| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Kijima, H Matsubara, S Murasawa, K Maruyama, Y Mori, N Ohkubo, I Komuro, Y Yazaki, T Iwasaka, M Inad. Mechanical stretch induces enhanced expression of angiotensin II receptor subtypes in neonatal rat cardiac myocytes. Circulation research. vol 79. issue 4. 1996-11-27. PMID:8831515. |
mechanical stress plays a pivotal role in the development of cardiac hypertrophy during hemodynamic overload, and angiotensin (ang) ii secreted from stretched myocytes plays an important role in mechanical stretch-induced hypertrophy. |
1996-11-27 |
2023-08-12 |
rat |
| G W Booz, K M Bake. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 28. issue 4. 1996-11-07. PMID:8843890. |
we compared the ability of angiotensin ii (ang ii) to induce hypertrophy of neonatal rat ventricular myocytes with that of endothelin-1. |
1996-11-07 |
2023-08-12 |
rat |
| G W Booz, K M Bake. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 28. issue 4. 1996-11-07. PMID:8843890. |
these findings have potential clinical significance in that regression of hypertension-induced cardiac hypertrophy by at1 antagonists may be in part due to an unopposed antigrowth effect of ang ii mediated via at2. |
1996-11-07 |
2023-08-12 |
rat |
| B I Levy, J Benessiano, D Henrion, L Caputo, C Heymes, M Duriez, P Poitevin, J L Samue. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. The Journal of clinical investigation. vol 98. issue 2. 1996-09-23. PMID:8755652. |
therefore, we investigated the effect of at1 or at2 subtype receptor chronic blockade by losartan or pd123319 on the vascular hypertrophy in rats with ang ii-induced hypertension. |
1996-09-23 |
2023-08-12 |
rat |
| B I Levy, J Benessiano, D Henrion, L Caputo, C Heymes, M Duriez, P Poitevin, J L Samue. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. The Journal of clinical investigation. vol 98. issue 2. 1996-09-23. PMID:8755652. |
chronic blockade of at1i in rats receiving ang ii resulted in normal arterial pressure, but it induced significant aortic hypertrophy and fibrosis. |
1996-09-23 |
2023-08-12 |
rat |
| B I Levy, J Benessiano, D Henrion, L Caputo, C Heymes, M Duriez, P Poitevin, J L Samue. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. The Journal of clinical investigation. vol 98. issue 2. 1996-09-23. PMID:8755652. |
chronic blockade of at2 receptors in ang ii-induced hypertensive rats had no effect on arterial pressure, but antagonized the effect of ang ii on arterial hypertrophy and fibrosis, suggesting that in vivo vasotrophic effects of ang ii are at least partially mediated via at2 subtype receptors. |
1996-09-23 |
2023-08-12 |
rat |
| K Iwami, N Ashizawa, Y S Do, K Graf, W A Hsue. Comparison of ANG II with other growth factors on Egr-1 and matrix gene expression in cardiac fibroblasts. The American journal of physiology. vol 270. issue 6 Pt 2. 1996-09-19. PMID:8764262. |
the purpose of the present investigation was to compare the effects of angiotensin ii (ang ii) other growth factors implicated to play a role in ventricular hypertrophy on cardiac fibroblast changes associated with cardiac remodeling. |
1996-09-19 |
2023-08-12 |
rat |
| K Iwami, N Ashizawa, Y S Do, K Graf, W A Hsue. Comparison of ANG II with other growth factors on Egr-1 and matrix gene expression in cardiac fibroblasts. The American journal of physiology. vol 270. issue 6 Pt 2. 1996-09-19. PMID:8764262. |
thus ang ii, relative to ne, et, and egf, appears to play a prominent and direct role in fibroblast changes associated with cardiac hypertrophy. |
1996-09-19 |
2023-08-12 |
rat |
| S W Rabkin, J E Damen, V Goutsouliak, G Krysta. Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa protein. American journal of hypertension. vol 9. issue 3. 1996-08-30. PMID:8695021. |
ang ii induced tyr phos of this protein in dahl s rats on a low salt diet and dahl r rats on a high salt diet, both of which show mild cardiac hypertrophy. |
1996-08-30 |
2023-08-12 |
rat |
| S W Rabkin, J E Damen, V Goutsouliak, G Krysta. Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa protein. American journal of hypertension. vol 9. issue 3. 1996-08-30. PMID:8695021. |
thus cardiac hypertrophy is characterized by an abundant 120 kda cytosolic tyr phos protein, which is apparent with ang ii stimulation in milder degrees of cardiac hypertrophy, and is most likely an as yet uncharacterized protein. |
1996-08-30 |
2023-08-12 |
rat |
