| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Sabri, B I Levy, P Poitevin, L Caputo, E Faggin, F Marotte, L Rappaport, J L Samue. Differential roles of AT1 and AT2 receptor subtypes in vascular trophic and phenotypic changes in response to stimulation with angiotensin II. Arteriosclerosis, thrombosis, and vascular biology. vol 17. issue 2. 1997-04-03. PMID:9081679. |
administration of only losartan to normal rats reproduced the ang ii-induced vascular hypertrophy, with no effect on vsmc phenotype. |
1997-04-03 |
2023-08-12 |
rat |
| G Wolf, R A Stah. Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1. Kidney international. vol 50. issue 6. 1997-02-28. PMID:8943498. |
angiotensin ii (ang ii) induces hypertrophy of cultured proximal tubular epithelial cells including the llc-pk1 cell line. |
1997-02-28 |
2023-08-12 |
Not clear |
| G Wolf, R A Stah. Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1. Kidney international. vol 50. issue 6. 1997-02-28. PMID:8943498. |
treatment of llc-pk1 cells with p27kip1 antisense, but not missense, oligonucleotides abolished the ang ii-mediated cell hypertrophy as measured by de novo protein synthesis and total protein content, and facilitated entry into the s-phase of the cell cycle. |
1997-02-28 |
2023-08-12 |
Not clear |
| G Wolf, R A Stah. Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1. Kidney international. vol 50. issue 6. 1997-02-28. PMID:8943498. |
furthermore, this induction of the cdk-inhibitor appears pivotal in the hypertrophy induced by ang ii and elucidates the molecular mechanisms associated with this growth response in proximal tubular cells. |
1997-02-28 |
2023-08-12 |
Not clear |
| J Sadoshima, H Aoki, S Izum. Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes. Circulation research. vol 80. issue 2. 1997-02-25. PMID:9012745. |
using cultured neonatal rat cardiac myocytes, we examined the effect of angiotensin ii (ang ii), a hypertrophic stimulus, on mrna and protein expression of cyclins and cyclin-dependent protein kinases (cdks), activity of cdks, and phosphorylation of retinoblastoma gene product (prb). |
1997-02-25 |
2023-08-12 |
rat |
| K H Choi, S W Kang, H Y Lee, D S Ha. The effects of high glucose concentration on angiotensin II- or transforming growth factor-beta-induced DNA synthesis, hypertrophy and collagen synthesis in cultured rat mesangial cells. Yonsei medical journal. vol 37. issue 5. 1997-02-06. PMID:8997162. |
in order to investigate whether the intracellular signaling pathways inducing proliferation, hypertrophy and matrix synthesis of mesangial cells are altered in a diabetic environment, we evaluated the effects of a high concentration of extracellular glucose(25 mm; 450 mg/dl) on [3h]thymidine uptake, hypertrophy, and [3h]proline incorporation into a collagenase-sensitive protein, induced by angiotensin ii(ang ii) or transforming growth factor(tgf)-beta, in cultured rat mesangial cells. |
1997-02-06 |
2023-08-12 |
rat |
| K H Choi, S W Kang, H Y Lee, D S Ha. The effects of high glucose concentration on angiotensin II- or transforming growth factor-beta-induced DNA synthesis, hypertrophy and collagen synthesis in cultured rat mesangial cells. Yonsei medical journal. vol 37. issue 5. 1997-02-06. PMID:8997162. |
in conclusion, although the signaling pathway for dna synthesis by ang ii or tgf-beta are influenced, possibly mediated by pkc-independent mechanism(s), the pathway inducing hypertrophy or collagen synthesis by both agents appears to be unchanged under the high extracellular glucose concentration in cultured rat mesangial cells. |
1997-02-06 |
2023-08-12 |
rat |
| S Kudoh, I Komuro, T Mizuno, T Yamazaki, Y Zou, I Shiojima, N Takekoshi, Y Yazak. Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circulation research. vol 80. issue 1. 1997-01-27. PMID:8978332. |
many lines of evidence have suggested that angiotensin ii (ang ii)plays an important role in cardiac hypertrophy. |
1997-01-27 |
2023-08-12 |
rat |
| S Kudoh, I Komuro, T Mizuno, T Yamazaki, Y Zou, I Shiojima, N Takekoshi, Y Yazak. Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circulation research. vol 80. issue 1. 1997-01-27. PMID:8978332. |
in conclusion, ang ii may activate jnk in cultured cardiac myocytes through an increase in intracellular ca2+ and activation of protein kinase c, and the activated jnk may regulate gene expression by activating ap-1 during ang ii-induced cardiac hypertrophy. |
1997-01-27 |
2023-08-12 |
rat |
| T Takahashi, Y Kawahara, M Okuda, M Yokoyam. Increasing cAMP antagonizes hypertrophic response to angiotensin II without affecting Ras and MAP kinase activation in vascular smooth muscle cells. FEBS letters. vol 397. issue 1. 1997-01-14. PMID:8941720. |
