| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V M Mann, J M Cooper, A H Schapir. Quantitation of a mitochondrial DNA deletion in Parkinson's disease. FEBS letters. vol 299. issue 3. 1992-04-16. PMID:1544498. |
a 5 kilobase deletion in mitochondrial dna (mtdna) has been reported to be responsible for the specific complex i deficiency in the substantia nigra (sn) of the parkinson's disease (pd) brain. |
1992-04-16 |
2023-08-11 |
human |
| V Leviel, B Guibert, J Mallet, N Faucon-Bigue. Induction of tyrosine hydroxylase in the rat substantia nigra by local injection of forskolin. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1686787. |
forskolin (fsk) was locally injected into the substantia nigra (sn) of anesthetised rats. |
1992-04-15 |
2023-08-11 |
rat |
| M E Hall, J M Stewar. The substance P fragment SP(1-7) stimulates motor behavior and nigral dopamine release. Pharmacology, biochemistry, and behavior. vol 41. issue 1. 1992-04-02. PMID:1371611. |
earlier studies have shown that the undecapeptide substance p (sp) alters motor behavior and dopamine metabolism following injection into the substantia nigra (sn) in rat, even though the sn appears largely devoid of sp-specific (nk-1) receptors. |
1992-04-02 |
2023-08-11 |
rat |
| M E Old. Enhanced dopamine metabolism in accumbens leads to motor activity and concurrently to increased output from nondopamine neurons in ventral tegmental area and substantia nigra. Physiology & behavior. vol 51. issue 1. 1992-03-23. PMID:1311110. |
we previously have reported that nondopamine (non-da) neurons in substantia nigra (sn) and ventral tegmental area (vta) of the rat show increased discharge rates during amphetamine (amph) and apomorphine (apo)-induced motor activity. |
1992-03-23 |
2023-08-11 |
rat |
| S Morgan, G Nomikos, J P Husto. Changes in the nigrostriatal projection associated with recovery from lesion-induced behavioral asymmetry. Behavioural brain research. vol 46. issue 2. 1992-03-23. PMID:1786123. |
rats, with 6-ohda injected into the substantia nigra (sn) on one side, were either assigned to a group with a 48-hour survival period, or one with a 15-day recovery period. |
1992-03-23 |
2023-08-11 |
rat |
| C F Baxter, C C Oh, C G Wasterlain, L K Ozaki, R A Baldwi. Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state. Neurochemical research. vol 16. issue 3. 1992-03-10. PMID:1780028. |
seizure susceptibility and gaba metabolism were altered in the substantia nigra [sn] of adult male sprague dawley rats when these animals were acclimating to an altered plasma osmolality. |
1992-03-10 |
2023-08-11 |
rat |
| M Mavridis, F C Colpaert, M J Milla. Differential modulation of (+)-amphetamine-induced rotation in unilateral substantia nigra-lesioned rats by alpha 1 as compared to alpha 2 agonists and antagonists. Brain research. vol 562. issue 2. 1992-03-03. PMID:1685341. |
in rats sustaining unilateral 6-hydroxy-dopamine lesions of the substantia nigra (sn), the indirect dopaminergic agonist, (+)-amphetamine (amph), dose-dependently induced robust, ipsilateral rotation: this could be dose-dependently abolished by the dopamine (d2/d1) antagonist, haloperidol. |
1992-03-03 |
2023-08-11 |
rat |
| H Nissbrandt, G Engberg, E Pilebla. The effects of GBR 12909, a dopamine re-uptake inhibitor, on monoaminergic neurotransmission in rat striatum, limbic forebrain, cortical hemispheres and substantia nigra. Naunyn-Schmiedeberg's archives of pharmacology. vol 344. issue 1. 1992-03-02. PMID:1663587. |
in order to investigate the physiological importance of the membrane pump in eliminating released dopamine (da) we have studied the effects of the putative selective dopamine re-uptake inhibitor, gbr 12909, on synthesis and metabolism of monoamines in the rat striatum, limbic forebrain, cortical hemispheres and substantia nigra (sn). |
1992-03-02 |
2023-08-11 |
rat |
| K R Melia, K Rasmussen, R Z Terwilliger, J W Haycock, E J Nestler, R S Duma. Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments. Journal of neurochemistry. vol 58. issue 2. 1992-02-13. PMID:1345939. |
chronic (5 days) cold exposure significantly increased levels of th immunoreactivity in the lc, as previously reported, but not in substantia nigra (sn) or ventral tegmentum (vt), two dopaminergic nuclei studied for comparison. |
1992-02-13 |
2023-08-11 |
rat |
| S C Hu, F W Chang, Y J Sung, W M Hsu, E H Le. Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the substantia nigra and the locus coeruleus in BALB/c mice. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1684822. |
