komuro, Y Zou, S Kudoh, K Kijima, H Matsubara, T Sugaya, K Murakami, Y Yazak. Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice. Circulation research. vol 82. issue 7. 1998-05-05. PMID:9562437. |
using at1a knockout (ko) mice, we examined whether ang ii is indispensable for pressure overload-induced cardiac hypertrophy in the present study. |
1998-05-05 |
2023-08-12 |
mouse |
| H Aoki, S Izumo, J Sadoshim. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circulation research. vol 82. issue 6. 1998-04-24. PMID:9546375. |
therefore, we examined (1) whether rho is activated by the hypertrophic stimulus, angiotensin ii (ang ii), and (2) whether rho mediates the ang ii-induced organization of actin fibers in cultured neonatal rat cardiac myocytes. |
1998-04-24 |
2023-08-12 |
rat |
| Y Zou, I Komuro, T Yamazaki, S Kudoh, R Aikawa, W Zhu, I Shiojima, Y Hiroi, K Tobe, T Kadowaki, Y Yazak. Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. Circulation research. vol 82. issue 3. 1998-03-23. PMID:9486662. |
angiotensin ii (ang ii) induces hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. |
1998-03-23 |
2023-08-12 |
Not clear |
| O Aharonovitz, S Aboulafia-Etzion, J Leor, A Battler, Y Grano. Stimulation of 42/44 kDa mitogen-activated protein kinases by arginine vasopressin in rat cardiomyocytes. Biochimica et biophysica acta. vol 1401. issue 1. 1998-02-20. PMID:9459490. |
vasoconstrictors, such as angiotensin ii (ang ii), are involved in the regulatory mechanisms of post myocardial infarction (mi) hypertrophy. |
1998-02-20 |
2023-08-12 |
rat |
| R L Price, W Carver, D G Simpson, L Fu, J Zhao, T K Borg, L Terraci. The effects of angiotensin II and specific angiotensin receptor blockers on embryonic cardiac development and looping patterns. Developmental biology. vol 192. issue 2. 1998-02-13. PMID:9441690. |
in whole embryo culture, ang ii added to the culture media resulted in increased ventricular growth and myocyte hypertrophy when treated embryos were compared to cultured littermate controls. |
1998-02-13 |
2023-08-12 |
rat |
| S W Rabkin, P S Sunga, J S Sanghera, S L Pelec. Reduction of angiotensin II-induced activation of mitogen-activated protein kinase in cardiac hypertrophy. Cellular and molecular life sciences : CMLS. vol 53. issue 11-12. 1998-02-13. PMID:9447248. |
to investigate the regulation of map kinases in the heart in response to angiotensin ii (ang ii), once cardiac hypertrophy has become established, ventricular and skeletal muscle explants were studied from dahl s salt-sensitive and dahl r salt-resistant rats that were on a high (6% nacl) salt supplement in their diet. |
1998-02-13 |
2023-08-12 |
rat |
| S W Rabkin, P S Sunga, J S Sanghera, S L Pelec. Reduction of angiotensin II-induced activation of mitogen-activated protein kinase in cardiac hypertrophy. Cellular and molecular life sciences : CMLS. vol 53. issue 11-12. 1998-02-13. PMID:9447248. |
these results are consistent with a disturbance in the regulation of cell-signalling pathways in cardiac hypertrophy in which the map kinase response to ang ii is dramatically altered. |
1998-02-13 |
2023-08-12 |
rat |
| K A Peifley, J A Winkle. Angiotensin II and endothelin-1 increase fibroblast growth factor-2 mRNA expression in vascular smooth muscle cells. Biochemical and biophysical research communications. vol 242. issue 1. 1998-02-12. PMID:9439636. |
the vasoactive hormone angiotensin ii (ang ii) can stimulate vascular smooth muscle cell (smc) hypertrophy and proliferation; thus, it may have an important role in the pathogenesis of hypertension, atherosclerosis and restenosis. |
1998-02-12 |
2023-08-12 |
rat |
| J Wharton, K Morgan, R A Rutherford, J D Catravas, A Chester, B F Whitehead, M R De Leval, M H Yacoub, J M Pola. Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. The Journal of pharmacology and experimental therapeutics. vol 284. issue 1. 1998-02-11. PMID:9435195. |
cardiac expression of angiotensin ii (ang ii) at1 and at2 receptor subtypes is species dependent, and changes in their relative proportion may influence myocardial hypertrophy and fibrosis. |
1998-02-11 |
2023-08-12 |
human |
| F G Spinale, H H Holzgrefe, J D Walker, R Mukherjee, S B Kribbs, J R Powell, M Antonacci. Angiotensin II subtype-1 receptor blockade during the development of left ventricular hypertrophy in dogs: effects on ventricular and myocyte function. Journal of cardiovascular pharmacology. vol 30. issue 5. 1998-02-10. PMID:9388045. |
however, whether and to what extent at1 ang ii-receptor blockade may influence lv and myocyte function during the hypertrophic process remains unclear. |
1998-02-10 |
2023-08-12 |
Not clear |
| F G Spinale, H H Holzgrefe, J D Walker, R Mukherjee, S B Kribbs, J R Powell, M Antonacci. Angiotensin II subtype-1 receptor blockade during the development of left ventricular hypertrophy in dogs: effects on ventricular and myocyte function. Journal of cardiovascular pharmacology. vol 30. issue 5. 1998-02-10. PMID:9388045. |
thus at1 ang ii-receptor blockade instituted in this model of developing lv hypertrophy, significantly reduced lv mass but did not reduce the degree of lv dilation. |
1998-02-10 |
2023-08-12 |
Not clear |
| F G Spinale, H H Holzgrefe, J D Walker, R Mukherjee, S B Kribbs, J R Powell, M Antonacci. Angiotensin II subtype-1 receptor blockade during the development of left ventricular hypertrophy in dogs: effects on ventricular and myocyte function. Journal of cardiovascular pharmacology. vol 30. issue 5. 1998-02-10. PMID:9388045. |
at1 ang ii-receptor blockade improved certain indices of myocyte contractile function from untreated hypertrophy values. |
1998-02-10 |
2023-08-12 |
Not clear |
| F G Spinale, H H Holzgrefe, J D Walker, R Mukherjee, S B Kribbs, J R Powell, M Antonacci. Angiotensin II subtype-1 receptor blockade during the development of left ventricular hypertrophy in dogs: effects on ventricular and myocyte function. Journal of cardiovascular pharmacology. vol 30. issue 5. 1998-02-10. PMID:9388045. |
these findings suggest that in this pacing-recovery model, the development of lv hypertrophy and myocyte contractile dysfunction may be caused, at least in part, by at1 ang ii-receptor activation. |
1998-02-10 |
2023-08-12 |
Not clear |
| R H Ritchie, J D Marsh, W D Lancaster, C A Diglio, R J Schiebinge. Bradykinin blocks angiotensin II-induced hypertrophy in the presence of endothelial cells. Hypertension (Dallas, Tex. : 1979). vol 31. issue 1. 1998-02-03. PMID:9449388. |
manifestation of this mechanism appears to require bradykinin-stimulated release of paracrine factor(s) from endothelial cells, which are also able to block the hypertrophic effects of ang ii. |
1998-02-03 |
2023-08-12 |
rat |