angiotensin ii (ang ii), a potent hypertrophic factor for vascular smooth muscle cells (vsmc), induces activation of the ras proto-oncogene product (ras) and mitogen-activated protein (map) kinases, and tyrosine phosphorylation of a focal adhesion-associated protein, paxillin. |
1997-01-14 |
2023-08-12 |
Not clear |
| T Takahashi, Y Kawahara, M Okuda, M Yokoyam. Increasing cAMP antagonizes hypertrophic response to angiotensin II without affecting Ras and MAP kinase activation in vascular smooth muscle cells. FEBS letters. vol 397. issue 1. 1997-01-14. PMID:8941720. |
these results indicate that increasing camp antagonizes the hypertrophic response to ang ii without affecting ras and map kinase activation in vsmc and suggest that it does not interrupt signaling from the ang ii receptor to focal adhesions. |
1997-01-14 |
2023-08-12 |
Not clear |
| S N Iyer, M K Raizada, M J Katovic. AT1 receptor density changes during development of hypertension in hyperinsulinemic rats. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 18. issue 6. 1997-01-08. PMID:8842564. |
these results suggest that chronic fructose treatment activates the renin-angiotensin system, which is manifested by an increase in plasma ang ii, elevation of blood pressure, cardiac hypertrophy, and changes in at1 receptor density. |
1997-01-08 |
2023-08-12 |
rat |
| P W Anderson, X Y Zhang, J Tian, J D Correale, X P Xi, D Yang, K Graf, R E Law, W A Hsue. Insulin and angiotensin II are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney international. vol 50. issue 3. 1997-01-06. PMID:8872947. |
angiotensin ii (ang ii) and insulin are implicated in the mesangial cell hypertrophy and excessive accumulation of mesangial matrix seen in glomerulosclerosis. |
1997-01-06 |
2023-08-12 |
rat |
| K Persson, R K Pandita, K Waldeck, K E Andersso. Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility. The American journal of physiology. vol 271. issue 5 Pt 2. 1997-01-03. PMID:8945952. |
the renin-angiotensin system has been implicated in vascular and cardiac hypertrophy, but the involvement of angiotensin ii (ang ii) as a trophic factor in the lower urinary tract has not been investigated. |
1997-01-03 |
2023-08-12 |
rat |
| K Persson, R K Pandita, K Waldeck, K E Andersso. Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility. The American journal of physiology. vol 271. issue 5 Pt 2. 1997-01-03. PMID:8945952. |
in conclusion, no evidence was found for involvement of ang ii in development of bladder hypertrophy. |
1997-01-03 |
2023-08-12 |
rat |
| R E Schmieder, M R Langenfeld, A Friedrich, H P Schobel, C D Gatzka, H Weihprech. Angiotensin II related to sodium excretion modulates left ventricular structure in human essential hypertension. Circulation. vol 94. issue 6. 1996-12-17. PMID:8822984. |
urinary sodium excretion and angiotensin ii (ang ii), which are linked in a physiological feedback mechanism, have both been described to be blood pressure-independent determinants of left ventricular hypertrophy in essential hypertension. |
1996-12-17 |
2023-08-12 |
human |
| R E Schmieder, M R Langenfeld, A Friedrich, H P Schobel, C D Gatzka, H Weihprech. Angiotensin II related to sodium excretion modulates left ventricular structure in human essential hypertension. Circulation. vol 94. issue 6. 1996-12-17. PMID:8822984. |
we conducted a study to investigate the interaction of sodium excretion with ang ii and its potential impact on myocardial hypertrophy. |
1996-12-17 |
2023-08-12 |
human |
| D F Liao, J L Duff, G Daum, S L Pelech, B C Ber. Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells, Role of Raf. Circulation research. vol 79. issue 5. 1996-12-09. PMID:8888693. |
however, ang ii causes cell hypertrophy, whereas pdgf causes hyperplasia. |
1996-12-09 |
2023-08-12 |
rat |
| R M Touyz, J Fareh, G Thibault, E L Schiffri. Intracellular Ca2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 28. issue 5. 1996-12-06. PMID:8901826. |
the vasoactive peptides angiotensin ii (ang ii) and endothelin-1 (et-1) have been implicated in cardiac hypertrophy. |
1996-12-06 |
2023-08-12 |
rat |
| P E McEwan, G B Lindop, C J Kenyo. Control of cell proliferation in the rat adrenal gland in vivo by the renin-angiotensin system. The American journal of physiology. vol 271. issue 1 Pt 1. 1996-12-03. PMID:8760097. |
ang ii and sodium restriction caused hypertrophy of the zona glomerulosa with two- to threefold increases in brdurd indexes. |
1996-12-03 |
2023-08-12 |
rat |