the purpose of the present study was to determine whether 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), administered systemically or as a local infusion, has a direct neurotoxic action upon dopamine (da) neurons in the substantia nigra (sn) and norepinephrine (ne) neurons in the locus coeruleus (lc) in balb/c mice. |
1992-02-07 |
2023-08-11 |
mouse |
| A R Granata, S T Kita. Inhibitory substantia nigra inputs to the pedunculopontine neurons. Experimental brain research. vol 86. issue 3. 1992-02-07. PMID:1761086. |
responses of 43 pedunculopontine area (ppn area) neurons to electrical stimulation of the substantia nigra (sn) were studied in anesthetized rats. |
1992-02-07 |
2023-08-11 |
rat |
| G Pezzoli, A Zecchinelli, S Ricciardi, R E Burke, S Fahn, G Scarlato, A Carenz. Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats. Movement disorders : official journal of the Movement Disorder Society. vol 6. issue 4. 1992-02-05. PMID:1684638. |
we assessed the effect of a 35-day delayed intracerebroventricular (icv) infusion of epidermal growth factor (egf) on the survival and function of the substantia nigra (sn) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. |
1992-02-05 |
2023-08-11 |
rat |
| A Elverfors, H Nissbrand. Reserpine-insensitive dopamine release in the substantia nigra? Brain research. vol 557. issue 1-2. 1992-01-22. PMID:1720998. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic pathway, but also from the dendrites in the substantia nigra (sn). |
1992-01-22 |
2023-08-11 |
Not clear |
| P Robledo, J Fege. Acute monoaminergic depletion in the rat potentiates the excitatory effect of the subthalamic nucleus in the substantia nigra pars reticulata but not in the pallidal complex. Journal of neural transmission. General section. vol 86. issue 2. 1992-01-02. PMID:1683238. |
recent neurochemical evidence suggests that chemical or electrical stimulation of the subthalamic nucleus (sth) increases dopamine release in the substantia nigra (sn) with a subsequent decrease in the striatum. |
1992-01-02 |
2023-08-11 |
rat |
| E Stefanini, M Frau, G L Gess. Increase in D2 dopamine receptors in the substantia nigra after chronic (-)-sulpiride treatment. Brain research. vol 555. issue 2. 1991-12-23. PMID:1834311. |
changes in d2 dopamine (da) receptors in the substantia nigra (sn) and caudate nucleus (cn) homogenates were studied in rats following chronic treatment with the specific d2 receptor antagonist (-)-sulpiride (50 mg/kg s.c. twice daily for 8 days). |
1991-12-23 |
2023-08-11 |
rat |
| M Vankova, M Arluison, P A Boyer, S Bourgoin, M Quigno. Enkephalin-containing nerve cell bodies in the substantia nigra of the rat: demonstration by immunohistochemistry and in situ hybridization. Brain research bulletin. vol 27. issue 1. 1991-12-23. PMID:1933430. |
the use of a new and very sensitive immunohistochemical method, combined with intracerebral injections of colchicine, has allowed us to show that a number of nerve cell bodies immunoreactive for met-enkephalin are present in several mesencephalic nuclei of the rat, including the different subdivisions of the substantia nigra (sn). |
1991-12-23 |
2023-08-11 |
rat |
| D Ben-Shachar, M B Youdi. Intranigral iron injection induces behavioral and biochemical "parkinsonism" in rats. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1940919. |
elevated iron concentrations in the substantia nigra (sn) pars compacta have been implicated in the development of idiopathic parkinson's disease. |
1991-12-18 |
2023-08-11 |
rat |
| A Jedrzejewska, J Dymeck. Intrastriatal grafts of adrenal medulla in hemiparkinsonian rats--ultrastructural study. Acta neurobiologiae experimentalis. vol 50. issue 4-5. 1991-11-13. PMID:2130657. |
the aim of the study was to investigate the ultrastructure of the right striatum after intrastriatal adrenal medulla grafts in wistar rats with a 6-ohda unilateral lesion of the compact part of the right substantia nigra (sn). |
1991-11-13 |
2023-08-11 |
rat |
| P A Rao, P B Molinoff, J N Joyc. Ontogeny of dopamine D1 and D2 receptor subtypes in rat basal ganglia: a quantitative autoradiographic study. Brain research. Developmental brain research. vol 60. issue 2. 1991-10-21. PMID:1832594. |
the differential development of the da receptors was also evident in the substantia nigra (sn) and globus pallidus (gp). |
1991-10-21 |
2023-08-11 |
rat |
| J R Taylor, J D Elsworth, R H Roth, J R Sladek, T J Collier, D E Redmon. Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls. Experimental brain research. vol 85. issue 2. 1991-10-21. PMID:1893983. |
fetal substantia nigra (sn) cells were transplanted into the caudate nucleus (cn) of four vervet monkeys (cercopithecus aethiops sabaeus) that had been treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
1991-10-21 |
2023-08-11 |
human |