| P M Lear, L J Heller, J R Prohask. Cardiac hypertrophy in copper-deficient rats is not attenuated by angiotensin II receptor antagonist L-158,809. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 212. issue 3. 1996-08-15. PMID:8677275. |
we tested the hypothesis that cardiac hypertrophy which accompanies copper (cu) deficiency was mediated by angiotensin ii (ang ii). |
1996-08-15 |
2023-08-12 |
rat |
| P M Lear, L J Heller, J R Prohask. Cardiac hypertrophy in copper-deficient rats is not attenuated by angiotensin II receptor antagonist L-158,809. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 212. issue 3. 1996-08-15. PMID:8677275. |
since ang ii blockage lowered hw/bw and lv/bw in both groups, the stimulus for cardiac hypertrophy in cu-deficient rats remains unknown. |
1996-08-15 |
2023-08-12 |
rat |
| H Akimoto, H Ito, M Tanaka, S Adachi, M Hata, M Lin, H Fujisaki, F Marumo, M Hiro. Heparin and heparan sulfate block angiotensin II-induced hypertrophy in cultured neonatal rat cardiomyocytes. A possible role of intrinsic heparin-like molecules in regulation of cardiomyocyte hypertrophy. Circulation. vol 93. issue 4. 1996-07-15. PMID:8641011. |
to elucidate a possible role of endogenous heparin-like molecules in regulating cardiomyocyte hypertrophy, we investigated the effects of heparin and heparan sulfate on angiotensin (ang) ii-induced hypertrophy in cultured neonatal rat cardiomyocytes. |
1996-07-15 |
2023-08-12 |
rat |
| O Mikami, I Nagaoka, K Hasunuma, H Takahash. [Angiotensin II receptors in a rat model of hypobaric hypoxic pulmonary hypertension]. Nihon Kyobu Shikkan Gakkai zasshi. vol 34. issue 2. 1996-06-19. PMID:8622275. |
after 3 days of hypobaric hypoxia (380 torr), the at(1a) mrna level and the index of ang ii receptors had increased, but right ventricular hypertrophy was not still evident. |
1996-06-19 |
2023-08-12 |
rat |
| H Takano, I Komuro, Y Zou, S Kudoh, T Yamazaki, Y Yazak. Activation of p70 S6 protein kinase is necessary for angiotensin II-induced hypertrophy in neonatal rat cardiac myocytes. FEBS letters. vol 379. issue 3. 1996-05-15. PMID:8603701. |
although many lines of evidence have suggested that angiotensin ii (ang ii) plays an important role in development of cardiac hypertrophy, the mechanism by which ang ii increases protein synthesis in cardiac myocytes remains unclear. |
1996-05-15 |
2023-08-12 |
rat |
| H Takano, I Komuro, Y Zou, S Kudoh, T Yamazaki, Y Yazak. Activation of p70 S6 protein kinase is necessary for angiotensin II-induced hypertrophy in neonatal rat cardiac myocytes. FEBS letters. vol 379. issue 3. 1996-05-15. PMID:8603701. |
these results suggest that ang ii induces cardiac hypertrophy by activating p70s6k. |
1996-05-15 |
2023-08-12 |
rat |
| G Wolf, F N Ziyadeh, G Zahner, R A Stah. Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: attenuation after stable transfection with the c-mas oncogene. Kidney international. vol 48. issue 6. 1996-03-27. PMID:8587241. |
angiotensin ii (ang ii) stimulates cellular hypertrophy of cultured murine proximal tubular cells (mct cells). |
1996-03-27 |
2023-08-12 |
Not clear |
| G Wolf, F N Ziyadeh, G Zahner, R A Stah. Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: attenuation after stable transfection with the c-mas oncogene. Kidney international. vol 48. issue 6. 1996-03-27. PMID:8587241. |
this ang ii-mediated hypertrophy depends on the endogenous induction and autocrine action of transforming growth factor-beta (tgf-beta). |
1996-03-27 |
2023-08-12 |
Not clear |
| G Wolf, F N Ziyadeh, G Zahner, R A Stah. Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: attenuation after stable transfection with the c-mas oncogene. Kidney international. vol 48. issue 6. 1996-03-27. PMID:8587241. |
we have previously demonstrated that permanent transfection of mct cells with the c-mas oncogene, whose protein product encodes a serpentine receptor-like moiety coupled to g proteins without an hitherto identified ligand, changes the hypertrophic actions of ang ii into a proliferative response (am j physiol 263: f931-f938, 1992). |
1996-03-27 |
2023-08-12 |
Not clear |
| F Fyhrquist, K Metsärinne, I Tikkane. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. Journal of human hypertension. vol 9 Suppl 5. 1996-03-20. PMID:8583476. |
exciting new discoveries concerned with polymorphisms of genes coding for angiotensin converting enzyme (ace) and angiotensinogen suggest that ang ii may be genetically associated with increased risk for myocardial infarction, hypertension and left ventricular hypertrophy. |
1996-03-20 |
2023-08-12 |
Not clear |